NKX2-2-AS1

Summary

NKX2-2-AS1 (NKX2-2 antisense RNA 1, HGNC:37154) is a long non-coding RNA gene on chromosome 20p11.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37154
Approved symbol	NKX2-2-AS1
Name	NKX2-2 antisense RNA 1
Location	20p11.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	NKX2-2AS
Ensembl gene	ENSG00000258197
Ensembl biotype	lncRNA
Entrez	100874189
RNAcentral	URS0002A4B38F — lncRNA, 1590 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000549659, ENST00000692862, ENST00000751549, ENST00000751550

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000549659 — 2 exons

Exon	Start	End
ENSE00002355228	21511447	21511727
ENSE00002371096	21511953	21512309

Expression profiles

Bgee: expression breadth broad, 72 present calls, max score 94.28.

Top tissues by expression

72 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortex of kidney	UBERON:0001225	94.28	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.12	gold quality
islet of Langerhans	UBERON:0000006	72.72	gold quality
pancreas	UBERON:0001264	68.98	gold quality
prefrontal cortex	UBERON:0000451	67.34	gold quality
cortical plate	UBERON:0005343	65.85	gold quality
primary visual cortex	UBERON:0002436	65.78	gold quality
frontal cortex	UBERON:0001870	65.58	gold quality
ventricular zone	UBERON:0003053	64.14	gold quality
ganglionic eminence	UBERON:0004023	62.38	gold quality
duodenum	UBERON:0002114	61.30	gold quality
cerebral cortex	UBERON:0000956	61.08	gold quality
superior frontal gyrus	UBERON:0002661	58.43	gold quality
putamen	UBERON:0001874	58.19	gold quality
temporal lobe	UBERON:0001871	57.72	gold quality
brain	UBERON:0000955	57.31	gold quality
anterior cingulate cortex	UBERON:0009835	56.43	gold quality
corpus callosum	UBERON:0002336	56.04	gold quality
amygdala	UBERON:0001876	55.83	gold quality
nucleus accumbens	UBERON:0001882	53.17	gold quality
liver	UBERON:0002107	52.74	silver quality
substantia nigra	UBERON:0002038	52.54	gold quality
cerebellum	UBERON:0002037	52.26	gold quality
right frontal lobe	UBERON:0002810	51.56	gold quality
endometrium	UBERON:0001295	51.48	gold quality
caudate nucleus	UBERON:0001873	51.10	gold quality
blood	UBERON:0000178	50.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	50.62	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	50.14	gold quality
cerebellar cortex	UBERON:0002129	49.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Authors found that suppression of the noncoding RNA Nkx2-2as promoted Sonic Hedgehog (Shh)-potentiated MB development. Nkx2-2as functioned as a competing endogenous RNA against miR-103 and miR-107, sequestering them and thereby derepressing their tumor suppressive targets BTG2 and LATS1 and impeding cell division and migration. (PMID:29229597)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.