NETO1

Summary

NETO1 (neuropilin and tolloid like 1, HGNC:13823) is a protein-coding gene on chromosome 18q22.3, encoding Neuropilin and tolloid-like protein 1 (Q8TDF5). Involved in the development and/or maintenance of neuronal circuitry.

This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Source: NCBI Gene 81832 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 59 total — 1 pathogenic
• MANE Select transcript: NM_138966

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13823
Approved symbol	NETO1
Name	neuropilin and tolloid like 1
Location	18q22.3
Locus type	gene with protein product
Status	Approved
Aliases	BTCL1, BCTL1
Ensembl gene	ENSG00000166342
Ensembl biotype	protein_coding
OMIM	607973
Entrez	81832

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 9 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000327305, ENST00000397929, ENST00000577184, ENST00000579169, ENST00000579730, ENST00000582281, ENST00000583169, ENST00000876951, ENST00000916239, ENST00000916240, ENST00000916241

RefSeq mRNA: 8 — MANE Select: NM_138966 NM_001201465, NM_001354017, NM_001354018, NM_001354020, NM_001354021, NM_001354022, NM_138966, NM_138999

CCDS: CCDS12000, CCDS42444

Canonical transcript exons

ENST00000327305 — 11 exons

Exon	Start	End
ENSE00001179943	72794363	72794404
ENSE00001179973	72867264	72867987
ENSE00001305635	72750062	72750620
ENSE00001305895	72783678	72783906
ENSE00001326249	72794117	72794244
ENSE00001327400	72749014	72749088
ENSE00001634081	72756034	72756147
ENSE00002722002	72743756	72748164
ENSE00003617319	72858826	72859074
ENSE00003630223	72865188	72865241
ENSE00003669678	72864808	72864945

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 88.98.

FANTOM5 (CAGE): breadth broad, TPM avg 3.8885 / max 139.1868, expressed in 369 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
172407	3.1389	357
172408	0.3992	117
172409	0.2294	92
172405	0.0589	41
172406	0.0443	29
172404	0.0178	6

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	88.98	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.00	gold quality
anterior cingulate cortex	UBERON:0009835	85.21	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.12	gold quality
frontal cortex	UBERON:0001870	83.41	gold quality
neocortex	UBERON:0001950	82.90	gold quality
caudate nucleus	UBERON:0001873	82.46	gold quality
putamen	UBERON:0001874	82.21	gold quality
nucleus accumbens	UBERON:0001882	82.21	gold quality
right frontal lobe	UBERON:0002810	81.73	gold quality
cerebral cortex	UBERON:0000956	81.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.75	gold quality
amygdala	UBERON:0001876	77.81	gold quality
Ammon’s horn	UBERON:0001954	77.77	gold quality
forebrain	UBERON:0001890	76.01	gold quality
primary visual cortex	UBERON:0002436	74.92	gold quality
buccal mucosa cell	CL:0002336	74.72	gold quality
temporal lobe	UBERON:0001871	73.67	gold quality
superior frontal gyrus	UBERON:0002661	73.30	gold quality
cortical plate	UBERON:0005343	73.12	gold quality
brain	UBERON:0000955	71.36	gold quality
Brodmann (1909) area 46	UBERON:0006483	71.31	gold quality
occipital lobe	UBERON:0002021	71.16	gold quality
hypothalamus	UBERON:0001898	70.48	gold quality
postcentral gyrus	UBERON:0002581	70.09	gold quality
parietal lobe	UBERON:0001872	69.37	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.20	gold quality
Brodmann (1909) area 23	UBERON:0013554	69.10	gold quality
entorhinal cortex	UBERON:0002728	67.93	gold quality
stromal cell of endometrium	CL:0002255	67.35	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-11121	yes	657.20
E-GEOD-98556	yes	431.44
E-GEOD-137537	yes	20.18
E-ANND-3	yes	4.61

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GATA3

miRNA regulators (miRDB)

91 targeting NETO1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-4698	99.84	71.41	4303

Literature-anchored findings (GeneRIF, showing 5)

• Mouse neto1 plays a critical role in spatial learning and memory through the regulation of NMDAR subunit abundance at synapses. (PMID:19243221)
• no evidence for the association of NETO1 with schizophrenia in the Japanese population (PMID:22205981)
• Neto1 is concluded to be a component of amyloid precursor protein /NMDA receptor trafficking complexes (PMID:23621516)
• Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 and Neto2 on the desensitization properties of GluK1 homomeric receptors (PMID:26277340)
• High neuropilin and tolloid-like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton. (PMID:32638511)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	neto1	ENSDARG00000068483
danio_rerio	neto1l	ENSDARG00000071596
mus_musculus	Neto1	ENSMUSG00000050321
rattus_norvegicus	Neto1	ENSRNOG00000014006

Paralogs (35): NRXN3 (ENSG00000021645), TLL1 (ENSG00000038295), CP (ENSG00000047457), DCBLD2 (ENSG00000057019), HEPH (ENSG00000089472), TLL2 (ENSG00000095587), NRP1 (ENSG00000099250), PCOLCE (ENSG00000106333), CNTNAP3 (ENSG00000106714), CUBN (ENSG00000107611), CNTNAP1 (ENSG00000108797), NRXN2 (ENSG00000110076), MEP1A (ENSG00000112818), NRP2 (ENSG00000118257), CUZD1 (ENSG00000138161), MFGE8 (ENSG00000140545), MEP1B (ENSG00000141434), PDGFC (ENSG00000145431), CNTNAP4 (ENSG00000152910), CNTNAP3B (ENSG00000154529), CNTNAP5 (ENSG00000155052), CDCP2 (ENSG00000157211), PCOLCE2 (ENSG00000163710), EDIL3 (ENSG00000164176), BMP1 (ENSG00000168487), PDGFD (ENSG00000170962), NETO2 (ENSG00000171208), CNTNAP2 (ENSG00000174469), NRXN1 (ENSG00000179915), HEPHL1 (ENSG00000181333), F8 (ENSG00000185010), ASTL (ENSG00000188886), F5 (ENSG00000198734), MFRP (ENSG00000235718), CNTNAP3C (ENSG00000283378)

Protein

Protein identifiers

Neuropilin and tolloid-like protein 1 — Q8TDF5 (reviewed: Q8TDF5)

Alternative names: Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1

All UniProt accessions (2): Q8TDF5, J3QRF5

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.

Subunit / interactions. Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains.

Subcellular location. Cell membrane. Postsynaptic density membrane Cell membrane Secreted.

Tissue specificity. Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8TDF5-3	3	yes
Q8TDF5-1	1, Soluble, sNETO1
Q8TDF5-2	2

RefSeq proteins (8): NP_001188394, NP_001340946, NP_001340947, NP_001340949, NP_001340950, NP_001340951, NP_620416, NP_620552 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000859	CUB_dom	Domain
IPR002172	LDrepeatLR_classA_rpt	Repeat
IPR023415	LDLR_class-A_CS	Conserved_site
IPR035914	Sperma_CUB_dom_sf	Homologous_superfamily
IPR036055	LDL_receptor-like_sf	Homologous_superfamily

Pfam: PF00057, PF00431

UniProt features (25 total): disulfide bond 7, splice variant 3, domain 3, glycosylation site 2, topological domain 2, sequence variant 2, signal peptide 1, chain 1, sequence conflict 1, transmembrane region 1, short sequence motif 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TDF5-F1	71.83	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 417

Disulfide bonds (7): 41–68, 96–118, 172–202, 229–251, 292–304, 299–317, 311–326

Glycosylation sites (2): 306, 340

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 228 (showing top): GOBP_MEMORY, GOBP_COGNITION, GOBP_AXO_DENDRITIC_TRANSPORT, GOBP_BEHAVIOR, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY, GOBP_ASSOCIATIVE_LEARNING, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_CELL_CELL_SIGNALING, STARK_HYPPOCAMPUS_22Q11_DELETION_UP, GOBP_REGULATION_OF_SYNAPTIC_PLASTICITY, GOBP_REGULATION_OF_POSTSYNAPTIC_MEMBRANE_POTENTIAL, GOBP_LEARNING, GOBP_REGULATION_OF_CELLULAR_LOCALIZATION, IRF1_Q6

GO Biological Process (7): memory (GO:0007613), visual learning (GO:0008542), regulation of long-term neuronal synaptic plasticity (GO:0048169), neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645), anterograde axonal transport of neurotransmitter receptor complex (GO:0140231), positive regulation of excitatory postsynaptic potential (GO:2000463), receptor localization to synapse (GO:0097120)

GO Molecular Function (2): ionotropic glutamate receptor binding (GO:0035255), protein binding (GO:0005515)

GO Cellular Component (11): extracellular region (GO:0005576), postsynaptic density (GO:0014069), excitatory synapse (GO:0060076), Schaffer collateral - CA1 synapse (GO:0098685), postsynaptic density membrane (GO:0098839), glutamatergic synapse (GO:0098978), axon cytoplasm (GO:1904115), plasma membrane (GO:0005886), membrane (GO:0016020), synapse (GO:0045202), postsynaptic membrane (GO:0045211)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
synapse	3
receptor localization to synapse	2
cellular anatomical structure	2
learning or memory	1
visual behavior	1
associative learning	1
regulation of neuronal synaptic plasticity	1
protein-containing complex localization	1
regulation of postsynaptic membrane neurotransmitter receptor levels	1
protein localization to postsynaptic specialization membrane	1
neurotransmitter receptor transport	1
anterograde axonal protein transport	1
positive regulation of signal transduction	1
excitatory postsynaptic potential	1
modulation of excitatory postsynaptic potential	1
localization	1
glutamate receptor binding	1
binding	1
asymmetric synapse	1
postsynaptic specialization	1
postsynaptic density	1
postsynaptic membrane	1
postsynaptic specialization membrane	1
axon	1
neuron projection cytoplasm	1
membrane	1
cell periphery	1
cell junction	1
synaptic membrane	1
postsynapse	1

Protein interactions and networks

STRING

1144 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NETO1	GRIK2	Q13002	872
NETO1	GRIK1	P39086	773
NETO1	KARS1	Q15046	724
NETO1	SPADH	A0A494C103	623
NETO1	GRIN2A	Q12879	621
NETO1	C1S	P09871	602
NETO1	SEMA3E	O15041	600
NETO1	GRIK4	Q16099	593
NETO1	GRIK5	Q16478	543
NETO1	NTNG1	Q9Y2I2	526
NETO1	NTNG2	Q96CW9	517
NETO1	CAPNS2	Q96L46	515
NETO1	FBXO15	Q8NCQ5	514
NETO1	GRIK3	Q13003	507
NETO1	CACNG2	Q9Y698	506

IntAct

3 interactions, top by confidence:

A	B	Type	Score
CHRNB2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
RSPH1	NETO1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (11): NETO1 (Affinity Capture-RNA), NETO1 (Affinity Capture-Western), NETO1 (Affinity Capture-Western), NETO1 (Affinity Capture-Western), NETO1 (Affinity Capture-Western), NETO1 (Affinity Capture-MS), NETO1 (Proximity Label-MS), NETO1 (Two-hybrid), NETO1 (Reconstituted Complex), NETO1 (Affinity Capture-RNA), NETO1 (Affinity Capture-Luminescence)

ESM2 similar proteins: A1XQX1, A2A690, D0PRN2, F1LTE0, O73612, P0DI97, P13590, P15209, P52795, P52796, P52799, P52800, P58400, P97401, P98172, Q01973, Q03351, Q0PMD2, Q13330, Q16288, Q16620, Q17QD6, Q28142, Q28143, Q5RF67, Q62599, Q63373, Q63604, Q6NW40, Q6PFE7, Q8C4U3, Q8C985, Q8IYR6, Q8K4B0, Q8N474, Q8R4I7, Q8TDF5, Q8VHW2, Q8VHW5, Q91044

Diamond homologs: A8Q2D1, C6K2K4, C6KFA3, D5FM38, O43897, O57460, P48740, P79953, P97435, P98064, Q4A3R3, Q5E9P5, Q60997, Q62381, Q6F3F9, Q7Z408, Q86SQ4, Q86UP6, Q8BNJ6, Q8BQH6, Q8BU25, Q8BZE1, Q8CHN8, Q8CIZ5, Q8NC67, Q8R4I7, Q8TDF5, Q90WD8, Q923L3, Q95218, Q96PZ7, Q9EQT1, Q9JJS0, Q9NQ36, Q9QZT0, Q9UGM3, Q9W332, A8WCC4, B3EX01, B8VIV4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

59 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	47
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2578813	GRCh37/hg19 18q22.1-23(chr18:63476940-77960815)x1	Pathogenic

SpliceAI

2639 predictions. Top by Δscore:

Variant	Effect	Δscore
18:72750623:A:C	acceptor_gain	1.0000
18:72750628:T:C	acceptor_gain	1.0000
18:72750628:T:TC	acceptor_gain	1.0000
18:72750637:G:C	acceptor_gain	1.0000
18:72750637:G:GC	acceptor_gain	1.0000
18:72756028:CATTA:C	donor_loss	1.0000
18:72756029:ATTAC:A	donor_loss	1.0000
18:72756030:TTA:T	donor_loss	1.0000
18:72756031:TA:T	donor_loss	1.0000
18:72756032:A:T	donor_loss	1.0000
18:72756033:C:T	donor_loss	1.0000
18:72756033:CCT:C	donor_gain	1.0000
18:72756148:C:CC	acceptor_gain	1.0000
18:72783676:A:AC	donor_gain	1.0000
18:72783677:C:CC	donor_gain	1.0000
18:72783677:CGTT:C	donor_gain	1.0000
18:72783680:T:A	donor_gain	1.0000
18:72783803:G:C	donor_gain	1.0000
18:72783907:C:CG	acceptor_loss	1.0000
18:72783908:T:G	acceptor_loss	1.0000
18:72794406:T:C	acceptor_gain	1.0000
18:72858820:A:AC	donor_gain	1.0000
18:72858821:C:CC	donor_gain	1.0000
18:72859072:CGG:C	acceptor_gain	1.0000
18:72859075:C:CC	acceptor_gain	1.0000
18:72864802:CCTTA:C	donor_loss	1.0000
18:72864803:CTTA:C	donor_loss	1.0000
18:72864804:TTA:T	donor_loss	1.0000
18:72864805:TACCT:T	donor_loss	1.0000
18:72864806:A:T	donor_loss	1.0000

AlphaMissense

3551 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:72756053:C:A	W321C	1.000
18:72756053:C:G	W321C	1.000
18:72794144:C:A	W204C	1.000
18:72794144:C:G	W204C	1.000
18:72794146:A:G	W204R	1.000
18:72794146:A:T	W204R	1.000
18:72858897:A:G	L133P	1.000
18:72858984:C:G	R104P	1.000
18:72859050:A:G	L82P	1.000
18:72756065:A:C	C317W	0.999
18:72756066:C:G	C317S	0.999
18:72756066:C:T	C317Y	0.999
18:72756067:A:G	C317R	0.999
18:72756067:A:T	C317S	0.999
18:72756083:G:C	C311W	0.999
18:72756084:C:G	C311S	0.999
18:72756084:C:T	C311Y	0.999
18:72756085:A:G	C311R	0.999
18:72756085:A:T	C311S	0.999
18:72756104:A:C	C304W	0.999
18:72756105:C:G	C304S	0.999
18:72756106:A:G	C304R	0.999
18:72756106:A:T	C304S	0.999
18:72756119:G:C	C299W	0.999
18:72756120:C:G	C299S	0.999
18:72756120:C:T	C299Y	0.999
18:72756121:A:G	C299R	0.999
18:72756121:A:T	C299S	0.999
18:72783736:C:A	W270C	0.999
18:72783736:C:G	W270C	0.999

dbSNP variants (sampled 300 via entrez): RS1000023769 (18:72854461 A>G), RS1000024583 (18:72792818 A>G), RS1000026280 (18:72819094 T>C), RS1000058084 (18:72754421 T>C), RS1000071969 (18:72744342 G>A,T), RS1000084470 (18:72834186 A>T), RS1000094399 (18:72860903 T>C), RS1000208150 (18:72804194 C>G), RS1000236341 (18:72815158 G>A), RS1000242588 (18:72851227 C>A,T), RS1000261444 (18:72777644 G>A), RS1000270843 (18:72838658 G>A), RS1000274762 (18:72759924 C>T), RS1000283683 (18:72844498 C>T), RS1000335642 (18:72844214 T>C)

Disease associations

OMIM: gene MIM:607973 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001511_4	Economic and political preferences (time)	6.000000e-07
GCST001856_49	Thyroid hormone levels	3.000000e-08
GCST002304_11	Fractional exhaled nitric oxide (childhood)	1.000000e-06
GCST002304_3	Fractional exhaled nitric oxide (childhood)	3.000000e-06
GCST005171_13	QT interval	7.000000e-07
GCST009391_1418	Metabolite levels	1.000000e-06
GCST009391_999	Metabolite levels	1.000000e-06
GCST010244_179	Triglyceride levels	2.000000e-08
GCST90026412_6	Severe autoimmune type 2 diabetes	6.000000e-06

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004827	economic and social preference
EFO:0004730	hormone measurement
EFO:0005536	nitric oxide exhalation measurement
EFO:0004682	QT interval
EFO:0010452	adenosine diphosphate measurement
EFO:0010540	thiamine measurement
EFO:0004530	triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	7
Benzo(a)pyrene	affects methylation, increases methylation	2
Estradiol	affects expression, affects cotreatment, increases expression	2
Testosterone	affects cotreatment, decreases expression, increases expression	2
Aflatoxin B1	decreases methylation	2
methylmercuric chloride	increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
terbufos	increases methylation	1
trichostatin A	increases expression	1
arsenite	increases methylation	1
sodium arsenite	decreases expression, increases abundance, affects cotreatment	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
benzo(e)pyrene	affects methylation	1
aflatoxin B2	increases methylation	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Decitabine	increases expression	1
Fulvestrant	increases methylation, affects cotreatment	1
Acetaminophen	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Calcitriol	decreases expression, affects cotreatment	1
Fonofos	increases methylation	1
Formaldehyde	increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Methapyrilene	increases methylation	1
Parathion	increases methylation	1
Phenylmercuric Acetate	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.