NHSL1-AS1

Summary

NHSL1-AS1 (NHSL1 antisense RNA 1, HGNC:40947) is a long non-coding RNA gene on chromosome 6q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40947
Approved symbol	NHSL1-AS1
Name	NHSL1 antisense RNA 1
Location	6q24.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ46906
Ensembl gene	ENSG00000225177
Ensembl biotype	lncRNA
Entrez	441172
RNAcentral	URS000075DB5F — lncRNA, 1022 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000428044, ENST00000432673, ENST00000447494, ENST00000458733, ENST00000664532, ENST00000719387, ENST00000719388, ENST00000719389, ENST00000719390, ENST00000719391

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000428044 — 3 exons

Exon	Start	End
ENSE00001696271	138696995	138697027
ENSE00001722262	138696597	138696755
ENSE00001752641	138694319	138694547

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 92.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.0481 / max 75.0330, expressed in 1466 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
70121	3.7917	1417
70118	0.4352	176
70119	0.2973	141
70117	0.1938	85
70116	0.1557	64
70120	0.1086	26
204223	0.0659	24

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
caudate nucleus	UBERON:0001873	92.00	gold quality
nucleus accumbens	UBERON:0001882	91.79	gold quality
putamen	UBERON:0001874	91.53	gold quality
amygdala	UBERON:0001876	91.11	gold quality
temporal lobe	UBERON:0001871	91.06	gold quality
lower esophagus mucosa	UBERON:0035834	89.33	gold quality
substantia nigra	UBERON:0002038	88.68	gold quality
Ammon’s horn	UBERON:0001954	86.85	gold quality
hypothalamus	UBERON:0001898	86.81	gold quality
right lobe of liver	UBERON:0001114	86.39	gold quality
spleen	UBERON:0002106	85.72	gold quality
anterior cingulate cortex	UBERON:0009835	85.22	gold quality
right frontal lobe	UBERON:0002810	83.48	gold quality
spinal cord	UBERON:0002240	82.71	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.67	gold quality
brain	UBERON:0000955	82.64	gold quality
stromal cell of endometrium	CL:0002255	82.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	82.48	gold quality
tibial nerve	UBERON:0001323	82.42	gold quality
cerebral cortex	UBERON:0000956	82.41	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.87	gold quality
esophagus mucosa	UBERON:0002469	81.22	gold quality
liver	UBERON:0002107	80.87	gold quality
monocyte	CL:0000576	80.57	gold quality
frontal cortex	UBERON:0001870	80.27	gold quality
leukocyte	CL:0000738	79.67	gold quality
primary visual cortex	UBERON:0002436	79.58	gold quality
omental fat pad	UBERON:0010414	78.79	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.78	gold quality
right adrenal gland cortex	UBERON:0035827	78.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.