NIFK-AS1

Summary

NIFK-AS1 (NIFK antisense RNA 1, HGNC:27385) is a long non-coding RNA gene on chromosome 2q14.3.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 254128 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27385
Approved symbol	NIFK-AS1
Name	NIFK antisense RNA 1
Location	2q14.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236859
Ensembl biotype	lncRNA
Entrez	254128
RNAcentral	URS000075B305 — lncRNA, 1267 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000413904, ENST00000414554, ENST00000419902, ENST00000439321, ENST00000447668, ENST00000654001, ENST00000658781, ENST00000659307, ENST00000662168, ENST00000666647, ENST00000667483, ENST00000668016, ENST00000669018, ENST00000670491, ENST00000671498, ENST00000690074, ENST00000802937, ENST00000802938, ENST00000802939, ENST00000802940, ENST00000802941, ENST00000802942, ENST00000802943, ENST00000802944

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413904 — 2 exons

Exon	Start	End
ENSE00001602997	121649798	121649911
ENSE00001775599	121650468	121651535

Expression profiles

Bgee: expression breadth ubiquitous, 237 present calls, max score 93.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.4044 / max 172.2434, expressed in 1610 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22343	2.8184	1304
22342	1.4128	808
22344	0.1733	70

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
medial globus pallidus	UBERON:0002477	93.20	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.99	gold quality
globus pallidus	UBERON:0001875	91.10	gold quality
spinal cord	UBERON:0002240	90.87	gold quality
oviduct epithelium	UBERON:0004804	89.08	gold quality
tendon of biceps brachii	UBERON:0008188	88.58	gold quality
substantia nigra	UBERON:0002038	88.09	gold quality
tendon	UBERON:0000043	87.18	gold quality
midbrain	UBERON:0001891	87.02	gold quality
calcaneal tendon	UBERON:0003701	86.81	gold quality
hypothalamus	UBERON:0001898	86.19	gold quality
inferior vagus X ganglion	UBERON:0005363	86.19	gold quality
amygdala	UBERON:0001876	86.07	gold quality
corpus callosum	UBERON:0002336	86.07	gold quality
putamen	UBERON:0001874	85.59	gold quality
Ammon’s horn	UBERON:0001954	83.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.33	gold quality
subthalamic nucleus	UBERON:0001906	83.10	gold quality
germinal epithelium of ovary	UBERON:0001304	82.48	gold quality
caudate nucleus	UBERON:0001873	82.16	gold quality
thymus	UBERON:0002370	81.73	gold quality
nucleus accumbens	UBERON:0001882	81.63	gold quality
medulla oblongata	UBERON:0001896	81.42	gold quality
lateral globus pallidus	UBERON:0002476	81.26	gold quality
parietal pleura	UBERON:0002400	81.09	gold quality
temporal lobe	UBERON:0001871	80.73	gold quality
substantia nigra pars reticulata	UBERON:0001966	80.70	gold quality
tibia	UBERON:0000979	80.65	gold quality
anterior cingulate cortex	UBERON:0009835	80.60	gold quality
descending thoracic aorta	UBERON:0002345	80.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• NIFK-AS1 inhibits M2 polarization of macrophages in endometrial cancer through targeting miR-146a (PMID:30176290)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.