NIP7

Summary

NIP7 (nucleolar pre-rRNA processing protein NIP7, HGNC:24328) is a protein-coding gene on chromosome 16q22.1, encoding 60S ribosome subunit biogenesis protein NIP7 homolog (Q9Y221). Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. It is a common-essential gene (DepMap: required in 100.0% of cancer cell lines).

Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm.

Source: NCBI Gene 51388 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 36 total
• Cancer dependency (DepMap): dependent in 100.0% of screened cell lines (common-essential)
• MANE Select transcript: NM_016101

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24328
Approved symbol	NIP7
Name	nucleolar pre-rRNA processing protein NIP7
Location	16q22.1
Locus type	gene with protein product
Status	Approved
Aliases	CGI-37, FLJ10296, HSPC031, KD93
Ensembl gene	ENSG00000132603
Ensembl biotype	protein_coding
OMIM	619204
Entrez	51388

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 6 protein_coding, 3 retained_intron

ENST00000254940, ENST00000254941, ENST00000562131, ENST00000562523, ENST00000563364, ENST00000565034, ENST00000567202, ENST00000569637, ENST00000937746

RefSeq mRNA: 2 — MANE Select: NM_016101 NM_001199434, NM_016101

CCDS: CCDS10877, CCDS56003

Canonical transcript exons

ENST00000254940 — 5 exons

Exon	Start	End
ENSE00000904600	69340006	69340092
ENSE00000904606	69341180	69341320
ENSE00001872045	69341533	69343106
ENSE00001912636	69339772	69339885
ENSE00003668941	69340194	69340332

Expression profiles

Bgee: expression breadth ubiquitous, 267 present calls, max score 94.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.6124 / max 332.3969, expressed in 1813 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154814	17.1330	1785
154813	4.3633	1551
154815	0.1008	20
154812	0.0153	5

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	94.93	gold quality
pharyngeal mucosa	UBERON:0000355	88.40	gold quality
esophagus squamous epithelium	UBERON:0006920	88.34	gold quality
oral cavity	UBERON:0000167	87.94	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.92	gold quality
islet of Langerhans	UBERON:0000006	87.92	gold quality
nipple	UBERON:0002030	87.57	gold quality
oocyte	CL:0000023	86.95	gold quality
gingiva	UBERON:0001828	86.92	gold quality
superior surface of tongue	UBERON:0007371	86.53	gold quality
rectum	UBERON:0001052	86.52	gold quality
epithelium of esophagus	UBERON:0001976	86.42	gold quality
esophagus mucosa	UBERON:0002469	86.42	gold quality
gingival epithelium	UBERON:0001949	86.33	gold quality
mucosa of transverse colon	UBERON:0004991	86.31	gold quality
cauda epididymis	UBERON:0004360	86.28	gold quality
mucosa of sigmoid colon	UBERON:0004993	86.19	gold quality
adrenal tissue	UBERON:0018303	86.15	gold quality
leukocyte	CL:0000738	85.97	gold quality
colonic mucosa	UBERON:0000317	85.97	gold quality
lymph node	UBERON:0000029	85.96	gold quality
monocyte	CL:0000576	85.88	gold quality
mononuclear cell	CL:0000842	85.75	gold quality
squamous epithelium	UBERON:0006914	85.70	gold quality
bone marrow	UBERON:0002371	85.66	gold quality
tonsil	UBERON:0002372	85.63	gold quality
stromal cell of endometrium	CL:0002255	85.47	gold quality
endometrium	UBERON:0001295	85.42	gold quality
corpus epididymis	UBERON:0004359	85.24	gold quality
penis	UBERON:0000989	85.10	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-3929	yes	663.08
E-ANND-3	yes	6.55
E-HCAD-5	no	2.20

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

96 targeting NIP7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 100.0% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 5)

• KD93 is a novel protein expressed in human hematopoietic stem/progenitor cells (PMID:15522784)
• SBDS is found in complexes containing the human Nip7 ortholog. (PMID:17643419)
• Downregulation of NIP7 affects pre-rRNA processing, causing an imbalance of the 40S/60S subunit ratio. (PMID:20798176)
• The results presented in this work indicate a close functional interaction between NIP7 and FTSJ3 during pre-rRNA processing and show that FTSJ3 participates in ribosome synthesis in human cells. (PMID:22195017)
• The Cox regression model revealed that only NIP7, RPL10L, and MCM2 exhibited significant correlation with distant recurrence-free survival in liposarcoma in the GSE30929 dataset, and the regression coefficients were -0.676, -0.703, and 0.868, respectively (PMID:30317246)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nip7	ENSDARG00000059075
mus_musculus	Nip7	ENSMUSG00000031917
rattus_norvegicus	Nip7	ENSRNOG00000020391
drosophila_melanogaster	CG7006	FBGN0039233
caenorhabditis_elegans	C43E11.9	WBGENE00016607

Paralogs (2): CKS2 (ENSG00000123975), CKS1B (ENSG00000173207)

Protein

Protein identifiers

60S ribosome subunit biogenesis protein NIP7 homolog — Q9Y221 (reviewed: Q9Y221)

Alternative names: KD93, Nucleolar pre-rRNA processing protein NIP7

All UniProt accessions (4): Q9Y221, J3QLW7, J3QRD6, J3QRR4

UniProt curated annotations — full annotation on UniProt →

Function. Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.

Subunit / interactions. Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. May interact with SBDS. Interacts with FTSJ3. Interacts with DDX24.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Expressed in hematopoietic stem/progenitor cells.

Similarity. Belongs to the NIP7 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y221-1	1	yes
Q9Y221-2	2

RefSeq proteins (2): NP_001186363, NP_057185* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002478	PUA	Domain
IPR005155	UPF0113_PUA	Domain
IPR015947	PUA-like_sf	Homologous_superfamily
IPR016686	Ribosomal_synth_fac_NIP7	Family
IPR036974	PUA_sf	Homologous_superfamily
IPR040598	NIP7_N	Domain
IPR055359	Nip7_N_euk	Domain

Pfam: PF03657, PF17833

UniProt features (30 total): helix 12, strand 9, turn 2, region of interest 2, chain 1, domain 1, splice variant 1, sequence variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

8 structures.

PDB	Method	Resolution (Å)
1SQW	X-RAY DIFFRACTION	1.9
8FKV	ELECTRON MICROSCOPY	2.47
1T5Y	X-RAY DIFFRACTION	2.5
8FKW	ELECTRON MICROSCOPY	2.5
8FKX	ELECTRON MICROSCOPY	2.59
8FKY	ELECTRON MICROSCOPY	2.67
8FKT	ELECTRON MICROSCOPY	2.81
8FKU	ELECTRON MICROSCOPY	2.82

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y221-F1	93.91	0.87

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

Position	Phenotype
55	markedly reduced interaction with ddx24.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol

MSigDB gene sets: 166 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, ELVIDGE_HYPOXIA_DN, GOBP_RIBOSOME_BIOGENESIS, chr16q22, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_RIBOSOME_ASSEMBLY, TERAMOTO_OPN_TARGETS_CLUSTER_3, GOBP_ORGANELLE_ASSEMBLY, TIEN_INTESTINE_PROBIOTICS_24HR_UP, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, GRADE_COLON_AND_RECTAL_CANCER_UP, REACTOME_METABOLISM_OF_RNA, GOCC_PRERIBOSOME

GO Biological Process (3): ribosome assembly (GO:0042255), ribosomal large subunit biogenesis (GO:0042273), ribosome biogenesis (GO:0042254)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), preribosome, large subunit precursor (GO:0030687), nucleus (GO:0005634), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
ribosome biogenesis	2
ribonucleoprotein complex biogenesis	2
nuclear lumen	2
membraneless organelle assembly	1
nucleic acid binding	1
binding	1
intracellular membraneless organelle	1
cytoplasm	1
preribosome	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2630 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NIP7	NOL8	Q76FK4	954
NIP7	EXOSC8	Q96B26	915
NIP7	FTSJ3	Q8IY81	838
NIP7	RSL24D1	Q9UHA3	825
NIP7	NOP2	P46087	820
NIP7	RPF2	Q9H7B2	794
NIP7	WDR12	Q9GZL7	784
NIP7	NOP53	Q9NZM5	771
NIP7	EBNA1BP2	Q99848	757
NIP7	NSA2	O95478	744
NIP7	NIFK	Q9BYG3	739
NIP7	PAK1IP1	Q9NWT1	716
NIP7	RRAGA	Q7L523	709
NIP7	RRAGC	Q9HB90	708
NIP7	RRAGD	Q9NQL2	705

IntAct

130 interactions, top by confidence:

A	B	Type	Score
CBFB	RUNX1	psi-mi:“MI:0914”(association)	0.870
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
NOP2	NIP7	psi-mi:“MI:0915”(physical association)	0.670
DNAJC8	SF3B1	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
NECAB2	NIP7	psi-mi:“MI:0915”(physical association)	0.560
NIP7	CRX	psi-mi:“MI:0915”(physical association)	0.560
NIP7	LZTS2	psi-mi:“MI:0915”(physical association)	0.560
CRX	NIP7	psi-mi:“MI:0915”(physical association)	0.560
LZTS2	NIP7	psi-mi:“MI:0915”(physical association)	0.560
NIP7	NECAB2	psi-mi:“MI:0915”(physical association)	0.560
NIP7	OPTN	psi-mi:“MI:0915”(physical association)	0.560
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
ZC3HAV1	KHNYN	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
SRPK2	RRP9	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
NHSL3	NCK2	psi-mi:“MI:0914”(association)	0.530
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410

BioGRID (223): NIP7 (Two-hybrid), NIP7 (Two-hybrid), NECAB2 (Two-hybrid), LZTS2 (Two-hybrid), NIP7 (Affinity Capture-MS), NIP7 (Affinity Capture-MS), NIP7 (Affinity Capture-MS), NIP7 (Affinity Capture-MS), NIP7 (Affinity Capture-MS), NIP7 (Affinity Capture-MS), NIP7 (Two-hybrid), CEBPZ (Co-fractionation), DDX24 (Co-fractionation), GLTSCR2 (Co-fractionation), NIP7 (Co-fractionation)

ESM2 similar proteins: A1JU75, A2BK57, A4QND5, A4ZUA5, A6URG2, B0G104, B5Y822, O14228, O26715, O26868, O27544, O28112, O28293, O28826, O29145, O83462, P02962, P0C2V7, P0C8H0, P0C8H2, P0C8H3, P0CAA4, P24154, P50348, P55489, P58828, P80305, Q07739, Q09MI6, Q14FG5, Q3V4V8, Q4T2X8, Q50533, Q56P27, Q58254, Q5PB42, Q5R9J1, Q65143, Q65189, Q6DFH9

Diamond homologs: A4QND5, B0G104, Q08962, Q1MTQ9, Q4T2X8, Q503P2, Q56P27, Q5R9J1, Q6DFH9, Q9CXK8, Q9WV50, Q9Y221

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 137 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	13	18.3×	2e-11
Viral mRNA Translation	13	18.3×	2e-11
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	13	18.1×	2e-11
Selenocysteine synthesis	13	17.4×	3e-11
Eukaryotic Translation Termination	13	17.4×	3e-11
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	13	17.0×	3e-11
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	13	17.0×	3e-11
rRNA modification in the nucleus and cytosol	8	16.6×	7e-07

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal large subunit biogenesis	8	29.1×	4e-08
positive regulation of transcription by RNA polymerase I	5	26.6×	1e-04
rRNA processing	17	19.7×	8e-15
cytoplasmic translation	13	19.7×	3e-11
ribosomal small subunit biogenesis	9	16.8×	4e-07
negative regulation of viral genome replication	5	15.3×	2e-03
translation	13	10.9×	4e-08
regulation of alternative mRNA splicing, via spliceosome	5	10.0×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

36 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

656 predictions. Top by Δscore:

Variant	Effect	Δscore
16:69339618:G:GT	donor_gain	1.0000
16:69339886:G:GG	donor_gain	1.0000
16:69340088:GTGAG:G	donor_gain	1.0000
16:69340185:C:G	acceptor_gain	1.0000
16:69340190:TTAGT:T	acceptor_loss	1.0000
16:69340191:TA:T	acceptor_loss	1.0000
16:69340192:A:AG	acceptor_gain	1.0000
16:69340192:A:G	acceptor_loss	1.0000
16:69340192:AGT:A	acceptor_gain	1.0000
16:69340193:G:GA	acceptor_gain	1.0000
16:69340193:GT:G	acceptor_gain	1.0000
16:69340193:GTG:G	acceptor_gain	1.0000
16:69340193:GTGA:G	acceptor_gain	1.0000
16:69340328:CCAAG:C	donor_loss	1.0000
16:69340329:CAAGG:C	donor_loss	1.0000
16:69340330:AAG:A	donor_loss	1.0000
16:69340332:GGTT:G	donor_loss	1.0000
16:69341167:A:AG	acceptor_gain	1.0000
16:69341177:TAGT:T	acceptor_loss	1.0000
16:69341178:A:AG	acceptor_gain	1.0000
16:69341178:AGT:A	acceptor_loss	1.0000
16:69341179:G:GT	acceptor_gain	1.0000
16:69341179:GT:G	acceptor_gain	1.0000
16:69341179:GTA:G	acceptor_gain	1.0000
16:69341179:GTAT:G	acceptor_gain	1.0000
16:69341179:GTATA:G	acceptor_gain	1.0000
16:69341319:TGGTG:T	donor_loss	1.0000
16:69341321:G:GC	donor_loss	1.0000
16:69341322:TGA:T	donor_loss	1.0000
16:69341323:G:GG	donor_loss	1.0000

AlphaMissense

1170 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:69340250:G:A	G67E	1.000
16:69340262:G:A	G71E	1.000
16:69341187:T:A	V97D	1.000
16:69341189:T:A	W98R	1.000
16:69341189:T:C	W98R	1.000
16:69341240:A:G	K115E	1.000
16:69341242:A:C	K115N	1.000
16:69341242:A:T	K115N	1.000
16:69341537:T:C	F143S	1.000
16:69341539:G:T	G144W	1.000
16:69341540:G:A	G144E	1.000
16:69341549:C:A	A147D	1.000
16:69341608:G:C	A167P	1.000
16:69339840:T:C	L4S	0.999
16:69339840:T:G	L4W	0.999
16:69340059:T:C	F37S	0.999
16:69340062:G:C	R38P	0.999
16:69340077:G:C	R43P	0.999
16:69340249:G:A	G67R	0.999
16:69340249:G:C	G67R	0.999
16:69340249:G:T	G67W	0.999
16:69340250:G:T	G67V	0.999
16:69340261:G:A	G71R	0.999
16:69340261:G:C	G71R	0.999
16:69340262:G:T	G71V	0.999
16:69340286:T:C	F79S	0.999
16:69340304:C:A	A85D	0.999
16:69340328:C:A	A93D	0.999
16:69341185:A:C	K96N	0.999
16:69341185:A:T	K96N	0.999

dbSNP variants (sampled 300 via entrez): RS1000102220 (16:69338897 G>A,T), RS1000451372 (16:69338637 C>A,G,T), RS1000788071 (16:69338162 A>T), RS1000840290 (16:69338374 A>G), RS1000952872 (16:69343156 T>C), RS1001995505 (16:69338111 C>T), RS1002114621 (16:69343243 T>C,G), RS1002576812 (16:69340424 A>G,T), RS1002583776 (16:69342922 C>T), RS1003185354 (16:69341930 A>G,T), RS1004303760 (16:69338182 C>A,T), RS1005080818 (16:69342310 G>T), RS1005544636 (16:69342565 G>A), RS1006032107 (16:69339798 C>A,G,T), RS1007074419 (16:69339846 A>C,G)

Disease associations

OMIM: gene MIM:619204 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005951_13	Body mass index	5.000000e-11
GCST007006_16	Logical memory (delayed recall) in normal cognition	7.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004874	memory performance

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, decreases expression, affects cotreatment, increases abundance, increases expression	3
cobaltous chloride	decreases expression, decreases reaction	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
Valproic Acid	affects expression, increases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
sodium arsenate	decreases expression	1
trichostatin A	affects expression	1
arsenite	affects binding, increases reaction	1
zinc chloride	decreases reaction, decreases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	increases expression	1
Vorinostat	affects cotreatment, increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Estradiol	increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Methyl Methanesulfonate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.