NLGN1-AS1

Summary

NLGN1-AS1 (NLGN1 antisense RNA 1, HGNC:40676) is a long non-coding RNA gene on chromosome 3q26.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40676
Approved symbol	NLGN1-AS1
Name	NLGN1 antisense RNA 1
Location	3q26.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228213
Ensembl biotype	lncRNA
Entrez	100874010
RNAcentral	URS00000B58AE — lncRNA, 815 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000423873, ENST00000457192

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423873 — 4 exons

Exon	Start	End
ENSE00001602793	173914890	173914989
ENSE00001687353	173920526	173920796
ENSE00001716569	173910498	173910869
ENSE00001774275	173912546	173912617

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 84.56.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	84.56	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.40	gold quality
sural nerve	UBERON:0015488	70.44	gold quality
calcaneal tendon	UBERON:0003701	70.19	gold quality
stomach	UBERON:0000945	67.97	gold quality
urinary bladder	UBERON:0001255	63.17	silver quality
muscle of leg	UBERON:0001383	58.94	gold quality
lung	UBERON:0002048	58.61	gold quality
adult mammalian kidney	UBERON:0000082	58.56	gold quality
uterine cervix	UBERON:0000002	57.87	silver quality
kidney	UBERON:0002113	57.70	gold quality
heart	UBERON:0000948	56.22	gold quality
thyroid gland	UBERON:0002046	56.03	silver quality
hindlimb stylopod muscle	UBERON:0004252	55.53	gold quality
endometrium	UBERON:0001295	55.16	gold quality
primary visual cortex	UBERON:0002436	54.59	gold quality
intestine	UBERON:0000160	52.75	gold quality
small intestine	UBERON:0002108	52.31	silver quality
adrenal gland	UBERON:0002369	52.11	gold quality
islet of Langerhans	UBERON:0000006	51.80	gold quality
blood	UBERON:0000178	51.76	silver quality
monocyte	CL:0000576	51.75	gold quality
adrenal tissue	UBERON:0018303	51.00	gold quality
prefrontal cortex	UBERON:0000451	49.79	gold quality
superior frontal gyrus	UBERON:0002661	49.62	gold quality
thoracic mammary gland	UBERON:0005200	48.92	silver quality
cerebellar cortex	UBERON:0002129	47.12	silver quality
multicellular organism	UBERON:0000468	46.90	gold quality
cerebellar hemisphere	UBERON:0002245	46.69	silver quality
ovary	UBERON:0000992	46.58	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A regulatory circuit of lncRNA NLGN1-AS1 and Wnt signalling controls clear cell renal cell carcinoma phenotypes through FZD4-modulated pathways. (PMID:36170021)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.