NCRUPAR

Summary

NCRUPAR (non-protein coding RNA, upstream of F2R/PAR1, HGNC:37153) is a long non-coding RNA gene on chromosome 5q13.3.

This non-coding RNA gene has been reported to have a positive regulatory affect during embryogenesis on the adjacent coagulation factor II (thrombin) receptor gene by Madamanchi et. al (PMID:12084570).

Source: NCBI Gene 100302746 — RefSeq curated summary.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37153
Approved symbol	NCRUPAR
Name	non-protein coding RNA, upstream of F2R/PAR1
Location	5q13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ncR-uPAR, NCRNA00193
Entrez	100302746
RNAcentral	URS000075DACD — lncRNA, 486 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Downregulation of ncRuPAR is associated with colorectal cancer. (PMID:25119598)
• Long non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling. (PMID:36438913)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001944370 (5:76711491 A>G,T), RS1003256731 (5:76713261 T>G), RS1004058631 (5:76710501 C>G), RS1005085786 (5:76712204 A>G), RS1005336700 (5:76711921 A>G), RS1005818163 (5:76712274 G>A), RS1006086668 (5:76711877 A>G), RS1007529304 (5:76711175 C>T), RS1007790752 (5:76710840 T>C), RS1008343647 (5:76711311 G>A), RS1008441571 (5:76710971 G>A), RS1008935504 (5:76712577 A>G), RS1010174562 (5:76713151 G>T), RS1010732679 (5:76713217 A>G), RS1011727040 (5:76711261 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008755_1	Phenylephrine infusion rate during anesthesia	2.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation	1
Cisplatin	increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.