NBAT1

Summary

NBAT1 (neuroblastoma associated transcript 1, HGNC:49075) is a long non-coding RNA gene on chromosome 6p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49075
Approved symbol	NBAT1
Name	neuroblastoma associated transcript 1
Location	6p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NBAT-1
Ensembl gene	ENSG00000260455
Ensembl biotype	lncRNA
OMIM	616206
Entrez	729177
RNAcentral	URS0000759BF6 — lncRNA, 2308 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000566912, ENST00000823290, ENST00000823291, ENST00000823292, ENST00000823293, ENST00000823294, ENST00000823295

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000566912 — 3 exons

Exon	Start	End
ENSE00002585740	22147040	22147193
ENSE00002623346	22133205	22136669
ENSE00002626160	22146679	22146751

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 66.75.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	66.75	gold quality
colonic epithelium	UBERON:0000397	66.00	silver quality
cortical plate	UBERON:0005343	65.81	gold quality
thymus	UBERON:0002370	63.05	gold quality
endometrium	UBERON:0001295	61.78	gold quality
quadriceps femoris	UBERON:0001377	61.63	gold quality
ganglionic eminence	UBERON:0004023	60.15	gold quality
ventricular zone	UBERON:0003053	59.37	silver quality
stromal cell of endometrium	CL:0002255	58.66	gold quality
cerebellar vermis	UBERON:0004720	58.50	gold quality
prefrontal cortex	UBERON:0000451	57.61	gold quality
spleen	UBERON:0002106	57.47	silver quality
calcaneal tendon	UBERON:0003701	57.17	gold quality
urinary bladder	UBERON:0001255	55.95	gold quality
bone marrow	UBERON:0002371	55.71	silver quality
nucleus accumbens	UBERON:0001882	55.38	gold quality
skeletal muscle tissue	UBERON:0001134	55.04	silver quality
liver	UBERON:0002107	54.28	silver quality
frontal cortex	UBERON:0001870	53.72	gold quality
adrenal tissue	UBERON:0018303	53.31	gold quality
superior frontal gyrus	UBERON:0002661	53.16	gold quality
kidney	UBERON:0002113	52.89	gold quality
sural nerve	UBERON:0015488	52.79	silver quality
putamen	UBERON:0001874	52.74	gold quality
caudate nucleus	UBERON:0001873	52.14	gold quality
cerebral cortex	UBERON:0000956	51.79	gold quality
smooth muscle tissue	UBERON:0001135	51.16	gold quality
brain	UBERON:0000955	50.94	gold quality
monocyte	CL:0000576	50.81	silver quality
blood	UBERON:0000178	50.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• Loss of NBAT-1 contributes to aggressive neuroblastoma by increasing proliferation and impairing differentiation of neuronal precursors. (PMID:25517750)
• DKK1 is found to be regulated by NBAT1 in a PRC2 dependent manner, and is responsible for NBAT1’s effects in inhibiting migration and invasion of breast cancer cells. (PMID:26378045)
• The overexpression of lncRNA NBAT-1 could inhibit the proliferation and cell cycle, promote the apoptosis of A549 cells, and down-regulate the expression level of RAC1. (PMID:29687849)
• Up-regulation of NBAT1 inhibited proliferative activities of glioblastoma tumor cells by regulating Akt activity. (PMID:29771423)
• NBAT-1 overexpression remarkably upregulated PTEN expression in gastric cancer (GC) cells. Low expression of NBAT-1 promotes GC development by downregulating PTEN expression. (PMID:31128020)
• Low NBAT1 expression is associated with cell proliferation, migration, and invasion in renal carcinoma. (PMID:31298469)
• Expression of long noncoding RNA NBAT1 is associated with the outcome of patients with non-small cell lung cancer. (PMID:32844929)
• Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma. (PMID:33372039)
• Long noncoding RNA NBAT1 suppresses hepatocellular carcinoma progression via competitively associating with IGF2BP1 and decreasing c-Myc expression. (PMID:33387362)
• Serum lncRNAs, NBAT-1, and FOXCUT signature in hepatocellular carcinoma developed on top of chronic hepatitis C. (PMID:36440815)
• Expression level and clinical significance of NBAT-1 in human cancers: a systematic review and meta-analysis. (PMID:38243168)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.