NCCRP1

Summary

NCCRP1 (NCCRP1, F-box associated domain containing, HGNC:33739) is a protein-coding gene on chromosome 19q13.2, encoding F-box only protein 50 (Q6ZVX7). Promotes cell proliferation.

Predicted to contribute to ubiquitin protein ligase activity. Involved in positive regulation of cell population proliferation. Located in cytosol.

Source: NCBI Gene 342897 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_001001414

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33739
Approved symbol	NCCRP1
Name	NCCRP1, F-box associated domain containing
Location	19q13.2
Locus type	gene with protein product
Status	Approved
Aliases	LOC342897, NCCRP-1, FBXO50
Ensembl gene	ENSG00000188505
Ensembl biotype	protein_coding
OMIM	615901
Entrez	342897

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000339852, ENST00000855675

RefSeq mRNA: 1 — MANE Select: NM_001001414 NM_001001414

CCDS: CCDS12529

Canonical transcript exons

ENST00000339852 — 6 exons

Exon	Start	End
ENSE00001364171	39199170	39199265
ENSE00001372877	39198053	39198115
ENSE00001373664	39196964	39197319
ENSE00001374775	39200346	39200484
ENSE00001374852	39200616	39201884
ENSE00001389639	39198202	39198253

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 99.56.

FANTOM5 (CAGE): breadth broad, TPM avg 4.9297 / max 1564.3523, expressed in 314 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175688	4.0548	284
175687	0.8749	211

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	99.56	gold quality
esophagus mucosa	UBERON:0002469	97.82	gold quality
skin of leg	UBERON:0001511	97.57	gold quality
zone of skin	UBERON:0000014	97.56	gold quality
skin of abdomen	UBERON:0001416	97.55	gold quality
vagina	UBERON:0000996	87.69	gold quality
body of pancreas	UBERON:0001150	77.06	gold quality
esophagus	UBERON:0001043	76.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.75	gold quality
tonsil	UBERON:0002372	73.75	gold quality
minor salivary gland	UBERON:0001830	73.69	gold quality
saliva-secreting gland	UBERON:0001044	72.38	gold quality
pancreas	UBERON:0001264	71.15	gold quality
adult mammalian kidney	UBERON:0000082	64.33	gold quality
placenta	UBERON:0001987	63.83	gold quality
ectocervix	UBERON:0012249	62.72	gold quality
vermiform appendix	UBERON:0001154	62.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	62.02	gold quality
uterine cervix	UBERON:0000002	61.70	gold quality
kidney	UBERON:0002113	61.10	gold quality
urinary bladder	UBERON:0001255	60.83	gold quality
islet of Langerhans	UBERON:0000006	60.38	gold quality
cortex of kidney	UBERON:0001225	58.83	gold quality
duodenum	UBERON:0002114	58.80	gold quality
metanephros cortex	UBERON:0010533	57.29	gold quality
mucosa of transverse colon	UBERON:0004991	56.82	gold quality
rectum	UBERON:0001052	56.63	gold quality
left uterine tube	UBERON:0001303	55.80	gold quality
thoracic mammary gland	UBERON:0005200	55.46	gold quality
lymph node	UBERON:0000029	55.21	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7381	yes	825.43
E-ANND-3	yes	4.07
E-MTAB-5061	no	3.53

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

51 targeting NCCRP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-4276	99.56	67.66	2514
HSA-MIR-4489	99.50	65.56	785
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-7854-3P	99.08	66.26	1117
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-6889-3P	98.84	67.35	1198

Literature-anchored findings (GeneRIF, showing 2)

• to characterize human NCCRP1 and to elucidate its relationship to carbonic anhydrase IX (PMID:22087255)
• High FBXO50 expression is associated with Gastric Cancer. (PMID:28560594)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	nccrp1	ENSDARG00000035326
mus_musculus	Nccrp1	ENSMUSG00000047586
rattus_norvegicus	Nccrp1	ENSRNOG00000054506

Paralogs (5): FBXO2 (ENSG00000116661), FBXO6 (ENSG00000116663), FBXO44 (ENSG00000132879), FBXO27 (ENSG00000161243), FBXO17 (ENSG00000269190)

Protein

Protein identifiers

F-box only protein 50 — Q6ZVX7 (reviewed: Q6ZVX7)

Alternative names: NCC receptor protein 1 homolog, Non-specific cytotoxic cell receptor protein 1 homolog

All UniProt accessions (1): Q6ZVX7

UniProt curated annotations — full annotation on UniProt →

Function. Promotes cell proliferation.

Subcellular location. Cytoplasm.

Tissue specificity. Expressed in the esophagus, oral cavity, skin, tongue and reproductive organs.

RefSeq proteins (1): NP_001001414* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007397	F-box-assoc_dom	Domain
IPR008979	Galactose-bd-like_sf	Homologous_superfamily
IPR039752	F-box_only	Family

Pfam: PF04300

UniProt features (7 total): modified residue 3, chain 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZVX7-F1	86.68	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 31, 37, 49

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 83 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, BENPORATH_ES_WITH_H3K27ME3, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_CATABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_SCF_DEPENDENT_PROTEASOMAL_UBIQUITIN_DEPENDENT_PROTEIN_CATABOLIC_PROCESS, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GOBP_ERAD_PATHWAY, GOBP_PROTEIN_CATABOLIC_PROCESS, GOBP_GLYCOPROTEIN_METABOLIC_PROCESS, GOCC_SCF_UBIQUITIN_LIGASE_COMPLEX, GOCC_TRANSFERASE_COMPLEX, GOBP_PROTEOLYSIS, GOCC_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX

GO Biological Process (4): glycoprotein catabolic process (GO:0006516), positive regulation of cell population proliferation (GO:0008284), SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146), ERAD pathway (GO:0036503)

GO Molecular Function (2): protein binding (GO:0005515), ubiquitin protein ligase activity (GO:0061630)

GO Cellular Component (4): cytoplasm (GO:0005737), cytosol (GO:0005829), SCF ubiquitin ligase complex (GO:0019005), extracellular exosome (GO:0070062)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
glycoprotein metabolic process	1
protein catabolic process	1
carbohydrate derivative catabolic process	1
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
response to endoplasmic reticulum stress	1
response to chemical	1
binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
intracellular anatomical structure	1
cytoplasm	1
cullin-RING ubiquitin ligase complex	1
extracellular vesicle	1

Protein interactions and networks

STRING

368 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NCCRP1	MFAP4	P55083	372
NCCRP1	FBXO34	Q9NWN3	355
NCCRP1	SPRR2F	Q96RM1	348
NCCRP1	FBXO42	Q6P3S6	330
NCCRP1	RWDD2B	P57060	313
NCCRP1	PRSS36	Q5K4E3	311
NCCRP1	LY6G6F	Q5SQ64	310
NCCRP1	FBXO46	Q6PJ61	300
NCCRP1	CD8A	P01732	297
NCCRP1	DHRS1	Q96LJ7	285
NCCRP1	SACK1C	Q9BQN1	283
NCCRP1	SLCO5A1	Q9H2Y9	275
NCCRP1	FBXW12	Q6X9E4	272
NCCRP1	A2ML1	A8K2U0	269
NCCRP1	RHCG	Q9UBD6	263

IntAct

116 interactions, top by confidence:

A	B	Type	Score
FANCG	FANCA	psi-mi:“MI:0914”(association)	0.960
POT1	TERF2	psi-mi:“MI:0914”(association)	0.890
ASH2L	KMT2D	psi-mi:“MI:0914”(association)	0.890
RIN1	NRAS	psi-mi:“MI:0914”(association)	0.840
POLR2L	RCCD1	psi-mi:“MI:0914”(association)	0.640
CCNC	MED19	psi-mi:“MI:0914”(association)	0.640
ALDH3A1	RCCD1	psi-mi:“MI:0914”(association)	0.640
CFAP298	PEX7	psi-mi:“MI:0914”(association)	0.620
NCCRP1	DDI1	psi-mi:“MI:0915”(physical association)	0.560
FES	DSP	psi-mi:“MI:0914”(association)	0.560
ZSCAN12	A2ML1	psi-mi:“MI:0914”(association)	0.530
FTH1	A2ML1	psi-mi:“MI:0914”(association)	0.530
TBC1D22B	A2ML1	psi-mi:“MI:0914”(association)	0.530
CCDC51	TGM5	psi-mi:“MI:0914”(association)	0.530
DPPA4	ALOX12B	psi-mi:“MI:0914”(association)	0.530
MRPL38	DUSP14	psi-mi:“MI:0914”(association)	0.530
UCP2	CST4	psi-mi:“MI:0914”(association)	0.530
STK16	FLG	psi-mi:“MI:0914”(association)	0.530
ZIC1	CTSV	psi-mi:“MI:0914”(association)	0.530
CLINT1	PIK3C2A	psi-mi:“MI:0914”(association)	0.530
POMK	CLGN	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
ESR1		psi-mi:“MI:0914”(association)	0.460
NCCRP1	CFTR	psi-mi:“MI:0915”(physical association)	0.370
STK4	ANXA2P2	psi-mi:“MI:0914”(association)	0.350
WTAP	DDX39A	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350

BioGRID (124): NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS), NCCRP1 (Affinity Capture-MS)

ESM2 similar proteins: A0A8I5KY20, A2A9Q0, A9JSM3, C9JI98, D4A2Q0, D4ABX8, E7ERA6, F1SAM7, F2Z333, O94819, P0C7J6, P0CG25, P13224, P56400, Q04785, Q0GA42, Q17QZ8, Q1RMK9, Q2MJR0, Q2WF71, Q504Y2, Q50LG9, Q5RJI4, Q6IEE6, Q6IEE7, Q6IQX7, Q6P6N5, Q6PJG9, Q6UKI2, Q6UX72, Q6ZMC9, Q6ZT52, Q6ZVX7, Q7Z6J2, Q80XU8, Q86UD0, Q86VR8, Q8BQB4, Q8IZ52, Q8QZV0

Diamond homologs: G3X9C2, Q17QK6, Q3SX24, Q568V3, Q6AY27, Q6DIA9, Q6ZVX7, Q80UW2, Q8NI29, Q923V4, Q96EF6, Q9H4M3, Q9N0C8, Q9NRD1, Q9QZM8, Q9UK22, Q8BK26, Q9QZN4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

712 predictions. Top by Δscore:

Variant	Effect	Δscore
19:39197258:G:GT	donor_gain	1.0000
19:39197319:GGTG:G	donor_loss	1.0000
19:39197320:G:C	donor_loss	1.0000
19:39197345:G:GT	donor_gain	1.0000
19:39198051:AGG:A	acceptor_loss	1.0000
19:39198112:CTGGG:C	donor_loss	1.0000
19:39198114:GG:G	donor_gain	1.0000
19:39198115:GG:G	donor_gain	1.0000
19:39198116:G:GA	donor_loss	1.0000
19:39198116:G:GG	donor_gain	1.0000
19:39198117:TAAG:T	donor_loss	1.0000
19:39198197:T:A	acceptor_gain	1.0000
19:39198198:GCA:G	acceptor_loss	1.0000
19:39198199:CAG:C	acceptor_loss	1.0000
19:39198200:A:AG	acceptor_gain	1.0000
19:39198200:AG:A	acceptor_gain	1.0000
19:39198201:G:GG	acceptor_gain	1.0000
19:39198201:GG:G	acceptor_gain	1.0000
19:39198201:GGC:G	acceptor_gain	1.0000
19:39198201:GGCA:G	acceptor_gain	1.0000
19:39198201:GGCAA:G	acceptor_gain	1.0000
19:39198250:AAAGG:A	donor_loss	1.0000
19:39198251:AAGG:A	donor_loss	1.0000
19:39198252:AGG:A	donor_loss	1.0000
19:39198253:GGTG:G	donor_loss	1.0000
19:39198254:G:GG	donor_gain	1.0000
19:39199168:A:AG	acceptor_gain	1.0000
19:39199168:AGCT:A	acceptor_gain	1.0000
19:39199168:AGCTG:A	acceptor_gain	1.0000
19:39199169:G:GA	acceptor_gain	1.0000

AlphaMissense

1729 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:39199182:G:C	K155N	0.995
19:39199182:G:T	K155N	0.995
19:39200629:T:C	F234S	0.995
19:39200665:T:C	F246S	0.995
19:39197294:C:A	N104K	0.994
19:39197294:C:G	N104K	0.994
19:39199256:T:A	V180D	0.994
19:39199261:G:C	D182H	0.993
19:39198216:T:A	W139R	0.992
19:39198216:T:C	W139R	0.992
19:39199171:T:A	W152R	0.992
19:39199171:T:C	W152R	0.992
19:39199199:T:A	L161H	0.991
19:39200476:T:A	W227R	0.991
19:39200476:T:C	W227R	0.991
19:39200478:G:C	W227C	0.991
19:39200478:G:T	W227C	0.991
19:39200734:T:A	V269E	0.991
19:39199173:G:C	W152C	0.990
19:39199173:G:T	W152C	0.990
19:39199250:T:A	I178N	0.990
19:39200655:T:C	F243L	0.990
19:39200657:T:A	F243L	0.990
19:39200657:T:G	F243L	0.990
19:39200722:C:T	T265I	0.990
19:39200728:C:T	S267F	0.990
19:39198207:T:C	F136L	0.989
19:39198209:C:A	F136L	0.989
19:39198209:C:G	F136L	0.989
19:39200628:T:C	F234L	0.989

dbSNP variants (sampled 300 via entrez): RS1000471949 (19:39196368 G>A), RS1000754098 (19:39197814 T>G), RS1000823063 (19:39196564 G>A), RS1001197160 (19:39195802 G>A), RS1001207343 (19:39197547 T>C), RS1001228504 (19:39195524 A>G), RS1001816369 (19:39201374 G>A), RS1002234034 (19:39196925 TC>T), RS1002478150 (19:39198944 C>A), RS1002677519 (19:39200031 C>G), RS1004458430 (19:39198547 C>T), RS1004580354 (19:39200227 G>T), RS1004799931 (19:39200006 G>A,C,T), RS1006253594 (19:39201521 G>A), RS1006273657 (19:39195584 T>G)

Disease associations

OMIM: gene MIM:615901 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Particulate Matter	increases abundance, increases expression, decreases expression	3
Air Pollutants	decreases expression, increases abundance	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Valproic Acid	increases expression, affects expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
sodium arsenate	increases abundance, decreases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, decreases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
sulforaphane	decreases expression	1
butyraldehyde	increases expression	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, increases expression	1
abrine	increases expression	1
licochalcone B	decreases expression	1
prothioconazole	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation, affects methylation	1
Cadmium	decreases expression, increases abundance	1
Cisplatin	decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Furaldehyde	affects cotreatment, increases expression	1
Lead	decreases expression	1
Lipopolysaccharides	increases expression, decreases reaction	1
Plant Extracts	decreases expression, affects cotreatment	1
Smoke	increases abundance, decreases expression	1
Sodium Chloride	affects cotreatment, increases expression, decreases expression	1
Lactic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.