NDOR1

Summary

NDOR1 (NADPH dependent diflavin oxidoreductase 1, HGNC:29838) is a protein-coding gene on chromosome 9q34.3, encoding NADPH-dependent diflavin oxidoreductase 1 (Q9UHB4). NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. It is a common-essential gene (DepMap: required in 90.5% of cancer cell lines).

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 27158 — RefSeq curated summary.

At a glance

• GWAS associations: 19
• Clinical variants (ClinVar): 157 total
• Cancer dependency (DepMap): dependent in 90.5% of screened cell lines (common-essential)
• MANE Select transcript: NM_014434

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29838
Approved symbol	NDOR1
Name	NADPH dependent diflavin oxidoreductase 1
Location	9q34.3
Locus type	gene with protein product
Status	Approved
Aliases	NR1, bA350O14.9, CIAE1
Ensembl gene	ENSG00000188566
Ensembl biotype	protein_coding
OMIM	606073
Entrez	27158

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 2 retained_intron

ENST00000371521, ENST00000427047, ENST00000458322, ENST00000612145, ENST00000613750, ENST00000684003, ENST00000861139, ENST00000938577

RefSeq mRNA: 4 — MANE Select: NM_014434 NM_001144026, NM_001144027, NM_001144028, NM_014434

CCDS: CCDS48061, CCDS48062, CCDS48063, CCDS7036

Canonical transcript exons

ENST00000684003 — 14 exons

Exon	Start	End
ENSE00003801601	137215095	137215202
ENSE00003803027	137215659	137215805
ENSE00003803201	137216094	137216188
ENSE00003803549	137215899	137216017
ENSE00003806914	137212502	137212599
ENSE00003807674	137206232	137206309
ENSE00003807736	137214204	137214413
ENSE00003807752	137214798	137215018
ENSE00003808424	137214570	137214691
ENSE00003808803	137215407	137215521
ENSE00003810390	137213967	137214068
ENSE00003810910	137213780	137213878
ENSE00003918994	137205700	137205912
ENSE00003920194	137216272	137219361

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 92.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.9176 / max 333.5770, expressed in 1809 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
99670	23.9176	1809

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	92.55	gold quality
right lobe of thyroid gland	UBERON:0001119	86.49	gold quality
mucosa of transverse colon	UBERON:0004991	86.49	gold quality
metanephros cortex	UBERON:0010533	86.36	gold quality
apex of heart	UBERON:0002098	86.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.99	gold quality
spleen	UBERON:0002106	85.93	gold quality
right uterine tube	UBERON:0001302	85.75	gold quality
small intestine Peyer’s patch	UBERON:0003454	85.68	gold quality
left lobe of thyroid gland	UBERON:0001120	85.63	gold quality
body of stomach	UBERON:0001161	85.41	gold quality
tibial nerve	UBERON:0001323	84.69	gold quality
lower esophagus mucosa	UBERON:0035834	84.65	gold quality
transverse colon	UBERON:0001157	84.64	gold quality
right adrenal gland	UBERON:0001233	84.63	gold quality
right frontal lobe	UBERON:0002810	84.44	gold quality
cerebellar hemisphere	UBERON:0002245	84.43	gold quality
cerebellar cortex	UBERON:0002129	84.31	gold quality
mucosa of stomach	UBERON:0001199	84.29	gold quality
left uterine tube	UBERON:0001303	84.29	gold quality
thyroid gland	UBERON:0002046	84.14	gold quality
skin of leg	UBERON:0001511	84.11	gold quality
right adrenal gland cortex	UBERON:0035827	84.09	gold quality
right testis	UBERON:0004534	84.08	gold quality
ectocervix	UBERON:0012249	84.05	gold quality
left testis	UBERON:0004533	83.93	gold quality
skin of abdomen	UBERON:0001416	83.84	gold quality
upper lobe of left lung	UBERON:0008952	83.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.72	gold quality
lower esophagus	UBERON:0013473	83.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

93 targeting NDOR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-378G	99.71	64.90	1106
HSA-MIR-4530	99.69	66.47	1509
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-4687-3P	99.48	66.41	968

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 90.5% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 4)

• characterized in detail the redox and electron transfer properties of the component flavin-binding domains of protein NR1 (PMID:12631275)
• NR1 may represent a minor pathway in the cell for redox regulation of methionine synthase (PMID:12871938)
• Data show that that all seven currently known NMDAR subunits (NR1, NR2A, NR2B, NR2C, NR2D, NR3A and NR3B) are expressed in astrocytes, but at different levels. (PMID:21152063)
• the molecular basis of recognition between Ndor1 and anamorsin and of the electron transfer process, was investigated. (PMID:23596212)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ndor1	ENSDARG00000007429
mus_musculus	Ndor1	ENSMUSG00000006471
rattus_norvegicus	Ndor1	ENSRNOG00000010616
drosophila_melanogaster	CG13667	FBGN0035890
caenorhabditis_elegans		WBGENE00001485

Paralogs (5): NOS2 (ENSG00000007171), NOS1 (ENSG00000089250), MTRR (ENSG00000124275), POR (ENSG00000127948), NOS3 (ENSG00000164867)

Protein

Protein identifiers

NADPH-dependent diflavin oxidoreductase 1 — Q9UHB4 (reviewed: Q9UHB4)

Alternative names: NADPH-dependent FMN and FAD-containing oxidoreductase, Novel reductase 1

All UniProt accessions (1): Q9UHB4

UniProt curated annotations — full annotation on UniProt →

Function. NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair. In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A.

Subunit / interactions. Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Interacts with DCPS.

Subcellular location. Cytoplasm. Perinuclear region.

Tissue specificity. Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt’s lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.

Similarity. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9UHB4-1	1	yes
Q9UHB4-2	2
Q9UHB4-3	3
Q9UHB4-4	4

RefSeq proteins (4): NP_001137498, NP_001137499, NP_001137500, NP_055249* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001094	Flavdoxin-like	Domain
IPR001433	OxRdtase_FAD/NAD-bd	Domain
IPR001709	Flavoprot_Pyr_Nucl_cyt_Rdtase	Domain
IPR003097	CysJ-like_FAD-binding	Domain
IPR008254	Flavodoxin/NO_synth	Domain
IPR017927	FAD-bd_FR_type	Domain
IPR017938	Riboflavin_synthase-like_b-brl	Homologous_superfamily
IPR023173	NADPH_Cyt_P450_Rdtase_alpha	Homologous_superfamily
IPR028879	NDOR1	Family
IPR029039	Flavoprotein-like_sf	Homologous_superfamily
IPR039261	FNR_nucleotide-bd	Homologous_superfamily

Pfam: PF00175, PF00258, PF00667

Enzyme classification (BRENDA):

• EC 1.5.1.30 — flavin reductase (NADPH) (BRENDA: 19 organisms, 71 substrates, 35 inhibitors, 59 Km, 26 kcat entries)

Substrate kinetics (BRENDA)

9 substrates with measured Km, best-characterized 9. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
NADPH	—	22
FMN	—	20
FAD	0.0036–0.236	4
RIBOFLAVIN	0.0013–0.04	4
NADH	0.208–0.65	3
2-THIOFMN	0.007	1
GALACTOFLAVIN	0.04	1
OXIDIZED RIBOFLAVIN	0.053	1
CIBACRON MARINE	—	0

Catalyzed reactions (Rhea), 1 shown:

• 2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+) (RHEA:67716)

UniProt features (39 total): binding site 12, strand 8, helix 7, splice variant 4, turn 3, domain 2, chain 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4H2D	X-RAY DIFFRACTION	1.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UHB4-F1	93.20	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (12): 416–419; 460; 515–516; 521–525; 558; 596; 12–17; 59–62; 97–106; 132; 350; 382–385

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly
R-HSA-1430728	Metabolism

MSigDB gene sets: 101 (showing top): WHITEHURST_PACLITAXEL_SENSITIVITY, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, GOBP_ELECTRON_TRANSPORT_CHAIN, LIAO_METASTASIS, WHN_B, GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_NAD_P_H, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, GOMF_FMN_BINDING, GOMF_FAD_BINDING, GOMF_NADPH_BINDING, GOMF_NADP_BINDING, GOMF_FLAVIN_ADENINE_DINUCLEOTIDE_BINDING, GOMF_ADENYL_NUCLEOTIDE_BINDING, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN

GO Biological Process (2): iron-sulfur cluster assembly (GO:0016226), electron transport chain (GO:0022900)

GO Molecular Function (12): NADPH-hemoprotein reductase activity (GO:0003958), electron transfer activity (GO:0009055), FMN binding (GO:0010181), oxidoreductase activity (GO:0016491), oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (GO:0016653), flavin adenine dinucleotide binding (GO:0050660), NADP binding (GO:0050661), NADPH binding (GO:0070402), FAD binding (GO:0071949), NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity (GO:0160246), protein binding (GO:0005515), oxidoreductase activity, acting on NAD(P)H (GO:0016651)

GO Cellular Component (6): nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), intermediate filament cytoskeleton (GO:0045111), perinuclear region of cytoplasm (GO:0048471), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
anion binding	3
cytoplasm	2
metallo-sulfur cluster assembly	1
generation of precursor metabolites and energy	1
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	1
molecular_function	1
ribonucleotide binding	1
catalytic activity	1
oxidoreductase activity, acting on NAD(P)H	1
nucleotide binding	1
adenyl nucleotide binding	1
NADP binding	1
flavin adenine dinucleotide binding	1
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	1
binding	1
oxidoreductase activity	1
nuclear lumen	1
intracellular anatomical structure	1
cytoskeleton	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1239 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NDOR1	CIAPIN1	Q6FI81	964
NDOR1	DCPS	Q96C86	952
NDOR1	NUBP1	P53384	762
NDOR1	MTR	Q99707	754
NDOR1	CIAO3	Q9H6Q4	709
NDOR1	CIAO1	O76071	672
NDOR1	ABCB7	O75027	667
NDOR1	GLRX3	O76003	649
NDOR1	MMS19	Q96T76	649
NDOR1	CIAO2B	Q9Y3D0	642
NDOR1	LYRM4	Q9HD34	595
NDOR1	NUBP2	Q9Y5Y2	583
NDOR1	NFS1	Q9Y697	574
NDOR1	BOLA2	Q9H3K6	543
NDOR1	CYCS	P00001	543

IntAct

122 interactions, top by confidence:

A	B	Type	Score
CIAPIN1	GLRX3	psi-mi:“MI:0914”(association)	0.960
NDOR1	CIAPIN1	psi-mi:“MI:0915”(physical association)	0.890
CIAPIN1	NDOR1	psi-mi:“MI:0915”(physical association)	0.890
TCHP	NDOR1	psi-mi:“MI:0915”(physical association)	0.780
NDOR1	TCHP	psi-mi:“MI:0915”(physical association)	0.780
TCF4	NDOR1	psi-mi:“MI:0915”(physical association)	0.670
MTUS2	NDOR1	psi-mi:“MI:0915”(physical association)	0.670
NDOR1	TCF4	psi-mi:“MI:0915”(physical association)	0.670
NDOR1	MTUS2	psi-mi:“MI:0915”(physical association)	0.670
NDOR1		psi-mi:“MI:0915”(physical association)	0.560
EFHC2	NDOR1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (64): NDOR1 (Two-hybrid), NDOR1 (Two-hybrid), CIAPIN1 (Two-hybrid), CCDC33 (Two-hybrid), EFHC2 (Two-hybrid), TCHP (Two-hybrid), NDOR1 (Affinity Capture-MS), NDOR1 (Affinity Capture-MS), NDOR1 (Two-hybrid), NDOR1 (Two-hybrid), NDOR1 (Two-hybrid), NDOR1 (Two-hybrid), NDOR1 (Two-hybrid), NDOR1 (Two-hybrid), NDOR1 (Two-hybrid)

ESM2 similar proteins: A2AI05, D3ZDK7, E1BNQ4, O55240, O70249, P21139, P24298, P25409, P50336, P51175, P56602, P97849, Q03426, Q1JPJ0, Q27979, Q2KJF7, Q3T0A0, Q3ZKN0, Q498R1, Q4JIJ2, Q5E9M9, Q5E9T8, Q5R7A2, Q5RK23, Q60714, Q60HD5, Q6AYG0, Q6NRG5, Q6P1M0, Q6P3E7, Q6PCB7, Q6PFP6, Q7TSA0, Q8BNV1, Q8BZG5, Q8C1A3, Q8CHP8, Q8IXI1, Q8JZN7, Q8QZR5

Diamond homologs: A0A2U1KZS6, A0A2U1LIM9, A0A7T9QPQ1, A0KTH4, A1AEV0, A2QS05, A5F3I4, A6TD49, A7MJ63, A7ZQK7, A8A3P5, A8ANX1, A8G9X6, A9LZ73, A9MF16, B1IU77, C5YJG8, O08336, O08394, O19114, O19132, O32214, O54705, O62699, P00388, P00389, P04175, P14779, P16435, P16603, P19618, P29474, P29475, P29476, P29477, P35228, P36587, P37039, P37040, P37116

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

157 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	136
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2555 predictions. Top by Δscore:

Variant	Effect	Δscore
9:137205832:G:GT	donor_gain	1.0000
9:137213775:CACAG:C	acceptor_loss	1.0000
9:137213778:A:AG	acceptor_gain	1.0000
9:137213779:G:GG	acceptor_gain	1.0000
9:137213779:G:GT	acceptor_loss	1.0000
9:137213874:CTGGG:C	donor_gain	1.0000
9:137213876:GGG:G	donor_gain	1.0000
9:137213877:GG:G	donor_gain	1.0000
9:137213877:GGG:G	donor_gain	1.0000
9:137213878:GG:G	donor_gain	1.0000
9:137213879:G:GG	donor_gain	1.0000
9:137213879:GTGA:G	donor_loss	1.0000
9:137213880:T:G	donor_loss	1.0000
9:137214202:A:AG	acceptor_gain	1.0000
9:137214203:G:GG	acceptor_gain	1.0000
9:137214203:GCCT:G	acceptor_gain	1.0000
9:137214370:G:GT	donor_gain	1.0000
9:137214567:C:G	acceptor_gain	1.0000
9:137214568:A:AG	acceptor_gain	1.0000
9:137214569:G:GA	acceptor_gain	1.0000
9:137214569:GCT:G	acceptor_gain	1.0000
9:137214569:GCTTT:G	acceptor_gain	1.0000
9:137214687:GCCAG:G	donor_gain	1.0000
9:137214690:AGGTG:A	donor_loss	1.0000
9:137214691:GGT:G	donor_loss	1.0000
9:137214692:GT:G	donor_loss	1.0000
9:137214693:T:G	donor_loss	1.0000
9:137214812:AC:A	acceptor_gain	1.0000
9:137214813:C:CA	acceptor_gain	1.0000
9:137214971:G:GT	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000011821 (9:137212730 G>A,C), RS1000246543 (9:137216482 G>A), RS1000316314 (9:137205948 G>A), RS1000521730 (9:137208162 A>G,T), RS1000574292 (9:137218334 G>A), RS1000762532 (9:137219213 A>G), RS1000831270 (9:137211265 G>A), RS1000903179 (9:137218466 G>A,T), RS1001244281 (9:137216861 C>G), RS1001879897 (9:137218921 A>T), RS1001913493 (9:137205120 T>C), RS1001986964 (9:137204743 T>A), RS1001991141 (9:137214135 G>A,T), RS1002022091 (9:137214023 T>A), RS1002105422 (9:137210204 A>G,T)

Disease associations

OMIM: gene MIM:606073 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

19 associations (top):

Study	Trait	p-value
GCST004602_179	Mean corpuscular volume	8.000000e-16
GCST004605_48	Mean corpuscular hemoglobin concentration	7.000000e-09
GCST004611_49	High light scatter reticulocyte count	3.000000e-14
GCST004612_105	High light scatter reticulocyte percentage of red cells	2.000000e-16
GCST004619_213	Reticulocyte fraction of red cells	7.000000e-18
GCST004622_28	Reticulocyte count	7.000000e-14
GCST004630_234	Mean corpuscular hemoglobin	6.000000e-21
GCST008058_6	Estimated glomerular filtration rate	4.000000e-10
GCST008059_249	Estimated glomerular filtration rate	2.000000e-10
GCST90002385_472	High light scatter reticulocyte count	9.000000e-32
GCST90002386_393	High light scatter reticulocyte percentage of red cells	2.000000e-39
GCST90002387_348	Immature fraction of reticulocytes	2.000000e-18
GCST90002390_406	Mean corpuscular hemoglobin	5.000000e-56
GCST90002391_248	Mean corpuscular hemoglobin concentration	2.000000e-16
GCST90002392_604	Mean corpuscular volume	5.000000e-45
GCST90002397_701	Mean spheric corpuscular volume	6.000000e-11
GCST90002403_250	Red blood cell count	1.000000e-15
GCST90002405_479	Reticulocyte count	8.000000e-28
GCST90002406_292	Reticulocyte fraction of red cells	3.000000e-38

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0007986	reticulocyte count
EFO:0004527	mean corpuscular hemoglobin
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, affects expression, increases abundance, increases expression	2
Aflatoxin B1	decreases methylation, increases methylation	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
zinc chromate	decreases expression, increases abundance	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
chromium hexavalent ion	decreases expression, increases abundance	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
bisphenol S	decreases methylation	1
Sunitinib	increases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Air Pollutants	affects expression, increases abundance	1
Aldehydes	decreases expression	1
Arsenic	affects cotreatment, affects expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Catechin	increases expression, affects cotreatment	1
Niclosamide	decreases expression	1
Ozone	affects expression, increases abundance	1
Smoke	decreases expression	1
Testosterone	increases expression	1
Valproic Acid	increases methylation	1
Sodium Selenite	increases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.