NKX2-1-AS1

Summary

NKX2-1-AS1 (NKX2-1 antisense RNA 1, HGNC:40585) is a long non-coding RNA gene on chromosome 14q13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40585
Approved symbol	NKX2-1-AS1
Name	NKX2-1 antisense RNA 1
Location	14q13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253563
Ensembl biotype	lncRNA
Entrez	100506237
RNAcentral	URS00003B5B5C — lncRNA, 1775 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000521292, ENST00000716760, ENST00000716761, ENST00000716762, ENST00000716763, ENST00000716764, ENST00000716765

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000521292 — 2 exons

Exon	Start	End
ENSE00002093185	36521644	36523016
ENSE00002138283	36519278	36519679

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 79.95.

Top tissues by expression

169 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	79.95	gold quality
right lobe of thyroid gland	UBERON:0001119	75.97	gold quality
left lobe of thyroid gland	UBERON:0001120	75.42	gold quality
thyroid gland	UBERON:0002046	74.58	gold quality
tendon of biceps brachii	UBERON:0008188	63.97	gold quality
upper lobe of left lung	UBERON:0008952	62.94	gold quality
upper lobe of lung	UBERON:0008948	61.53	gold quality
right lung	UBERON:0002167	61.19	gold quality
adenohypophysis	UBERON:0002196	60.40	gold quality
tendon	UBERON:0000043	58.82	silver quality
cerebellar hemisphere	UBERON:0002245	58.77	gold quality
lung	UBERON:0002048	58.02	gold quality
nasal cavity epithelium	UBERON:0005384	57.21	gold quality
decidua	UBERON:0002450	55.06	gold quality
calcaneal tendon	UBERON:0003701	54.96	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	54.79	gold quality
parotid gland	UBERON:0001831	54.73	gold quality
heart right ventricle	UBERON:0002080	53.62	gold quality
bronchial epithelial cell	CL:0002328	53.40	gold quality
bronchus	UBERON:0002185	52.78	gold quality
duodenum	UBERON:0002114	50.96	gold quality
cartilage tissue	UBERON:0002418	50.87	gold quality
saliva-secreting gland	UBERON:0001044	50.51	gold quality
postcentral gyrus	UBERON:0002581	50.29	gold quality
hypothalamus	UBERON:0001898	50.24	gold quality
pituitary gland	UBERON:0000007	50.09	gold quality
buccal mucosa cell	CL:0002336	50.02	gold quality
prefrontal cortex	UBERON:0000451	50.00	silver quality
superior frontal gyrus	UBERON:0002661	49.18	gold quality
mammalian vulva	UBERON:0000997	48.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• NKX2-1-AS1 interferes with NKX2-1 protein binding to the CD274-promoter, likely by NKX2-1 protein-NKX2-1-AS1 interactions. (PMID:30258080)
• LncRNA NKX2-1-AS1 promotes tumor progression and angiogenesis via upregulation of SERPINE1 expression and activation of the VEGFR-2 signaling pathway in gastric cancer. (PMID:33512745)
• NKX2-1-AS1 promotes the lymphangiogenesis of lung adenocarcinoma through regulation of ERG-mediated FABP4. (PMID:38309204)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.