NAPG

Summary

NAPG (NSF attachment protein gamma, HGNC:7642) is a protein-coding gene on chromosome 18p11.22, encoding Gamma-soluble NSF attachment protein (Q99747). Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. It is a selective cancer dependency (DepMap: 66.6% of cell lines).

This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.

Source: NCBI Gene 8774 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 56 total — 2 pathogenic
• Cancer dependency (DepMap): dependent in 66.6% of screened cell lines
• MANE Select transcript: NM_003826

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7642
Approved symbol	NAPG
Name	NSF attachment protein gamma
Location	18p11.22
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000134265
Ensembl biotype	protein_coding
OMIM	603216
Entrez	8774

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 6 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000322897, ENST00000580224, ENST00000580483, ENST00000580746, ENST00000582472, ENST00000582978, ENST00000583367, ENST00000945386, ENST00000945387, ENST00000945388, ENST00000945389

RefSeq mRNA: 1 — MANE Select: NM_003826 NM_003826

CCDS: CCDS45827

Canonical transcript exons

ENST00000322897 — 12 exons

Exon	Start	End
ENSE00002705350	10526027	10526158
ENSE00002732267	10550077	10552764
ENSE00003504783	10533536	10533553
ENSE00003513192	10546326	10546404
ENSE00003529068	10540329	10540399
ENSE00003532962	10539988	10540054
ENSE00003535665	10532711	10532795
ENSE00003579684	10534466	10534496
ENSE00003606011	10548967	10549096
ENSE00003659994	10548299	10548378
ENSE00003662373	10530770	10530837
ENSE00003725102	10539762	10539871

Expression profiles

Bgee: expression breadth ubiquitous, 277 present calls, max score 96.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.2207 / max 961.6922, expressed in 1812 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
169418	11.6136	1757
169417	10.6469	1766
169414	1.5594	858
169420	0.4008	154

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	96.41	gold quality
pons	UBERON:0000988	96.32	gold quality
adrenal tissue	UBERON:0018303	92.52	gold quality
substantia nigra pars compacta	UBERON:0001965	92.22	gold quality
Brodmann (1909) area 23	UBERON:0013554	92.01	gold quality
islet of Langerhans	UBERON:0000006	91.86	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.59	gold quality
lateral nuclear group of thalamus	UBERON:0002736	91.57	gold quality
middle temporal gyrus	UBERON:0002771	91.47	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.21	gold quality
prefrontal cortex	UBERON:0000451	91.00	gold quality
calcaneal tendon	UBERON:0003701	90.65	gold quality
substantia nigra pars reticulata	UBERON:0001966	90.53	gold quality
spinal cord	UBERON:0002240	90.45	gold quality
superior vestibular nucleus	UBERON:0007227	90.14	gold quality
Ammon’s horn	UBERON:0001954	89.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.83	gold quality
right frontal lobe	UBERON:0002810	89.79	gold quality
nucleus accumbens	UBERON:0001882	89.78	gold quality
primary visual cortex	UBERON:0002436	89.77	gold quality
cingulate cortex	UBERON:0003027	89.77	gold quality
anterior cingulate cortex	UBERON:0009835	89.60	gold quality
superior frontal gyrus	UBERON:0002661	89.53	gold quality
parietal lobe	UBERON:0001872	89.48	gold quality
cerebral cortex	UBERON:0000956	89.36	gold quality
postcentral gyrus	UBERON:0002581	89.25	gold quality
cerebellar hemisphere	UBERON:0002245	89.15	gold quality
corpus callosum	UBERON:0002336	89.14	gold quality
cerebellar cortex	UBERON:0002129	89.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.72

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

128 targeting NAPG, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 66.6% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• The functional domains of this protein are mapped. (PMID:12554740)
• Our study supports NAPG as a candidate for susceptibility to bipolar disorder as several combinations of haplotype were found to be associated with bipolar disorder. (PMID:19429185)
• study did not support NAPG as a susceptible gene for schizophrenia in the Chinese Han population (PMID:22113424)
• NAPG mutation in family members with hereditary hemorrhagic telangiectasia in China. (PMID:34112136)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	napga	ENSDARG00000006617
danio_rerio	napgb	ENSDARG00000043012
mus_musculus	Napg	ENSMUSG00000024581
rattus_norvegicus	Napg	ENSRNOG00000018914
drosophila_melanogaster	gammaSnap1	FBGN0028552
drosophila_melanogaster	gammaSnap2	FBGN0266721
caenorhabditis_elegans		WBGENE00013345
caenorhabditis_elegans		WBGENE00044794

Paralogs (2): NAPA (ENSG00000105402), NAPB (ENSG00000125814)

Protein

Protein identifiers

Gamma-soluble NSF attachment protein — Q99747 (reviewed: Q99747)

Alternative names: N-ethylmaleimide-sensitive factor attachment protein gamma

All UniProt accessions (5): Q99747, J3KTJ6, J3QKW4, J3QS28, Q6FHY4

UniProt curated annotations — full annotation on UniProt →

Function. Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Subunit / interactions. Interacts with RAB11FIP5. Interacts with VTI1A.

Subcellular location. Membrane. Golgi apparatus.

Similarity. Belongs to the SNAP family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q99747-1	1	yes
Q99747-2	2

RefSeq proteins (1): NP_003817* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000744	NSF_attach	Family
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily

Pfam: PF14938

UniProt features (10 total): modified residue 3, sequence variant 2, chain 1, region of interest 1, compositionally biased region 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99747-F1	91.67	0.87

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 284, 287, 308

Function

Pathways and Gene Ontology

Reactome pathways

14 pathways

ID	Pathway
R-HSA-204005	COPII-mediated vesicle transport
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811438	Intra-Golgi traffic
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network
R-HSA-199977	ER to Golgi Anterograde Transport
R-HSA-199991	Membrane Trafficking
R-HSA-392499	Metabolism of proteins
R-HSA-446203	Asparagine N-linked glycosylation
R-HSA-5653656	Vesicle-mediated transport
R-HSA-597592	Post-translational protein modification
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8856688	Golgi-to-ER retrograde transport
R-HSA-948021	Transport to the Golgi and subsequent modification

MSigDB gene sets: 0 (showing top):

GO Biological Process (7): intracellular protein transport (GO:0006886), intra-Golgi vesicle-mediated transport (GO:0006891), protein stabilization (GO:0050821), membrane fusion (GO:0061025), protein-containing complex assembly (GO:0065003), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192)

GO Molecular Function (3): soluble NSF attachment protein activity (GO:0005483), syntaxin binding (GO:0019905), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), lysosomal membrane (GO:0005765), Golgi apparatus (GO:0005794), SNARE complex (GO:0031201), extracellular exosome (GO:0070062), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-9 pathways:

Category	Pathways
Intra-Golgi and retrograde Golgi-to-ER traffic	3
ER to Golgi Anterograde Transport	2
Membrane Trafficking	2
Golgi-to-ER retrograde transport	1
Transport to the Golgi and subsequent modification	1
Vesicle-mediated transport	1
Post-translational protein modification	1
Metabolism of proteins	1
Asparagine N-linked glycosylation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
intracellular protein localization	2
transport	2
intracellular membrane-bounded organelle	2
protein transport	1
intracellular transport	1
Golgi vesicle transport	1
regulation of protein stability	1
membrane organization	1
cellular component assembly	1
protein-containing complex organization	1
establishment of protein localization	1
cellular process	1
protein-macromolecule adaptor activity	1
SNARE binding	1
binding	1
lysosome	1
lytic vacuole membrane	1
endomembrane system	1
membrane protein complex	1
extracellular vesicle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1070 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NAPG	NAPA	P54920	974
NAPG	NSF	P46459	828
NAPG	STX2	P32856	796
NAPG	STX4	Q12846	713
NAPG	GNA12	Q03113	641
NAPG	GOSR1	O95249	597
NAPG	STX16	O14662	551
NAPG	CDH5	P33151	549
NAPG	NAPB	Q9H115	532
NAPG	VAMP2	P19065	510
NAPG	STXBP1	P61764	490
NAPG	SNAP25	P13795	489
NAPG	STX12	Q86Y82	483
NAPG	LZIC	Q8WZA0	468
NAPG	VAMP3	Q15836	460

IntAct

107 interactions, top by confidence:

A	B	Type	Score
STX11	SNAP23	psi-mi:“MI:0914”(association)	0.900
STX18	NBAS	psi-mi:“MI:0914”(association)	0.810
VPS25	VPS36	psi-mi:“MI:0914”(association)	0.800
NAPA	SNAP23	psi-mi:“MI:0914”(association)	0.780
NAPG	NSF	psi-mi:“MI:0914”(association)	0.640
STX7	SNAP23	psi-mi:“MI:0914”(association)	0.640
STX12	SNAP23	psi-mi:“MI:0914”(association)	0.640
NAPA	NBAS	psi-mi:“MI:0914”(association)	0.530
FAM177A1	SLC27A2	psi-mi:“MI:0914”(association)	0.530
PIPOX	ZNF217	psi-mi:“MI:0914”(association)	0.530
PRPSAP2	CCNB1	psi-mi:“MI:0914”(association)	0.530
VAMP5	NBAS	psi-mi:“MI:0914”(association)	0.530
NUFIP1	PDE2A	psi-mi:“MI:0914”(association)	0.530
CPNE5	RAD21	psi-mi:“MI:0914”(association)	0.530
STX3	NBAS	psi-mi:“MI:0914”(association)	0.530
FAIM	WDR47	psi-mi:“MI:0914”(association)	0.500
BET1	SNAP23	psi-mi:“MI:0914”(association)	0.420
NAPG		psi-mi:“MI:0915”(physical association)	0.370
Kif13b	TCF3	psi-mi:“MI:0914”(association)	0.350
Tecpr2	PUF60	psi-mi:“MI:0914”(association)	0.350
PLEKHA7	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
VAMP5	ESYT2	psi-mi:“MI:0914”(association)	0.350
STX6	NBAS	psi-mi:“MI:0914”(association)	0.350
VAMP4	NBAS	psi-mi:“MI:0914”(association)	0.350

BioGRID (150): RAB11FIP5 (Reconstituted Complex), RAB11FIP5 (Two-hybrid), NAPG (Affinity Capture-Western), Rab11fip5 (Reconstituted Complex), TUBG1 (Reconstituted Complex), NAPG (Affinity Capture-MS), NAPG (Affinity Capture-MS), NAPG (Affinity Capture-MS), NAPG (Affinity Capture-MS), AKAP11 (Affinity Capture-MS), NAPA (Affinity Capture-MS), SCFD2 (Affinity Capture-MS), PRKACB (Affinity Capture-MS), PRKAR1B (Affinity Capture-MS), VAMP4 (Affinity Capture-MS)

ESM2 similar proteins: A1Z6M6, A8XHX1, O16259, O35814, O54981, P0C1I1, P15705, P23231, P26882, P31948, P32602, P34560, P78603, P81127, Q05036, Q08752, Q20683, Q20938, Q2U0E0, Q3ZBZ8, Q4P7J4, Q4R8N7, Q54DA8, Q54IP0, Q54NP6, Q5B3U7, Q5R8D8, Q60864, Q6BLG8, Q6BXZ7, Q6CBP4, Q6CFI3, Q6CFJ0, Q6CL78, Q6DGG0, Q75D68, Q7SI58, Q7ZWU1, Q8ILC1, Q8VWG7

Diamond homologs: P81127, Q99747, Q9CWZ7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 97 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Intra-Golgi traffic	7	29.3×	1e-06
Retrograde transport at the Trans-Golgi-Network	6	21.2×	5e-05
COPII-mediated vesicle transport	5	13.2×	2e-03
COPI-dependent Golgi-to-ER retrograde traffic	7	12.5×	1e-04
COPI-mediated anterograde transport	7	12.4×	1e-04
Intra-Golgi and retrograde Golgi-to-ER traffic	7	11.8×	1e-04
Golgi-to-ER retrograde transport	5	10.7×	3e-03
Membrane Trafficking	9	5.4×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
obsolete vesicle docking	7	60.9×	8e-09
vesicle fusion	7	47.9×	3e-08
intra-Golgi vesicle-mediated transport	6	35.9×	2e-06
membrane fusion	5	35.5×	3e-05
endocytic recycling	5	15.2×	2e-03
intracellular protein transport	12	8.8×	2e-06
protein transport	10	5.0×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	33
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
146198	GRCh38/hg38 18p11.32-11.21(chr18:148963-14081888)x4	Pathogenic
1526593	GRCh37/hg19 18p11.32-11.21(chr18:136226-14983938)	Pathogenic

SpliceAI

2201 predictions. Top by Δscore:

Variant	Effect	Δscore
18:10526154:AAATA:A	donor_gain	1.0000
18:10526155:AATA:A	donor_gain	1.0000
18:10526156:ATA:A	donor_gain	1.0000
18:10526157:TA:T	donor_gain	1.0000
18:10526158:AG:A	donor_loss	1.0000
18:10526159:GTGA:G	donor_gain	1.0000
18:10526161:GA:G	donor_gain	1.0000
18:10526163:G:GG	donor_gain	1.0000
18:10528985:T:TA	acceptor_gain	1.0000
18:10528987:T:TA	acceptor_gain	1.0000
18:10528988:G:A	acceptor_gain	1.0000
18:10530768:A:AG	acceptor_gain	1.0000
18:10530769:G:GG	acceptor_gain	1.0000
18:10532793:G:GT	donor_gain	1.0000
18:10533509:A:AG	acceptor_gain	1.0000
18:10533510:A:G	acceptor_gain	1.0000
18:10533514:T:TA	acceptor_gain	1.0000
18:10539481:G:GT	donor_gain	1.0000
18:10539732:T:A	acceptor_gain	1.0000
18:10539744:T:A	acceptor_gain	1.0000
18:10539753:T:TA	acceptor_gain	1.0000
18:10539758:A:AG	acceptor_gain	1.0000
18:10539761:GGA:G	acceptor_gain	1.0000
18:10539867:GGAAA:G	donor_gain	1.0000
18:10539868:GAAA:G	donor_gain	1.0000
18:10539868:GAAAG:G	donor_gain	1.0000
18:10539869:A:T	donor_gain	1.0000
18:10539870:AAGT:A	donor_loss	1.0000
18:10539871:AG:A	donor_loss	1.0000
18:10539872:G:GG	donor_gain	1.0000

AlphaMissense

2041 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:10526127:G:T	G9W	1.000
18:10530814:C:A	A34D	1.000
18:10532746:G:C	A54P	1.000
18:10533550:C:A	A75D	1.000
18:10534483:G:A	G82E	1.000
18:10548327:T:C	L205P	1.000
18:10526128:G:A	G9E	0.999
18:10530813:G:C	A34P	0.999
18:10530817:C:A	A35D	0.999
18:10530834:G:C	A41P	0.999
18:10532724:A:C	K46N	0.999
18:10532724:A:T	K46N	0.999
18:10532728:G:C	A48P	0.999
18:10532770:G:C	A62P	0.999
18:10533540:T:C	F72L	0.999
18:10533542:T:A	F72L	0.999
18:10533542:T:G	F72L	0.999
18:10533546:G:C	A74P	0.999
18:10533547:C:A	A74D	0.999
18:10533549:G:C	A75P	0.999
18:10534479:G:C	A81P	0.999
18:10534482:G:A	G82R	0.999
18:10534482:G:C	G82R	0.999
18:10539783:G:C	A94P	0.999
18:10539804:G:C	A101P	0.999
18:10539805:C:A	A101D	0.999
18:10539843:G:C	A114P	0.999
18:10539844:C:A	A114E	0.999
18:10539847:C:A	A115D	0.999
18:10539862:G:C	R120P	0.999

dbSNP variants (sampled 300 via entrez): RS1000087769 (18:10535764 GTAATAA>G,GTAA,GTAATAATAA), RS1000139316 (18:10542074 TG>T), RS1000408137 (18:10524300 A>C,T), RS1000544444 (18:10535501 C>T), RS1000549051 (18:10551005 T>G), RS1000758091 (18:10524534 C>T), RS1000781762 (18:10525553 G>T), RS1000796145 (18:10528055 G>A), RS1000915305 (18:10528312 G>T), RS1001090760 (18:10536912 T>G), RS1001121630 (18:10534298 A>G), RS1001122987 (18:10528445 A>G,T), RS1001175320 (18:10528092 A>G), RS1001345729 (18:10525899 C>T), RS1001406042 (18:10534101 C>T)

Disease associations

OMIM: gene MIM:603216 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST001210_1	Non-small cell lung cancer	1.000000e-06
GCST003875_20	Gut microbiota (bacterial taxa)	3.000000e-11
GCST003875_21	Gut microbiota (bacterial taxa)	3.000000e-11
GCST003875_22	Gut microbiota (bacterial taxa)	3.000000e-11
GCST009391_1108	Metabolite levels	3.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007874	gut microbiome measurement
EFO:0007883	taxonomic microbiome measurement
EFO:0010448	3-hydroxyphenylacetic acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, decreases methylation	5
Benzo(a)pyrene	decreases methylation, increases expression	3
Tobacco Smoke Pollution	affects expression, increases expression	2
FR900359	decreases phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	increases expression	1
bisphenol A	increases expression	1
potassium perchlorate	decreases expression	1
methylparaben	increases expression	1
sodium arsenite	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
microcystin RR	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Vorinostat	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	increases expression	1
Caffeine	decreases phosphorylation	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.