NOC2L

Summary

NOC2L (NOC2 like nucleolar associated transcriptional repressor, HGNC:24517) is a protein-coding gene on chromosome 1p36.33, encoding Nucleolar complex protein 2 homolog (Q9Y3T9). Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. It is a selective cancer dependency (DepMap: 83.5% of cell lines).

Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).

Source: NCBI Gene 26155 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 202 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 83.5% of screened cell lines
• MANE Select transcript: NM_015658

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24517
Approved symbol	NOC2L
Name	NOC2 like nucleolar associated transcriptional repressor
Location	1p36.33
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP564C186, NET7, NET15, NIR, PPP1R112
Ensembl gene	ENSG00000188976
Ensembl biotype	protein_coding
OMIM	610770
Entrez	26155

Gene structure

Transcript identifiers

Ensembl transcripts: 69 — 64 protein_coding, 3 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000327044, ENST00000469563, ENST00000477976, ENST00000483767, ENST00000487214, ENST00000496938, ENST00000870725, ENST00000870726, ENST00000870727, ENST00000870728, ENST00000870729, ENST00000870730, ENST00000870731, ENST00000870732, ENST00000870733, ENST00000870734, ENST00000870735, ENST00000870736, ENST00000870737, ENST00000870738, ENST00000870739, ENST00000934932, ENST00000934933, ENST00000934934, ENST00000934935, ENST00000934936, ENST00000934937, ENST00000934938, ENST00000934939, ENST00000934940, ENST00000934941, ENST00000934942, ENST00000934943, ENST00000934944, ENST00000934945, ENST00000934946, ENST00000934947, ENST00000934948, ENST00000934949, ENST00000934950, ENST00000934951, ENST00000934952, ENST00000934953, ENST00000934954, ENST00000934955, ENST00000934956, ENST00000934957, ENST00000934958, ENST00000934959, ENST00000968805, ENST00000968806, ENST00000968807, ENST00000968808, ENST00000968809, ENST00000968810, ENST00000968811, ENST00000968812, ENST00000968813, ENST00000968814, ENST00000968815, ENST00000968816, ENST00000968817, ENST00000968818, ENST00000968819, ENST00000968820, ENST00000968821, ENST00000968822, ENST00000968823, ENST00000968824

RefSeq mRNA: 1 — MANE Select: NM_015658 NM_015658

CCDS: CCDS3

Canonical transcript exons

ENST00000327044 — 19 exons

Exon	Start	End
ENSE00001375393	945057	945146
ENSE00001380352	954004	954082
ENSE00001926296	959215	959256
ENSE00003486680	944203	944800
ENSE00003500440	948490	948603
ENSE00003521833	951127	951238
ENSE00003527689	952000	952139
ENSE00003554589	946402	946545
ENSE00003560627	953175	953288
ENSE00003567731	956894	957025
ENSE00003589494	956095	956215
ENSE00003591928	958929	959081
ENSE00003602238	953782	953892
ENSE00003603800	946173	946286
ENSE00003620005	957099	957273
ENSE00003638394	952412	952600
ENSE00003657824	948131	948232
ENSE00003682181	945518	945653
ENSE00003687250	955923	956013

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 97.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.4801 / max 270.8328, expressed in 1814 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9669	34.4689	1814
9668	0.0112	6

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	97.55	gold quality
right uterine tube	UBERON:0001302	95.95	gold quality
left testis	UBERON:0004533	95.60	gold quality
right testis	UBERON:0004534	95.54	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.38	gold quality
skin of leg	UBERON:0001511	95.33	gold quality
gastrocnemius	UBERON:0001388	95.21	gold quality
cerebellar hemisphere	UBERON:0002245	95.11	gold quality
skin of abdomen	UBERON:0001416	94.92	gold quality
cerebellar cortex	UBERON:0002129	94.90	gold quality
adenohypophysis	UBERON:0002196	94.68	gold quality
esophagus mucosa	UBERON:0002469	94.68	gold quality
right lobe of liver	UBERON:0001114	94.65	gold quality
endocervix	UBERON:0000458	94.64	gold quality
muscle of leg	UBERON:0001383	94.61	gold quality
mucosa of transverse colon	UBERON:0004991	94.57	gold quality
left uterine tube	UBERON:0001303	94.38	gold quality
apex of heart	UBERON:0002098	94.32	gold quality
metanephros cortex	UBERON:0010533	94.31	gold quality
ectocervix	UBERON:0012249	94.29	gold quality
body of pancreas	UBERON:0001150	94.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.92	gold quality
body of uterus	UBERON:0009853	93.92	gold quality
esophagus	UBERON:0001043	93.87	gold quality
right frontal lobe	UBERON:0002810	93.86	gold quality
body of stomach	UBERON:0001161	93.67	gold quality
right lobe of thyroid gland	UBERON:0001119	93.54	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.52	gold quality
left ovary	UBERON:0002119	93.47	gold quality
lower esophagus	UBERON:0013473	93.44	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-86618	no	178.04
E-ANND-3	no	5.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting NOC2L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-4527	99.66	67.43	714
HSA-MIR-6848-3P	99.64	66.49	885
HSA-MIR-6503-5P	99.62	66.96	597
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-6843-3P	99.26	66.42	915
HSA-MIR-3164	99.02	68.39	1071
HSA-MIR-6820-3P	99.02	68.50	1035
HSA-MIR-4501	98.72	67.19	921
HSA-MIR-12120	98.05	68.44	1768
HSA-MIR-5685	97.02	64.34	1004
HSA-MIR-4690-3P	97.02	64.72	981
HSA-MIR-5002-3P	95.75	67.04	542

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 83.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 5)

• Upon recruitment by p53, NIR represses transcription of both p53-dependent reporters and endogenous target genes (PMID:16322561)
• Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. (PMID:20959462)
• A transcriptional repressor NIR functions in the rRNA biogenesis of both the 40S and 60S subunits. (PMID:22363708)
• LncRNA NOC2L-4.1 functions as a tumor oncogene in cervical cancer progression by regulating the miR-630/YAP1 pathway. (PMID:31099044)
• NIR promotes progression of colorectal cancer through regulating RB. (PMID:32931817)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	noc2l	ENSDARG00000001754
mus_musculus	Noc2l	ENSMUSG00000095567
rattus_norvegicus	Noc2l	ENSRNOG00000021392
drosophila_melanogaster	Noc2	FBGN0032925
caenorhabditis_elegans		WBGENE00007413

Protein

Protein identifiers

Nucleolar complex protein 2 homolog — Q9Y3T9 (reviewed: Q9Y3T9)

Alternative names: NOC2-like protein, Novel INHAT repressor

All UniProt accessions (1): Q9Y3T9

UniProt curated annotations — full annotation on UniProt →

Function. Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.

Subunit / interactions. Interacts with p53/TP53. Interacts (via the N- and C-terminus domains) with AURKB (via the middle kinase domain). Interacts with TP63 isoform TA*-gamma (via activation domain). Interacts with histone H3 (via N-terminus and non-acetylated form preferentially). Associates with core histones and nucleosomes.

Subcellular location. Nucleus. Nucleoplasm. Nucleolus.

Induction. Up-regulated by IL4 and CD40L in B-cells.

Similarity. Belongs to the NOC2 family.

RefSeq proteins (1): NP_056473* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005343	Noc2	Family
IPR016024	ARM-type_fold	Homologous_superfamily

Pfam: PF03715

UniProt features (21 total): modified residue 7, compositionally biased region 5, region of interest 3, sequence variant 3, sequence conflict 2, chain 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8FKV	ELECTRON MICROSCOPY	2.47
8FKW	ELECTRON MICROSCOPY	2.5
8FKX	ELECTRON MICROSCOPY	2.59
8FKY	ELECTRON MICROSCOPY	2.67

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3T9-F1	70.96	0.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (7): 56, 93, 672, 673, 678, 746, 49

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation

MSigDB gene sets: 142 (showing top): GOBP_RIBOSOME_BIOGENESIS, BENPORATH_ES_WITH_H3K27ME3, GOBP_CELLULAR_RESPONSE_TO_UV, GOBP_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS, GOBP_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS, GOBP_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS, MUELLER_PLURINET, GOBP_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_APOPTOTIC_SIGNALING_PATHWAY, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, GOBP_RESPONSE_TO_UV, GOBP_RESPONSE_TO_RADIATION, GOBP_REGULATION_OF_B_CELL_APOPTOTIC_PROCESS

GO Biological Process (7): negative regulation of transcription by RNA polymerase II (GO:0000122), negative regulation of B cell apoptotic process (GO:0002903), apoptotic process (GO:0006915), cellular response to UV (GO:0034644), ribosomal large subunit biogenesis (GO:0042273), transcription initiation-coupled chromatin remodeling (GO:0045815), negative regulation of intrinsic apoptotic signaling pathway (GO:2001243)

GO Molecular Function (7): chromatin binding (GO:0003682), transcription corepressor activity (GO:0003714), RNA binding (GO:0003723), nucleosome binding (GO:0031491), histone binding (GO:0042393), DNA-binding transcription factor binding (GO:0140297), protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730), cytosol (GO:0005829), Noc1p-Noc2p complex (GO:0030690), Noc2p-Noc3p complex (GO:0030691)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Regulation of TP53 Activity	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of DNA-templated transcription	2
binding	2
nuclear lumen	2
cellular anatomical structure	2
intracellular membraneless organelle	2
preribosome, large subunit precursor	2
Noc complex	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
B cell apoptotic process	1
regulation of B cell apoptotic process	1
negative regulation of lymphocyte apoptotic process	1
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
response to UV	1
cellular response to light stimulus	1
ribonucleoprotein complex biogenesis	1
ribosome biogenesis	1
transcription initiation at RNA polymerase II promoter	1
positive regulation of gene expression, epigenetic	1
intrinsic apoptotic signaling pathway	1
negative regulation of intracellular signal transduction	1
negative regulation of apoptotic signaling pathway	1
regulation of intrinsic apoptotic signaling pathway	1
transcription coregulator activity	1
nucleic acid binding	1
chromatin binding	1
protein-containing complex binding	1
protein binding	1
transcription factor binding	1
intracellular membrane-bounded organelle	1
cytoplasm	1
90S preribosome	1

Protein interactions and networks

STRING

2990 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NOC2L	CPSF4	O95639	882
NOC2L	TAF1B	Q53T94	825
NOC2L	CD1A	P06126	702
NOC2L	CD1B	P29016	698
NOC2L	CD1C	P29017	656
NOC2L	NKRF	O15226	579
NOC2L	GLUL	P15104	571
NOC2L	NIFK	Q9BYG3	559
NOC2L	CYCS	P00001	535
NOC2L	TP53	P04637	529
NOC2L	PMAIP1	Q13794	497
NOC2L	BOP1	Q14137	475
NOC2L	MORN3	Q6PF18	442
NOC2L	MAK16	Q9BXY0	440
NOC2L	NOL6	Q9H6R4	423
NOC2L	WDR74	Q6RFH5	423

IntAct

191 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
MECP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
TP53	NOC2L	psi-mi:“MI:0914”(association)	0.630
NOC2L	TP53	psi-mi:“MI:0407”(direct interaction)	0.630
NOC2L	TP53	psi-mi:“MI:0915”(physical association)	0.630
TP53	NOC2L	psi-mi:“MI:0915”(physical association)	0.630
EED	EPOP	psi-mi:“MI:0914”(association)	0.530
PLEKHO1	UBA6	psi-mi:“MI:0914”(association)	0.530
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
SCN3B	ABCC5	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
PRKCZ	IPO5	psi-mi:“MI:0914”(association)	0.530

BioGRID (381): NOC2L (Affinity Capture-RNA), NOC2L (Affinity Capture-RNA), NOC2L (Affinity Capture-RNA), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), NOC2L (Affinity Capture-MS), LRIF1 (Two-hybrid), CEBPZ (Co-fractionation), DDX52 (Co-fractionation)

ESM2 similar proteins: A0A8I6ASZ5, A0JN53, A4IG66, D3Z8X7, D3ZND0, G3X992, O00750, O08836, O70576, P0DKR2, Q15021, Q1JQC5, Q1L5Z9, Q1LWH4, Q1LXZ7, Q2YD98, Q3T1I9, Q3TV65, Q3UJU9, Q4R5Q4, Q5EAU9, Q5JTW2, Q5R6Z1, Q5TC12, Q61249, Q66H15, Q6NY52, Q6P5E6, Q6PBQ2, Q6PI26, Q80TE0, Q80V31, Q80XC6, Q8BIW9, Q8BM55, Q8K2Z4, Q8R3L2, Q8VDP4, Q8WVB6, Q92574

Diamond homologs: O13874, P39744, Q9Y3T9, Q3SYU1, Q9P7G0, Q9VIF0, Q9WV70

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 219 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	15	12.7×	1e-10
Viral mRNA Translation	15	12.7×	1e-10
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	15	12.6×	1e-10
Selenocysteine synthesis	15	12.0×	2e-10
Eukaryotic Translation Termination	15	12.0×	2e-10
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	15	11.8×	2e-10
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	15	11.8×	2e-10
Formation of a pool of free 40S subunits	15	11.2×	3e-10

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	16	15.0×	1e-11
ribosomal large subunit biogenesis	6	13.5×	1e-03
negative regulation of viral genome replication	6	11.4×	2e-03
ribosomal small subunit biogenesis	9	10.4×	5e-05
translation	18	9.4×	5e-10
regulation of alternative mRNA splicing, via spliceosome	7	8.7×	2e-03
negative regulation of translation	8	8.0×	1e-03
rRNA processing	11	7.9×	5e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

202 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	152
Likely benign	17
Benign	6

Top pathogenic / likely-pathogenic (0)

SpliceAI

3986 predictions. Top by Δscore:

Variant	Effect	Δscore
1:943696:A:AG	acceptor_gain	1.0000
1:943696:AG:A	acceptor_gain	1.0000
1:943697:G:GT	acceptor_gain	1.0000
1:943697:GG:G	acceptor_gain	1.0000
1:943697:GGT:G	acceptor_gain	1.0000
1:943697:GGTC:G	acceptor_gain	1.0000
1:943697:GGTCT:G	acceptor_gain	1.0000
1:943804:CCCAG:C	donor_loss	1.0000
1:943806:CAGG:C	donor_loss	1.0000
1:943807:AGG:A	donor_loss	1.0000
1:943808:GG:G	donor_loss	1.0000
1:943810:T:G	donor_loss	1.0000
1:944691:G:A	donor_gain	1.0000
1:944701:T:TA	donor_gain	1.0000
1:944798:CAT:C	acceptor_gain	1.0000
1:944800:TCT:T	acceptor_loss	1.0000
1:944801:CTGC:C	acceptor_loss	1.0000
1:945055:AC:A	donor_gain	1.0000
1:945055:ACCCT:A	donor_gain	1.0000
1:945056:C:CA	donor_gain	1.0000
1:945056:CCCT:C	donor_gain	1.0000
1:945056:CCCTC:C	donor_gain	1.0000
1:945059:T:TA	donor_gain	1.0000
1:945074:T:TA	donor_gain	1.0000
1:945077:T:TA	donor_gain	1.0000
1:945086:T:TA	donor_gain	1.0000
1:945089:T:TA	donor_gain	1.0000
1:945142:TATCC:T	acceptor_gain	1.0000
1:945143:ATCC:A	acceptor_gain	1.0000
1:945144:TCC:T	acceptor_gain	1.0000

AlphaMissense

4902 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:952469:G:C	F378L	0.997
1:952469:G:T	F378L	0.997
1:952471:A:G	F378L	0.997
1:957193:A:G	L87P	0.997
1:952088:A:G	W415R	0.996
1:952088:A:T	W415R	0.996
1:953273:A:G	W302R	0.996
1:953273:A:T	W302R	0.996
1:957195:G:C	F86L	0.996
1:957195:G:T	F86L	0.996
1:957197:A:G	F86L	0.996
1:952440:A:G	L388P	0.995
1:952115:A:G	W406R	0.994
1:952115:A:T	W406R	0.994
1:952437:C:G	R389P	0.994
1:952113:C:A	W406C	0.993
1:952113:C:G	W406C	0.993
1:952098:G:C	C411W	0.991
1:952458:C:G	R382P	0.991
1:952452:A:G	L384P	0.989
1:953175:C:A	K334N	0.989
1:953175:C:G	K334N	0.989
1:952123:A:T	V403E	0.988
1:957226:A:G	L76P	0.988
1:952100:A:G	C411R	0.987
1:952432:C:G	A391P	0.986
1:952585:A:C	Y340D	0.986
1:956911:A:G	W157R	0.986
1:956911:A:T	W157R	0.986
1:957204:G:C	F83L	0.986

dbSNP variants (sampled 300 via entrez): RS1000008901 (1:958723 A>G), RS1000863568 (1:948243 G>C,T), RS1000874657 (1:944746 G>A,C), RS1000993358 (1:951560 G>C), RS1001299910 (1:944978 A>C,G), RS1001328077 (1:950667 ACACAG>A), RS1001512918 (1:954310 C>T), RS1001681776 (1:957931 A>G), RS1001732729 (1:958155 G>A,C), RS1001970046 (1:957169 A>T), RS1002086733 (1:955157 C>A), RS1002165788 (1:953452 C>A), RS1002240891 (1:960751 C>A), RS1002243745 (1:955329 G>A), RS1002424672 (1:948399 T>C)

Disease associations

OMIM: gene MIM:610770 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005434_1	Pancreatic cancer	8.000000e-14
GCST009305_9	California verbal learning test score	7.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004874	memory performance

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067289 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 3 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.20	Kd	636.8	nM	CHEMBL3752910
6.20	ED50	636.8	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 4 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148877: Binding affinity to human NOC2L incubated for 45 mins by Kinobead based pull down assay	kd	0.6368	uM

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression, increases abundance	4
Arsenic	increases expression, affects methylation, increases abundance	2
Dexamethasone	decreases expression, affects cotreatment, increases expression	2
Estradiol	increases expression	2
Smoke	increases abundance, increases expression, decreases expression	2
Valproic Acid	increases expression, increases methylation	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	increases expression	1
deoxynivalenol	increases expression	1
manganese chloride	decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
coumarin	affects phosphorylation	1
CGP 52608	affects binding, increases reaction	1
monomethylarsonous acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Benztropine	increases expression	1
Caffeine	decreases phosphorylation	1
Clozapine	increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Manganese	decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651919	Binding	Binding affinity to human NOC2L incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.