NCK1-DT

Summary

NCK1-DT (NCK1 divergent transcript, HGNC:49645) is a long non-coding RNA gene on chromosome 3q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49645
Approved symbol	NCK1-DT
Name	NCK1 divergent transcript
Location	3q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	SLC35G2-AS1
Ensembl gene	ENSG00000239213
Ensembl biotype	lncRNA
Entrez	101927597
RNAcentral	URS000075B4D1 — lncRNA, 1073 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 29 lncRNA

ENST00000461864, ENST00000470236, ENST00000474250, ENST00000661609, ENST00000663856, ENST00000666310, ENST00000666660, ENST00000667524, ENST00000670711, ENST00000716158, ENST00000762151, ENST00000762152, ENST00000762153, ENST00000762154, ENST00000762155, ENST00000762156, ENST00000762157, ENST00000762158, ENST00000762159, ENST00000762160, ENST00000762161, ENST00000762162, ENST00000762163, ENST00000762164, ENST00000762165, ENST00000762166, ENST00000762167, ENST00000762168, ENST00000762169

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000461864 — 3 exons

Exon	Start	End
ENSE00001953761	136846528	136846586
ENSE00004117059	136841102	136842569
ENSE00004117065	136861747	136862084

Expression profiles

Bgee: expression breadth ubiquitous, 208 present calls, max score 85.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.5065 / max 87.8376, expressed in 1439 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44742	3.8432	1370
44743	0.6633	392

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.84	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.43	gold quality
monocyte	CL:0000576	78.43	gold quality
leukocyte	CL:0000738	78.18	gold quality
oocyte	CL:0000023	77.14	gold quality
sural nerve	UBERON:0015488	75.55	gold quality
islet of Langerhans	UBERON:0000006	75.40	gold quality
granulocyte	CL:0000094	74.33	gold quality
ileal mucosa	UBERON:0000331	74.30	gold quality
tibialis anterior	UBERON:0001385	74.19	silver quality
colonic epithelium	UBERON:0000397	73.34	gold quality
lymph node	UBERON:0000029	73.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.08	gold quality
muscle of leg	UBERON:0001383	72.66	gold quality
thymus	UBERON:0002370	71.84	gold quality
bone marrow cell	CL:0002092	71.81	silver quality
spleen	UBERON:0002106	71.70	gold quality
gastrocnemius	UBERON:0001388	71.69	gold quality
gall bladder	UBERON:0002110	71.44	gold quality
rectum	UBERON:0001052	71.25	gold quality
cerebellar cortex	UBERON:0002129	71.05	gold quality
vermiform appendix	UBERON:0001154	71.02	gold quality
cerebellar hemisphere	UBERON:0002245	70.96	gold quality
calcaneal tendon	UBERON:0003701	70.96	gold quality
pancreas	UBERON:0001264	70.64	gold quality
mucosa of transverse colon	UBERON:0004991	70.59	gold quality
ganglionic eminence	UBERON:0004023	70.57	gold quality
vastus lateralis	UBERON:0001379	70.52	silver quality
quadriceps femoris	UBERON:0001377	70.45	silver quality
cerebellum	UBERON:0002037	70.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• NCK1-AS1 functioned as a molecular sponge for miR-6857, antagonizing its ability to repress CDK1/6 protein translation. Findings suggest that NCK1-AS1/miR-6857/CDK1 crosstalk serve as a critical effector in cervical cancer progression. (PMID:29416014)
• NCK1-AS1 Increases Drug Resistance of Glioma Cells to Temozolomide by Modulating miR-137/TRIM24. (PMID:31750728)
• NCK1-AS1 promotes NCK1 expression to facilitate tumorigenesis and chemo-resistance in ovarian cancer. (PMID:31761329)
• LncRNA NCK1-AS1 promotes non-small cell lung cancer progression via regulating miR-512-5p/p21 axis. (PMID:32858372)
• Upregulation of lncRNA NCK1-AS1 predicts poor prognosis and contributes to non-small cell lung cancer proliferation by regulating CDK1. (PMID:33629305)
• NCK1-AS1 promotes the progression of lung squamous cell carcinoma through transcriptionally upregulating NCK1 via interacting with MYC. (PMID:33629937)
• LncRNA NCK1-AS1 Aggravates Hepatocellular Carcinoma by the miR-22-3p/YARS Axis to Activate PI3K/AKT Signaling. (PMID:35306563)
• LncRNA NCK1-AS1-mediated regulatory functions in human diseases. (PMID:36131072)
• Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis. (PMID:36412985)
• NCK1-AS1 promotes the proliferation, migration, invasion, and EMT of non-small cell lung cancer by regulating the miR-361-5p/ADAM10 axis. (PMID:36912070)
• A review on the role of NCK1 Antisense RNA 1 (NCK1-AS1) in diverse disorders. (PMID:37028107)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.