NLE1

Summary

NLE1 (notchless homolog 1, HGNC:19889) is a protein-coding gene on chromosome 17q12, encoding Notchless protein homolog 1 (Q9NVX2). Plays a role in regulating Notch activity. It is a common-essential gene (DepMap: required in 98.3% of cancer cell lines).

Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus and nucleoplasm.

Source: NCBI Gene 54475 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 83 total
• Cancer dependency (DepMap): dependent in 98.3% of screened cell lines (common-essential)
• MANE Select transcript: NM_018096

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19889
Approved symbol	NLE1
Name	notchless homolog 1
Location	17q12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10458, Rsa4
Ensembl gene	ENSG00000073536
Ensembl biotype	protein_coding
OMIM	620924
Entrez	54475

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 5 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000360831, ENST00000442241, ENST00000586869, ENST00000588019, ENST00000588642, ENST00000589367, ENST00000593176, ENST00000932057

RefSeq mRNA: 2 — MANE Select: NM_018096 NM_001014445, NM_018096

CCDS: CCDS11291, CCDS45647

Canonical transcript exons

ENST00000442241 — 13 exons

Exon	Start	End
ENSE00000714191	35133339	35133498
ENSE00000714194	35135249	35135451
ENSE00000714196	35136169	35136215
ENSE00000887621	35133171	35133241
ENSE00001187538	35142258	35142303
ENSE00001623134	35128730	35132449
ENSE00002347287	35141979	35142122
ENSE00003505929	35137001	35137193
ENSE00003514198	35139849	35140066
ENSE00003536942	35137814	35137890
ENSE00003542494	35139235	35139314
ENSE00003650048	35137543	35137640
ENSE00003654021	35136362	35136497

Expression profiles

Bgee: expression breadth ubiquitous, 169 present calls, max score 90.83.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.3112 / max 116.2935, expressed in 1685 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
165343	9.3112	1685

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.83	gold quality
body of pancreas	UBERON:0001150	88.57	gold quality
cortical plate	UBERON:0005343	84.96	gold quality
ganglionic eminence	UBERON:0004023	82.72	gold quality
pancreas	UBERON:0001264	82.48	gold quality
ventricular zone	UBERON:0003053	81.27	gold quality
stromal cell of endometrium	CL:0002255	81.20	gold quality
left ovary	UBERON:0002119	81.08	gold quality
prefrontal cortex	UBERON:0000451	80.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	80.73	gold quality
embryo	UBERON:0000922	80.66	gold quality
gastrocnemius	UBERON:0001388	80.14	gold quality
right ovary	UBERON:0002118	79.78	gold quality
body of stomach	UBERON:0001161	79.70	gold quality
mucosa of transverse colon	UBERON:0004991	79.43	gold quality
muscle of leg	UBERON:0001383	79.25	gold quality
left adrenal gland	UBERON:0001234	79.13	gold quality
left adrenal gland cortex	UBERON:0035825	79.13	gold quality
right adrenal gland	UBERON:0001233	79.12	gold quality
esophagus mucosa	UBERON:0002469	78.79	gold quality
right adrenal gland cortex	UBERON:0035827	78.67	gold quality
body of uterus	UBERON:0009853	77.95	gold quality
omental fat pad	UBERON:0010414	77.93	gold quality
peritoneum	UBERON:0002358	77.86	gold quality
ovary	UBERON:0000992	77.80	gold quality
granulocyte	CL:0000094	77.75	gold quality
left uterine tube	UBERON:0001303	77.56	gold quality
left coronary artery	UBERON:0001626	77.28	gold quality
stomach	UBERON:0000945	77.24	gold quality
adrenal gland	UBERON:0002369	77.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting NLE1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-1825	99.72	68.11	1089
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-149-5P	99.25	67.16	1315
HSA-MIR-4763-3P	99.10	67.83	2649
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-4725-5P	98.67	65.42	628
HSA-MIR-504-5P	98.67	65.40	631
HSA-MIR-4722-5P	98.46	66.34	1611
HSA-MIR-3138	98.41	67.53	744
HSA-MIR-4450	98.26	68.35	725
HSA-MIR-4768-3P	98.16	66.02	2330
HSA-MIR-4303	98.01	68.13	2304
HSA-MIR-6787-5P	97.54	63.85	457
HSA-MIR-3127-5P	97.52	65.24	786
HSA-MIR-3200-5P	97.34	65.97	826
HSA-MIR-148B-5P	97.29	66.30	992
HSA-MIR-6874-3P	97.29	66.34	975
HSA-MIR-6856-3P	96.47	66.27	781
HSA-MIR-8081	96.42	67.75	738
HSA-MIR-24-1-5P	95.57	65.85	492
HSA-MIR-24-2-5P	95.57	66.16	484
HSA-MIR-31-3P	95.17	69.82	575

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.3% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• SMAD4 Loss Induces c-MYC-Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis. (PMID:36219392)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nle1	ENSDARG00000057105
mus_musculus	Nle1	ENSMUSG00000020692
rattus_norvegicus	Nle1	ENSRNOG00000008287
drosophila_melanogaster	Nle	FBGN0021874
caenorhabditis_elegans		WBGENE00021074

Protein

Protein identifiers

Notchless protein homolog 1 — Q9NVX2 (reviewed: Q9NVX2)

All UniProt accessions (5): Q9NVX2, A0A0A0MRH0, K7EK23, K7EN33, K7ERN7

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival.

Subunit / interactions. Associates with the pre-60S ribosomal particle. Interacts (via WD repeats) with uL18. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the NLE1/RSA4 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NVX2-1	1	yes
Q9NVX2-2	2

RefSeq proteins (2): NP_001014445, NP_060566* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001632	WD40_G-protein_beta-like	Domain
IPR001680	WD40_rpt	Repeat
IPR012972	NLE	Domain
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR020472	WD40_PAC1	Repeat
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400, PF08154

UniProt features (26 total): repeat 8, sequence variant 5, strand 4, modified residue 2, helix 2, initiator methionine 1, chain 1, region of interest 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

14 structures.

PDB	Method	Resolution (Å)
6WAJ	X-RAY DIFFRACTION	1.9
8QL1	X-RAY DIFFRACTION	2.3
8FL3	ELECTRON MICROSCOPY	2.53
8FL2	ELECTRON MICROSCOPY	2.67
8RL2	ELECTRON MICROSCOPY	2.84
8FL4	ELECTRON MICROSCOPY	2.89
8FL0	ELECTRON MICROSCOPY	2.91
9QIW	ELECTRON MICROSCOPY	3.04
8INK	ELECTRON MICROSCOPY	3.2
8IPD	ELECTRON MICROSCOPY	3.2
8IPY	ELECTRON MICROSCOPY	3.2
8IR1	ELECTRON MICROSCOPY	3.3
8IR3	ELECTRON MICROSCOPY	3.5
8IPX	ELECTRON MICROSCOPY	4.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVX2-F1	93.94	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 79

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 166 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, GOBP_BLASTOCYST_FORMATION, MUELLER_PLURINET, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, GOBP_IN_UTERO_EMBRYONIC_DEVELOPMENT, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY, GOBP_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION, GOBP_NEGATIVE_REGULATION_OF_CELL_CYCLE, GOBP_SOMITOGENESIS, GOBP_REGULATION_OF_CELL_CYCLE

GO Biological Process (11): mitotic cell cycle (GO:0000278), somitogenesis (GO:0001756), kidney development (GO:0001822), inner cell mass cell differentiation (GO:0001826), Notch signaling pathway (GO:0007219), regulation of Notch signaling pathway (GO:0008593), ribosomal large subunit biogenesis (GO:0042273), negative regulation of mitotic cell cycle (GO:0045930), skeletal system morphogenesis (GO:0048705), hematopoietic stem cell homeostasis (GO:0061484), positive regulation of canonical Wnt signaling pathway (GO:0090263)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): nucleoplasm (GO:0005654), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nuclear lumen	2
cell cycle	1
mitotic nuclear division	1
anterior/posterior pattern specification	1
segmentation	1
chordate embryonic development	1
anatomical structure formation involved in morphogenesis	1
somite development	1
animal organ development	1
renal system development	1
blastocyst formation	1
cell differentiation	1
cell surface receptor signaling pathway	1
Notch signaling pathway	1
regulation of signal transduction	1
ribonucleoprotein complex biogenesis	1
ribosome biogenesis	1
mitotic cell cycle	1
regulation of mitotic cell cycle	1
negative regulation of cell cycle	1
skeletal system development	1
animal organ morphogenesis	1
homeostasis of number of cells	1
positive regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
binding	1
cellular anatomical structure	1
intracellular membraneless organelle	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2156 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NLE1	NOP56	O00567	551
NLE1	MDN1	Q9NU22	509
NLE1	RSL24D1	Q9UHA3	476
NLE1	ZNF529	Q6P280	466
NLE1	GNL3L	Q9NVN8	457
NLE1	GNL3	Q9BVP2	453
NLE1	BOP1	Q14137	443
NLE1	WDR18	Q9BV38	437
NLE1	WDR12	Q9GZL7	430
NLE1	NOP53	Q9NZM5	429
NLE1	SRPRB	Q9Y5M8	425
NLE1	NIP7	Q9Y221	412
NLE1	TAAR1	Q96RJ0	406
NLE1	NMD3	Q96D46	405
NLE1	NVL	O15381	403

IntAct

70 interactions, top by confidence:

A	B	Type	Score
CCT2	TXNDC9	psi-mi:“MI:0914”(association)	0.730
NOL12	RRP8	psi-mi:“MI:0914”(association)	0.640
MECP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
NSA2	GNL2	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
PLEKHO1	UBA6	psi-mi:“MI:0914”(association)	0.530
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
IGHMBP2	THAP12	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
NIFK	RSL1D1	psi-mi:“MI:0914”(association)	0.530
THAP7	RPS27A	psi-mi:“MI:0914”(association)	0.530
GNL3	NLE1	psi-mi:“MI:0915”(physical association)	0.500
NLE1	CHRM5	psi-mi:“MI:0915”(physical association)	0.370
EWSR1	NLE1	psi-mi:“MI:0915”(physical association)	0.370
Spire2	KLF4	psi-mi:“MI:0914”(association)	0.350
NOP9	ENDOV	psi-mi:“MI:0914”(association)	0.350
CHMP4B		psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
RRP1B	ZNF785	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350

BioGRID (578): NLE1 (Affinity Capture-MS), NLE1 (Affinity Capture-MS), NLE1 (Affinity Capture-MS), NLE1 (Affinity Capture-MS), NLE1 (Affinity Capture-MS), NLE1 (Two-hybrid), GBE1 (Co-fractionation), HNRNPH3 (Co-fractionation), MTHFD1 (Co-fractionation), NLE1 (Co-fractionation), NLE1 (Co-fractionation), SPAG7 (Co-fractionation), NLE1 (Affinity Capture-MS), NLE1 (Affinity Capture-Western), NLE1 (Affinity Capture-MS)

ESM2 similar proteins: A0AUS0, A4R2Q6, A5DL92, A5WVX1, A7RHG8, A8IR43, A8IRK7, A8QB65, A8XL02, A9UP22, B2B5V0, B3MJV8, B3N534, B3RQN1, B4GT01, B4JPT9, B4KKN1, B4LS78, B4P116, B5DG67, B7PY76, G0SFB5, P49177, P61480, P91343, Q0CLJ4, Q0VC24, Q29KQ0, Q2GXT0, Q58D20, Q5BJ90, Q5FVN8, Q5REE6, Q5RFF8, Q6CEW7, Q6NX08, Q756D0, Q7QJ33, Q8H594, Q8VEJ4

Diamond homologs: A0A223GEB2, A1L271, A2QPZ4, A4R3M4, A6H603, A6RRD4, B2VWG7, B3MHX6, B3MJV8, B4GT01, B4JPT9, B5DG67, B8N9H4, C0S902, C1GB49, C4R6H3, C4YPI7, C5GVJ9, C5JD40, E3LB80, G0S8H7, G1SJB4, G4MQX3, O14775, O18640, O24076, O24456, O42248, O42249, O94527, P0CS34, P0CS35, P25382, P25387, P38011, P40968, P46800, P49026, P49027, P52287

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 79 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	7	18.1×	1e-05
Viral mRNA Translation	7	18.1×	1e-05
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	7	17.9×	1e-05
Selenocysteine synthesis	7	17.2×	1e-05
Eukaryotic Translation Termination	7	17.2×	1e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	7	16.8×	1e-05
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	7	16.8×	1e-05
Formation of a pool of free 40S subunits	7	16.0×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	7	17.5×	3e-05
rRNA processing	8	15.3×	2e-05
translation	7	9.7×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

83 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1668 predictions. Top by Δscore:

Variant	Effect	Δscore
17:35129569:C:G	donor_gain	1.0000
17:35129575:GAGC:G	donor_gain	1.0000
17:35129578:C:G	donor_gain	1.0000
17:35129606:GT:G	donor_gain	1.0000
17:35129659:G:GG	donor_gain	1.0000
17:35130278:TCA:T	acceptor_loss	1.0000
17:35130279:CAGT:C	acceptor_loss	1.0000
17:35130280:A:AG	acceptor_gain	1.0000
17:35130280:AGT:A	acceptor_loss	1.0000
17:35130281:G:A	acceptor_loss	1.0000
17:35130281:G:GA	acceptor_gain	1.0000
17:35130281:GTTT:G	acceptor_gain	1.0000
17:35133169:A:AC	donor_gain	1.0000
17:35133169:ACAT:A	donor_gain	1.0000
17:35133170:C:CC	donor_gain	1.0000
17:35133170:CAT:C	donor_gain	1.0000
17:35133170:CATC:C	donor_gain	1.0000
17:35133334:CCTA:C	donor_loss	1.0000
17:35133336:TACC:T	donor_loss	1.0000
17:35133337:A:AC	donor_gain	1.0000
17:35133337:A:T	donor_loss	1.0000
17:35133338:C:CC	donor_gain	1.0000
17:35133338:CCT:C	donor_gain	1.0000
17:35133496:TAC:T	acceptor_gain	1.0000
17:35133497:ACCTG:A	acceptor_loss	1.0000
17:35133499:C:CC	acceptor_gain	1.0000
17:35133505:C:CT	acceptor_gain	1.0000
17:35133505:C:T	acceptor_gain	1.0000
17:35133506:A:T	acceptor_gain	1.0000
17:35134970:TGA:T	donor_gain	1.0000

AlphaMissense

3153 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:35133197:A:C	S473R	1.000
17:35133197:A:T	S473R	1.000
17:35133199:T:G	S473R	1.000
17:35133226:A:G	W464R	1.000
17:35133226:A:T	W464R	1.000
17:35133420:G:C	S431R	1.000
17:35133420:G:T	S431R	1.000
17:35133422:T:G	S431R	1.000
17:35135296:A:C	S389R	1.000
17:35135296:A:T	S389R	1.000
17:35135298:T:G	S389R	1.000
17:35135420:G:A	S348F	1.000
17:35137166:G:C	S221R	1.000
17:35137166:G:T	S221R	1.000
17:35137168:T:G	S221R	1.000
17:35139302:A:C	S131R	1.000
17:35139302:A:T	S131R	1.000
17:35139304:T:G	S131R	1.000
17:35132448:A:G	W483R	0.999
17:35132448:A:T	W483R	0.999
17:35133192:C:T	G475E	0.999
17:35133195:C:T	G474D	0.999
17:35133221:A:C	S465R	0.999
17:35133221:A:T	S465R	0.999
17:35133223:T:G	S465R	0.999
17:35133358:A:G	L452P	0.999
17:35133392:A:G	W441R	0.999
17:35133392:A:T	W441R	0.999
17:35133396:C:A	K439N	0.999
17:35133396:C:G	K439N	0.999

dbSNP variants (sampled 300 via entrez): RS1000163855 (17:35130645 G>A), RS1000190657 (17:35141190 A>G), RS1000318372 (17:35136458 C>T), RS1000365527 (17:35134995 T>C), RS1000425693 (17:35130934 C>G,T), RS1000649241 (17:35136717 G>A), RS1000679543 (17:35133874 C>T), RS1000822510 (17:35140085 G>A), RS1000896574 (17:35141490 G>A), RS1000919481 (17:35139814 A>C), RS1001054646 (17:35135077 A>G), RS1001423057 (17:35139851 T>C), RS1001455680 (17:35139559 TC>T), RS1001649997 (17:35134123 A>T), RS1001985352 (17:35132960 G>A)

Disease associations

OMIM: gene MIM:620924 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment, increases expression	2
sodium arsenite	decreases expression, increases expression	2
Estradiol	increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
trichostatin A	affects expression	1
potassium chromate(VI)	increases expression	1
nivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
nutlin 3	affects cotreatment, increases secretion	1
enzalutamide	affects expression	1
LDN 193189	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Cisplatin	decreases expression, decreases reaction	1
Dactinomycin	affects cotreatment, increases secretion	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Phenobarbital	affects expression	1
Piroxicam	decreases expression, decreases reaction	1
Quercetin	increases expression	1
Ribonucleotides	affects binding	1
Silicon Dioxide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.