NHEG1

Summary

NHEG1 (neuroblastoma highly expressed DDX5 stabilizing lncRNA 1, HGNC:56731) is a long non-coding RNA gene on chromosome 6q23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56731
Approved symbol	NHEG1
Name	neuroblastoma highly expressed DDX5 stabilizing lncRNA 1
Location	6q23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225391
Ensembl biotype	lncRNA
Entrez	100294720
RNAcentral	URS000075EE9B — lncRNA, 1360 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000418699, ENST00000432330

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418699 — 3 exons

Exon	Start	End
ENSE00001670942	136982165	136983153
ENSE00001771532	136990062	136990360
ENSE00001899381	136993174	136993234

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 74.55.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0022 / max 3.5730, expressed in 1 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
75806	0.0022	1

Top tissues by expression

158 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	74.55	gold quality
endothelial cell	CL:0000115	60.13	gold quality
leukocyte	CL:0000738	58.27	silver quality
nasal cavity epithelium	UBERON:0005384	55.84	gold quality
upper leg skin	UBERON:0004262	55.63	silver quality
ganglionic eminence	UBERON:0004023	55.25	silver quality
jejunal mucosa	UBERON:0000399	53.99	gold quality
oocyte	CL:0000023	53.92	gold quality
saphenous vein	UBERON:0007318	53.68	gold quality
nipple	UBERON:0002030	53.55	gold quality
lateral nuclear group of thalamus	UBERON:0002736	53.40	gold quality
jejunum	UBERON:0002115	52.98	gold quality
pericardium	UBERON:0002407	52.46	gold quality
urethra	UBERON:0000057	52.32	gold quality
pylorus	UBERON:0001166	52.13	gold quality
skin of abdomen	UBERON:0001416	52.13	gold quality
layer of synovial tissue	UBERON:0007616	52.06	gold quality
adrenal cortex	UBERON:0001235	52.04	gold quality
cardiac atrium	UBERON:0002081	51.99	gold quality
uterine cervix	UBERON:0000002	51.87	gold quality
cortex of kidney	UBERON:0001225	51.86	gold quality
lymph node	UBERON:0000029	51.79	gold quality
dorsal root ganglion	UBERON:0000044	51.72	gold quality
synovial joint	UBERON:0002217	51.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	51.67	silver quality
trigeminal ganglion	UBERON:0001675	51.67	gold quality
penis	UBERON:0000989	51.65	gold quality
thymus	UBERON:0002370	51.65	gold quality
medulla oblongata	UBERON:0001896	51.53	gold quality
inferior vagus X ganglion	UBERON:0005363	51.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA NHEG1/hsa-miR-665/HMGB1 axis is involved in the regulation of neuroblastoma progression. (PMID:34889712)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.