NEK11-AS1

Summary

NEK11-AS1 (NEK11 antisense RNA 1, HGNC:58249) is a long non-coding RNA gene on chromosome 3q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58249
Approved symbol	NEK11-AS1
Name	NEK11 antisense RNA 1
Location	3q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250129
Ensembl biotype	lncRNA
Entrez	139355204
RNAcentral	URS0002A6A2CC — lncRNA, 1910 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000506476, ENST00000511339, ENST00000513940, ENST00000841769, ENST00000841770, ENST00000841771

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000506476 — 3 exons

Exon	Start	End
ENSE00002082237	131054468	131054585
ENSE00004266318	131072230	131072341
ENSE00004266324	131052135	131053679

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 76.82.

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.82	silver quality
ganglionic eminence	UBERON:0004023	62.84	gold quality
placenta	UBERON:0001987	60.83	gold quality
stromal cell of endometrium	CL:0002255	58.55	gold quality
skeletal muscle tissue	UBERON:0001134	57.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	56.81	gold quality
muscle tissue	UBERON:0002385	56.59	gold quality
monocyte	CL:0000576	54.87	gold quality
bone marrow	UBERON:0002371	54.39	silver quality
liver	UBERON:0002107	53.49	silver quality
islet of Langerhans	UBERON:0000006	53.40	gold quality
blood	UBERON:0000178	53.30	gold quality
urinary bladder	UBERON:0001255	52.37	gold quality
calcaneal tendon	UBERON:0003701	52.37	silver quality
prefrontal cortex	UBERON:0000451	51.91	gold quality
right uterine tube	UBERON:0001302	51.47	gold quality
corpus callosum	UBERON:0002336	51.45	silver quality
adrenal tissue	UBERON:0018303	51.21	gold quality
vermiform appendix	UBERON:0001154	50.46	gold quality
endometrium	UBERON:0001295	49.88	gold quality
muscle of leg	UBERON:0001383	49.81	gold quality
rectum	UBERON:0001052	49.18	gold quality
primary visual cortex	UBERON:0002436	48.69	silver quality
gastrocnemius	UBERON:0001388	48.46	gold quality
lung	UBERON:0002048	47.31	gold quality
body of pancreas	UBERON:0001150	46.20	silver quality
ectocervix	UBERON:0012249	45.88	gold quality
fundus of stomach	UBERON:0001160	45.69	gold quality
heart	UBERON:0000948	45.53	gold quality
heart left ventricle	UBERON:0002084	45.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.93

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.