NEURL2

Summary

NEURL2 (neuralized E3 ubiquitin protein ligase 2, HGNC:16156) is a protein-coding gene on chromosome 20q13.12, encoding Neuralized-like protein 2 (Q9BR09). Plays an important role in the process of myofiber differentiation and maturation.

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants.

Source: NCBI Gene 140825 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 42 total
• GTEx eGene: eQTL in 21 tissues, sQTL in 6 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.58 (unconstrained)
• MANE Select transcript: NM_080749

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16156
Approved symbol	NEURL2
Name	neuralized E3 ubiquitin protein ligase 2
Location	20q13.12
Locus type	gene with protein product
Status	Approved
Aliases	dJ337O18.6, FLJ30259, Ozz, Ozz-E3
Ensembl gene	ENSG00000124257
Ensembl biotype	protein_coding
OMIM	608597
Entrez	140825

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

MANE Select: ENST00000372518

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 3: 1

ENST00000372518, ENST00000545238, ENST00001133870

RefSeq mRNA: 2 — MANE Select: NM_080749 NM_001278535, NM_080749

CCDS: CCDS13384

Canonical transcript exons

ENST00000372518 — 2 exons

Exon	Start	End
ENSE00001458001	45888634	45888873
ENSE00001458004	45890250	45891208

Expression profiles

Bgee: expression breadth ubiquitous, 185 present calls, max score 94.70.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7910 / max 54.2742, expressed in 443 samples.

Highest expression (Bgee): male germ line stem cell (sensu Vertebrata) in testis, apex of heart, mucosa of stomach, primordial germ cell in gonad, hindlimb stylopod muscle.

Genetic regulation across tissues (GTEx eQTL / sQTL)

NEURL2 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 21 tissues and its splicing (sQTL) in 6 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 27 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Adipose Subcutaneous	eqtl	5.0e-12	+0.28	20:46003393:C:T
Adipose Visceral Omentum	eqtl	1.9e-09	+0.30	20:45919331:C:T
Thyroid	eqtl	9.2e-08	+0.26	20:46006406:G:T
Spleen	eqtl	6.1e-07	+0.68	20:45927136:GC:G
Testis	eqtl	1.0e-06	-0.39	20:45894908:G:A
Lung	eqtl	1.6e-05	+0.33	20:45927136:GC:G
Colon Transverse	eqtl	1.7e-05	+0.27	20:46028310:C:T
Artery Aorta	eqtl	2.0e-05	+0.31	20:45916409:C:T
Skin Not Sun Exposed Suprapubic	eqtl	5.3e-05	+0.29	20:45919331:C:T
Esophagus Gastroesophageal Junction	eqtl	1.1e-04	+0.33	20:45919331:C:T
Esophagus Muscularis	eqtl	1.7e-04	+0.32	20:45953548:A:T
Skin Sun Exposed Lower leg	eqtl	7.7e-04	+0.20	20:45914155:C:A
Esophagus Mucosa	eqtl	1.4e-03	-0.84	20:45845224:G:A
Artery Tibial	eqtl	2.5e-03	-0.50	20:46627525:T:G
Breast Mammary Tissue	eqtl	4.7e-03	-0.27	20:45991015:C:G
Muscle Skeletal	eqtl	5.7e-03	+0.24	20:46233862:G:A
Heart Atrial Appendage	eqtl	8.3e-03	+0.25	20:45916409:C:T
Testis	sqtl	8.3e-03	+0.37	20:45860835:G:A
Nerve Tibial	eqtl	8.6e-03	+0.21	20:45919331:C:T
Colon Transverse	sqtl	9.7e-03	+0.75	20:45445910:C:T

FANTOM5 promoters

2 alternative TSS:

Promoter ID	TPM avg	Samples expressed
187496	0.3972	209
187497	0.3938	165

Top tissues by expression

showing 100 of 245 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.70	gold quality
apex of heart	UBERON:0002098	87.08	gold quality
mucosa of stomach	UBERON:0001199	84.61	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.87	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.60	gold quality
tendon of biceps brachii	UBERON:0008188	83.18	silver quality
thymus	UBERON:0002370	82.99	gold quality
muscle of leg	UBERON:0001383	81.91	gold quality
gastrocnemius	UBERON:0001388	81.89	gold quality
right adrenal gland cortex	UBERON:0035827	81.52	gold quality
quadriceps femoris	UBERON:0001377	81.38	silver quality
vastus lateralis	UBERON:0001379	80.97	silver quality
right adrenal gland	UBERON:0001233	80.21	gold quality
left ovary	UBERON:0002119	79.61	gold quality
right ovary	UBERON:0002118	79.58	gold quality
left adrenal gland	UBERON:0001234	79.29	gold quality
right coronary artery	UBERON:0001625	79.13	gold quality
omental fat pad	UBERON:0010414	79.01	gold quality
right lobe of liver	UBERON:0001114	78.99	gold quality
left coronary artery	UBERON:0001626	78.96	gold quality
peritoneum	UBERON:0002358	78.94	gold quality
left uterine tube	UBERON:0001303	78.88	gold quality
left adrenal gland cortex	UBERON:0035825	78.43	gold quality
heart left ventricle	UBERON:0002084	78.33	gold quality
lower esophagus	UBERON:0013473	78.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.28	gold quality
metanephros cortex	UBERON:0010533	78.10	gold quality
right atrium auricular region	UBERON:0006631	78.04	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.01	gold quality
coronary artery	UBERON:0001621	77.88	gold quality
adipose tissue of abdominal region	UBERON:0007808	77.87	gold quality
cardiac ventricle	UBERON:0002082	77.64	gold quality
adrenal cortex	UBERON:0001235	77.36	gold quality
cardiac atrium	UBERON:0002081	77.36	gold quality
thoracic aorta	UBERON:0001515	77.32	gold quality
ascending aorta	UBERON:0001496	77.25	gold quality
skeletal muscle tissue	UBERON:0001134	77.24	gold quality
heart	UBERON:0000948	77.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.88	gold quality
descending thoracic aorta	UBERON:0002345	76.69	gold quality
aorta	UBERON:0000947	76.63	gold quality
muscle tissue	UBERON:0002385	76.63	gold quality
popliteal artery	UBERON:0002250	76.36	gold quality
tibial artery	UBERON:0007610	76.34	gold quality
left ventricle myocardium	UBERON:0006566	76.32	gold quality
transverse colon	UBERON:0001157	75.95	gold quality
deltoid	UBERON:0001476	75.95	silver quality
biceps brachii	UBERON:0001507	75.86	gold quality
adult mammalian kidney	UBERON:0000082	75.82	gold quality
adrenal gland	UBERON:0002369	75.82	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.71	gold quality
ovary	UBERON:0000992	75.66	gold quality
subcutaneous adipose tissue	UBERON:0002190	75.41	gold quality
body of uterus	UBERON:0009853	75.31	gold quality
kidney epithelium	UBERON:0004819	75.14	gold quality
cardiac muscle of right atrium	UBERON:0003379	74.65	gold quality
right lobe of thyroid gland	UBERON:0001119	74.44	gold quality
stromal cell of endometrium	CL:0002255	74.29	gold quality
left lobe of thyroid gland	UBERON:0001120	74.24	gold quality
tibial nerve	UBERON:0001323	73.98	gold quality
ectocervix	UBERON:0012249	73.86	gold quality
small intestine	UBERON:0002108	73.32	gold quality
minor salivary gland	UBERON:0001830	73.26	gold quality
endocervix	UBERON:0000458	73.19	gold quality
colon	UBERON:0001155	72.97	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	72.88	silver quality
metanephros	UBERON:0000081	72.85	gold quality
thyroid gland	UBERON:0002046	72.76	gold quality
cortex of kidney	UBERON:0001225	72.72	gold quality
skin of leg	UBERON:0001511	72.63	gold quality
body of stomach	UBERON:0001161	72.54	gold quality
large intestine	UBERON:0000059	72.43	gold quality
intestine	UBERON:0000160	72.43	gold quality
adipose tissue	UBERON:0001013	72.43	gold quality
esophagus	UBERON:0001043	72.39	gold quality
spleen	UBERON:0002106	71.97	gold quality
mucosa of transverse colon	UBERON:0004991	71.76	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	71.55	silver quality
cerebellar hemisphere	UBERON:0002245	71.11	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.11	gold quality
saliva-secreting gland	UBERON:0001044	70.97	gold quality
cerebellar cortex	UBERON:0002129	70.96	gold quality
fundus of stomach	UBERON:0001160	70.71	gold quality
skin of abdomen	UBERON:0001416	70.70	gold quality
upper arm skin	UBERON:0004263	70.69	gold quality
gall bladder	UBERON:0002110	70.65	gold quality
lower esophagus mucosa	UBERON:0035834	70.26	gold quality
mouth mucosa	UBERON:0003729	70.13	gold quality
smooth muscle tissue	UBERON:0001135	70.04	gold quality
upper lobe of left lung	UBERON:0008952	69.89	gold quality
cerebellum	UBERON:0002037	69.84	gold quality
right uterine tube	UBERON:0001302	69.38	gold quality
body of pancreas	UBERON:0001150	69.17	gold quality
liver	UBERON:0002107	69.12	gold quality
right lung	UBERON:0002167	69.11	gold quality
pituitary gland	UBERON:0000007	69.01	gold quality
zone of skin	UBERON:0000014	68.89	gold quality
stomach	UBERON:0000945	68.84	gold quality
upper lobe of lung	UBERON:0008948	68.81	gold quality
myometrium	UBERON:0001296	68.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.91

HPA expression

RNA tissue specificity: Low tissue specificity

showing 60 of 79 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Skeletal muscle	tissue	17.8	medium
Choroid plexus	tissue	14.6
Nucleus accumbens	tissue	9.6
Tongue	tissue	8.3
Hippocampus	tissue	8.1	medium
Locus coeruleus	tissue	7.6
Postcentral gyrus	tissue	7.5
Thymus	tissue	7.1
Adipose tissue	tissue	5.3	not detected
Ovary	tissue	4.7	low
Small intestine	tissue	4.4	medium
Pituitary gland	tissue	4.1
Duodenum	tissue	4.1	medium
Vagina	tissue	4.0	medium
Retina	tissue	3.9
Heart muscle	tissue	3.8	not detected
Smooth muscle	tissue	3.7	not detected
Kidney	tissue	3.7	low
Skin 1	tissue	3.6	medium
Parathyroid gland	tissue	3.6	not detected
Basal ganglia	tissue	3.6	medium
Putamen	tissue	3.4
Liver	tissue	3.2	medium
Endometrium 1	tissue	3.1	not detected
Ventral forebrain	tissue	3.0
Cerebral cortex	tissue	2.8	low
Epididymis	tissue	2.8	low
Placenta	tissue	2.8	high
Thyroid gland	tissue	2.8	medium
Gallbladder	tissue	2.8	medium
Somatosensory cortex	tissue	2.8
Fallopian tube	tissue	2.7	medium
Septum	tissue	2.7
Seminal vesicle	tissue	2.6	not detected
Retrosplenial cortex	tissue	2.6
Hippocampal formation	tissue	2.5
Appendix	tissue	2.5	medium
Salivary gland	tissue	2.4	low
Motor cortex	tissue	2.4
Prostate	tissue	2.4	low
Adrenal gland	tissue	2.4	low
Frontal cortex	tissue	2.3
Retrosplenial and cingulate cortex	tissue	2.3
Occipital cortex	tissue	2.3
Prefrontal cortex	tissue	2.2
Colon	tissue	2.2	medium
Thalamus	tissue	2.2
Entorhinal cortex	tissue	2.2
Olfactory bulb	tissue	2.2
Amygdala	tissue	2.1
Caudate putamen	tissue	2.1
Temporal cortex	tissue	2.1
Insular cortex	tissue	2.1
Pons	tissue	2.0
Rectum	tissue	2.0	medium
Hypothalamus	tissue	2.0
Periaqueductal gray	tissue	2.0
Superior colliculi	tissue	1.9
Spinal cord	tissue	1.9
Stomach 1	tissue	1.8	high

Brain sub-regions (HPA Brain Atlas): detected in 190; highest nTPM — Flocculonodular lobe (15.1), Vermis (14.8), Cerebellar cortex (13.5), Piriform cortex (12.9), Frontal operculum (11.9).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting NEURL2 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

13 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-148A-5P	99.30	68.27	1141
HSA-MIR-500A-5P	98.76	69.13	1241
HSA-MIR-548Q	98.71	65.35	563
HSA-MIR-1-5P	98.70	68.66	1017
HSA-MIR-6837-3P	98.42	66.71	1149
HSA-MIR-6880-5P	98.08	65.59	1282
HSA-MIR-3194-5P	96.80	64.90	1027
HSA-MIR-4435	95.90	65.47	1201
HSA-MIR-4522	95.76	66.23	742
HSA-MIR-11400	94.03	67.12	81

Functional genomics

gnomAD constraint: pLI 1.76e-06, LOEUF 1.58, missense Z 0.329 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000372518 — one region, missense o/e 0.96.

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	neurl2	ENSDARG00000062446
mus_musculus	Neurl2	ENSMUSG00000039873

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:3043305) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 7 distinct phenotype terms.

Mouse phenotype (MP)	Records
decreased leukocyte cell number	1
abnormal skeletal muscle morphology	1
decreased body weight	1
abnormal coat appearance	1
increased heart weight	1
decreased circulating iron level	1
decreased circulating glucose level	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Rattus norvegicus	Q5M870	94.9%	Diamond
Drosophila melanogaster	P29503	80.6%	Diamond
Drosophila virilis	Q24746	80.6%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
SPATA25	protein-coding	128497
PLTP	protein-coding	5360
CTSA	protein-coding	5476
ZNF335	protein-coding	63925
PCIF1	protein-coding	63935
ZSWIM3	protein-coding	140831
ZSWIM1	protein-coding	90204
ACOT8	protein-coding	10005
SNX21	protein-coding	90203
TNNC2	protein-coding	7125

Protein

Protein identifiers

Neuralized-like protein 2 — Q9BR09 (reviewed: Q9BR09)

All UniProt accessions (2): H0YGA6, Q9BR09

UniProt curated annotations — full annotation on UniProt →

Function. Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.

Subunit / interactions. Probable component the ECS(NEURL2) E3 ubiquitin-protein ligase complex consisting of ELOB/Elongin B, ELOC/Elongin C, CUL5, RBX1 and NEURL2. Interacts with CTNNB1.

Subcellular location. Cytoplasm.

Tissue specificity. Expressed specifically in skeletal and cardiac muscles.

Domain organisation. The SOCS domain mediates the interaction with ELOB and ELOC, while the NHR domain may be involved in ubiquitination substrate binding.

Pathway. Protein modification; protein ubiquitination.

RefSeq proteins (2): NP_001265464, NP_542787* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001496	SOCS_box	Domain
IPR006573	NHR_dom	Domain
IPR036036	SOCS_box-like_dom_sf	Homologous_superfamily
IPR037962	Neuralized	Family
IPR043136	B30.2/SPRY_sf	Homologous_superfamily

Pfam: PF07177, PF07525

UniProt features (5 total): domain 2, chain 1, region of interest 1, sequence variant 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BR09-F1	83.30	0.53

Human Protein Atlas

Protein class: Predicted intracellular proteins, UniProt - Evidence at transcript level

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): vesicles

Antibody reliability (HPA): IH approved · IF approved

Function

Pathways and Gene Ontology

Reactome pathways

1 curated (TAS) of 3; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

3 pathways:

ID	Pathway	Evidence
R-HSA-8951664	Neddylation	curated
R-HSA-392499	Metabolism of proteins	—
R-HSA-597592	Post-translational protein modification	—

MSigDB gene sets: 106 (showing top): BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN, GOBP_STRIATED_MUSCLE_CELL_DIFFERENTIATION, AP2_Q3, GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS, GOBP_MUSCLE_STRUCTURE_DEVELOPMENT, GOBP_ACTOMYOSIN_STRUCTURE_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, PU1_Q6, RYTTCCTG_ETS2_B, RGAGGAARY_PU1_Q6, GOBP_MUSCLE_CELL_DEVELOPMENT, GOBP_MUSCLE_CELL_DIFFERENTIATION, MYCMAX_03, GOMF_ACYLTRANSFERASE_ACTIVITY

GO Biological Process (3): protein ubiquitination (GO:0016567), myofibril assembly (GO:0030239), intracellular signal transduction (GO:0035556)

GO Molecular Function (1): ubiquitin protein ligase activity (GO:0061630)

GO Cellular Component (2): cytosol (GO:0005829), cytoplasm (GO:0005737)

Reactome top-level categories

2 top-level categories:

Category	Pathways
Post-translational protein modification	1
Metabolism of proteins	1

GO top-level categories

12 GO namespaces:

Category	Terms
intracellular anatomical structure	2
cellular anatomical structure	2
protein modification by small protein conjugation	1
cellular component assembly involved in morphogenesis	1
actomyosin structure organization	1
striated muscle cell development	1
supramolecular fiber organization	1
membraneless organelle assembly	1
signal transduction	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
cytoplasm	1

Protein interactions and networks

STRING

showing 15 of 346 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NEURL2	SPATA25	Q9BR10	742
NEURL2	CISH	Q9NSE2	637
NEURL2	ZSWIM1	Q9BR11	593
NEURL2	NEURL1	O76050	527
NEURL2	ACOT8	O14734	500
NEURL2	ZNF335	Q9H4Z2	497
NEURL2	WFDC10B	Q8IUB3	491
NEURL2	SNX21	Q969T3	484
NEURL2	ASB5	Q8WWX0	473
NEURL2	CTNNB1	P35222	471
NEURL2	LSMEM1	Q8N8F7	461
NEURL2	FHL3	Q13643	455
NEURL2	WFDC3	Q8IUB2	441
NEURL2	PDRG1	Q9NUG6	424
NEURL2	ALPK3	Q96L96	416

IntAct

BioGRID (10 interactions; top human partners by supporting records): SMN1 (Affinity Capture-Western; 2 records), CTNNB1 (Biochemical Activity), EGFR (Negative Genetic), MYH6 (Biochemical Activity), PDCD6IP (Biochemical Activity), PTP4A3 (Positive Genetic), RBX1 (Reconstituted Complex), TCEB1 (Reconstituted Complex), UBE2H (Reconstituted Complex)

Disease & clinical

Genetic variants

Variant evidence for NEURL2: 42 ClinVar records (0 pathogenic / likely pathogenic).

ClinVar

42 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	3
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 25 predictions of 87):

Position(s)	Effect	Δscore	Sites
20:45890248–45890249	donor_loss	0.9700	6
20:45888874–45888875	acceptor_loss	0.9600	6
20:45888876	acceptor_loss	0.9400
20:45890327	donor_gain	0.8100
20:45890258	donor_gain	0.8000
20:45890245	donor_loss	0.7900
20:45890245	donor_loss	0.7700
20:45888880	acceptor_gain	0.7600
20:45890280	donor_gain	0.7000
20:45888888–45888889	acceptor_loss	0.6700	6

AlphaMissense

700 missense substitutions predicted likely pathogenic (of 1,826 scored), across 170 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
D231	8	0.990	0.996
F49	8	0.972	0.999
F66	8	0.967	0.997
F55	8	0.961	0.997
F26	8	0.959	0.996
D212	8	0.945	0.980
F233	8	0.940	0.998
H205	8	0.917	0.992
S56	8	0.897	0.998
D173	8	0.843	0.958
H80	8	0.836	0.964
H27	8	0.802	0.929
W77	7	0.986	0.997
N209	7	0.965	0.997
F99	7	0.952	0.992
W111	7	0.949	0.979
F113	7	0.934	0.988
M204	7	0.926	0.983
C255	7	0.910	0.991
S188	7	0.902	0.994

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

5 prognostic cancer types:

Cancer	Prognostic	p-value
Rectum Adenocarcinoma (TCGA)	favorable	1.13e-05
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)	favorable	0.000184
Liver Hepatocellular Carcinoma (TCGA)	unfavorable	0.000286
Pancreatic Adenocarcinoma (TCGA)	favorable	0.000705
Kidney Renal Papillary Cell Carcinoma (TCGA)	favorable	0.000859

Disease associations

OMIM: gene MIM:608597 | disease phenotypes:

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression	4
Tetrachlorodibenzodioxin	affects expression, increases expression	3
Nickel	increases expression	2
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	increases expression	1
Estradiol	decreases expression	1
Smoke	decreases expression	1
Triclosan	decreases expression	1
Urethane	decreases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	increases expression	1
Antirheumatic Agents	decreases expression	1
Okadaic Acid	decreases expression	1
Copper Sulfate	decreases expression	1
S-Nitrosoglutathione	affects expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.