NFIA-AS1

Summary

NFIA-AS1 (NFIA antisense RNA 1, HGNC:40402) is a long non-coding RNA gene on chromosome 1p31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40402
Approved symbol	NFIA-AS1
Name	NFIA antisense RNA 1
Location	1p31.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP5-833A20.1
Ensembl gene	ENSG00000237853
Ensembl biotype	lncRNA
Entrez	645030
RNAcentral	URS000075DF37 — lncRNA, 392 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 lncRNA, 1 retained_intron

ENST00000442027, ENST00000596354, ENST00000596404, ENST00000617929, ENST00000626805, ENST00000630199, ENST00000630993, ENST00000726048

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442027 — 4 exons

Exon	Start	End
ENSE00001638418	61248945	61249109
ENSE00001661475	61249948	61249981
ENSE00001693224	61251285	61251369
ENSE00004050203	61253411	61253537

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 97.02.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0479 / max 26.1629, expressed in 10 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12603	0.0479	10

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.02	gold quality
corpus callosum	UBERON:0002336	94.62	gold quality
left testis	UBERON:0004533	91.24	gold quality
right testis	UBERON:0004534	90.64	gold quality
testis	UBERON:0000473	90.41	gold quality
colonic epithelium	UBERON:0000397	88.66	gold quality
calcaneal tendon	UBERON:0003701	87.11	gold quality
bone marrow cell	CL:0002092	78.47	gold quality
muscle tissue	UBERON:0002385	76.18	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.79	gold quality
skeletal muscle tissue	UBERON:0001134	73.05	gold quality
adrenal tissue	UBERON:0018303	71.54	gold quality
tonsil	UBERON:0002372	70.94	gold quality
bone marrow	UBERON:0002371	69.29	gold quality
ganglionic eminence	UBERON:0004023	68.77	gold quality
liver	UBERON:0002107	68.38	gold quality
primary visual cortex	UBERON:0002436	67.83	gold quality
monocyte	CL:0000576	62.83	gold quality
heart	UBERON:0000948	61.83	gold quality
kidney	UBERON:0002113	61.42	gold quality
heart left ventricle	UBERON:0002084	61.26	gold quality
muscle of leg	UBERON:0001383	61.23	gold quality
right atrium auricular region	UBERON:0006631	61.05	gold quality
right lobe of liver	UBERON:0001114	60.71	gold quality
urinary bladder	UBERON:0001255	60.52	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	60.12	gold quality
prefrontal cortex	UBERON:0000451	58.97	gold quality
islet of Langerhans	UBERON:0000006	58.82	gold quality
thoracic mammary gland	UBERON:0005200	58.45	gold quality
blood	UBERON:0000178	58.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.02

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long noncoding RNA RP5-833A20.1 mediated signaling was essential to the regulation of cholesterol homeostasis and inflammatory reactions. (PMID:25265644)
• These results demonstrated that RP5833A20.1 inhibited tumor cell proliferation, induced apoptosis and inhibited cellcycle progression by suppressing the expression of NFIA in U251 cells. (PMID:27779670)
• MIR222 and lncRNA NFIA-AS1 are down-regulated and different expressions in different TNM stages. (PMID:30775882)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.