NGDN

Summary

NGDN (neuroguidin, HGNC:20271) is a protein-coding gene on chromosome 14q11.2, encoding Neuroguidin (Q8NEJ9). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. It is a selective cancer dependency (DepMap: 43.5% of cell lines).

Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).

Source: NCBI Gene 25983 — RefSeq curated summary.

At a glance

• GWAS associations: 15
• Clinical variants (ClinVar): 76 total
• Cancer dependency (DepMap): dependent in 43.5% of screened cell lines
• MANE Select transcript: NM_001042635

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20271
Approved symbol	NGDN
Name	neuroguidin
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP564O092, LCP5, lpd-2, NGD, CANu1
Ensembl gene	ENSG00000129460
Ensembl biotype	protein_coding
OMIM	610777
Entrez	25983

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 22 retained_intron, 10 protein_coding

ENST00000397154, ENST00000408901, ENST00000553336, ENST00000553439, ENST00000555128, ENST00000556103, ENST00000556378, ENST00000556483, ENST00000556580, ENST00000556699, ENST00000556953, ENST00000557097, ENST00000703184, ENST00000703185, ENST00000703186, ENST00000703187, ENST00000703188, ENST00000703189, ENST00000703190, ENST00000703191, ENST00000703192, ENST00000703193, ENST00000703194, ENST00000703195, ENST00000703196, ENST00000703197, ENST00000703256, ENST00000703257, ENST00000703258, ENST00000924623, ENST00000924624, ENST00000955477

RefSeq mRNA: 2 — MANE Select: NM_001042635 NM_001042635, NM_015514

CCDS: CCDS32051, CCDS41926

Canonical transcript exons

ENST00000408901 — 11 exons

Exon	Start	End
ENSE00001579299	23477503	23477560
ENSE00002485717	23477200	23477356
ENSE00003988296	23475726	23475778
ENSE00003988297	23475558	23475642
ENSE00003988312	23476029	23476152
ENSE00003988313	23476239	23476407
ENSE00003988322	23475171	23475308
ENSE00003988479	23478007	23478173
ENSE00003988480	23470042	23470101
ENSE00003988482	23469703	23469727
ENSE00003988486	23470906	23470977

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 96.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.6772 / max 177.2784, expressed in 1759 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138931	9.6772	1759

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	96.17	gold quality
calcaneal tendon	UBERON:0003701	95.60	gold quality
ventricular zone	UBERON:0003053	95.32	gold quality
left ovary	UBERON:0002119	95.01	gold quality
body of uterus	UBERON:0009853	94.99	gold quality
right ovary	UBERON:0002118	94.90	gold quality
tibial nerve	UBERON:0001323	94.79	gold quality
skin of abdomen	UBERON:0001416	94.78	gold quality
skin of leg	UBERON:0001511	94.42	gold quality
endocervix	UBERON:0000458	94.17	gold quality
ganglionic eminence	UBERON:0004023	94.16	gold quality
left uterine tube	UBERON:0001303	94.05	gold quality
gastrocnemius	UBERON:0001388	94.01	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.01	gold quality
cortical plate	UBERON:0005343	93.94	gold quality
cerebellar hemisphere	UBERON:0002245	93.93	gold quality
popliteal artery	UBERON:0002250	93.88	gold quality
tibial artery	UBERON:0007610	93.88	gold quality
cerebellar cortex	UBERON:0002129	93.85	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.81	gold quality
islet of Langerhans	UBERON:0000006	93.74	gold quality
muscle of leg	UBERON:0001383	93.69	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.63	gold quality
omental fat pad	UBERON:0010414	93.62	gold quality
peritoneum	UBERON:0002358	93.61	gold quality
zone of skin	UBERON:0000014	93.55	gold quality
left lobe of thyroid gland	UBERON:0001120	93.55	gold quality
mucosa of stomach	UBERON:0001199	93.55	gold quality
aorta	UBERON:0000947	93.54	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-110499	no	526.73
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting NGDN, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-7113-5P	97.88	67.33	1735
HSA-MIR-3664-3P	97.85	67.62	1452
HSA-MIR-6085	96.57	64.11	621
HSA-MIR-6813-5P	94.68	64.20	588

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 43.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• Study isolated a novel human gene, to be called as CANu1, by the large-scale genome-wide association analysis to screen specific Single nucleotide polymorphisms in colon cancer. (PMID:18547334)
• poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus (PMID:22727665)
• the results of this study in vitro confirmed that NGDN over-expression can increase the sensitivity of human myeloid multidrug-resistant leukemia cells to chemotherapeutic drugs (PMID:25887473)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ngdn	ENSDARG00000045372
mus_musculus	Ngdn	ENSMUSG00000022204
rattus_norvegicus	Ngdn	ENSRNOG00000018069
drosophila_melanogaster	CG11030	FBGN0031736
caenorhabditis_elegans	lpd-2	WBGENE00003059

Paralogs (1): UTP3 (ENSG00000132467)

Protein

Protein identifiers

Neuroguidin — Q8NEJ9 (reviewed: Q8NEJ9)

Alternative names: Centromere accumulated nuclear protein 1, EIF4E-binding protein

All UniProt accessions (6): Q8NEJ9, A0A8V8TQS3, A0A8V8TRJ3, G3V4G1, H0YJ17, H0YJQ1

UniProt curated annotations — full annotation on UniProt →

Function. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1*. Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner.

Subunit / interactions. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with CPEB1 and EIF4E.

Subcellular location. Nucleus. Nucleolus. Chromosome. Centromere. Cytoplasm. Cell projection. Axon. Dendrite. Filopodium.

Miscellaneous. May be due to a competing donor splice site.

Similarity. Belongs to the SAS10 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8NEJ9-1	1	yes
Q8NEJ9-2	2

RefSeq proteins (2): NP_001036100, NP_056329 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007146	Sas10/Utp3/C1D	Family

Pfam: PF04000

UniProt features (19 total): modified residue 6, region of interest 3, splice variant 2, sequence variant 2, coiled-coil region 2, compositionally biased region 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7MQ8	ELECTRON MICROSCOPY	3.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NEJ9-F1	75.85	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 121, 142, 143, 204, 214, 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 154 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_MATURATION_OF_SSU_RRNA, MORF_UBE2I, PUJANA_CHEK2_PCC_NETWORK, GOBP_TRANSLATION, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, WANG_LMO4_TARGETS_DN, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, GOBP_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA, GOCC_NEURON_PROJECTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOCC_FILOPODIUM, GOCC_CHROMOSOMAL_REGION

GO Biological Process (3): maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000462), regulation of translation (GO:0006417), ribosomal small subunit biogenesis (GO:0042274)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (12): chromosome, centromeric region (GO:0000775), nucleoplasm (GO:0005654), nucleolus (GO:0005730), mitochondrion (GO:0005739), filopodium (GO:0030175), axon (GO:0030424), dendrite (GO:0030425), small-subunit processome (GO:0032040), nucleus (GO:0005634), chromosome (GO:0005694), cytoplasm (GO:0005737), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
nuclear lumen	2
intracellular membraneless organelle	2
intracellular membrane-bounded organelle	2
neuron projection	2
maturation of SSU-rRNA	1
translation	1
post-transcriptional regulation of gene expression	1
regulation of protein metabolic process	1
ribonucleoprotein complex biogenesis	1
ribosome biogenesis	1
nucleic acid binding	1
binding	1
chromosomal region	1
cytoplasm	1
actin-based cell projection	1
dendritic tree	1
nucleolus	1
preribosome	1
t-UTP complex	1
nuclear protein-containing complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2185 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NGDN	EIF4E	P06730	998
NGDN	CPEB1	Q9BZB8	961
NGDN	NOL10	Q9BSC4	862
NGDN	TENT2	Q6PIY7	861
NGDN	PARN	O95453	839
NGDN	SYMPK	Q92797	820
NGDN	EIF4ENIF1	Q9NRA8	793
NGDN	AATF	Q9NY61	791
NGDN	EIF4G1	Q04637	721
NGDN	ABT1	Q9ULW3	705
NGDN	PNLDC1	Q8NA58	705
NGDN	RPTOR	Q8N122	704
NGDN	PAPOLB	Q9NRJ5	688
NGDN	PAPOLA	P51003	686
NGDN	PAPOLG	Q9BWT3	686

IntAct

115 interactions, top by confidence:

A	B	Type	Score
AATF	NGDN	psi-mi:“MI:0915”(physical association)	0.810
AATF	NGDN	psi-mi:“MI:0914”(association)	0.810
PKN3	ARHGAP10	psi-mi:“MI:0914”(association)	0.680
rep	MPHOSPH10	psi-mi:“MI:0914”(association)	0.660
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
MFAP1	NGDN	psi-mi:“MI:0915”(physical association)	0.560
CSNK2B	NGDN	psi-mi:“MI:0915”(physical association)	0.560
NOM1	NGDN	psi-mi:“MI:0915”(physical association)	0.560
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
KRR1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
NOL10	DDX10	psi-mi:“MI:0914”(association)	0.530
	NGDN	psi-mi:“MI:0915”(physical association)	0.500
NGDN	SLC16A1	psi-mi:“MI:0915”(physical association)	0.400
RRP1B	ZNF785	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (158): AATF (Two-hybrid), NGDN (Affinity Capture-MS), NGDN (Affinity Capture-MS), NGDN (Affinity Capture-MS), NGDN (Affinity Capture-MS), NGDN (Affinity Capture-MS), UTP3 (Co-fractionation), NGDN (Affinity Capture-MS), NGDN (Biochemical Activity), NGDN (Affinity Capture-MS), NGDN (Affinity Capture-MS), NGDN (Affinity Capture-MS), NGDN (Affinity Capture-MS), NGDN (Proximity Label-MS), NGDN (Affinity Capture-MS)

ESM2 similar proteins: A1A5P2, A6QNR1, A8WY26, D3ZND0, O15213, O59678, P27672, P78316, Q0V8M0, Q15050, Q24K12, Q28IV8, Q2KIH4, Q2KII6, Q3T0Q8, Q3T0Z5, Q3UFY0, Q4KLC4, Q5M985, Q5RAS1, Q5RJT2, Q5TAP6, Q5TJE7, Q5ZKM1, Q640M1, Q6EJB6, Q6P0I6, Q6PFJ1, Q8BK35, Q8IY81, Q8N9T8, Q8NEJ9, Q8R3N1, Q8VDQ9, Q96BZ8, Q96EU6, Q9BRP8, Q9BRR8, Q9BVJ6, Q9C086

Diamond homologs: Q09713, Q2KII6, Q8NEJ9, Q9DB96, Q28IV8, Q4KLC4, Q5M985, Q6PFJ1, Q6AXX4, Q8L3P4, Q9JI13, Q9NQZ2, Q1MTS0, Q9I7W5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 111 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	11	44.7×	7e-15
Cap-dependent Translation Initiation	11	44.7×	7e-15
SARS-CoV-1 modulates host translation machinery	11	44.7×	7e-15
Eukaryotic Translation Elongation	11	40.3×	2e-14
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	11	39.4×	3e-14
Nonsense-Mediated Decay (NMD)	11	33.7×	2e-13
Peptide chain elongation	20	33.4×	1e-23
Viral mRNA Translation	20	33.4×	1e-23

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	21	37.8×	4e-25
ribosomal small subunit biogenesis	13	28.7×	1e-13
translation	19	19.0×	8e-17
rRNA processing	10	13.8×	5e-07
RNA processing	5	10.6×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	61
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1143 predictions. Top by Δscore:

Variant	Effect	Δscore
14:23470040:AGGG:A	acceptor_gain	1.0000
14:23470041:GGGG:G	acceptor_gain	1.0000
14:23470098:GCAA:G	donor_gain	1.0000
14:23470102:G:GG	donor_gain	1.0000
14:23470889:ATTT:A	acceptor_gain	1.0000
14:23470889:ATTTG:A	acceptor_gain	1.0000
14:23470892:T:A	acceptor_gain	1.0000
14:23470893:G:A	acceptor_gain	1.0000
14:23470898:A:AG	acceptor_gain	1.0000
14:23470900:TTTCA:T	acceptor_loss	1.0000
14:23470901:TTCAG:T	acceptor_loss	1.0000
14:23470902:TCAGG:T	acceptor_loss	1.0000
14:23470904:A:AG	acceptor_gain	1.0000
14:23470904:AG:A	acceptor_gain	1.0000
14:23470904:AGGT:A	acceptor_gain	1.0000
14:23470905:G:A	acceptor_loss	1.0000
14:23470905:G:GT	acceptor_gain	1.0000
14:23470905:GG:G	acceptor_gain	1.0000
14:23470905:GGT:G	acceptor_gain	1.0000
14:23470905:GGTG:G	acceptor_gain	1.0000
14:23470975:AAGG:A	donor_loss	1.0000
14:23470975:AAGGT:A	donor_gain	1.0000
14:23470976:AGG:A	donor_gain	1.0000
14:23470977:GGTAA:G	donor_gain	1.0000
14:23470978:G:GG	donor_gain	1.0000
14:23470978:GTA:G	donor_gain	1.0000
14:23470979:T:A	donor_gain	1.0000
14:23475154:T:A	acceptor_gain	1.0000
14:23475159:T:A	acceptor_gain	1.0000
14:23475164:A:AG	acceptor_gain	1.0000

AlphaMissense

2063 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:23476320:T:C	L209P	0.997
14:23476320:T:A	L209H	0.996
14:23477212:G:C	E242D	0.996
14:23477212:G:T	E242D	0.996
14:23475592:T:C	L106P	0.994
14:23477211:A:T	E242V	0.994
14:23475304:G:C	R93P	0.993
14:23476119:T:C	Y171H	0.990
14:23477228:C:A	R248S	0.989
14:23475202:T:C	L59P	0.987
14:23477309:T:C	F275L	0.987
14:23477311:C:A	F275L	0.987
14:23477311:C:G	F275L	0.987
14:23475609:A:G	K112E	0.986
14:23475611:G:C	K112N	0.986
14:23475611:G:T	K112N	0.986
14:23476308:T:A	V205D	0.986
14:23476292:G:C	A200P	0.985
14:23475235:T:C	L70P	0.984
14:23476311:T:A	I206N	0.984
14:23476344:C:A	P217Q	0.984
14:23475194:A:C	K56N	0.983
14:23475194:A:T	K56N	0.983
14:23475217:T:C	L64P	0.983
14:23476120:A:G	Y171C	0.983
14:23476320:T:G	L209R	0.983
14:23475613:T:C	L113P	0.982
14:23476119:T:G	Y171D	0.982
14:23476301:A:C	S203R	0.982
14:23476303:C:A	S203R	0.982

dbSNP variants (sampled 300 via entrez): RS1000009557 (14:23474579 A>C,G), RS1000615173 (14:23476038 G>A,C), RS1000677117 (14:23473991 C>G,T), RS1001025190 (14:23475674 G>A,C), RS1001403420 (14:23474974 C>T), RS1001455882 (14:23474724 T>G), RS1001842060 (14:23470874 C>T), RS1002354505 (14:23478651 G>T), RS1002376027 (14:23470561 G>A), RS1002465148 (14:23472902 G>A), RS1002657377 (14:23473079 G>A), RS1002846471 (14:23470146 T>C), RS1002962381 (14:23470432 T>A), RS1003078753 (14:23476310 A>G), RS1003118971 (14:23475515 T>C,G)

Disease associations

OMIM: gene MIM:610777 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

15 associations (top):

Study	Trait	p-value
GCST010796_5083	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-20
GCST010796_5084	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-08
GCST010796_5085	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-09
GCST010796_5086	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-11
GCST010796_5087	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-12
GCST010796_5088	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-13
GCST010796_5089	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-14
GCST010796_5090	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-15
GCST010796_5091	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-16
GCST010796_5092	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-17
GCST010796_5093	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-18
GCST010796_5094	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-19
GCST010796_5095	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-19
GCST010796_5096	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-19
GCST010796_5097	Electrocardiogram morphology (amplitude at temporal datapoints)	9.000000e-20

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	affects expression, increases expression	2
FR900359	affects phosphorylation	1
dicrotophos	decreases expression	1
bisphenol A	decreases expression	1
deoxynivalenol	increases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
zinc chromate	increases expression, increases abundance	1
coumarin	increases phosphorylation	1
chromium hexavalent ion	increases abundance, increases expression	1
cylindrospermopsin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
LDN 193189	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Caffeine	decreases phosphorylation	1
Copper	affects binding, decreases expression	1
Disulfiram	affects binding, decreases expression	1
Formaldehyde	increases expression	1
Ribonucleotides	affects binding	1
Dronabinol	decreases expression	1
Thiram	increases expression	1
Valproic Acid	affects expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.