NKTR

Summary

NKTR (natural killer cell triggering receptor, HGNC:7833) is a protein-coding gene on chromosome 3p22.1, encoding NK-tumor recognition protein (P30414). PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells.

Source: NCBI Gene 4820 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 173 total
• Cancer driver (intOGen): activating (oncogene-like) across 1 cancer types
• MANE Select transcript: NM_005385

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7833
Approved symbol	NKTR
Name	natural killer cell triggering receptor
Location	3p22.1
Locus type	gene with protein product
Status	Approved
Aliases	p104, CypNK
Ensembl gene	ENSG00000114857
Ensembl biotype	protein_coding
OMIM	161565
Entrez	4820

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 13 retained_intron, 11 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000232978, ENST00000429888, ENST00000442970, ENST00000445842, ENST00000459950, ENST00000460807, ENST00000460910, ENST00000464315, ENST00000465584, ENST00000466553, ENST00000468735, ENST00000472127, ENST00000472258, ENST00000478488, ENST00000487466, ENST00000490189, ENST00000498730, ENST00000508351, ENST00000937553, ENST00000937554, ENST00000937555, ENST00000937556, ENST00000937557, ENST00000970640, ENST00000970641, ENST00000970642

RefSeq mRNA: 4 — MANE Select: NM_005385 NM_001349124, NM_001349125, NM_001349126, NM_005385

CCDS: CCDS2702

Canonical transcript exons

ENST00000232978 — 17 exons

Exon	Start	End
ENSE00003463077	42621429	42621516
ENSE00003467679	42634613	42634700
ENSE00003469432	42632601	42632823
ENSE00003481575	42643902	42644003
ENSE00003483101	42636868	42639750
ENSE00003490644	42619664	42619708
ENSE00003496963	42600984	42601064
ENSE00003516116	42633580	42633735
ENSE00003526934	42643339	42643395
ENSE00003532787	42631171	42631316
ENSE00003575141	42645888	42648735
ENSE00003580172	42642501	42642596
ENSE00003613809	42619020	42619127
ENSE00003622159	42635221	42635366
ENSE00003639347	42617570	42617644
ENSE00003641623	42630546	42630575
ENSE00003740429	42600686	42600778

Expression profiles

Bgee: expression breadth ubiquitous, 298 present calls, max score 98.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.3666 / max 320.8463, expressed in 1810 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36262	21.1614	1793
36264	2.9688	1328
36263	1.9966	910
36268	0.2397	79

Top tissues by expression

301 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pylorus	UBERON:0001166	98.58	gold quality
cardia of stomach	UBERON:0001162	98.46	gold quality
caput epididymis	UBERON:0004358	98.36	gold quality
cauda epididymis	UBERON:0004360	98.33	gold quality
cranial nerve II	UBERON:0000941	98.23	gold quality
calcaneal tendon	UBERON:0003701	98.05	gold quality
corpus epididymis	UBERON:0004359	97.91	gold quality
superior surface of tongue	UBERON:0007371	97.88	gold quality
visceral pleura	UBERON:0002401	97.83	gold quality
corpus callosum	UBERON:0002336	97.77	gold quality
superficial temporal artery	UBERON:0001614	97.75	gold quality
sural nerve	UBERON:0015488	97.72	gold quality
lateral globus pallidus	UBERON:0002476	97.68	gold quality
urethra	UBERON:0000057	97.67	gold quality
renal medulla	UBERON:0000362	97.58	gold quality
right uterine tube	UBERON:0001302	97.41	gold quality
secondary oocyte	CL:0000655	97.40	gold quality
substantia nigra pars reticulata	UBERON:0001966	97.37	gold quality
trabecular bone tissue	UBERON:0002483	97.31	gold quality
trigeminal ganglion	UBERON:0001675	97.29	gold quality
inferior olivary complex	UBERON:0002127	97.29	gold quality
left ovary	UBERON:0002119	97.28	gold quality
pericardium	UBERON:0002407	97.27	gold quality
mucosa of stomach	UBERON:0001199	97.25	gold quality
tendon	UBERON:0000043	97.24	gold quality
buccal mucosa cell	CL:0002336	97.23	gold quality
nerve	UBERON:0001021	97.22	gold quality
tibial nerve	UBERON:0001323	97.22	gold quality
inferior vagus X ganglion	UBERON:0005363	97.21	gold quality
right ovary	UBERON:0002118	97.20	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-122	yes	21.26
E-MTAB-8410	yes	9.20
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

157 targeting NKTR, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-520D-5P	99.98	73.34	4883

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nktr	ENSDARG00000059097
mus_musculus	Nktr	ENSMUSG00000032525
rattus_norvegicus	Nktr	ENSRNOG00000049128
drosophila_melanogaster	Cyp40	FBGN0036020
caenorhabditis_elegans		WBGENE00000885

Paralogs (22): PPIE (ENSG00000084072), PPIL2 (ENSG00000100023), PPIF (ENSG00000108179), PPWD1 (ENSG00000113593), PPIL4 (ENSG00000131013), PPIL1 (ENSG00000137168), PPIG (ENSG00000138398), CWC27 (ENSG00000153015), PPIB (ENSG00000166794), PPIC (ENSG00000168938), PPID (ENSG00000171497), PPIH (ENSG00000171960), PPIL6 (ENSG00000185250), PPIA (ENSG00000196262), PPIAL4G (ENSG00000236334), PPIL3 (ENSG00000240344), PPIAL4A (ENSG00000263353), PPIAL4H (ENSG00000270339), PPIAL4E (ENSG00000271567), PPIAL4F (ENSG00000279782), PPIAL4C (ENSG00000288867), PPIAL4D (ENSG00000289549)

Protein

Protein identifiers

NK-tumor recognition protein — P30414 (reviewed: P30414)

Alternative names: Natural-killer cells cyclophilin-related protein, Peptidyl-prolyl cis-trans isomerase NKTR, Rotamase

All UniProt accessions (3): P30414, A8K7K2, C9JMM5

UniProt curated annotations — full annotation on UniProt →

Function. PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells.

Subcellular location. Cell membrane.

Activity regulation. Inhibited by cyclosporin A (CsA).

RefSeq proteins (4): NP_001336053, NP_001336054, NP_001336055, NP_005376* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002130	Cyclophilin-type_PPIase_dom	Domain
IPR020892	Cyclophilin-type_PPIase_CS	Conserved_site
IPR029000	Cyclophilin-like_dom_sf	Homologous_superfamily

Pfam: PF00160

Catalyzed reactions (Rhea), 1 shown:

• [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) (RHEA:16237)

UniProt features (89 total): compositionally biased region 28, modified residue 16, cross-link 13, strand 11, region of interest 7, turn 5, sequence variant 4, helix 3, chain 1, domain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2HE9	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P30414-F1	43.87	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (29): 379, 401, 416, 463, 471, 613, 648, 866, 887, 889, 891, 907, 1077, 1146, 1155, 1203, 323, 578, 581, 639 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 183 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, AMIT_EGF_RESPONSE_60_HELA, GAUSSMANN_MLL_AF4_FUSION_TARGETS_C_UP, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_PROTEIN_MATURATION, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN, BLALOCK_ALZHEIMERS_DISEASE_UP, MODULE_206, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN, chr3p22, GOBP_PROTEIN_FOLDING, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, BASAKI_YBX1_TARGETS_DN, SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC, CHANDRAN_METASTASIS_UP

GO Biological Process (2): protein folding (GO:0006457), protein peptidyl-prolyl isomerization (GO:0000413)

GO Molecular Function (3): peptidyl-prolyl cis-trans isomerase activity (GO:0003755), cyclosporin A binding (GO:0016018), isomerase activity (GO:0016853)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cellular process	1
protein maturation	1
peptidyl-proline modification	1
cis-trans isomerase activity	1
catalytic activity, acting on a protein	1
binding	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

3084 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NKTR	CLK1	P49759	762
NKTR	IL2RB	P14784	735
NKTR	PIN4	Q9Y237	667
NKTR	NOLC1	Q14978	600
NKTR	GRB2	P29354	578
NKTR	SRSF2	Q01130	548
NKTR	MAPRE1	Q15691	540
NKTR	MAPK9	P45984	539
NKTR	IL2	P01585	520
NKTR	ZNF398	Q8TD17	511
NKTR	POLR2A	P24928	492
NKTR	CCDC73	Q6ZRK6	433
NKTR	CD8A	P01732	431
NKTR	PLCG1	P19174	417
NKTR	CTLA4	P16410	411

IntAct

108 interactions, top by confidence:

A	B	Type	Score
CSNK2A1	EIF3J	psi-mi:“MI:0914”(association)	0.810
PRPF19	AQR	psi-mi:“MI:0914”(association)	0.790
SNRPD2	GEMIN2	psi-mi:“MI:0914”(association)	0.710
CSNK2B	RPS6KA5	psi-mi:“MI:0914”(association)	0.660
PNN	CASC3	psi-mi:“MI:0914”(association)	0.640
DHX38	DHX16	psi-mi:“MI:0914”(association)	0.630
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
ZNF707	ZNF316	psi-mi:“MI:0914”(association)	0.530
SNIP1	CASC3	psi-mi:“MI:0914”(association)	0.530
ZC3H18	AQR	psi-mi:“MI:0914”(association)	0.530
ZNF816	LRP4	psi-mi:“MI:0914”(association)	0.530
ZNF311	CENPB	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
SRPK2	RRP9	psi-mi:“MI:0914”(association)	0.530
WSB2	UBB	psi-mi:“MI:0914”(association)	0.530
ZNF786	NKTR	psi-mi:“MI:0914”(association)	0.530
ZNF263	AHCYL1	psi-mi:“MI:0914”(association)	0.530
RPL13	RRP8	psi-mi:“MI:0914”(association)	0.530
CPSF6	DDX39A	psi-mi:“MI:0914”(association)	0.480
NKTR	RSL1D1	psi-mi:“MI:0915”(physical association)	0.400
Spred2	TARS3	psi-mi:“MI:0914”(association)	0.350
Ccdc9	ACIN1	psi-mi:“MI:0914”(association)	0.350
ARRB2		psi-mi:“MI:0914”(association)	0.350

BioGRID (137): NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Proximity Label-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS), NKTR (Affinity Capture-MS)

ESM2 similar proteins: A0A1I8MUL8, A2AG58, A2AJT9, A6ZWC8, B3LKV0, B5VT41, B9UYK6, C1IWT1, C5IY45, C7GJ78, C8ZIQ5, E7KIY3, E7KVI3, E7M1C7, E7QAA9, E7QLB7, O14269, O23372, O94687, P0CO26, P0CO27, P11596, P30414, P30415, P33419, P97868, Q03063, Q08D57, Q18221, Q1LY77, Q23935, Q24669, Q3UC65, Q3YPH5, Q4R626, Q5LJZ2, Q5R840, Q5RAA7, Q5U2S0, Q66J90

Diamond homologs: A0A0R0H9T5, A2AR02, A8X8D0, D4AY02, O49886, O55035, O74729, O93826, O94273, P0C1H7, P0C1H9, P0C1I1, P0C1I2, P0C1I3, P0C1I7, P0C1I8, P0C1I9, P0CP82, P0CP83, P14088, P14832, P18253, P21568, P21569, P23284, P24367, P24368, P24369, P24525, P25007, P25719, P26882, P30414, P30415, P34790, P34791, P34887, P35627, P52009, P52010

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 135 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA 3’-end processing	10	19.5×	7e-09
Transport of Mature Transcript to Cytoplasm	5	18.8×	2e-04
mRNA Splicing	16	17.4×	2e-13
RNA Polymerase II Transcription Termination	8	17.4×	1e-06
mRNA Splicing - Minor Pathway	7	15.5×	1e-05
Transport of Mature mRNA derived from an Intron-Containing Transcript	10	15.1×	7e-08
Processing of Capped Intron-Containing Pre-mRNA	17	13.8×	7e-13
mRNA Splicing - Major Pathway	25	13.5×	5e-19

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of mRNA splicing, via spliceosome	8	50.2×	4e-10
spliceosomal complex assembly	7	34.5×	2e-07
RNA splicing, via transesterification reactions	5	25.6×	1e-04
U2-type prespliceosome assembly	5	25.6×	1e-04
spliceosomal snRNP assembly	5	23.8×	2e-04
mRNA splicing, via spliceosome	19	14.3×	5e-14
cytoplasmic translation	9	13.7×	3e-06
RNA splicing	16	11.6×	2e-10

Disease & clinical

Cancer significance

From intOGen — cancer-driver classification: activating (oncogene-like) across 1 cancer types — AML.

Clinical variants and AI predictions

ClinVar

173 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	155
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3305 predictions. Top by Δscore:

Variant	Effect	Δscore
3:42601060:GCCGG:G	donor_gain	1.0000
3:42617568:A:AG	acceptor_gain	1.0000
3:42617568:AGTT:A	acceptor_gain	1.0000
3:42617569:G:GA	acceptor_gain	1.0000
3:42617569:GTT:G	acceptor_gain	1.0000
3:42617569:GTTG:G	acceptor_gain	1.0000
3:42619055:T:G	donor_gain	1.0000
3:42620521:T:TA	acceptor_gain	1.0000
3:42620522:G:A	acceptor_gain	1.0000
3:42621517:G:GG	donor_gain	1.0000
3:42630073:G:GG	donor_gain	1.0000
3:42630454:T:TA	acceptor_gain	1.0000
3:42630465:T:G	acceptor_gain	1.0000
3:42631169:AG:A	acceptor_gain	1.0000
3:42631170:GG:G	acceptor_gain	1.0000
3:42631312:AGATG:A	donor_gain	1.0000
3:42631313:GATG:G	donor_gain	1.0000
3:42631313:GATGG:G	donor_gain	1.0000
3:42631315:TGGT:T	donor_loss	1.0000
3:42631318:TAA:T	donor_loss	1.0000
3:42632596:A:AG	acceptor_gain	1.0000
3:42632599:A:G	acceptor_gain	1.0000
3:42632600:G:GA	acceptor_gain	1.0000
3:42632771:G:GT	donor_gain	1.0000
3:42632797:GAA:G	donor_gain	1.0000
3:42632820:AAGGG:A	donor_loss	1.0000
3:42632821:AGGG:A	donor_loss	1.0000
3:42632822:GG:G	donor_gain	1.0000
3:42632822:GGGTA:G	donor_loss	1.0000
3:42632823:GG:G	donor_gain	1.0000

AlphaMissense

9614 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:42617585:T:C	F25S	1.000
3:42617591:T:C	L27P	1.000
3:42617605:T:C	C32R	1.000
3:42617606:G:A	C32Y	1.000
3:42617607:T:G	C32W	1.000
3:42617619:C:G	C36W	1.000
3:42617625:C:A	N38K	1.000
3:42617625:C:G	N38K	1.000
3:42617626:T:C	F39L	1.000
3:42617627:T:C	F39S	1.000
3:42617628:C:A	F39L	1.000
3:42617628:C:G	F39L	1.000
3:42617636:T:C	L42S	1.000
3:42617638:T:C	C43R	1.000
3:42617639:G:A	C43Y	1.000
3:42617640:C:G	C43W	1.000
3:42619056:T:C	L57S	1.000
3:42619077:T:C	F64S	1.000
3:42619079:C:G	H65D	1.000
3:42619082:C:A	R66S	1.000
3:42619083:G:C	R66P	1.000
3:42619097:T:C	F71L	1.000
3:42619098:T:C	F71S	1.000
3:42619099:T:A	F71L	1.000
3:42619099:T:G	F71L	1.000
3:42619109:G:C	G75R	1.000
3:42619112:G:A	G76R	1.000
3:42619112:G:C	G76R	1.000
3:42619112:G:T	G76W	1.000
3:42619113:G:A	G76E	1.000

dbSNP variants (sampled 300 via entrez): RS1000096676 (3:42635362 G>T), RS1000222763 (3:42649071 C>T), RS1000294934 (3:42617421 C>A,T), RS1000315928 (3:42608563 G>A), RS1000346802 (3:42617851 T>A), RS1000389281 (3:42600621 C>A), RS1000394085 (3:42628253 T>C), RS1000408730 (3:42639791 C>G), RS1000463444 (3:42648808 C>T), RS1000496822 (3:42601449 T>C), RS1000561597 (3:42647604 C>T), RS1000604012 (3:42640344 C>T), RS1000616995 (3:42610804 A>C), RS1000646084 (3:42625426 TG>T,TGG), RS1000773441 (3:42600951 T>A,C)

Disease associations

OMIM: gene MIM:161565 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, decreases methylation	4
bisphenol A	increases expression, affects cotreatment, decreases expression	2
sodium arsenite	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
TAK-243	decreases sumoylation	1
geldanamycin	increases expression	1
testosterone enanthate	affects expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	decreases expression	1
coumarin	affects phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Arsenic Trioxide	decreases expression	1
Vorinostat	decreases expression	1
Acetaminophen	increases expression	1
Arsenic	affects methylation	1
Caffeine	affects phosphorylation	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	decreases expression, affects cotreatment	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.