NEXN-AS1

Summary

NEXN-AS1 (NEXN antisense RNA 1, HGNC:31983) is a long non-coding RNA gene on chromosome 1p31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31983
Approved symbol	NEXN-AS1
Name	NEXN antisense RNA 1
Location	1p31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ90637
Ensembl gene	ENSG00000235927
Ensembl biotype	lncRNA
OMIM	618370
Entrez	374987
RNAcentral	URS000032A8EE — lncRNA, 2292 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000421331

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421331 — 3 exons

Exon	Start	End
ENSE00001405944	77881348	77881898
ENSE00001689155	77889468	77889539
ENSE00001762111	77887600	77889268

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 67.91.

Top tissues by expression

215 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	67.91	silver quality
hindlimb stylopod muscle	UBERON:0004252	66.78	gold quality
gastrocnemius	UBERON:0001388	66.40	gold quality
muscle of leg	UBERON:0001383	65.49	gold quality
stromal cell of endometrium	CL:0002255	62.45	gold quality
heart left ventricle	UBERON:0002084	62.34	gold quality
cardiac ventricle	UBERON:0002082	61.58	gold quality
monocyte	CL:0000576	60.49	gold quality
leukocyte	CL:0000738	59.79	gold quality
heart	UBERON:0000948	59.57	gold quality
right atrium auricular region	UBERON:0006631	59.30	gold quality
ventricular zone	UBERON:0003053	58.90	silver quality
cardiac atrium	UBERON:0002081	58.80	gold quality
popliteal artery	UBERON:0002250	57.17	gold quality
tibial artery	UBERON:0007610	57.15	gold quality
aorta	UBERON:0000947	56.79	gold quality
ascending aorta	UBERON:0001496	56.53	gold quality
thoracic aorta	UBERON:0001515	56.52	gold quality
apex of heart	UBERON:0002098	56.42	gold quality
right adrenal gland cortex	UBERON:0035827	54.79	gold quality
descending thoracic aorta	UBERON:0002345	54.61	gold quality
left coronary artery	UBERON:0001626	54.42	gold quality
right adrenal gland	UBERON:0001233	53.90	gold quality
left adrenal gland cortex	UBERON:0035825	53.69	gold quality
coronary artery	UBERON:0001621	53.42	gold quality
adrenal cortex	UBERON:0001235	52.93	gold quality
left adrenal gland	UBERON:0001234	52.91	gold quality
skeletal muscle tissue	UBERON:0001134	52.82	gold quality
lower lobe of lung	UBERON:0008949	52.22	silver quality
adrenal gland	UBERON:0002369	51.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility. (PMID:27713484)
• Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN. (PMID:30589415)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.