NKD1

Summary

NKD1 (NKD inhibitor of Wnt signaling pathway 1, HGNC:17045) is a protein-coding gene on chromosome 16q12.1, encoding Protein naked cuticle homolog 1 (Q969G9). Cell autonomous antagonist of the canonical Wnt signaling pathway.

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.

Source: NCBI Gene 85407 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 93 total
• MANE Select transcript: NM_033119

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17045
Approved symbol	NKD1
Name	NKD inhibitor of Wnt signaling pathway 1
Location	16q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000140807
Ensembl biotype	protein_coding
OMIM	607851
Entrez	85407

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 1 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000268459, ENST00000564336, ENST00000566396

RefSeq mRNA: 1 — MANE Select: NM_033119 NM_033119

CCDS: CCDS10743

Canonical transcript exons

ENST00000268459 — 10 exons

Exon	Start	End
ENSE00000945132	50621602	50621708
ENSE00000945133	50625485	50625580
ENSE00001293274	50633192	50649249
ENSE00001320873	50548396	50548578
ENSE00003482996	50632281	50632408
ENSE00003500109	50608294	50608360
ENSE00003522749	50630826	50630910
ENSE00003531012	50549422	50549555
ENSE00003598144	50630186	50630333
ENSE00003680815	50548717	50548749

Expression profiles

Bgee: expression breadth ubiquitous, 189 present calls, max score 88.43.

FANTOM5 (CAGE): breadth broad, TPM avg 5.4084 / max 1093.6095, expressed in 609 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154010	4.6946	545
154025	0.2518	5
153999	0.2236	44
154009	0.1707	55
154018	0.0355	12
153998	0.0321	15

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	88.43	gold quality
saphenous vein	UBERON:0007318	86.63	gold quality
lateral nuclear group of thalamus	UBERON:0002736	86.43	gold quality
popliteal artery	UBERON:0002250	85.09	gold quality
tibial artery	UBERON:0007610	85.06	gold quality
endothelial cell	CL:0000115	84.20	silver quality
sural nerve	UBERON:0015488	83.28	gold quality
aorta	UBERON:0000947	82.58	gold quality
lower lobe of lung	UBERON:0008949	82.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.18	gold quality
lower esophagus	UBERON:0013473	81.13	gold quality
descending thoracic aorta	UBERON:0002345	80.94	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.37	gold quality
thoracic aorta	UBERON:0001515	79.27	gold quality
ascending aorta	UBERON:0001496	78.97	gold quality
urethra	UBERON:0000057	78.88	gold quality
lung	UBERON:0002048	78.68	gold quality
upper lobe of left lung	UBERON:0008952	78.41	gold quality
right coronary artery	UBERON:0001625	78.09	gold quality
upper lobe of lung	UBERON:0008948	78.08	gold quality
tibia	UBERON:0000979	77.98	gold quality
inferior vagus X ganglion	UBERON:0005363	77.95	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.83	gold quality
buccal mucosa cell	CL:0002336	77.46	gold quality
mucosa of stomach	UBERON:0001199	77.26	gold quality
spinal cord	UBERON:0002240	77.15	gold quality
left coronary artery	UBERON:0001626	76.84	gold quality
dorsal plus ventral thalamus	UBERON:0001897	76.73	gold quality
coronary artery	UBERON:0001621	76.49	gold quality
caput epididymis	UBERON:0004358	76.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	5.18

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTNNB1

miRNA regulators (miRDB)

289 targeting NKD1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-548P	99.98	72.25	3784
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-548N	99.98	71.94	4170

Literature-anchored findings (GeneRIF, showing 14)

• Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling (PMID:19956716)
• Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC (PMID:21599923)
• Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer. (PMID:26097589)
• The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells. (PMID:27231134)
• Low NKD1 expression is associated with hepatocellular carcinoma. (PMID:27507614)
• Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells. (PMID:28032380)
• Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. (PMID:28107193)
• HNF1A-AS1 promoted HCC cell proliferation by repressing the NKD1 and p21 expression. (PMID:28292020)
• NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia. (PMID:28443469)
• the downregulation of NKD1 may be involved in the proliferation and migration of osteosarcoma cells through the activation of the canonical Wnt signaling pathway. (PMID:29115501)
• miR-532 is highly expressed in colorectal cancer cells and directly inhibits NKD1 expression (PMID:31472047)
• Let-7b-5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1. (PMID:36445120)
• Clinical Significance of NKD Inhibitor of WNT Signaling Pathway 1 (NKD1) in Glioblastoma. (PMID:36969985)
• [NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription]. (PMID:37202194)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	nkd1	ENSDARG00000020053
mus_musculus	Nkd1	ENSMUSG00000031661
drosophila_melanogaster	nkd	FBGN0002945
drosophila_melanogaster	PIP82	FBGN0024943

Paralogs (1): NKD2 (ENSG00000145506)

Protein

Protein identifiers

Protein naked cuticle homolog 1 — Q969G9 (reviewed: Q969G9)

All UniProt accessions (1): Q969G9

UniProt curated annotations — full annotation on UniProt →

Function. Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.

Subunit / interactions. Interacts with DVL1, DVL2, DVL3 and PPP2R3A.

Subcellular location. Cell membrane. Cytoplasm.

Tissue specificity. Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen.

Induction. Expression is induced by activation of the Wnt signaling pathway.

Similarity. Belongs to the NKD family.

RefSeq proteins (1): NP_149110* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002048	EF_hand_dom	Domain
IPR011992	EF-hand-dom_pair	Homologous_superfamily
IPR018247	EF_Hand_1_Ca_BS	Binding_site
IPR040140	Nkd-like	Family

UniProt features (22 total): region of interest 7, compositionally biased region 5, binding site 5, initiator methionine 1, chain 1, domain 1, lipid moiety-binding region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q969G9-F1	55.34	0.04

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 144; 146; 148; 150; 155

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 175 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_EPITHELIUM_DEVELOPMENT, TAATAAT_MIR126, HNF3ALPHA_Q6, GOBP_NON_CANONICAL_WNT_SIGNALING_PATHWAY, GOBP_REGULATION_OF_NON_CANONICAL_WNT_SIGNALING_PATHWAY, GOBP_GROWTH, GOBP_POSITIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE, GOBP_NEUROGENESIS, TAL1ALPHAE47_01, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, CAGCTG_AP4_Q5

GO Biological Process (12): eye photoreceptor cell differentiation (GO:0001754), axis elongation (GO:0003401), somatic muscle development (GO:0007525), Wnt signaling pathway (GO:0016055), negative regulation of Wnt signaling pathway (GO:0030178), positive regulation of MAPK cascade (GO:0043410), positive regulation of protein catabolic process (GO:0045732), convergent extension (GO:0060026), negative regulation of canonical Wnt signaling pathway (GO:0090090), regulation of cell migration involved in somitogenic axis elongation (GO:0090249), positive regulation of non-canonical Wnt signaling pathway (GO:2000052), positive regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000096)

GO Molecular Function (4): calcium ion binding (GO:0005509), PDZ domain binding (GO:0030165), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): protein phosphatase type 2A complex (GO:0000159), cytoplasm (GO:0005737), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
photoreceptor cell differentiation	1
eye morphogenesis	1
developmental growth involved in morphogenesis	1
muscle structure development	1
cell surface receptor signaling pathway	1
negative regulation of signal transduction	1
Wnt signaling pathway	1
regulation of Wnt signaling pathway	1
MAPK cascade	1
regulation of MAPK cascade	1
positive regulation of intracellular signal transduction	1
positive regulation of catabolic process	1
protein catabolic process	1
regulation of protein catabolic process	1
positive regulation of protein metabolic process	1
morphogenesis of an epithelium	1
negative regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
regulation of cell migration	1
cell migration involved in somitogenic axis elongation	1
positive regulation of Wnt signaling pathway	1
non-canonical Wnt signaling pathway	1
regulation of non-canonical Wnt signaling pathway	1
Wnt signaling pathway, planar cell polarity pathway	1
positive regulation of non-canonical Wnt signaling pathway	1
regulation of Wnt signaling pathway, planar cell polarity pathway	1
metal ion binding	1
protein domain specific binding	1
binding	1
cation binding	1
protein serine/threonine phosphatase complex	1
intracellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

864 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NKD1	DVL1	O14640	889
NKD1	AXIN2	Q9Y2T1	889
NKD1	CTNNB1	P35222	724
NKD1	DKK1	O94907	685
NKD1	DVL3	Q92997	673
NKD1	HNF4A	P41235	668
NKD1	TNFRSF19	Q9NS68	640
NKD1	WNT1	P04628	626
NKD1	RNF43	Q68DV7	619
NKD1	NRARP	Q7Z6K4	617
NKD1	DUSP6	Q16828	591
NKD1	WNT7B	P56706	589
NKD1	FZD1	Q9UP38	584
NKD1	LFNG	Q8NES3	583
NKD1	VANGL2	Q9ULK5	571

IntAct

48 interactions, top by confidence:

A	B	Type	Score
NKD1	PPP2R3A	psi-mi:“MI:0915”(physical association)	0.620
PPP2R3A	NKD1	psi-mi:“MI:0915”(physical association)	0.580
NKD1	PPP2R3A	psi-mi:“MI:0915”(physical association)	0.580
	NKD1	psi-mi:“MI:0915”(physical association)	0.560
DVL3	NKD1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP5-9	NKD1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-9	NKD1	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	NKD1	psi-mi:“MI:0915”(physical association)	0.560
NKD1	MDFI	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-6	NKD1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP12-3	NKD1	psi-mi:“MI:0915”(physical association)	0.560
NKD1	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	NKD1	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	NKD1	psi-mi:“MI:0915”(physical association)	0.560
NKD1	KRTAP9-8	psi-mi:“MI:0915”(physical association)	0.560
NKD1	MORF4L1	psi-mi:“MI:0915”(physical association)	0.560
NKD1	PPP2R1A	psi-mi:“MI:0914”(association)	0.530
NKD1	DVL3	psi-mi:“MI:0915”(physical association)	0.000
NKD1	KRTAP5-9	psi-mi:“MI:0915”(physical association)	0.000
NKD1	KRTAP10-9	psi-mi:“MI:0915”(physical association)	0.000
NKD1	CYSRT1	psi-mi:“MI:0915”(physical association)	0.000
NKD1	MDFI	psi-mi:“MI:0915”(physical association)	0.000
NKD1	KRTAP10-6	psi-mi:“MI:0915”(physical association)	0.000
NKD1	KRTAP12-3	psi-mi:“MI:0915”(physical association)	0.000
NKD1	KRTAP10-7	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (21): NKD1 (Affinity Capture-MS), NKD1 (Affinity Capture-RNA), NKD1 (Two-hybrid), DVL3 (Two-hybrid), MORF4L1 (Two-hybrid), KRTAP9-8 (Two-hybrid), KRTAP10-8 (Two-hybrid), KRTAP10-6 (Two-hybrid), CYSRT1 (Two-hybrid), KRTAP12-3 (Two-hybrid), KRTAP2-3 (Two-hybrid), KRTAP2-4 (Two-hybrid), KRTAP10-1 (Two-hybrid), KRTAP10-9 (Two-hybrid), KRTAP5-9 (Two-hybrid)

ESM2 similar proteins: A4D2P6, A5PJV8, A6NFD8, D4AE48, O00268, O00287, O35274, O35779, O43566, P04198, P12755, P55199, Q08DA0, Q0D2I5, Q2KJ58, Q504T8, Q5XKK7, Q60698, Q61976, Q6NZ67, Q6P582, Q6R891, Q6T4P5, Q7Z6J2, Q80YR4, Q86UD0, Q86UK7, Q8BXL9, Q8CEG5, Q8R4T5, Q8TF61, Q8VCG9, Q969F2, Q969G9, Q96HZ4, Q96SB3, Q99PV5, Q9BQ61, Q9BUN5, Q9BZE9

Diamond homologs: A4ZNR4, A4ZNR5, Q08AA9, Q16HE8, Q29DJ1, Q2TJA6, Q8VE28, Q969F2, Q969G9, Q99MH6, Q9VVV9, P42325, Q16982, Q75K28, P62760, P62761, P62762, P62763, P62764, Q4R5F7, Q5RD22

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
NKD1	down-regulates	DVL3	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 14 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	8	40.5×	2e-10

Disease & clinical

Clinical variants and AI predictions

ClinVar

93 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	81
Likely benign	4
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2397 predictions. Top by Δscore:

Variant	Effect	Δscore
16:50608358:A:T	donor_gain	1.0000
16:50621600:A:AG	acceptor_gain	1.0000
16:50621600:AGT:A	acceptor_gain	1.0000
16:50621601:G:GG	acceptor_gain	1.0000
16:50621601:GTG:G	acceptor_gain	1.0000
16:50621706:GAA:G	donor_gain	1.0000
16:50621708:AG:A	donor_loss	1.0000
16:50621709:G:GG	donor_gain	1.0000
16:50621709:G:T	donor_loss	1.0000
16:50621710:TAA:T	donor_loss	1.0000
16:50625483:A:AG	acceptor_gain	1.0000
16:50625484:G:GG	acceptor_gain	1.0000
16:50625578:GAG:G	donor_gain	1.0000
16:50625578:GAGGT:G	donor_loss	1.0000
16:50625579:AGG:A	donor_loss	1.0000
16:50625581:G:GC	donor_loss	1.0000
16:50625582:T:G	donor_loss	1.0000
16:50630312:A:T	donor_gain	1.0000
16:50630347:GGC:G	donor_gain	1.0000
16:50630382:G:GT	donor_gain	1.0000
16:50630812:C:CA	acceptor_gain	1.0000
16:50630813:G:A	acceptor_gain	1.0000
16:50630817:C:A	acceptor_gain	1.0000
16:50630909:AGG:A	donor_loss	1.0000
16:50630911:G:C	donor_loss	1.0000
16:50630912:T:A	donor_loss	1.0000
16:50632279:A:AC	acceptor_loss	1.0000
16:50632279:AG:A	acceptor_gain	1.0000
16:50632280:GG:G	acceptor_gain	1.0000
16:50632404:GCCTG:G	donor_gain	1.0000

AlphaMissense

3067 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:50625536:T:C	F140L	0.998
16:50625537:T:C	F140S	0.998
16:50625538:C:A	F140L	0.998
16:50625538:C:G	F140L	0.998
16:50625530:T:A	W138R	0.997
16:50625530:T:C	W138R	0.997
16:50630277:T:C	L185P	0.997
16:50630199:T:C	L159S	0.996
16:50632353:A:C	R256S	0.996
16:50632353:A:T	R256S	0.996
16:50632370:T:C	L262P	0.996
16:50625532:G:C	W138C	0.995
16:50625532:G:T	W138C	0.995
16:50632364:T:C	L260S	0.995
16:50548735:G:T	R15M	0.994
16:50630277:T:A	L185H	0.994
16:50548557:G:A	G2R	0.993
16:50548557:G:C	G2R	0.993
16:50548736:G:C	R15S	0.993
16:50548736:G:T	R15S	0.993
16:50548749:G:C	G20R	0.993
16:50630211:T:A	I163N	0.993
16:50632352:G:C	R256T	0.993
16:50548557:G:T	G2W	0.992
16:50625551:T:C	F145L	0.992
16:50625553:T:A	F145L	0.992
16:50625553:T:G	F145L	0.992
16:50630202:T:C	L160P	0.992
16:50632350:G:C	R255S	0.992
16:50632350:G:T	R255S	0.992

dbSNP variants (sampled 300 via entrez): RS1000008626 (16:50608206 G>A,T), RS1000086635 (16:50582150 A>G), RS1000092462 (16:50647583 C>A,T), RS1000118076 (16:50564153 A>C), RS1000127318 (16:50638074 G>C), RS1000203997 (16:50603621 A>C,G), RS1000215670 (16:50593814 A>T), RS1000218753 (16:50625699 C>A,G,T), RS1000229103 (16:50642792 A>C), RS1000251539 (16:50614747 A>G,T), RS1000312798 (16:50629527 G>C,T), RS1000352582 (16:50635107 C>T), RS1000372614 (16:50613508 C>G,T), RS1000398687 (16:50557621 G>T), RS1000435720 (16:50598012 G>A)

Disease associations

OMIM: gene MIM:607851 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST001438_12	Crohn’s disease	1.000000e-37
GCST002938_41	Copper levels	9.000000e-06
GCST004131_18	Inflammatory bowel disease	1.000000e-38
GCST004132_6	Crohn’s disease	6.000000e-99
GCST006628_18	Systolic blood pressure	3.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, increases methylation	5
Benzo(a)pyrene	decreases expression, increases methylation	4
Estradiol	decreases expression, increases expression, affects binding, affects reaction, increases reaction	3
bisphenol A	affects expression, decreases methylation	2
trichostatin A	affects cotreatment, increases expression	2
Vorinostat	decreases expression, affects cotreatment, increases expression	2
Panobinostat	increases expression, affects cotreatment	2
Niclosamide	decreases reaction, increases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	increases expression	1
propionaldehyde	increases expression	1
beta-lapachone	decreases expression	1
arsenite	increases methylation	1
butyraldehyde	increases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
pentanal	increases expression	1
casticin	increases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
XAV939	decreases reaction, increases expression	1
apatinib	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic Trioxide	affects cotreatment, decreases expression	1
Leflunomide	increases expression	1
Aldehydes	increases expression	1
Arbutin	decreases expression	1
Arsenic	affects methylation	1

Cellosaurus cell lines

2 cell lines: 1 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8RC	Ubigene HCT 116 NKD1 KO	Cancer cell line	Male
CVCL_D9LB	Ubigene HEK293 NKD1 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.