NEURL4

Summary

NEURL4 (neuralized E3 ubiquitin protein ligase 4, HGNC:34410) is a protein-coding gene on chromosome 17p13.1, encoding Neuralized-like protein 4 (Q96JN8). Promotes CCP110 ubiquitination and proteasome-dependent degradation.

The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants.

Source: NCBI Gene 84461 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 246 total
• MANE Select transcript: NM_032442

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34410
Approved symbol	NEURL4
Name	neuralized E3 ubiquitin protein ligase 4
Location	17p13.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1787
Ensembl gene	ENSG00000215041
Ensembl biotype	protein_coding
OMIM	615865
Entrez	84461

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 7 retained_intron, 6 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000315614, ENST00000399464, ENST00000570460, ENST00000571243, ENST00000571508, ENST00000571887, ENST00000572029, ENST00000572680, ENST00000573186, ENST00000573651, ENST00000574120, ENST00000576485, ENST00000576794, ENST00000576966, ENST00000906086, ENST00000948436

RefSeq mRNA: 2 — MANE Select: NM_032442 NM_001005408, NM_032442

CCDS: CCDS42251, CCDS42252

Canonical transcript exons

ENST00000399464 — 29 exons

Exon	Start	End
ENSE00001142445	7320759	7320923
ENSE00001273694	7324108	7324270
ENSE00001273733	7326711	7327009
ENSE00001273746	7327440	7327884
ENSE00001273892	7327165	7327230
ENSE00001273974	7321112	7321273
ENSE00001273982	7321361	7321459
ENSE00001273990	7321560	7321787
ENSE00001274015	7324799	7324980
ENSE00002637256	7315628	7316327
ENSE00002638471	7329031	7329335
ENSE00003468896	7317461	7317573
ENSE00003471095	7323814	7324012
ENSE00003475012	7318065	7318172
ENSE00003557285	7323485	7323563
ENSE00003568912	7318269	7318356
ENSE00003582150	7322948	7323123
ENSE00003595799	7317205	7317370
ENSE00003603387	7318495	7318674
ENSE00003631485	7323647	7323723
ENSE00003639165	7321865	7322010
ENSE00003673936	7319050	7319208
ENSE00003679944	7324395	7324480
ENSE00003680818	7322735	7322866
ENSE00003682291	7317788	7317932
ENSE00003703160	7325209	7325473
ENSE00003704498	7326255	7326343
ENSE00003706020	7326437	7326548
ENSE00003709627	7325641	7325713

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 95.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.0754 / max 46.4957, expressed in 1571 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
164211	4.0754	1571

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.36	gold quality
cerebellar hemisphere	UBERON:0002245	94.87	gold quality
cerebellum	UBERON:0002037	94.81	gold quality
cerebellar cortex	UBERON:0002129	94.81	gold quality
apex of heart	UBERON:0002098	94.76	gold quality
right frontal lobe	UBERON:0002810	93.92	gold quality
pituitary gland	UBERON:0000007	93.44	gold quality
metanephros cortex	UBERON:0010533	93.25	gold quality
right lobe of thyroid gland	UBERON:0001119	93.17	gold quality
right uterine tube	UBERON:0001302	92.54	gold quality
left lobe of thyroid gland	UBERON:0001120	92.52	gold quality
muscle layer of sigmoid colon	UBERON:0035805	92.48	gold quality
granulocyte	CL:0000094	92.45	gold quality
adenohypophysis	UBERON:0002196	92.41	gold quality
right ovary	UBERON:0002118	92.40	gold quality
thyroid gland	UBERON:0002046	92.25	gold quality
left ovary	UBERON:0002119	92.22	gold quality
body of uterus	UBERON:0009853	91.98	gold quality
mucosa of transverse colon	UBERON:0004991	91.88	gold quality
left uterine tube	UBERON:0001303	91.84	gold quality
frontal cortex	UBERON:0001870	91.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	91.74	gold quality
lower esophagus	UBERON:0013473	91.73	gold quality
transverse colon	UBERON:0001157	91.70	gold quality
mucosa of stomach	UBERON:0001199	91.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	91.59	gold quality
gastrocnemius	UBERON:0001388	91.58	gold quality
fundus of stomach	UBERON:0001160	91.57	gold quality
spleen	UBERON:0002106	91.50	gold quality
small intestine Peyer’s patch	UBERON:0003454	91.42	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6058	no	35.86
E-ANND-3	no	2.83

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

36 targeting NEURL4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-802	99.61	67.70	1254
HSA-MIR-3612	99.45	66.02	1333
HSA-MIR-650	99.45	65.77	1309
HSA-MIR-6797-3P	99.17	66.94	668
HSA-MIR-6506-5P	99.04	65.66	1386
HSA-MIR-6737-3P	98.95	68.56	1577
HSA-MIR-7157-3P	98.95	68.70	1582
HSA-MIR-5008-3P	98.73	67.50	1433
HSA-MIR-6761-5P	98.71	68.03	1504
HSA-MIR-619-5P	98.57	64.97	1988
HSA-MIR-4329	97.68	66.26	1003
HSA-MIR-8057	97.64	66.54	897
HSA-MIR-10398-5P	97.12	64.94	1051
HSA-MIR-4448	97.04	66.22	752
HSA-MIR-5702	96.68	68.21	958
HSA-MIR-642B-5P	96.37	67.26	745
HSA-MIR-4296	96.35	63.55	1233

Literature-anchored findings (GeneRIF, showing 4)

• the NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture (PMID:22261722)
• Neurl4 counteracts accumulation of CP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centres (PMID:22441691)
• The data support a model in which the daughter centriole promotes ciliogenesis through Neurl-4-dependent regulation of CP110 levels at the mother centriole. (PMID:28385950)
• Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. (PMID:35157000)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	neurl4	ENSDARG00000078127
mus_musculus	Neurl4	ENSMUSG00000047284
rattus_norvegicus	Neurl4	ENSRNOG00000016109
drosophila_melanogaster	Neurl4	FBGN0283503

Paralogs (3): NEURL1 (ENSG00000107954), NEURL3 (ENSG00000163121), NEURL1B (ENSG00000214357)

Protein

Protein identifiers

Neuralized-like protein 4 — Q96JN8 (reviewed: Q96JN8)

All UniProt accessions (5): Q96JN8, I3L100, I3L2W2, I3L2Z9, K7EPS7

UniProt curated annotations — full annotation on UniProt →

Function. Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers.

Subunit / interactions. Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole.

Tissue specificity. Widely expressed at high levels (including brain).

Post-translational modifications. Ubiquitinated; undergoes HERC2-dependent ‘Lys-48’ ubiquitination. This ubiquitination leads to proteasomal degradation.

Domain organisation. The third NHR domain (NHR 3) is required for localization to both mother and daughter centrioles. NHR 1 restricts targeting to daughter centriole. NHR 3 and 4 are required for CCP110/CEP97-binding, but not for HERC2-binding. NHR 5 and 6 are important for HERC2-binding and centrosomal localization.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96JN8-1	1	yes
Q96JN8-2	2

RefSeq proteins (2): NP_001005408, NP_115818* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006573	NHR_dom	Domain
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR037962	Neuralized	Family
IPR043136	B30.2/SPRY_sf	Homologous_superfamily

Pfam: PF07177

UniProt features (37 total): strand 12, domain 6, region of interest 4, sequence conflict 4, compositionally biased region 3, modified residue 2, helix 2, chain 1, splice variant 1, sequence variant 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2E63	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96JN8-F1	76.26	0.41

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 502, 907

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 102 (showing top): TTCCGTT_MIR191, GOBP_MITOCHONDRIAL_DNA_METABOLIC_PROCESS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_MALE_GAMETE_GENERATION, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_DNA_DAMAGE_RESPONSE, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOCC_CENTRIOLE, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, GOCC_MITOCHONDRIAL_MATRIX, GOBP_DNA_METABOLIC_PROCESS, AAGCACA_MIR218, GOBP_DNA_REPAIR, GOMF_ACYLTRANSFERASE_ACTIVITY

GO Biological Process (2): spermatogenesis (GO:0007283), mitochondrial DNA repair (GO:0043504)

GO Molecular Function (4): DNA binding (GO:0003677), NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity (GO:0030701), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), centriole (GO:0005814), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	2
intracellular membraneless organelle	2
developmental process involved in reproduction	1
male gamete generation	1
DNA repair	1
mitochondrial DNA metabolic process	1
nucleic acid binding	1
pentosyltransferase activity	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
intracellular organelle lumen	1
microtubule organizing center	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

984 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NEURL4	CCP110	O43303	753
NEURL4	MAPK6	Q16659	729
NEURL4	UBE3A	P78355	672
NEURL4	HERC2	O95714	651
NEURL4	CEP97	Q8IW35	641
NEURL4	CEP290	O15078	596
NEURL4	CEP120	Q8N960	577
NEURL4	STIL	Q15468	533
NEURL4	KTN1	Q86UP2	531
NEURL4	ERCC3	P19447	521
NEURL4	CEP170	Q5SW79	520
NEURL4	USP33	Q8TEY7	520
NEURL4	DRC2	Q8IXS2	513
NEURL4	CEP76	Q8TAP6	506
NEURL4	LRRK2	Q5S007	497

IntAct

133 interactions, top by confidence:

A	B	Type	Score
CEP97	CCP110	psi-mi:“MI:0914”(association)	0.950
CCP110	CEP290	psi-mi:“MI:0914”(association)	0.890
MAPK6	HERC2	psi-mi:“MI:0914”(association)	0.840
CCP110	CCNF	psi-mi:“MI:0914”(association)	0.790
CEP97	CEP290	psi-mi:“MI:0914”(association)	0.740
CEP76	CEP290	psi-mi:“MI:0914”(association)	0.740
PSMD2	PSMD11	psi-mi:“MI:0914”(association)	0.730
PSMC4	PSMD11	psi-mi:“MI:0914”(association)	0.670
DBNL	HERC2	psi-mi:“MI:0914”(association)	0.670
PSMC2	PSMD12	psi-mi:“MI:0914”(association)	0.640
DNAJC7	PLD2	psi-mi:“MI:0914”(association)	0.640
FAM98A	HERC2	psi-mi:“MI:0914”(association)	0.640
NEURL4	CCP110	psi-mi:“MI:0915”(physical association)	0.640
NEURL4	CCP110	psi-mi:“MI:0914”(association)	0.640
NEURL4	CCP110	psi-mi:“MI:0403”(colocalization)	0.640
CCP110	NEURL4	psi-mi:“MI:0407”(direct interaction)	0.640
MAPK6	ECI2	psi-mi:“MI:0914”(association)	0.530
PDGFD	DCTN6	psi-mi:“MI:0914”(association)	0.530
SPZ1	GAPDHS	psi-mi:“MI:0914”(association)	0.530
CDR2	IGSF3	psi-mi:“MI:0914”(association)	0.530
ZNF669	LRP4	psi-mi:“MI:0914”(association)	0.530
USP16	HERC2	psi-mi:“MI:0914”(association)	0.530
ZNF286A	HERC2	psi-mi:“MI:0914”(association)	0.530
ZNRD2	MYO9A	psi-mi:“MI:0914”(association)	0.530

BioGRID (216): NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Proximity Label-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS), NEURL4 (Affinity Capture-MS)

ESM2 similar proteins: A1L0Y2, A2ALK8, A2ARP1, A2Z8S0, A4IFG2, A8XT88, B1AVZ0, B3M1E1, B3P4N5, B4GZ20, B4HJC0, B4KA23, B4LVS8, B4NKI9, B4PVH6, B4QVW6, M9MRI4, O35242, O76050, P0C644, P26045, Q18223, Q29B63, Q29RQ5, Q3MHZ2, Q3UJK4, Q571F5, Q5M870, Q5NCX5, Q5PQR3, Q5R881, Q6PFW1, Q6PJ21, Q75G68, Q8BVR6, Q8C726, Q8CJC5, Q8R516, Q91YL3, Q91ZY8

Diamond homologs: A1L0Y2, Q5NCX5, Q96JN8, Q9BR09, Q9D0S4, A8MQ27, P29503, Q0MW30, Q24746, Q5M870, Q8CJC5, Q96EH8

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
HERC2	“down-regulates quantity by destabilization”	NEURL4	polyubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 142 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Autodegradation of the E3 ubiquitin ligase COP1	8	24.1×	2e-07
Regulation of activated PAK-2p34 by proteasome mediated degradation	7	22.2×	2e-06
Regulation of ornithine decarboxylase (ODC)	7	21.6×	2e-06
Vpu mediated degradation of CD4	7	21.1×	2e-06
Ubiquitin-dependent degradation of Cyclin D	7	21.1×	2e-06
Cross-presentation of soluble exogenous antigens (endosomes)	7	20.2×	2e-06
Vif-mediated degradation of APOBEC3G	7	20.2×	2e-06
The role of GTSE1 in G2/M progression after G2 checkpoint	11	20.1×	2e-09

GO biological processes:

GO term	Partners	Fold	FDR
mitotic spindle organization	6	12.9×	5e-03
proteasome-mediated ubiquitin-dependent protein catabolic process	11	4.5×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

246 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	195
Likely benign	15
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

4583 predictions. Top by Δscore:

Variant	Effect	Δscore
17:7316182:A:AC	donor_gain	1.0000
17:7316183:C:CC	donor_gain	1.0000
17:7316328:C:CC	acceptor_gain	1.0000
17:7317203:A:AC	donor_gain	1.0000
17:7317204:C:CA	donor_gain	1.0000
17:7317204:CTGCA:C	donor_gain	1.0000
17:7317371:CT:C	acceptor_loss	1.0000
17:7317371:CTGGG:C	acceptor_loss	1.0000
17:7318251:C:CA	donor_gain	1.0000
17:7319046:TCACC:T	donor_loss	1.0000
17:7319047:CA:C	donor_loss	1.0000
17:7319048:A:AC	donor_gain	1.0000
17:7319048:A:C	donor_loss	1.0000
17:7319049:C:CC	donor_gain	1.0000
17:7319049:C:CG	donor_loss	1.0000
17:7319206:CAC:C	acceptor_gain	1.0000
17:7319208:CCT:C	acceptor_loss	1.0000
17:7320754:CCCA:C	donor_loss	1.0000
17:7320755:CCA:C	donor_loss	1.0000
17:7320757:A:T	donor_loss	1.0000
17:7320758:C:CG	donor_loss	1.0000
17:7320923:CCTGG:C	acceptor_gain	1.0000
17:7321110:A:AC	donor_gain	1.0000
17:7321110:ACT:A	donor_gain	1.0000
17:7321110:ACTC:A	donor_gain	1.0000
17:7321111:C:CC	donor_gain	1.0000
17:7321111:CT:C	donor_gain	1.0000
17:7321111:CTC:C	donor_gain	1.0000
17:7321111:CTCC:C	donor_gain	1.0000
17:7321113:C:CA	donor_gain	1.0000

AlphaMissense

10134 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:7318508:C:A	G1284V	1.000
17:7318508:C:T	G1284E	1.000
17:7319181:A:G	W1185R	1.000
17:7319181:A:T	W1185R	1.000
17:7320832:G:T	A1151D	1.000
17:7320883:A:G	F1134S	1.000
17:7322832:A:C	C876W	1.000
17:7322833:C:T	C876Y	1.000
17:7322834:A:G	C876R	1.000
17:7322839:C:A	G874V	1.000
17:7322839:C:T	G874D	1.000
17:7322840:C:A	G874C	1.000
17:7322840:C:G	G874R	1.000
17:7322840:C:T	G874S	1.000
17:7322842:T:C	Y873C	1.000
17:7322843:A:G	Y873H	1.000
17:7322845:A:G	L872P	1.000
17:7322845:A:T	L872H	1.000
17:7322848:T:A	D871V	1.000
17:7322848:T:C	D871G	1.000
17:7322848:T:G	D871A	1.000
17:7322849:C:A	D871Y	1.000
17:7322849:C:G	D871H	1.000
17:7322851:A:T	V870D	1.000
17:7322857:G:T	A868E	1.000
17:7323005:A:C	Y846D	1.000
17:7323010:A:G	L844P	1.000
17:7323037:C:T	G835D	1.000
17:7323040:A:T	I834N	1.000
17:7323064:T:A	D826V	1.000

dbSNP variants (sampled 300 via entrez): RS1000208987 (17:7318413 C>T), RS1000263544 (17:7315770 G>A), RS1000294784 (17:7320590 T>C), RS1000447524 (17:7321540 C>A,T), RS1000454241 (17:7315448 G>A), RS1000800737 (17:7315548 T>G), RS1000811383 (17:7319848 G>A), RS1000871395 (17:7326012 T>A,C), RS1000880429 (17:7321181 A>G), RS1001002647 (17:7325898 C>G), RS1001184473 (17:7320112 G>A), RS1001228200 (17:7319714 A>C), RS1001496742 (17:7322362 T>G), RS1001546349 (17:7329372 G>A), RS1002404031 (17:7324339 C>A,T)

Disease associations

OMIM: gene MIM:615865 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST011097_2	Systemic lupus erythematosus	1.000000e-08
GCST90000025_118	Appendicular lean mass	7.000000e-10
GCST90014023_5	Type 1 diabetes	2.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment, affects expression, increases abundance	2
Air Pollutants	affects cotreatment, increases abundance, increases expression, increases oxidation, affects expression	2
Benzo(a)pyrene	increases methylation, increases mutagenesis	2
Ozone	increases oxidation, increases abundance, affects expression, affects cotreatment, increases expression	2
Cadmium Chloride	increases expression, decreases expression	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
ginger extract	affects cotreatment, affects expression, increases abundance	1
dicrotophos	increases expression	1
alpha-pinene	affects cotreatment, increases expression, increases oxidation, increases abundance	1
titanium dioxide	decreases methylation, increases expression	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	increases expression, increases oxidation, increases abundance, affects cotreatment	1
perfluorooctane sulfonic acid	increases expression	1
abrine	increases expression	1
Acrolein	affects cotreatment, increases expression, increases oxidation, increases abundance	1
Arsenic	affects methylation	1
Vehicle Emissions	increases abundance, increases expression	1
Oils, Volatile	affects expression, increases abundance, affects cotreatment	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1
Acrylamide	decreases expression	1
Particulate Matter	increases expression, increases abundance	1
Volatile Organic Compounds	affects cotreatment, increases expression, increases oxidation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.