NEK2-DT

Summary

NEK2-DT (NEK2 divergent transcript, HGNC:28085) is a long non-coding RNA gene on chromosome 1q32.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28085
Approved symbol	NEK2-DT
Name	NEK2 divergent transcript
Location	1q32.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231057
Ensembl biotype	lncRNA
Entrez	91548
RNAcentral	URS0000BC44A0 — lncRNA, 1424 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000415202, ENST00000421933, ENST00000443174, ENST00000667973, ENST00000703066, ENST00000832131, ENST00000832132, ENST00000832133, ENST00000832134, ENST00000832135, ENST00000832136

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415202 — 4 exons

Exon	Start	End
ENSE00001650970	211685566	211685806
ENSE00001678980	211677067	211677154
ENSE00001742770	211686470	211686790
ENSE00001776497	211675762	211675866

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 92.04.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	92.04	gold quality
muscle tissue	UBERON:0002385	81.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.85	gold quality
corpus callosum	UBERON:0002336	74.53	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.83	gold quality
fallopian tube	UBERON:0003889	69.58	gold quality
testis	UBERON:0000473	68.03	gold quality
left testis	UBERON:0004533	67.82	gold quality
right testis	UBERON:0004534	67.47	gold quality
duodenum	UBERON:0002114	65.78	gold quality
ventricular zone	UBERON:0003053	64.00	gold quality
right lung	UBERON:0002167	62.86	gold quality
ganglionic eminence	UBERON:0004023	61.67	gold quality
calcaneal tendon	UBERON:0003701	59.31	gold quality
endometrium	UBERON:0001295	58.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.12	gold quality
prefrontal cortex	UBERON:0000451	57.72	gold quality
lung	UBERON:0002048	57.14	gold quality
endocervix	UBERON:0000458	56.50	gold quality
upper lobe of left lung	UBERON:0008952	56.33	gold quality
placenta	UBERON:0001987	55.70	gold quality
caudate nucleus	UBERON:0001873	55.49	gold quality
amygdala	UBERON:0001876	54.59	gold quality
hypothalamus	UBERON:0001898	54.33	gold quality
blood	UBERON:0000178	53.65	gold quality
Ammon’s horn	UBERON:0001954	53.42	gold quality
monocyte	CL:0000576	52.36	silver quality
left uterine tube	UBERON:0001303	52.29	gold quality
liver	UBERON:0002107	51.88	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.