NEUROG2

Summary

NEUROG2 (neurogenin 2, HGNC:13805) is a protein-coding gene on chromosome 4q25, encoding Neurogenin-2 (Q9H2A3). Transcriptional regulator.

This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons.

Source: NCBI Gene 63973 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 30 total
• Transcription factor: yes — 27 downstream targets (CollecTRI)
• MANE Select transcript: NM_024019

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13805
Approved symbol	NEUROG2
Name	neurogenin 2
Location	4q25
Locus type	gene with protein product
Status	Approved
Aliases	Atoh4, Math4A, ngn-2, bHLHa8, NGN2
Ensembl gene	ENSG00000178403
Ensembl biotype	protein_coding
OMIM	606624
Entrez	63973

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000313341

RefSeq mRNA: 1 — MANE Select: NM_024019 NM_024019

CCDS: CCDS3698

Canonical transcript exons

ENST00000313341 — 2 exons

Exon	Start	End
ENSE00001212603	112515847	112516180
ENSE00001212610	112513516	112515476

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 97.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8826 / max 204.6808, expressed in 134 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53653	0.8826	134

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	97.24	gold quality
ventricular zone	UBERON:0003053	94.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.94	gold quality
cortical plate	UBERON:0005343	87.30	gold quality
embryo	UBERON:0000922	78.71	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.26	gold quality
cerebellar cortex	UBERON:0002129	58.68	gold quality
cerebellar hemisphere	UBERON:0002245	58.41	gold quality
putamen	UBERON:0001874	58.38	gold quality
gluteal muscle	UBERON:0002000	58.35	gold quality
triceps brachii	UBERON:0001509	58.16	gold quality
cerebellum	UBERON:0002037	57.50	gold quality
amygdala	UBERON:0001876	56.40	gold quality
caudate nucleus	UBERON:0001873	55.46	gold quality
Ammon’s horn	UBERON:0001954	54.13	gold quality
cerebellar vermis	UBERON:0004720	53.01	gold quality
pancreatic ductal cell	CL:0002079	51.23	silver quality
prefrontal cortex	UBERON:0000451	50.93	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.93	gold quality
epithelial cell of pancreas	CL:0000083	49.68	gold quality
temporal lobe	UBERON:0001871	49.38	gold quality
cervix squamous epithelium	UBERON:0006922	49.20	gold quality
hair follicle	UBERON:0002073	49.18	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
cingulate cortex	UBERON:0003027	48.81	gold quality
anterior cingulate cortex	UBERON:0009835	48.81	gold quality
quadriceps femoris	UBERON:0001377	48.64	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-10485	yes	544.08
E-MTAB-8894	yes	400.34
E-HCAD-5	yes	20.64
E-ANND-3	no	1.31

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

27 targets.

Target	Regulation
ASCL1	Repression
ATOH7
BTG2	Activation
CCND1	Repression
CCNE2	Repression
DLK1	Repression
DLL1	Activation
DLL3	Activation
ELAVL4	Activation
EOMES	Activation
ETV1	Repression
FEZF1
FEZF2
HES1
JAG2	Activation
MEG8	Repression
NEUROD1	Activation
NEUROD4	Activation
NEUROG2
PAX3
PAX6	Repression
PCSK6
RAP1B
RND2	Activation
RTL1	Repression
SIRT1
ZBTB18	Activation

JASPAR motifs

Motif	Name	Family
MA0669.1	NEUROG2	Tal-related
MA1642.1	NEUROG2	Tal-related
MA1642.2	NEUROG2	Tal-related

JASPAR matrix evidence (PMIDs): PMID:19389376

Upstream regulators (CollecTRI, top): ATOH7, BMP7, CTNNB1, ESR1, FEZF1, FGF19, FOXA1, FOXA2, HES1, HES5, HEYL, LMX1A, NEUROD1, NEUROG1, NEUROG2, NEUROG3, OTX2, PAX3, PAX6, SOX2, TCF3, UNCX, ZBTB18

miRNA regulators (miRDB)

109 targeting NEUROG2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-374A-5P	99.90	71.34	2923

Literature-anchored findings (GeneRIF, showing 14)

• expression of Ngn2 during the differentiation of neuronl human embryo stem cells. (PMID:17784840)
• Rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in dopamine neuron differentiation. (PMID:18242186)
• Novel compound heterozygous variants (Gly56Arg and Asp206Glu) were found in a 91-year normal male, suggesting that mutations in the coding region of the NEUROG2 gene play little or no role in the development of PD. (PMID:19879328)
• human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury (PMID:21209909)
• Results show that neurogenin-1 and -2 drive homogeneous differentiation of human stem cells into bipolar neurons in 4 days in defined media. (PMID:25403753)
• Study shows neurogenin 2 enhances the generation of patient-specific induced neuronal cells. (PMID:25912433)
• combining NGN2 programming with SMAD and WNT inhibition generates human patterned induced neurons (PMID:29791859)
• HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade. (PMID:32661334)
• Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors. (PMID:32783653)
• MiR-211 determines brain metastasis specificity through SOX11/NGN2 axis in triple-negative breast cancer. (PMID:33536579)
• NGN2 induces diverse neuron types from human pluripotency. (PMID:34358451)
• Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons. (PMID:34549796)
• Neurogenin-2 induced neuronal differentiation in co-cultured bone marrow stromal and neonatal cortical cells. (PMID:38385475)
• Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1. (PMID:38446849)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
mus_musculus	Neurog2	ENSMUSG00000027967
rattus_norvegicus	Neurog2	ENSRNOG00000010972
drosophila_melanogaster	amos	FBGN0003270
drosophila_melanogaster	ato	FBGN0010433
drosophila_melanogaster	tap	FBGN0015550
drosophila_melanogaster	Oli	FBGN0032651
caenorhabditis_elegans		WBGENE00001961
caenorhabditis_elegans		WBGENE00003018
caenorhabditis_elegans		WBGENE00003595
caenorhabditis_elegans		WBGENE00009540
caenorhabditis_elegans		WBGENE00013665

Paralogs (15): NEUROG3 (ENSG00000122859), NEUROD4 (ENSG00000123307), BHLHE23 (ENSG00000125533), NEUROD1 (ENSG00000162992), NEUROD6 (ENSG00000164600), ATOH8 (ENSG00000168874), NEUROD2 (ENSG00000171532), ATOH1 (ENSG00000172238), OLIG3 (ENSG00000177468), ATOH7 (ENSG00000179774), BHLHA15 (ENSG00000180535), BHLHE22 (ENSG00000180828), NEUROG1 (ENSG00000181965), OLIG1 (ENSG00000184221), OLIG2 (ENSG00000205927)

Protein

Protein identifiers

Neurogenin-2 — Q9H2A3 (reviewed: Q9H2A3)

Alternative names: Class A basic helix-loop-helix protein 8, Protein atonal homolog 4

All UniProt accessions (1): Q9H2A3

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’).

Subunit / interactions. Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location. Nucleus.

RefSeq proteins (1): NP_076924* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011598	bHLH_dom	Domain
IPR032655	Ngn-2_bHLH	Domain
IPR036638	HLH_DNA-bd_sf	Homologous_superfamily
IPR050359	bHLH_transcription_factors	Family

Pfam: PF00010

UniProt features (5 total): region of interest 2, chain 1, domain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H2A3-F1	64.98	0.27

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): AHRARNT_01, chr4q25, TAATAAT_MIR126, BENPORATH_ES_WITH_H3K27ME3, TGCACTT_MIR519C_MIR519B_MIR519A, GCANCTGNY_MYOD_Q6, TTTGTAG_MIR520D, GOBP_NEUROGENESIS, TGACCTY_ERR1_Q2, GOBP_FOREBRAIN_DEVELOPMENT, ATGTTAA_MIR302C, COUP_01, GOBP_POSITIVE_REGULATION_OF_MOLECULAR_FUNCTION, HNF4_DR1_Q3, HNF4_01

GO Biological Process (7): sensory organ development (GO:0007423), forebrain development (GO:0030900), positive regulation of transcription by RNA polymerase II (GO:0045944), obsolete positive regulation of DNA-binding transcription factor activity (GO:0051091), axon development (GO:0061564), nervous system development (GO:0007399), cell differentiation (GO:0030154)

GO Molecular Function (6): DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), protein dimerization activity (GO:0046983), E-box binding (GO:0070888), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	2
animal organ development	1
brain development	1
anatomical structure development	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
neuron projection development	1
system development	1
cellular developmental process	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
protein binding	1
RNA polymerase II cis-regulatory region sequence-specific DNA binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1632 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NEUROG2	ASCL1	P50553	971
NEUROG2	PAX6	P26367	901
NEUROG2	ISL1	P20663	891
NEUROG2	LHX3	Q9UBR4	889
NEUROG2	LMX1A	Q8TE12	871
NEUROG2	SOX1	O00570	862
NEUROG2	SOX2	P48431	841
NEUROG2	POU4F1	Q01851	827
NEUROG2	OLIG2	Q13516	813
NEUROG2	LHX1	P48742	804
NEUROG2	RND2	P52198	795
NEUROG2	ISL2	Q96A47	794
NEUROG2	LDB1	Q86U70	773
NEUROG2	LHX2	P50458	749
NEUROG2	SOX3	P35714	746

IntAct

6 interactions, top by confidence:

A	B	Type	Score
PFDN5	NEUROG2	psi-mi:“MI:0915”(physical association)	0.560
NEUROG2	Dlg4	psi-mi:“MI:0407”(direct interaction)	0.440
TCF4	HMGB1	psi-mi:“MI:0914”(association)	0.350
PFDN5	NEUROG2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (9): NEUROG2 (Synthetic Growth Defect), NEUROG2 (Two-hybrid), NEUROG2 (Negative Genetic), NEUROG2 (Cross-Linking-MS (XL-MS)), NEUROG2 (Affinity Capture-MS), NEUROG2 (Affinity Capture-MS), NEUROG2 (Affinity Capture-MS), NEUROG2 (Affinity Capture-MS), NEUROG2 (Affinity Capture-Western)

ESM2 similar proteins: A6NEQ2, A7MB34, A8MYZ6, O02754, O02755, O02756, O15522, O35392, O60548, O70191, O70220, O77728, P05554, P16443, P17542, P17676, P21272, P22091, P28033, P49715, P49716, P53566, P54845, P70447, Q00322, Q03484, Q10586, Q13461, Q15744, Q32PF6, Q5PQP0, Q5T953, Q60843, Q60925, Q63244, Q6P788, Q70KY4, Q7RTS3, Q8N350, Q8NDY6

Diamond homologs: A8E5T6, B6VQA1, O09029, O09105, O13125, O13126, O16867, O35437, O42202, O42606, O43680, O45489, O57598, O88940, O96004, O96642, P10627, P13903, P46581, P48985, P48986, P48987, P57100, P57101, P57102, P59101, P61295, P61296, P70447, P70562, P70595, P70660, P70661, P79765, P79766, P79782, P79920, P97832, Q08DI0, Q0V9X5

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
NEUROG3	“down-regulates quantity by repression”	NEUROG2	“transcriptional regulation”
HES1	“down-regulates quantity by repression”	NEUROG2	“transcriptional regulation”
HES5	“down-regulates quantity by repression”	NEUROG2	“transcriptional regulation”
NEUROG2	up-regulates	Neurogenesis

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

122 predictions. Top by Δscore:

Variant	Effect	Δscore
4:112515472:ACATC:A	acceptor_gain	1.0000
4:112515473:CATC:C	acceptor_gain	1.0000
4:112515473:CATCC:C	acceptor_gain	1.0000
4:112515475:TC:T	acceptor_gain	1.0000
4:112515476:CC:C	acceptor_gain	1.0000
4:112515477:CT:C	acceptor_loss	1.0000
4:112515478:T:C	acceptor_loss	1.0000
4:112515481:C:CT	acceptor_gain	1.0000
4:112515846:CTTA:C	donor_gain	1.0000
4:112515474:ATC:A	acceptor_gain	0.9900
4:112515477:C:CC	acceptor_gain	0.9900
4:112515477:C:T	acceptor_gain	0.9900
4:112515481:C:T	acceptor_gain	0.9900
4:112515482:G:T	acceptor_gain	0.9900
4:112515843:TTAC:T	donor_loss	0.9900
4:112515845:A:AC	donor_gain	0.9900
4:112515845:ACTTA:A	donor_loss	0.9900
4:112515846:C:CC	donor_gain	0.9900
4:112515846:CT:C	donor_gain	0.9900
4:112515846:CTT:C	donor_gain	0.9900
4:112515846:CTTAG:C	donor_gain	0.9900
4:112515850:G:C	donor_gain	0.9800
4:112515842:CTTA:C	donor_gain	0.9500
4:112515849:A:AC	donor_gain	0.9500
4:112515841:A:AC	donor_gain	0.8900
4:112515842:C:CC	donor_gain	0.8900
4:112515865:G:A	donor_gain	0.8800
4:112515809:C:CT	donor_gain	0.8300
4:112515348:T:TA	donor_gain	0.7700
4:112515810:C:CT	donor_gain	0.7600

AlphaMissense

1720 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:112514985:A:G	L164P	1.000
4:112514985:A:T	L164H	1.000
4:112514994:A:C	I161S	1.000
4:112514994:A:G	I161T	1.000
4:112514994:A:T	I161N	1.000
4:112514997:T:C	Y160C	1.000
4:112514998:A:C	Y160D	1.000
4:112514998:A:G	Y160H	1.000
4:112515006:G:T	A157D	1.000
4:112515009:A:G	F156S	1.000
4:112515012:C:G	R155P	1.000
4:112515015:A:C	L154R	1.000
4:112515015:A:G	L154P	1.000
4:112515015:A:T	L154Q	1.000
4:112515021:T:A	E152V	1.000
4:112515024:A:C	I151S	1.000
4:112515024:A:T	I151N	1.000
4:112515026:C:A	K150N	1.000
4:112515026:C:G	K150N	1.000
4:112515027:T:A	K150M	1.000
4:112515028:T:C	K150E	1.000
4:112515028:T:G	K150Q	1.000
4:112515030:G:A	T149I	1.000
4:112515033:A:G	L148P	1.000
4:112515057:G:T	P140H	1.000
4:112515058:G:A	P140S	1.000
4:112515060:A:T	L139H	1.000
4:112515070:G:T	R136S	1.000
4:112515072:A:G	L135P	1.000
4:112515072:A:T	L135Q	1.000

dbSNP variants (sampled 300 via entrez): RS1000782099 (4:112515422 C>A), RS1000990135 (4:112514837 C>T), RS1001897165 (4:112514511 G>A,T), RS1001983168 (4:112515812 C>A,T), RS1002963445 (4:112517060 A>C), RS1004470346 (4:112515203 G>A), RS1005210649 (4:112516090 T>C), RS1005445259 (4:112513663 G>A), RS1006887143 (4:112516747 T>G), RS1007170239 (4:112516594 C>A,G), RS1007948197 (4:112517602 T>C,G), RS1008171228 (4:112517969 G>A), RS1008536444 (4:112516224 A>G), RS1008615740 (4:112515291 C>A,T), RS1009014082 (4:112513519 T>A,C,G)

Disease associations

OMIM: gene MIM:606624 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002337_110	Amyotrophic lateral sclerosis (sporadic)	3.000000e-06
GCST005951_145	Body mass index	4.000000e-08
GCST010143_1	Meat-related diet	3.000000e-08
GCST010701_20	Cortical surface area (MOSTest)	1.000000e-242
GCST010702_74	Subcortical volume (MOSTest)	2.000000e-11
GCST010703_129	Brain morphology (MOSTest)	3.000000e-08
GCST011053_9	Neuroblastoma (pediatric)	2.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	2
Chir 99021	affects binding, affects cotreatment, increases expression	2
Tretinoin	affects cotreatment, increases expression, decreases expression	2
Valproic Acid	decreases methylation, increases expression	2
securinine	decreases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
ascorbate-2-phosphate	affects binding, affects cotreatment, increases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
arsenite	increases methylation	1
mono-(2-ethylhexyl)phthalate	increases expression	1
doxylamine succinate	increases expression	1
abrine	increases expression	1
nilotinib	increases expression	1
XAV939	affects binding, affects cotreatment, increases expression	1
LDN 193189	affects cotreatment, increases expression	1
theaflavin-3,3’-digallate	affects expression	1
Dabigatran	increases expression	1
Leflunomide	increases expression	1
Abacavir	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Methanol	increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Caffeine	increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Fluorouracil	decreases expression	1
Folic Acid	increases expression	1
Phenytoin	increases expression	1
Smoke	increases expression	1
Thalidomide	increases expression	1

Cellosaurus cell lines

93 cell lines: 70 embryonic stem cell, 23 induced pluripotent stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A4L5	SEES3-1V human NEUROG2, clone1	Embryonic stem cell	Male
CVCL_A4L6	SEES3-1V human NEUROG2, clone2	Embryonic stem cell	Male
CVCL_A4L7	SEES3-1V human NEUROG2, clone3	Embryonic stem cell	Male
CVCL_C4EK	H9 AAVS1-TRE3G-NGN2	Embryonic stem cell	Female
CVCL_C4EL	H9 AAVS1-TRE3G-NGN2 ATG12-/-	Embryonic stem cell	Female
CVCL_C4EM	H9 AAVS1-TRE3G-NGN2 PINK1-/-	Embryonic stem cell	Female
CVCL_C4EN	H9 AAVS1-TRE3G-NGN2 FBXO7-/-	Embryonic stem cell	Female
CVCL_C7XJ	Pre-i3Neuron NGN2 iPSC clone 1	Induced pluripotent stem cell	Male
CVCL_C7XK	Pre-i3Neuron NGN2 iPSC LRRK2-p.G2019S knock-in	Induced pluripotent stem cell	Male
CVCL_D1IA	H9 AAVS1-TRE3G-NGN2 RETREG3-/-	Embryonic stem cell	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.