NNT-AS1

Summary

NNT-AS1 (NNT antisense RNA 1, HGNC:49005) is a long non-coding RNA gene on chromosome 5p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49005
Approved symbol	NNT-AS1
Name	NNT antisense RNA 1
Location	5p12
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-159F24.1
Ensembl gene	ENSG00000248092
Ensembl biotype	lncRNA
Entrez	100652772
RNAcentral	URS000075C8F1 — lncRNA, 3304 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000500258, ENST00000503484, ENST00000506247, ENST00000513560, ENST00000515466, ENST00000606697, ENST00000656020, ENST00000668986, ENST00000793905, ENST00000793906, ENST00000793907

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500258 — 3 exons

Exon	Start	End
ENSE00001969919	43583467	43583566
ENSE00001989772	43602778	43603063
ENSE00002055061	43579130	43579200

Expression profiles

Bgee: expression breadth ubiquitous, 240 present calls, max score 95.18.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1167 / max 86.1217, expressed in 1713 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
61579	8.4187	1706
61577	0.4029	228
61578	0.2951	156

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
biceps brachii	UBERON:0001507	95.18	gold quality
deltoid	UBERON:0001476	94.99	gold quality
vastus lateralis	UBERON:0001379	94.51	gold quality
quadriceps femoris	UBERON:0001377	94.16	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	93.64	gold quality
heart right ventricle	UBERON:0002080	92.82	gold quality
skeletal muscle tissue	UBERON:0001134	92.15	gold quality
myocardium	UBERON:0002349	92.13	gold quality
muscle tissue	UBERON:0002385	90.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.28	gold quality
ventricular zone	UBERON:0003053	87.67	gold quality
cardiac ventricle	UBERON:0002082	87.30	gold quality
heart left ventricle	UBERON:0002084	87.12	gold quality
ganglionic eminence	UBERON:0004023	86.80	gold quality
muscle of leg	UBERON:0001383	86.69	gold quality
gastrocnemius	UBERON:0001388	86.20	gold quality
oviduct epithelium	UBERON:0004804	86.19	gold quality
cortical plate	UBERON:0005343	85.95	gold quality
heart	UBERON:0000948	85.78	gold quality
lateral globus pallidus	UBERON:0002476	85.43	gold quality
cardiac atrium	UBERON:0002081	85.28	gold quality
body of tongue	UBERON:0011876	85.19	gold quality
right atrium auricular region	UBERON:0006631	85.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.67	gold quality
lateral nuclear group of thalamus	UBERON:0002736	84.39	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	84.23	gold quality
subthalamic nucleus	UBERON:0001906	84.12	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.89	gold quality
corpus epididymis	UBERON:0004359	83.84	gold quality
spinal cord	UBERON:0002240	83.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• our studies implied that NNT-AS1 may involve in the development and progression of CRC via its regulation of cell proliferation, migration, and invasion by NNT-AS1-mediated activating of MAPK/Erk signaling pathway and EMT. (PMID:27966450)
• lncRNA NNT-AS1 could act as an oncogenic lncRNA that promote cervical cancer cell growth and invasion via modulation of Wnt/b-catenin signaling pathway. (PMID:28628975)
• Inhibition of NNT-AS1 suppresses cell proliferation and tumor growth in vitro and in vivo and knockdown of NNT-AS1 suppresses migration and invasion abilities in vitro. (PMID:29518771)
• All the above findings revealed a fact that NNT-AS1 affects breast cancer progression through modulating miR-142-3p/ZEB1 axis. (PMID:29710510)
• In the present study, we showed that the expression of NNT-AS1 was upregulated in non-small cell lung cancer (NSCLC) tissues and cell lines. (PMID:29857296)
• Long non-coding RNA NNT-AS1 sponges miR-424/E2F1 to promote the tumorigenesis and cell cycle progression of gastric cancer. (PMID:30006956)
• High NNT-AS1 expression is associated with gastric cancer proliferation and invasion. (PMID:30324628)
• High NNT-AS1 expression is associated with osteosarcoma progression. (PMID:30489194)
• LncRNA NNT-AS1 promotes non-small cell lung cancer progression through regulating miR-22-3p/YAP1 axis. (PMID:31923353)
• LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis. (PMID:32420808)
• Long noncoding RNA NNTAS1 knockdown represses the progression of gastric cancer via modulating the miR1425p/SOX4/Wnt/betacatenin signaling pathway. (PMID:32468065)
• LncRNA NNT-AS1 promotes lung squamous cell carcinoma progression by regulating the miR-22/FOXM1 axis. (PMID:32514270)
• Long noncoding RNA NNT-AS1 functions as an oncogene in breast cancer via repressing ZFP36 expression. (PMID:32691576)
• Long non-coding RNA NNT-AS1 regulates proliferation, apoptosis, inflammation and airway remodeling of chronic obstructive pulmonary disease via targeting miR-582-5p/FBXO11 axis. (PMID:32768929)
• Upregulated expression of LncRNA nicotinamide nucleotide transhydrogenase antisense RNA 1 is correlated with unfavorable clinical outcomes in cancers. (PMID:32928135)
• Overexpression of NNT-AS1 Activates TGF-beta Signaling to Decrease Tumor CD4 Lymphocyte Infiltration in Hepatocellular Carcinoma. (PMID:33426064)
• The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia in children. (PMID:33479472)
• Serum long noncoding RNA NNTAS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR496/RAP2C axis in colorectal cancer. (PMID:34132374)
• The long non-coding RNA NNT-AS1 promotes clear cell renal cell carcinoma progression via regulation of the miR-137/ Y-box binding protein 1 axis. (PMID:34643163)
• LncRNA NNT-AS1 regulates proliferation, ECM accumulation and inflammation of human mesangial cells induced by high glucose through miR-214-5p/smad4. (PMID:34742256)
• Insights on the potential oncogenic impact of long non-coding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 in different cancer types; integrating pathway(s) and clinical outcome(s) association. (PMID:36327824)
• NNT-AS1 in CAFs-derived exosomes promotes progression and glucose metabolism through miR-889-3p/HIF-1alpha in pancreatic adenocarcinoma. (PMID:38521881)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.