◎ Sugi Atlas

Atlas / Gene / NKX6-1

NKX6-1

gene
On this page

Also known as Nkx6.1

Summary

NKX6-1 (NK6 homeobox 1, HGNC:7839) is a protein-coding gene on chromosome 4q21.23, encoding Homeobox protein Nkx-6.1 (P78426). Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes.

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].

Source: NCBI Gene 4825 — RefSeq curated summary.

At a glance

  • GWAS associations: 2
  • Clinical variants (ClinVar): 32 total
  • Transcription factor: yes — 23 downstream targets (CollecTRI)
  • MANE Select transcript: NM_006168

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:7839
Approved symbolNKX6-1
NameNK6 homeobox 1
Location4q21.23
Locus typegene with protein product
StatusApproved
AliasesNkx6.1
Ensembl geneENSG00000163623
Ensembl biotypeprotein_coding
OMIM602563
Entrez4825

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000295886, ENST00000515820

RefSeq mRNA: 1 — MANE Select: NM_006168 NM_006168

CCDS: CCDS3607

Canonical transcript exons

ENST00000295886 — 3 exons

ExonStartEnd
ENSE000010766488449755984499292
ENSE000034709738449567284495844
ENSE000039102918449198584493549

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 95.72.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6898 / max 171.6845, expressed in 196 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
529390.4572126
529400.210397
529380.02234

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
lower esophagus muscularis layerUBERON:003583395.72gold quality
lower esophagusUBERON:001347395.67gold quality
esophagogastric junction muscularis propriaUBERON:003584193.75gold quality
mucosa of stomachUBERON:000119993.40gold quality
islet of LangerhansUBERON:000000688.47gold quality
esophagusUBERON:000104385.10gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047384.86gold quality
lower esophagus mucosaUBERON:003583483.35gold quality
esophagus mucosaUBERON:000246976.89gold quality
pancreasUBERON:000126476.52gold quality
body of pancreasUBERON:000115072.45gold quality
skeletal muscle tissue of biceps brachiiUBERON:000450265.93gold quality
type B pancreatic cellCL:000016965.49gold quality
stromal cell of endometriumCL:000225564.86gold quality
left lobe of thyroid glandUBERON:000112064.19gold quality
skeletal muscle tissue of rectus abdominisUBERON:000451162.29gold quality
thyroid glandUBERON:000204661.67gold quality
cartilage tissueUBERON:000241861.28gold quality
biceps brachiiUBERON:000150761.21gold quality
substantia nigraUBERON:000203861.05gold quality
heart right ventricleUBERON:000208060.61gold quality
midbrainUBERON:000189160.41gold quality
spermCL:000001960.40gold quality
myocardiumUBERON:000234960.37gold quality
parotid glandUBERON:000183159.97gold quality
male germ cellCL:000001559.75gold quality
tendon of biceps brachiiUBERON:000818859.37gold quality
cardia of stomachUBERON:000116259.26gold quality
nasal cavity epitheliumUBERON:000538458.27gold quality
gingival epitheliumUBERON:000194957.99gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 5.

ExperimentMarker?Max mean expression
E-MTAB-5061yes198.66
E-HCAD-31yes20.84
E-GEOD-81608yes17.70
E-ENAD-27yes11.57
E-GEOD-83139yes9.64
E-ANND-3no3.78

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

23 targets.

TargetRegulation
ARX
BLK
CCNE1Activation
CEL
DNER
E2F1
GCGUnknown
GLP1R
HNF1AUnknown
IAPP
IL6Activation
INSUnknown
MAFAUnknown
NKX6-1
OLIG2Activation
PC
PCSK1
PDX1Repression
SLC2A2
TPM1
TRIB3
UGT1A1
WNT1

JASPAR motifs

MotifNameFamily
MA0674.1NKX6-1NK
MA0674.2NKX6-1NK

JASPAR matrix evidence (PMIDs): PMID:18585359

Upstream regulators (CollecTRI, top): E2F1, FOXO1, MAFA, NEUROG3, NKX2-2, NKX6-1, PDX1, PPARA, SHH

Literature-anchored findings (GeneRIF, showing 23)

  • Nkx6.1 is a bifunctional transcription factor that serves to maintain the specific expression of its own gene during beta-cell differentiation while simultaneously effecting broader gene repression events (PMID:15056733)
  • overexpression of Nkx6.1 in islets caused an increase in the level of [(3)H]thymidine incorporation that was twice the control level, along with complete retention of glucose-stimulated insulin secretion (PMID:18347054)
  • Alterations of gastric NKX6.1 expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia. (PMID:18754095)
  • identified an NKX6.1 recognition sequence in the distal region of the HNF1alpha promoter and demonstrated specific binding of NKX6.1 in beta cells (PMID:20106981)
  • Data suggest that NKX6.1 activates immature pancreatic markers but not pancreatic hormone gene expression in human liver cells, and suggest a potential role for NKX6.1 in promoting PDX-1 reprogrammed maturation along a beta-cell-like lineage. (PMID:21108535)
  • Smooth muscle cells expressing nestin and Nkx6.1 are the main cell population derived from culturing human spinal cord cells in adherent conditions with serum. (PMID:21985235)
  • MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet beta cell function, with loss of MAFA (and/or MAFB) representing an early indicator of beta cell inactivity (PMID:23863625)
  • Mice transplanted with NKX6.1-low cells remained hyperglycemic throughout the 5-month post-transplant period whereas diabetes was reversed in NKX6.1-high recipients within 3 months. (PMID:23897760)
  • NKX6-1 reveals wide variations in methylation levels in normal control samples of cervical adenocarcinomas. (PMID:24407576)
  • a significant relationship was observed between NKX6.1 and EMT marker expression levels, and NKX6.1 knockdown inhibited cell invasion, and overexpression of NKX6.1 promotes cell proliferation in vitro. (PMID:25596704)
  • study evaluated the potential use of NKX6-1 as a diagnostic marker for well-differentiated neuroendocrine tumors (PMID:25871618)
  • NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor. (PMID:26257059)
  • NKX6.1 is a factor for IL-6-regulated growth and tumor formation in basal-like breast cancer. (PMID:27032575)
  • Efficiency of differentiation of Induced pluripotent stem cells to insulin producing cells can be increased by concurrent expression of PDX1 and NKX6.1 during progenitor cells maturation. (PMID:27998294)
  • Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs). (PMID:28835709)
  • Data demonstrated that patients with NKX6.1 methylation presented poorer 5-year overall survival (P = 0.0167) and disease-free survival (P = 0.0083) than patients without NKX6.1 methylation after receiving adjuvant chemotherapy. (PMID:29363224)
  • Intermediate and high-grade tumors expressed NKX6.1. (PMID:30284410)
  • NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer. (PMID:32707737)
  • MiR-190b impedes pancreatic beta cell proliferation and insulin secretion by targeting NKX6-1 and may associate to gestational diabetes mellitus. (PMID:32862769)
  • NKX6.1 transcription factor: a crucial regulator of pancreatic beta cell development, identity, and proliferation. (PMID:33121533)
  • NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma. (PMID:33906647)
  • Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects. (PMID:34493754)
  • NKX6-1 Is a Less Sensitive But Specific Biomarker of Chromophobe Renal Cell Carcinoma. (PMID:35256556)

Cross-species orthologs

10 orthologs

OrganismSymbolGene ID
danio_rerionkx6.1ENSDARG00000022569
mus_musculusNkx6-1ENSMUSG00000035187
rattus_norvegicusNkx6-1ENSRNOG00000002149
drosophila_melanogasterNK7.1FBGN0024321
drosophila_melanogasterHGTXFBGN0040318
drosophila_melanogasterscroFBGN0287186
caenorhabditis_elegansceh-9WBGENE00000434
caenorhabditis_elegansWBGENE00000447
caenorhabditis_elegansWBGENE00000450
caenorhabditis_elegansWBGENE00000584

Paralogs (13): NKX3-2 (ENSG00000109705), NKX2-3 (ENSG00000119919), NKX2-4 (ENSG00000125816), NKX2-2 (ENSG00000125820), NKX2-8 (ENSG00000136327), NKX2-1 (ENSG00000136352), NKX6-2 (ENSG00000148826), NKX6-3 (ENSG00000165066), NKX3-1 (ENSG00000167034), NKX2-6 (ENSG00000180053), NKX2-5 (ENSG00000183072), NKX1-2 (ENSG00000229544), NKX1-1 (ENSG00000235608)

Protein

Protein identifiers

Homeobox protein Nkx-6.1 — P78426 (reviewed: P78426)

Alternative names: Homeobox protein NK-6 homolog A

All UniProt accessions (2): F8VWZ9, P78426

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.

Subcellular location. Nucleus.

Tissue specificity. Pancreatic beta cells.

Domain organisation. The C-terminal domain contributes to sequence-specific DNA-binding.

RefSeq proteins (1): NP_006159* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000047HTH_motifConserved_site
IPR001356HDDomain
IPR009057Homeodomain-like_sfHomologous_superfamily
IPR017970Homeobox_CSConserved_site
IPR020479HD_metazoaDomain
IPR050394Homeobox_NK-likeFamily

Pfam: PF00046

UniProt features (12 total): region of interest 4, compositionally biased region 4, chain 1, DNA-binding region 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-P78426-F161.880.17

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 189

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

IDPathway
R-HSA-210745Regulation of gene expression in beta cells
R-HSA-210747Regulation of gene expression in early pancreatic precursor cells
R-HSA-9925561Developmental Lineage of Pancreatic Acinar Cells
R-HSA-9925563Developmental Lineage of Pancreatic Ductal Cells
R-HSA-9937080Developmental Lineage of Multipotent Pancreatic Progenitor Cells

MSigDB gene sets: 244 (showing top): GOBP_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT, BENPORATH_ES_WITH_H3K27ME3, GOBP_NEURON_PROJECTION_EXTENSION, GOBP_RESPONSE_TO_PEPTIDE, GOBP_EPITHELIAL_CELL_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_GLIOGENESIS, GOBP_REGULATION_OF_DEVELOPMENTAL_GROWTH, GOBP_INSULIN_SECRETION, GOBP_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION, GOBP_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS, GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION, GOBP_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION

GO Biological Process (32): negative regulation of transcription by RNA polymerase II (GO:0000122), pancreatic A cell differentiation (GO:0003310), regulation of transcription by RNA polymerase II (GO:0006357), transcription by RNA polymerase II (GO:0006366), smoothened signaling pathway (GO:0007224), response to xenobiotic stimulus (GO:0009410), animal organ morphogenesis (GO:0009887), glucose mediated signaling pathway (GO:0010255), spinal cord motor neuron cell fate specification (GO:0021520), cell differentiation (GO:0030154), regulation of axon extension (GO:0030516), pancreas development (GO:0031016), positive regulation of insulin secretion (GO:0032024), response to nicotine (GO:0035094), type B pancreatic cell proliferation (GO:0044342), positive regulation of neuron differentiation (GO:0045666), positive regulation of transcription by RNA polymerase II (GO:0045944), oligodendrocyte differentiation (GO:0048709), positive regulation of oligodendrocyte differentiation (GO:0048714), negative regulation of oligodendrocyte differentiation (GO:0048715), cellular response to cytokine stimulus (GO:0071345), cellular response to peptide hormone stimulus (GO:0071375), type B pancreatic cell maturation (GO:0072560), positive regulation of type B pancreatic cell development (GO:2000078), regulation of neuron migration (GO:2001222), type B pancreatic cell differentiation (GO:0003309), type B pancreatic cell development (GO:0003323), regulation of DNA-templated transcription (GO:0006355), central nervous system neuron differentiation (GO:0021953), neurogenesis (GO:0022008), neuron differentiation (GO:0030182), endocrine pancreas development (GO:0031018)

GO Molecular Function (9): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), chromatin binding (GO:0003682), RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
Developmental Cell Lineages of the Exocrine Pancreas3
Regulation of beta-cell development2

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
RNA polymerase II transcription regulatory region sequence-specific DNA binding4
regulation of transcription by RNA polymerase II3
transcription by RNA polymerase II3
regulation of DNA-templated transcription2
response to chemical2
animal organ development2
oligodendrocyte differentiation2
regulation of oligodendrocyte differentiation2
DNA-binding transcription factor activity, RNA polymerase II-specific2
negative regulation of DNA-templated transcription1
endocrine pancreas development1
enteroendocrine cell differentiation1
DNA-templated transcription1
cell surface receptor signaling pathway1
anatomical structure morphogenesis1
hexose mediated signaling1
cellular response to glucose stimulus1
spinal cord motor neuron differentiation1
neuron fate specification1
cellular developmental process1
regulation of developmental growth1
axon extension1
regulation of extent of cell growth1
insulin secretion1
positive regulation of protein secretion1
regulation of insulin secretion1
positive regulation of peptide hormone secretion1
epithelial cell proliferation1
neuron differentiation1
positive regulation of cell differentiation1
regulation of neuron differentiation1
positive regulation of DNA-templated transcription1
central nervous system development1
glial cell differentiation1
positive regulation of glial cell differentiation1
negative regulation of glial cell differentiation1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
negative regulation of transcription by RNA polymerase II1

Protein interactions and networks

STRING

1320 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
NKX6-1NEUROG3Q9Y4Z2882
NKX6-1ISL1P20663873
NKX6-1SLC2A2P11168861
NKX6-1GCGP01275833
NKX6-1FOXA2Q9Y261827
NKX6-1INSP01308819
NKX6-1MAFBQ9Y5Q3814
NKX6-1NEUROD1Q13562797
NKX6-1PTF1AQ7RTS3795
NKX6-1RFX6Q8HWS3791
NKX6-1TLE3Q04726742
NKX6-1SLIT1O75093722
NKX6-1SSTP01166712
NKX6-1PPYP01298707
NKX6-1ONECUT1Q9UBC0694

IntAct

2 interactions, top by confidence:

ABTypeScore
RBPJSAMD1psi-mi:“MI:0914”(association)0.350

BioGRID (5): NKX6-1 (Affinity Capture-MS), NKX6-1 (Affinity Capture-MS), NKX6-1 (Affinity Capture-MS), NKX6-1 (Affinity Capture-MS), NKX6-1 (Proximity Label-MS)

ESM2 similar proteins: A0A8V0YY16, A0JPN1, A7MB54, A8MTJ6, O35762, O42115, O57601, O88181, O95096, P09065, P23683, P28356, P31311, P31315, P32443, P39020, P42581, P42586, P43697, P48031, P49640, P50222, P50476, P52951, P52954, P52955, P78426, P81067, P81068, P97334, Q14549, Q14774, Q1KKY1, Q1XID0, Q2NKI2, Q2VL76, Q2VL80, Q4V5A3, Q5SQQ9, Q60554

Diamond homologs: A0JPN1, A1YG85, A5PKG8, A6NJ46, A6NMT0, A7MB54, A9L937, B0VXK3, D2KQB0, E7FDX5, M0R6D8, O08686, O13023, O35762, O42365, O43364, O43711, O55144, O88181, O93366, O93367, O93590, P0C1T1, P10035, P14652, P14837, P20009, P28468, P31245, P31246, P31261, P31314, P42583, P42584, P43120, P43345, P43688, P50219, P52945, P52950

SIGNOR signaling

2 interactions.

AEffectBMechanism
MAFA“up-regulates quantity by expression”NKX6-1“transcriptional regulation”
PDX1“up-regulates quantity by expression”NKX6-1“transcriptional regulation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

32 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance30
Likely benign0
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

596 predictions. Top by Δscore:

VariantEffectΔscore
4:84493545:CAGAC:Cacceptor_gain1.0000
4:84493547:GAC:Gacceptor_gain1.0000
4:84495667:CTCA:Cdonor_loss1.0000
4:84495668:TCAC:Tdonor_loss1.0000
4:84495669:CA:Cdonor_loss1.0000
4:84495670:A:ACdonor_gain1.0000
4:84495671:C:CCdonor_gain1.0000
4:84495671:CCT:Cdonor_gain1.0000
4:84495673:TTG:Tdonor_gain1.0000
4:84495841:TGAT:Tacceptor_gain1.0000
4:84495841:TGATC:Tacceptor_gain1.0000
4:84495842:GAT:Gacceptor_gain1.0000
4:84495842:GATCT:Gacceptor_gain1.0000
4:84495843:AT:Aacceptor_gain1.0000
4:84495843:ATCTG:Aacceptor_gain1.0000
4:84495844:TC:Tacceptor_loss1.0000
4:84495844:TCTG:Tacceptor_gain1.0000
4:84495845:C:CCacceptor_gain1.0000
4:84495845:C:Gacceptor_loss1.0000
4:84495845:CTGTG:Cacceptor_gain1.0000
4:84495846:T:Gacceptor_gain1.0000
4:84495847:G:Cacceptor_gain1.0000
4:84495854:CCAA:Cacceptor_gain1.0000
4:84495855:C:CTacceptor_gain1.0000
4:84495855:C:Tacceptor_gain1.0000
4:84495856:A:Tacceptor_gain1.0000
4:84495857:A:ACacceptor_gain1.0000
4:84495857:A:Cacceptor_gain1.0000
4:84495863:A:Tacceptor_gain1.0000
4:84493546:AGAC:Aacceptor_gain0.9900

AlphaMissense

2328 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
4:84493504:C:GA297P1.000
4:84493506:G:TA296D1.000
4:84493507:C:GA296P1.000
4:84493509:T:GH295P1.000
4:84493514:C:AK293N1.000
4:84493514:C:GK293N1.000
4:84493515:T:AK293M1.000
4:84493516:T:CK293E1.000
4:84493517:C:AR292S1.000
4:84493517:C:GR292S1.000
4:84493518:C:AR292M1.000
4:84493518:C:GR292T1.000
4:84493519:T:AR292W1.000
4:84493519:T:CR292G1.000
4:84493520:C:AW291C1.000
4:84493520:C:GW291C1.000
4:84493521:C:GW291S1.000
4:84493522:A:GW291R1.000
4:84493522:A:TW291R1.000
4:84493523:C:AK290N1.000
4:84493523:C:GK290N1.000
4:84493524:T:AK290M1.000
4:84493524:T:GK290T1.000
4:84493525:T:CK290E1.000
4:84493525:T:GK290Q1.000
4:84493527:G:AT289I1.000
4:84493530:C:AR288L1.000
4:84493530:C:GR288P1.000
4:84493530:C:TR288Q1.000
4:84493531:G:AR288W1.000

dbSNP variants (sampled 300 via entrez): RS1000110297 (4:84500546 C>T), RS1000369321 (4:84500659 G>A), RS1000458036 (4:84494747 C>G), RS1000560251 (4:84499182 C>T), RS10005941 (4:84501117 C>T), RS1000630993 (4:84497311 G>A), RS1000748481 (4:84497137 A>G), RS1000998170 (4:84499628 G>C), RS1001058275 (4:84493218 C>G,T), RS1001061066 (4:84491680 C>A), RS1001343102 (4:84493573 G>A), RS1001455225 (4:84499811 C>T), RS1001642316 (4:84499426 G>T), RS1001933317 (4:84492328 C>G), RS1001966842 (4:84499616 T>A,C)

Disease associations

OMIM: gene MIM:602563 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

StudyTraitp-value
GCST007847_43Type 2 diabetes2.000000e-12
GCST010118_38Type 2 diabetes2.000000e-16

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

ChemicalActions (top 5)PubMed papers
Aflatoxin B1decreases methylation, increases methylation2
FR900359increases phosphorylation1
bisphenol Aaffects methylation1
kojic aciddecreases expression1
arseniteincreases methylation1
sodium arseniteincreases expression1
jinfukangdecreases expression, affects cotreatment1
Resveratrolaffects cotreatment, decreases expression1
Air Pollutantsincreases abundance, increases expression1
Benzo(a)pyreneincreases methylation1
Cisplatinaffects cotreatment, decreases expression1
Glucoseincreases reaction, increases secretion1
Plant Extractsaffects cotreatment, decreases expression1
Valproic Aciddecreases methylation1
Particulate Matterincreases abundance, increases expression1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_A4Q9SEES3-1V human NKX6-1, clone1Embryonic stem cellMale
CVCL_A4R0SEES3-1V human NKX6-1, clone2Embryonic stem cellMale
CVCL_A4R1SEES3-1V human NKX6-1, clone3Embryonic stem cellMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot