NIHCOLE

Summary

NIHCOLE (ncRNA involved in NHEJ oncogenic ligation efficiency, HGNC:53024) is a long non-coding RNA gene on chromosome 5q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53024
Approved symbol	NIHCOLE
Name	ncRNA involved in NHEJ oncogenic ligation efficiency
Location	5q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-138J23.1
Ensembl gene	ENSG00000251026
Ensembl biotype	lncRNA
Entrez	107986389
RNAcentral	URS0002A1D4C6 — lncRNA, 1809 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000514769, ENST00000662211, ENST00000665271, ENST00000666145, ENST00000666455, ENST00000721479, ENST00000721481, ENST00000721482, ENST00000721483, ENST00000721484, ENST00000721485, ENST00000731153

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000514769 — 5 exons

Exon	Start	End
ENSE00002043597	104104174	104104287
ENSE00002055134	104081880	104081947
ENSE00002069096	104105360	104105403
ENSE00002077347	104080908	104081041
ENSE00002084416	104079911	104080124

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 88.37.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.37	gold quality
bone marrow cell	CL:0002092	73.79	silver quality
cortex of kidney	UBERON:0001225	71.95	gold quality
liver	UBERON:0002107	64.98	silver quality
ventricular zone	UBERON:0003053	60.38	gold quality
placenta	UBERON:0001987	56.39	gold quality
blood	UBERON:0000178	51.47	gold quality
monocyte	CL:0000576	50.69	silver quality
smooth muscle tissue	UBERON:0001135	50.40	gold quality
endometrium	UBERON:0001295	50.27	silver quality
lymph node	UBERON:0000029	49.04	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	48.93	gold quality
superior frontal gyrus	UBERON:0002661	48.88	silver quality
adult mammalian kidney	UBERON:0000082	48.68	gold quality
islet of Langerhans	UBERON:0000006	47.57	gold quality
urinary bladder	UBERON:0001255	46.66	silver quality
thyroid gland	UBERON:0002046	46.59	silver quality
calcaneal tendon	UBERON:0003701	46.50	silver quality
prefrontal cortex	UBERON:0000451	46.10	silver quality
muscle of leg	UBERON:0001383	46.08	gold quality
gall bladder	UBERON:0002110	45.99	gold quality
gastrocnemius	UBERON:0001388	45.59	gold quality
right lobe of thyroid gland	UBERON:0001119	45.39	gold quality
subcutaneous adipose tissue	UBERON:0002190	45.35	gold quality
heart left ventricle	UBERON:0002084	44.54	silver quality
frontal cortex	UBERON:0001870	44.47	silver quality
cerebellar hemisphere	UBERON:0002245	44.30	silver quality
cerebellum	UBERON:0002037	44.26	silver quality
right hemisphere of cerebellum	UBERON:0014890	44.25	silver quality
endocervix	UBERON:0000458	44.13	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LINC02163 regulates growth and epithelial-to-mesenchymal transition phenotype via miR-593-3p/FOXK1 axis in gastric cancer cells (PMID:29893595)
• LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis. (PMID:32524841)
• Upregulated long noncoding RNAs LINC02163 and FEZF1-AS1 exert oncogenic roles in colorectal cancer. (PMID:32932277)
• Long Noncoding RNA NIHCOLE Promotes Ligation Efficiency of DNA Double-Strand Breaks in Hepatocellular Carcinoma. (PMID:34321241)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.