NBR2

Summary

NBR2 (neighbor of BRCA1 lncRNA 2, HGNC:20691) is a long non-coding RNA gene on chromosome 17q21.31.

This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response.

Source: NCBI Gene 10230 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20691
Approved symbol	NBR2
Name	neighbor of BRCA1 lncRNA 2
Location	17q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00192
Ensembl gene	ENSG00000198496
Ensembl biotype	lncRNA
OMIM	618708
Entrez	10230
RNAcentral	URS0000A77648 — lncRNA, 1512 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000356906, ENST00000460115, ENST00000467245, ENST00000657841, ENST00000790195, ENST00000790196, ENST00000790197, ENST00000790198, ENST00000790199, ENST00000790200, ENST00000790201, ENST00000790202, ENST00000790203, ENST00000790204, ENST00000790205, ENST00000790206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000356906 — 4 exons

Exon	Start	End
ENSE00001295162	43139816	43140333
ENSE00002944137	43138657	43138922
ENSE00003828833	43131208	43131270
ENSE00004170207	43125420	43125770

Expression profiles

Bgee: expression breadth ubiquitous, 214 present calls, max score 87.29.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.8719 / max 182.2081, expressed in 1798 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
161053	8.9850	1766
161054	6.8869	1617

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oviduct epithelium	UBERON:0004804	87.29	gold quality
mucosa of transverse colon	UBERON:0004991	86.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.49	gold quality
right lobe of liver	UBERON:0001114	82.35	gold quality
right lobe of thyroid gland	UBERON:0001119	81.68	gold quality
left lobe of thyroid gland	UBERON:0001120	81.58	gold quality
thyroid gland	UBERON:0002046	81.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	80.88	gold quality
transverse colon	UBERON:0001157	80.86	gold quality
right uterine tube	UBERON:0001302	80.71	gold quality
secondary oocyte	CL:0000655	80.46	gold quality
buccal mucosa cell	CL:0002336	80.36	silver quality
right ovary	UBERON:0002118	80.10	gold quality
body of stomach	UBERON:0001161	79.84	gold quality
lower esophagus mucosa	UBERON:0035834	79.69	gold quality
minor salivary gland	UBERON:0001830	79.60	gold quality
colonic epithelium	UBERON:0000397	79.36	gold quality
stromal cell of endometrium	CL:0002255	79.27	gold quality
spleen	UBERON:0002106	79.18	gold quality
right adrenal gland	UBERON:0001233	79.04	gold quality
rectum	UBERON:0001052	79.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.97	gold quality
small intestine	UBERON:0002108	78.95	gold quality
prostate gland	UBERON:0002367	78.91	gold quality
skin of leg	UBERON:0001511	78.77	gold quality
body of pancreas	UBERON:0001150	78.69	gold quality
right adrenal gland cortex	UBERON:0035827	78.65	gold quality
skin of abdomen	UBERON:0001416	78.61	gold quality
left ovary	UBERON:0002119	78.51	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Data indicate that long non-coding RNAs (lncRNAs) NBR2 (neighbour of BRCA1 gene 2) interacts with AMP-activated kinase (AMPK) and promotes AMPK kinase activity during energy stress. (PMID:26999735)
• Data indicate that long non-coding RNAs (lncRNAs) NBR2 (neighbour of BRCA1 gene 2) modulates cancer cell sensitivity to phenformin through NBR2 regulation of GLUT1 expression at transcriptional level. (PMID:27792451)
• NBR2-GLUT1 axis may serve as an adaptive response in cancer cells to survive in response to phenformin treatment. (PMID:27792451)
• High NBR2 expression is associated with breast cancer. (PMID:28249151)
• data suggested that miR-19a negatively controlled the autophagy of hepatocytes attenuated in D-GalN/LPS-stimulated hepatocytes via regulating NBR2 and AMPK/PPARalpha signaling. (PMID:28586153)
• LncRNA NBR2 inhibits EMT progression by regulating Notch1 pathway in NSCLC. (PMID:31599420)
• This study revealed a novel mechanism by which long noncoding RNA NBR2 mediates curcumin suppression of colorectal cancer proliferation by activating adenosine monophosphate-activated protein kinase and inactivating the mTOR signaling pathway. (PMID:31888414)
• LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma. (PMID:33378941)
• LncRNA NBR2 aggravates hepatoblastoma cell malignancy and promotes cell proliferation under glucose starvation through the miR-22/TCF7 axis. (PMID:33651649)
• NBR2 promotes the proliferation of glioma cells via inhibiting p15 expression. (PMID:34076984)
• Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM. (PMID:34506209)
• LncRNA NBR2 Regulates Cancer Cell Stemness and Predicts Survival in Non-small Cell Cancer Patients by Downregulating TGF-beta1. (PMID:35909269)
• NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis. (PMID:35951458)
• Long non-coding RNA NBR2 suppresses the progression of colorectal cancer by downregulating miR-19a to regulate M2 macrophage polarization. (PMID:38149567)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.