NDUFB2

Summary

NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2, HGNC:7697) is a protein-coding gene on chromosome 7q34, encoding NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial (O95178). Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. It is a selective cancer dependency (DepMap: 19.0% of cell lines).

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I.

Source: NCBI Gene 4708 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 18 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 19.0% of screened cell lines
• MANE Select transcript: NM_004546

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7697
Approved symbol	NDUFB2
Name	NADH:ubiquinone oxidoreductase subunit B2
Location	7q34
Locus type	gene with protein product
Status	Approved
Aliases	AGGG, CI-AGGG
Ensembl gene	ENSG00000090266
Ensembl biotype	protein_coding
OMIM	603838
Entrez	4708

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 25 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000247866, ENST00000460088, ENST00000461457, ENST00000462847, ENST00000464564, ENST00000464566, ENST00000465506, ENST00000471136, ENST00000472695, ENST00000475276, ENST00000476181, ENST00000476279, ENST00000476470, ENST00000479181, ENST00000482954, ENST00000882733, ENST00000882734, ENST00000882735, ENST00000931392, ENST00000931393, ENST00000931394, ENST00000931395, ENST00000931396, ENST00000931397, ENST00000931398, ENST00000931399, ENST00000931400, ENST00000948626, ENST00000948627

RefSeq mRNA: 1 — MANE Select: NM_004546 NM_004546

CCDS: CCDS5862

Canonical transcript exons

ENST00000247866 — 4 exons

Exon	Start	End
ENSE00001838830	140706563	140706643
ENSE00001920266	140696708	140696842
ENSE00003632160	140704860	140704963
ENSE00003668515	140702866	140703010

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 99.72.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 55.8522 / max 425.0696, expressed in 1821 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
81509	53.2775	1821
81510	1.8494	1129
81511	0.7254	464

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	99.72	gold quality
heart right ventricle	UBERON:0002080	99.48	gold quality
right lobe of thyroid gland	UBERON:0001119	99.42	gold quality
nephron tubule	UBERON:0001231	99.40	gold quality
right atrium auricular region	UBERON:0006631	99.39	gold quality
prefrontal cortex	UBERON:0000451	99.37	gold quality
left lobe of thyroid gland	UBERON:0001120	99.36	gold quality
renal glomerulus	UBERON:0000074	99.33	gold quality
metanephric glomerulus	UBERON:0004736	99.33	gold quality
endothelial cell	CL:0000115	99.31	gold quality
mucosa of transverse colon	UBERON:0004991	99.30	gold quality
nucleus accumbens	UBERON:0001882	99.28	gold quality
thyroid gland	UBERON:0002046	99.27	gold quality
diaphragm	UBERON:0001103	99.26	gold quality
caudate nucleus	UBERON:0001873	99.23	gold quality
putamen	UBERON:0001874	99.23	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.23	gold quality
Brodmann (1909) area 9	UBERON:0013540	99.23	gold quality
renal medulla	UBERON:0000362	99.22	gold quality
cardiac ventricle	UBERON:0002082	99.21	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	99.21	gold quality
metanephros cortex	UBERON:0010533	99.21	gold quality
heart left ventricle	UBERON:0002084	99.20	gold quality
body of tongue	UBERON:0011876	99.19	gold quality
cortex of kidney	UBERON:0001225	99.18	gold quality
parotid gland	UBERON:0001831	99.18	gold quality
right frontal lobe	UBERON:0002810	99.18	gold quality
cervix squamous epithelium	UBERON:0006922	99.17	gold quality
biceps brachii	UBERON:0001507	99.16	gold quality
cingulate cortex	UBERON:0003027	99.16	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-ENAD-20	yes	1122.89
E-MTAB-7316	yes	24.28
E-HCAD-10	yes	12.03
E-MTAB-10042	yes	11.80
E-CURD-112	yes	9.71
E-MTAB-10596	no	885.49
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting NDUFB2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-493-5P	99.96	72.47	2382
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-6758-3P	99.57	67.55	1078
HSA-MIR-4797-5P	99.39	68.01	1354
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-149-5P	99.25	67.16	1315
HSA-MIR-485-5P	99.10	64.78	1889
HSA-MIR-6884-5P	99.10	64.50	1987
HSA-MIR-500A-5P	98.76	69.13	1241
HSA-MIR-6784-3P	98.39	64.88	662
HSA-MIR-6862-3P	97.92	64.86	531
HSA-MIR-6765-3P	97.83	64.59	1165
HSA-MIR-6511A-3P	97.60	66.61	713
HSA-MIR-6511B-3P	97.60	66.61	713
HSA-MIR-362-5P	95.87	66.02	554
HSA-MIR-500B-5P	95.87	66.04	557

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 19.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• NADH:ubiquinone oxidoreductase gene may have a role in the regulation of molecular changes during the global cardiac ischemia/reperfusion injury during CPB (PMID:14718445)
• Association of abnormal NDUFB2 and UQCRH expression with venous thromboembolism in patients with liver cirrhosis. (PMID:38181234)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ndufb2	ENSDARG00000045490
mus_musculus	Ndufb2	ENSMUSG00000002416
rattus_norvegicus	Ndufb2	ENSRNOG00000026616
rattus_norvegicus	Ndufb2	ENSRNOG00000084454
caenorhabditis_elegans		WBGENE00009712

Protein

Protein identifiers

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial — O95178 (reviewed: O95178)

Alternative names: Complex I-AGGG, NADH-ubiquinone oxidoreductase AGGG subunit

All UniProt accessions (8): O95178, A4D1T5, C9IZW8, C9IZZ2, C9JRV4, C9JXM4, F8WCJ6, H7C5B8

UniProt curated annotations — full annotation on UniProt →

Function. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subunit / interactions. Complex I is composed of 45 different subunits.

Subcellular location. Mitochondrion inner membrane.

Similarity. Belongs to the complex I NDUFB2 subunit family.

RefSeq proteins (1): NP_004537* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026627	NDUFB2_animal	Family

Pfam: PF14813

UniProt features (4 total): transit peptide 1, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

7 structures.

PDB	Method	Resolution (Å)
9I4I	ELECTRON MICROSCOPY	2.63
9TI4	ELECTRON MICROSCOPY	2.66
9CWT	ELECTRON MICROSCOPY	3.44
5XTC	ELECTRON MICROSCOPY	3.7
5XTD	ELECTRON MICROSCOPY	3.7
5XTH	ELECTRON MICROSCOPY	3.9
5XTI	ELECTRON MICROSCOPY	17.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95178-F1	73.56	0.20

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-611105	Respiratory electron transport
R-HSA-6799198	Complex I biogenesis
R-HSA-1428517	Aerobic respiration and respiratory electron transport
R-HSA-1430728	Metabolism

MSigDB gene sets: 211 (showing top): ATF_B, MODY_HIPPOCAMPUS_POSTNATAL, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, GOBP_ATP_BIOSYNTHETIC_PROCESS, GOBP_OXIDATIVE_PHOSPHORYLATION, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS

GO Biological Process (4): mitochondrial electron transport, NADH to ubiquinone (GO:0006120), aerobic respiration (GO:0009060), proton motive force-driven mitochondrial ATP synthesis (GO:0042776), proton transmembrane transport (GO:1902600)

GO Molecular Function (1): NADH dehydrogenase (ubiquinone) activity (GO:0008137)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), respiratory chain complex I (GO:0045271), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Aerobic respiration and respiratory electron transport	1
Respiratory electron transport	1
Metabolism	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
aerobic electron transport chain	1
mitochondrial ATP synthesis coupled electron transport	1
cellular respiration	1
mitochondrion	1
oxidative phosphorylation	1
proton motive force-driven ATP synthesis	1
monoatomic cation transmembrane transport	1
NADH dehydrogenase activity	1
electron transfer activity	1
proton transmembrane transporter activity	1
oxidoreduction-driven active transmembrane transporter activity	1
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	1
active monoatomic ion transmembrane transporter activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
NADH dehydrogenase complex	1
respiratory chain complex	1
transmembrane transporter complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

822 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NDUFB2	NDUFB4	O95168	973
NDUFB2	NDUFA10	O95299	918
NDUFB2	NDUFB10	O96000	917
NDUFB2	MRPS33	Q9Y291	875
NDUFB2	NDUFA7	O95182	856
NDUFB2	NDUFB3	O43676	846
NDUFB2	NDUFB7	P17568	829
NDUFB2	NDUFA2	O43678	817
NDUFB2	NDUFB9	Q9Y6M9	813
NDUFB2	NDUFAB1	O14561	807
NDUFB2	NDUFB8	O95169	778
NDUFB2	NDUFC1	O43677	721
NDUFB2	NDUFB5	O43674	685
NDUFB2	COXFA4	O00483	672
NDUFB2	NDUFS5	O43920	669

IntAct

6 interactions, top by confidence:

A	B	Type	Score
NDUFB2	PFKM	psi-mi:“MI:0915”(physical association)	0.370
NDUFA6	NDUFS8	psi-mi:“MI:0914”(association)	0.350
NDUFA7	NDUFS8	psi-mi:“MI:0914”(association)	0.350
NDUFV3	NDUFS8	psi-mi:“MI:0914”(association)	0.350
NDUFA1	NDUFS8	psi-mi:“MI:0914”(association)	0.350

BioGRID (30): NDUFB2 (Negative Genetic), NDUFB2 (Positive Genetic), NDUFB2 (Positive Genetic), NDUFB2 (Negative Genetic), NDUFB2 (Negative Genetic), NDUFB2 (Negative Genetic), NDUFB2 (Negative Genetic), NDUFB2 (Positive Genetic), NDUFB2 (Negative Genetic), NDUFB2 (Positive Genetic), NDUFB2 (Positive Genetic), NDUFB2 (Positive Genetic), NUP54 (Negative Genetic), PGK1 (Negative Genetic), PSMC6 (Negative Genetic)

ESM2 similar proteins: A3KP48, A8WGU8, O09111, O43674, O95169, O95178, P0C2B7, P0C2B9, P0CB69, P0CB70, P0CB85, P0CB86, P82649, P82927, P83565, Q02372, Q02380, Q0MQC7, Q0MQC9, Q0MQD6, Q0MQD7, Q0MQD8, Q0MQE6, Q0MQE7, Q0MQF5, Q0MQJ3, Q0MQJ4, Q0MQJ5, Q29259, Q2NKR7, Q4G0I0, Q4QQV3, Q4R4E0, Q5R4S3, Q5R504, Q5RFR4, Q6DQX6, Q6RUT7, Q8HXG5, Q96A26

Diamond homologs: O95178, Q02374, Q0MQC7, Q0MQC8, Q0MQC9, Q20412, Q9CPU2, Q61Z75

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
NDUFB2	“form complex”	“NADH-ubiquinone oxidoreductase-Mitochondrial respiratory chain complex I”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

18 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	10
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1204 predictions. Top by Δscore:

Variant	Effect	Δscore
7:140692026:GCACT:G	donor_gain	1.0000
7:140696835:GTCC:G	donor_gain	1.0000
7:140696839:GTCA:G	donor_gain	1.0000
7:140696843:G:GG	donor_gain	1.0000
7:140702864:AGT:A	acceptor_gain	1.0000
7:140702865:GT:G	acceptor_gain	1.0000
7:140702865:GTG:G	acceptor_gain	1.0000
7:140702865:GTGCC:G	acceptor_gain	1.0000
7:140703007:GCTG:G	donor_gain	1.0000
7:140703008:CTGGT:C	donor_loss	1.0000
7:140703010:GGT:G	donor_loss	1.0000
7:140703011:G:GG	donor_gain	1.0000
7:140703011:GTAA:G	donor_loss	1.0000
7:140704964:G:GG	donor_gain	1.0000
7:140690810:CAAG:C	donor_loss	0.9900
7:140690811:AAGGT:A	donor_loss	0.9900
7:140690812:AGG:A	donor_loss	0.9900
7:140690813:GGTGA:G	donor_loss	0.9900
7:140690815:T:A	donor_loss	0.9900
7:140692030:T:G	donor_gain	0.9900
7:140694655:T:TA	acceptor_gain	0.9900
7:140694659:CCAG:C	acceptor_loss	0.9900
7:140694660:CAG:C	acceptor_loss	0.9900
7:140694661:A:AG	acceptor_gain	0.9900
7:140694661:AGGT:A	acceptor_loss	0.9900
7:140694662:G:GG	acceptor_gain	0.9900
7:140694662:GGT:G	acceptor_gain	0.9900
7:140694662:GGTAA:G	acceptor_gain	0.9900
7:140696840:TCA:T	donor_gain	0.9900
7:140697445:A:T	donor_gain	0.9900

AlphaMissense

680 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:140704892:G:C	W92C	0.985
7:140704892:G:T	W92C	0.985
7:140704890:T:A	W92R	0.983
7:140704890:T:C	W92R	0.983
7:140702963:T:A	W66R	0.981
7:140702963:T:C	W66R	0.981
7:140704912:T:C	I99T	0.977
7:140704866:T:C	F84L	0.968
7:140704868:T:A	F84L	0.968
7:140704868:T:G	F84L	0.968
7:140702966:T:C	F67L	0.966
7:140702968:C:A	F67L	0.966
7:140702968:C:G	F67L	0.966
7:140702902:A:C	R45S	0.964
7:140702902:A:T	R45S	0.964
7:140704906:T:C	L97S	0.964
7:140702969:T:A	W68R	0.963
7:140702969:T:C	W68R	0.963
7:140704908:G:C	G98R	0.961
7:140704912:T:G	I99S	0.960
7:140704909:G:T	G98V	0.958
7:140704891:G:C	W92S	0.957
7:140702973:T:C	I69T	0.956
7:140702901:G:T	R45I	0.955
7:140704860:G:C	G82R	0.950
7:140702951:A:C	S62R	0.949
7:140702953:C:A	S62R	0.949
7:140702953:C:G	S62R	0.949
7:140702901:G:C	R45T	0.947
7:140702954:G:A	G63R	0.944

dbSNP variants (sampled 300 via entrez): RS1000223200 (7:140703929 A>G,T), RS1000324933 (7:140703527 A>G), RS1000636390 (7:140696975 G>A), RS1001017675 (7:140698862 A>T), RS1001153270 (7:140699086 A>G), RS1001279069 (7:140702163 T>A,C), RS1001537819 (7:140698440 A>G), RS1001611709 (7:140698130 A>G), RS1001830538 (7:140703992 T>A,C), RS1001876509 (7:140699988 T>C), RS1002062477 (7:140703848 T>C), RS1002110162 (7:140705891 G>C,T), RS1002281672 (7:140703563 C>T), RS1002565658 (7:140705541 G>A,T), RS1002753072 (7:140695468 C>T)

Disease associations

OMIM: gene MIM:603838 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2363065 (PROTEIN COMPLEX)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

8 potent at pChembl≥5 of 18 total, top 8 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.06	IC50	870	nM	R-(+)-MARMIN-6’-UNDECANOATE
6.04	IC50	920	nM	R-(+)-MARMIN-6’-LINOLEATE
5.63	IC50	2350	nM	R-(+)-MARMIN-6’-LINOLEATE
5.51	IC50	3080	nM	R-(+)-MARMIN-6’-OCTANOATE
5.43	IC50	3670	nM	R-(+)-MARMIN-6’-UNDECANOATE
5.43	IC50	3710	nM	R-(+)-MARMIN-6’-OCTANOATE
5.31	IC50	4900	nM	(+)-9’-ISOVALEROXYLARICIRESINOL
5.04	IC50	9100	nM	(+)-9’-ISOVALEROXYLARICIRESINOL

PubChem BioAssay actives

8 with measured affinity, of 28 total; 4 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
[(E,3R)-2-hydroxy-2,6-dimethyl-8-(2-oxochromen-7-yl)oxyoct-6-en-3-yl] undecanoate	739270: Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay	ic50	0.8700	uM
[(E,3R)-2-hydroxy-2,6-dimethyl-8-(2-oxochromen-7-yl)oxyoct-6-en-3-yl] (9Z,12Z)-octadeca-9,12-dienoate	739270: Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay	ic50	0.9200	uM
[(E,3R)-2-hydroxy-2,6-dimethyl-8-(2-oxochromen-7-yl)oxyoct-6-en-3-yl] octanoate	739270: Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay	ic50	3.0800	uM
[(2S,3R,4R)-2-(4-hydroxy-3-methoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-3-yl]methyl 3-methylbutanoate	739269: Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1,10-phenanthroline-induced HIF1 activation incubated for 30 mins prior to 1,10-phenanthroline-challenge measured after 16 hrs by luciferase reporter assay	ic50	4.9000	uM

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases methylation, affects cotreatment, increases expression	3
bisphenol A	decreases expression, affects expression	2
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
Cisplatin	increases expression	2
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
tanshinone	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
ochratoxin A	increases expression	1
tris(chloroethyl)phosphate	decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
chloropicrin	increases expression	1
bisphenol S	affects cotreatment, increases expression	1
Fulvestrant	increases methylation	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	increases expression, affects cotreatment, increases abundance	1
Atrazine	decreases expression	1
Cadmium	increases expression, increases abundance	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Flame Retardants	decreases expression, increases abundance	1
Fluorouracil	increases expression	1

ChEMBL screening assays

4 unique, capped per target: 4 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2353025	Binding	Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation at 30 uM incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay	Semisynthetic studies identify mitochondria poisons from botanical dietary supplements–geranyloxycoumarins from Aegle marmelos. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.