NCAL1

Summary

NCAL1 (NK cell activity associated lncRNA 1, HGNC:56663) is a long non-coding RNA gene on chromosome 2p11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56663
Approved symbol	NCAL1
Name	NK cell activity associated lncRNA 1
Location	2p11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000284879
Ensembl biotype	lncRNA
Entrez	128193293
RNAcentral	URS00026A2723 — lncRNA, 2241 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000643276, ENST00000646855

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000643276 — 18 exons

Exon	Start	End
ENSE00003814722	87738023	87738105
ENSE00003815091	87716612	87716790
ENSE00003815738	87737718	87737852
ENSE00003815902	87722301	87722419
ENSE00003816805	87606593	87606769
ENSE00003819158	87732387	87732621
ENSE00003820472	87583258	87583346
ENSE00003820682	87739017	87739214
ENSE00003820868	87735674	87735765
ENSE00003820952	87707762	87707910
ENSE00003820963	87725937	87726208
ENSE00003821229	87713359	87713437
ENSE00003822629	87719807	87720021
ENSE00003823497	87700984	87701053
ENSE00003827166	87714179	87714249
ENSE00003829146	87714048	87714084
ENSE00003829665	87704333	87704600
ENSE00003831213	87455476	87455645

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 86.64.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	86.64	gold quality
stromal cell of endometrium	CL:0002255	80.81	gold quality
liver	UBERON:0002107	80.81	gold quality
cerebellar hemisphere	UBERON:0002245	79.22	gold quality
cerebellar cortex	UBERON:0002129	79.12	gold quality
cerebellum	UBERON:0002037	79.01	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.57	gold quality
monocyte	CL:0000576	77.11	gold quality
leukocyte	CL:0000738	76.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.35	silver quality
bone marrow	UBERON:0002371	74.78	gold quality
bone marrow cell	CL:0002092	73.20	gold quality
islet of Langerhans	UBERON:0000006	72.86	gold quality
right coronary artery	UBERON:0001625	72.75	gold quality
blood	UBERON:0000178	72.12	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.09	gold quality
popliteal artery	UBERON:0002250	71.83	gold quality
tibial artery	UBERON:0007610	71.82	gold quality
adipose tissue	UBERON:0001013	71.80	gold quality
ascending aorta	UBERON:0001496	71.66	gold quality
thoracic aorta	UBERON:0001515	71.57	gold quality
omental fat pad	UBERON:0010414	71.54	gold quality
colonic epithelium	UBERON:0000397	71.09	silver quality
heart left ventricle	UBERON:0002084	70.72	gold quality
descending thoracic aorta	UBERON:0002345	70.68	gold quality
left coronary artery	UBERON:0001626	70.56	gold quality
spleen	UBERON:0002106	70.55	gold quality
calcaneal tendon	UBERON:0003701	70.55	gold quality
smooth muscle tissue	UBERON:0001135	70.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.57

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.