NOL8

Summary

NOL8 (nucleolar protein 8, HGNC:23387) is a protein-coding gene on chromosome 9q22.31, encoding Nucleolar protein 8 (Q76FK4). Plays an essential role in the survival of diffuse-type gastric cancer cells. It is a common-essential gene (DepMap: required in 90.6% of cancer cell lines).

NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).

Source: NCBI Gene 55035 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 198 total
• Cancer dependency (DepMap): dependent in 90.6% of screened cell lines (common-essential)
• MANE Select transcript: NM_017948

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23387
Approved symbol	NOL8
Name	nucleolar protein 8
Location	9q22.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20736, Nop132
Ensembl gene	ENSG00000198000
Ensembl biotype	protein_coding
OMIM	611534
Entrez	55035

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 14 protein_coding, 9 nonsense_mediated_decay, 5 retained_intron, 3 protein_coding_CDS_not_defined

ENST00000358855, ENST00000360868, ENST00000411621, ENST00000421075, ENST00000432670, ENST00000433029, ENST00000434228, ENST00000442668, ENST00000445919, ENST00000463593, ENST00000467230, ENST00000477862, ENST00000482475, ENST00000535387, ENST00000535649, ENST00000535807, ENST00000536593, ENST00000536624, ENST00000538215, ENST00000538802, ENST00000542053, ENST00000542573, ENST00000542613, ENST00000543260, ENST00000543985, ENST00000544321, ENST00000544867, ENST00000545444, ENST00000545558, ENST00000884405, ENST00000958984

RefSeq mRNA: 3 — MANE Select: NM_017948 NM_001256394, NM_001330722, NM_017948

CCDS: CCDS47993, CCDS59135, CCDS83384

Canonical transcript exons

ENST00000442668 — 17 exons

Exon	Start	End
ENSE00001467615	92297358	92297886
ENSE00002207654	92325306	92325350
ENSE00003466506	92299890	92300016
ENSE00003505649	92301551	92301822
ENSE00003510159	92324023	92324209
ENSE00003515851	92319221	92319356
ENSE00003541743	92310553	92310675
ENSE00003543451	92298257	92298336
ENSE00003551538	92305753	92305830
ENSE00003555060	92323441	92323503
ENSE00003555381	92318618	92318686
ENSE00003556685	92314267	92316138
ENSE00003579144	92310171	92310261
ENSE00003629345	92311146	92311259
ENSE00003666045	92321668	92321746
ENSE00003683950	92298884	92298954
ENSE00003694142	92306886	92307024

Expression profiles

Bgee: expression breadth ubiquitous, 282 present calls, max score 96.04.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 20.8902 / max 416.2548, expressed in 1789 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101414	19.9935	1785
101415	0.8967	557

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.66	gold quality
body of pancreas	UBERON:0001150	92.02	gold quality
cervix squamous epithelium	UBERON:0006922	91.80	gold quality
body of uterus	UBERON:0009853	91.66	gold quality
skin of abdomen	UBERON:0001416	91.65	gold quality
endocervix	UBERON:0000458	91.64	gold quality
tendon	UBERON:0000043	91.63	gold quality
left ovary	UBERON:0002119	91.57	gold quality
tibial nerve	UBERON:0001323	91.53	gold quality
right ovary	UBERON:0002118	91.51	gold quality
spleen	UBERON:0002106	91.37	gold quality
right uterine tube	UBERON:0001302	91.35	gold quality
skin of leg	UBERON:0001511	91.29	gold quality
sural nerve	UBERON:0015488	91.05	gold quality
left uterine tube	UBERON:0001303	90.80	gold quality
adrenal tissue	UBERON:0018303	90.70	gold quality
descending thoracic aorta	UBERON:0002345	90.57	gold quality
right coronary artery	UBERON:0001625	90.48	gold quality
ovary	UBERON:0000992	90.46	gold quality
peritoneum	UBERON:0002358	90.44	gold quality
omental fat pad	UBERON:0010414	90.44	gold quality
lymph node	UBERON:0000029	90.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.35	gold quality
zone of skin	UBERON:0000014	90.32	gold quality
vagina	UBERON:0000996	90.31	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.31	gold quality
right lobe of thyroid gland	UBERON:0001119	90.28	gold quality
granulocyte	CL:0000094	90.24	gold quality
colonic epithelium	UBERON:0000397	90.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.45

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

40 targeting NOL8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-4677-5P	99.70	70.09	1940
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-2115-3P	99.31	69.68	2026
HSA-MIR-3606-3P	99.11	69.84	3254
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-6794-3P	98.76	66.99	894
HSA-MIR-2467-3P	98.65	67.18	1969
HSA-MIR-548AO-5P	98.55	69.57	1362
HSA-MIR-548AX	98.55	69.58	1362
HSA-MIR-561-5P	98.25	68.13	1365
HSA-MIR-6841-3P	98.08	66.54	604

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 90.6% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• nucleolar protein 132(Nop132) is associated with the GTP form, but not the GDP form, of ras-related GTP binding protein RRAG A, suggesting that RRAG A might regulate Nop132 function (PMID:14660641)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nol8	ENSDARG00000044143
mus_musculus	Nol8	ENSMUSG00000021392
rattus_norvegicus	Nol8	ENSRNOG00000046968
drosophila_melanogaster	CG14230	FBGN0031062
caenorhabditis_elegans		WBGENE00010638

Protein

Protein identifiers

Nucleolar protein 8 — Q76FK4 (reviewed: Q76FK4)

Alternative names: Nucleolar protein Nop132

All UniProt accessions (12): A0A0A0MSJ1, F5GWN9, F5GXV1, F5H0I5, Q76FK4, F5H101, F5H532, F5H692, F5H797, F5H7D5, F5H8B8, F8WE42

UniProt curated annotations — full annotation on UniProt →

Function. Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.

Subunit / interactions. Interacts with the GTP form of RRAGA, RRAGC and RRAGD. Interacts with NIP7. Interacts with DDX18; the interaction is RNA-dependent. Interacts with DDX47; the interaction is RNA-dependent.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Expressed in various diffuse-type gastric cancers. Detected at lower levels in skeletal muscle.

Post-translational modifications. Phosphorylated.

Induction. Up-regulated in diffuse-type gastric cancers.

Isoforms (3)

UniProt ID	Names	Canonical?
Q76FK4-1	1	yes
Q76FK4-2	2
Q76FK4-4	4

RefSeq proteins (3): NP_001243323, NP_001317651, NP_060418* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000504	RRM_dom	Domain
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR034138	NOP8_RRM	Domain
IPR035979	RBD_domain_sf	Homologous_superfamily

Pfam: PF00076

UniProt features (68 total): modified residue 24, compositionally biased region 14, region of interest 8, sequence conflict 8, sequence variant 5, cross-link 3, coiled-coil region 2, splice variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q76FK4-F1	55.25	0.08

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (27): 268, 298, 302, 304, 331, 365, 376, 378, 381, 432, 723, 795, 801, 837, 838, 843, 845, 888, 890, 1036 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 140 (showing top): GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, SHEPARD_CRASH_AND_BURN_MUTANT_UP, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, chr9q22, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, CHANDRAN_METASTASIS_UP, GOBP_PROTEIN_LOCALIZATION_TO_NUCLEUS, GRADE_COLON_AND_RECTAL_CANCER_UP, GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN, MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN, MARSON_BOUND_BY_E2F4_UNSTIMULATED

GO Biological Process (2): rRNA processing (GO:0006364), protein localization to nucleolus (GO:1902570)

GO Molecular Function (3): RNA binding (GO:0003723), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (3): chromosome (GO:0005694), nucleolus (GO:0005730), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
intracellular membraneless organelle	2
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
protein localization to nucleus	1
nucleic acid binding	1
nuclear lumen	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1372 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NOL8	NIP7	Q9Y221	954
NOL8	RRAGC	Q9HB90	824
NOL8	RRAGD	Q9NQL2	819
NOL8	RRAGA	Q7L523	736
NOL8	ZNHIT6	Q9NWK9	485
NOL8	RRP36	Q96EU6	468
NOL8	TAF1D	Q9H5J8	446
NOL8	DDX47	Q9H0S4	445
NOL8	MRPL52	Q86TS9	437
NOL8	DAZAP1	Q96EP5	432
NOL8	POLR3C	Q9BUI4	427
NOL8	SLCO6A1	Q86UG4	406
NOL8	ARHGEF28	Q8N1W1	402
NOL8	POLE2	P56282	388
NOL8	MDC1	Q14676	387

IntAct

83 interactions, top by confidence:

A	B	Type	Score
MED19	MED19	psi-mi:“MI:0914”(association)	0.730
KPNA1	TCERG1	psi-mi:“MI:0914”(association)	0.640
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
FBL	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
SRPK2	RRP9	psi-mi:“MI:0914”(association)	0.530
ZSCAN31	DHX57	psi-mi:“MI:0914”(association)	0.530
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
NOL8	IMMT	psi-mi:“MI:0915”(physical association)	0.400
NOL8	TCERG1	psi-mi:“MI:0915”(physical association)	0.400
NOL8	MAF1b1	psi-mi:“MI:0915”(physical association)	0.370
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
rep	NVL	psi-mi:“MI:0914”(association)	0.350
rl3_rl3l_human	NKRF	psi-mi:“MI:0914”(association)	0.350
rl3_rl3l_human	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
NOP2	ZNF320	psi-mi:“MI:0914”(association)	0.350
RPL36	GTPBP10	psi-mi:“MI:0914”(association)	0.350
RPL28	GTPBP10	psi-mi:“MI:0914”(association)	0.350
ILF3	GTPBP10	psi-mi:“MI:0914”(association)	0.350
APOBEC3C	GTPBP10	psi-mi:“MI:0914”(association)	0.350
RPL13A	GTPBP10	psi-mi:“MI:0914”(association)	0.350
ABT1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
RPL15	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
FGFBP1	ZNF724	psi-mi:“MI:0914”(association)	0.350
FGF8	AP3B1	psi-mi:“MI:0914”(association)	0.350
RPL4	POLRMT	psi-mi:“MI:0914”(association)	0.350

BioGRID (168): NOL8 (Affinity Capture-RNA), NOL8 (Affinity Capture-RNA), NOL8 (Affinity Capture-RNA), NOL8 (Affinity Capture-MS), NOL8 (Affinity Capture-MS), NOL8 (Synthetic Lethality), NOL8 (Affinity Capture-MS), NOL8 (Affinity Capture-MS), NOL8 (Affinity Capture-MS), NOL8 (Affinity Capture-MS), NOL8 (Affinity Capture-MS), NOL8 (Affinity Capture-MS), NOL8 (Affinity Capture-MS), WDR89 (Affinity Capture-MS), URB1 (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q2UEI8, A0JNH9, A2BIL8, A8PUI7, B1H1S4, B2GUZ2, E7FAP1, E9Q309, F1R983, O60284, P49452, P51960, P86345, Q0P5H2, Q3T0A6, Q3T8J9, Q4KLP8, Q4QY64, Q4R731, Q535K8, Q563C3, Q58EL7, Q5FBB7, Q5QJE6, Q5VT06, Q5XG21, Q65Z40, Q6KAQ7, Q6NWJ0, Q6P0N0, Q6P6I6, Q76FK4, Q7YQM1, Q7YQM2, Q80WQ8, Q8C263, Q8C551, Q8IYH5, Q8NA57, Q8R2M2

Diamond homologs: Q3UHX0, Q76FK4, Q9FGT1, Q9HFE6, Q9VWD4, Q57014, O74400

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 106 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	13	22.6×	8e-13
Viral mRNA Translation	13	22.6×	8e-13
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	13	22.4×	8e-13
Selenocysteine synthesis	13	21.4×	1e-12
Eukaryotic Translation Termination	13	21.4×	1e-12
Response of EIF2AK4 (GCN2) to amino acid deficiency	14	21.3×	4e-13
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	13	21.0×	1e-12
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	13	21.0×	1e-12

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	14	27.9×	4e-14
negative regulation of translation	8	16.9×	4e-06
rRNA processing	10	15.2×	2e-07
translation	13	14.4×	2e-09
regulation of alternative mRNA splicing, via spliceosome	5	13.1×	3e-03
ribosomal small subunit biogenesis	5	12.2×	4e-03
RNA splicing	9	8.5×	1e-04
mRNA processing	7	5.9×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

198 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	160
Likely benign	13
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2734 predictions. Top by Δscore:

Variant	Effect	Δscore
9:92297882:CAATC:C	acceptor_gain	1.0000
9:92297887:C:CC	acceptor_gain	1.0000
9:92298251:A:AC	donor_gain	1.0000
9:92298252:C:CC	donor_gain	1.0000
9:92298253:TCACC:T	donor_loss	1.0000
9:92298254:CA:C	donor_loss	1.0000
9:92298255:A:AC	donor_gain	1.0000
9:92298255:A:C	donor_loss	1.0000
9:92298255:AC:A	donor_gain	1.0000
9:92298256:C:CC	donor_gain	1.0000
9:92298256:C:T	donor_loss	1.0000
9:92298256:CC:C	donor_gain	1.0000
9:92298256:CCA:C	donor_gain	1.0000
9:92298256:CCAT:C	donor_gain	1.0000
9:92298256:CCATA:C	donor_gain	1.0000
9:92298333:GAAC:G	acceptor_gain	1.0000
9:92298335:AC:A	acceptor_gain	1.0000
9:92298336:CCTAT:C	acceptor_gain	1.0000
9:92298337:C:CC	acceptor_gain	1.0000
9:92298338:T:A	acceptor_loss	1.0000
9:92298879:CTGA:C	donor_loss	1.0000
9:92298950:CTTCT:C	acceptor_gain	1.0000
9:92298951:TTCT:T	acceptor_gain	1.0000
9:92298953:CT:C	acceptor_gain	1.0000
9:92298954:TC:T	acceptor_loss	1.0000
9:92298955:C:CC	acceptor_gain	1.0000
9:92298956:T:C	acceptor_loss	1.0000
9:92298970:C:CT	acceptor_gain	1.0000
9:92298971:A:T	acceptor_gain	1.0000
9:92299884:GTTTA:G	donor_loss	1.0000

AlphaMissense

7831 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:92318672:G:C	S144R	0.997
9:92318672:G:T	S144R	0.997
9:92318674:T:G	S144R	0.997
9:92318683:A:G	W141R	0.996
9:92318683:A:T	W141R	0.996
9:92310220:G:C	F879L	0.995
9:92310220:G:T	F879L	0.995
9:92310222:A:G	F879L	0.995
9:92318666:A:C	F146L	0.995
9:92318666:A:T	F146L	0.995
9:92318668:A:G	F146L	0.995
9:92323482:G:T	A54E	0.995
9:92310202:A:C	F885L	0.994
9:92310202:A:T	F885L	0.994
9:92310204:A:G	F885L	0.994
9:92310221:A:G	F879S	0.993
9:92316125:T:C	D167G	0.991
9:92318673:C:A	S144I	0.991
9:92310574:A:C	F858L	0.990
9:92310574:A:T	F858L	0.990
9:92310576:A:G	F858L	0.990
9:92318658:A:T	V149D	0.990
9:92318660:T:A	R148S	0.990
9:92318660:T:G	R148S	0.990
9:92318681:C:A	W141C	0.990
9:92318681:C:G	W141C	0.990
9:92321676:A:C	F91L	0.990
9:92321676:A:T	F91L	0.990
9:92321678:A:G	F91L	0.990
9:92323484:A:C	F53L	0.990

dbSNP variants (sampled 300 via entrez): RS1000206376 (9:92317105 A>C), RS1000207659 (9:92323136 G>A), RS1000263503 (9:92325752 G>T), RS1000484012 (9:92309974 C>T), RS1000558245 (9:92319165 C>G), RS1000640533 (9:92303374 A>C,G), RS1000694786 (9:92303566 C>T), RS1001156711 (9:92310355 A>C,T), RS1001342348 (9:92325199 C>T), RS1001359878 (9:92298138 C>G), RS1001563256 (9:92317578 G>C), RS1001621057 (9:92311889 C>A), RS1001642918 (9:92297240 T>C), RS1001644122 (9:92301534 G>A), RS1001676134 (9:92304413 T>C)

Disease associations

OMIM: gene MIM:611534 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_16	Malaria	9.000000e-06
GCST010725_28	Malaria	6.000000e-06
GCST010725_95	Malaria	6.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	3
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	2
Air Pollutants	affects cotreatment, decreases expression, increases abundance	2
Hydrogen Peroxide	affects expression	2
Cadmium Chloride	decreases expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, decreases expression	1
TAK-243	decreases sumoylation	1
dicrotophos	decreases expression	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	affects cotreatment, decreases expression	1
salinomycin	decreases expression	1
beta-lapachone	decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
coumarin	decreases phosphorylation	1
methacrylaldehyde	affects cotreatment, decreases expression, increases abundance	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	decreases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases abundance	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Caffeine	affects phosphorylation	1
Cisplatin	affects cotreatment, decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Diethylstilbestrol	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.