NOP14

Summary

NOP14 (NOP14 nucleolar protein, HGNC:16821) is a protein-coding gene on chromosome 4p16.3, encoding Nucleolar protein 14 (P78316). Involved in nucleolar processing of pre-18S ribosomal RNA. It is a common-essential gene (DepMap: required in 98.0% of cancer cell lines).

This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 8602 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 230 total
• Cancer dependency (DepMap): dependent in 98.0% of screened cell lines (common-essential)
• MANE Select transcript: NM_001291978

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16821
Approved symbol	NOP14
Name	NOP14 nucleolar protein
Location	4p16.3
Locus type	gene with protein product
Status	Approved
Aliases	RES4-25, UTP2
Ensembl gene	ENSG00000087269
Ensembl biotype	protein_coding
OMIM	611526
Entrez	8602

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000314262, ENST00000398071, ENST00000416614, ENST00000502735, ENST00000507120, ENST00000878857, ENST00000878858, ENST00000919453, ENST00000966689, ENST00000966690

RefSeq mRNA: 3 — MANE Select: NM_001291978 NM_001291978, NM_001291979, NM_003703

CCDS: CCDS33945, CCDS77893

Canonical transcript exons

ENST00000416614 — 18 exons

Exon	Start	End
ENSE00000556298	2949934	2950213
ENSE00000699268	2941582	2941729
ENSE00000699269	2942192	2942351
ENSE00000699270	2944073	2944226
ENSE00000699272	2945128	2945229
ENSE00000699275	2946412	2946547
ENSE00000699277	2947526	2947611
ENSE00000699281	2951114	2951245
ENSE00000699283	2952275	2952397
ENSE00000699284	2953511	2953645
ENSE00000699285	2954424	2954563
ENSE00000699286	2956670	2956811
ENSE00000854907	2939188	2939343
ENSE00000854909	2948278	2948408
ENSE00001196817	2963125	2963406
ENSE00001312822	2957606	2957740
ENSE00001635773	2937936	2938930
ENSE00003624345	2939527	2939645

Expression profiles

Bgee: expression breadth ubiquitous, 257 present calls, max score 92.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.6852 / max 444.6013, expressed in 1823 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
51160	33.2927	1823
51161	0.2317	87
51162	0.1608	47

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.54	gold quality
pancreatic ductal cell	CL:0002079	91.26	gold quality
gastrocnemius	UBERON:0001388	91.16	gold quality
muscle of leg	UBERON:0001383	90.48	gold quality
islet of Langerhans	UBERON:0000006	88.98	gold quality
adrenal tissue	UBERON:0018303	88.70	gold quality
gingival epithelium	UBERON:0001949	88.32	silver quality
calcaneal tendon	UBERON:0003701	88.13	gold quality
tongue squamous epithelium	UBERON:0006919	88.03	silver quality
body of pancreas	UBERON:0001150	87.87	gold quality
pancreas	UBERON:0001264	87.83	gold quality
muscle organ	UBERON:0001630	87.53	gold quality
skin of leg	UBERON:0001511	86.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	86.79	gold quality
left ovary	UBERON:0002119	86.54	gold quality
skin of abdomen	UBERON:0001416	86.28	gold quality
stromal cell of endometrium	CL:0002255	85.96	gold quality
gingiva	UBERON:0001828	85.91	silver quality
lymph node	UBERON:0000029	85.90	gold quality
left adrenal gland	UBERON:0001234	85.74	gold quality
esophagus mucosa	UBERON:0002469	85.69	gold quality
mucosa of transverse colon	UBERON:0004991	85.66	gold quality
right lobe of liver	UBERON:0001114	85.60	gold quality
left adrenal gland cortex	UBERON:0035825	85.59	gold quality
ovary	UBERON:0000992	85.58	gold quality
right adrenal gland	UBERON:0001233	85.24	gold quality
cerebellar hemisphere	UBERON:0002245	85.18	gold quality
right adrenal gland cortex	UBERON:0035827	85.09	gold quality
cerebellar cortex	UBERON:0002129	85.08	gold quality
squamous epithelium	UBERON:0006914	85.07	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

14 targeting NOP14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-4643	99.49	67.63	1791
HSA-MIR-21-5P	99.46	70.54	1035
HSA-MIR-590-5P	99.25	70.76	930
HSA-MIR-138-2-3P	98.91	68.33	1643
HSA-MIR-4709-5P	98.51	67.25	1335
HSA-MIR-125A-3P	97.04	66.92	902
HSA-MIR-563	96.26	66.13	450
HSA-MIR-380-5P	95.68	67.32	512

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.0% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 8)

• our study provides new evidence for NOP14 in regulating PC cell proliferation and migration, and may provide new insights for clinical diagnosis and therapy. (PMID:22425761)
• NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway. (PMID:26213846)
• Targeting NOP14 allows for effective suppression of tumor invasion in a mutp53-dependent manner, implicating NOP14 inhibition as a potential approach for attenuating metastasis in p53-mutant tumors (PMID:28280038)
• we identified an identical homozygous NOP14 variant as a possible contributing factor for RPL in two Iranian families. (PMID:29440706)
• CCND1, DNMT3B and NOP14 were identified as direct targets of miR-502-5p. (PMID:31971654)
• NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3beta/beta-catenin signaling pathway. (PMID:34218653)
• Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer. (PMID:35473611)
• NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity. (PMID:38272224)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nop14	ENSDARG00000098859
mus_musculus	Nop14	ENSMUSG00000036693
rattus_norvegicus	Nop14	ENSRNOG00000012147
drosophila_melanogaster	l(3)07882	FBGN0010926
caenorhabditis_elegans	nol-14	WBGENE00021660

Protein

Protein identifiers

Nucleolar protein 14 — P78316 (reviewed: P78316)

Alternative names: Nucleolar complex protein 14

All UniProt accessions (2): P78316, E9PFK5

UniProt curated annotations — full annotation on UniProt →

Function. Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.

Subunit / interactions. Component of the ribosomal small subunit (SSU) processome.

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the NOP14 family.

Isoforms (2)

UniProt ID	Names	Canonical?
P78316-1	1	yes
P78316-2	2

RefSeq proteins (3): NP_001278907, NP_001278908, NP_003694 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007276	Nop14	Family

Pfam: PF04147

UniProt features (20 total): compositionally biased region 8, modified residue 4, region of interest 3, splice variant 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7MQA	ELECTRON MICROSCOPY	2.7
7MQ8	ELECTRON MICROSCOPY	3.6
7MQ9	ELECTRON MICROSCOPY	3.87

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P78316-F1	73.67	0.23

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 96, 146, 148, 349

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6790901	rRNA modification in the nucleus and cytosol
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol

MSigDB gene sets: 142 (showing top): TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP, GOBP_RIBOSOME_BIOGENESIS, GOBP_MATURATION_OF_SSU_RRNA, KANNAN_TP53_TARGETS_DN, GNF2_MCM5, PUJANA_CHEK2_PCC_NETWORK, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_MATURATION_OF_5_8S_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN, GOBP_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA, chr4p16, WANG_CISPLATIN_RESPONSE_AND_XPC_DN, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN

GO Biological Process (8): endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000447), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000462), endonucleolytic cleavage to generate mature 5’-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000472), endonucleolytic cleavage in 5’-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000480), rRNA processing (GO:0006364), maturation of SSU-rRNA (GO:0030490), ribosomal small subunit biogenesis (GO:0042274), ribosome biogenesis (GO:0042254)

GO Molecular Function (3): RNA binding (GO:0003723), enzyme binding (GO:0019899), snoRNA binding (GO:0030515)

GO Cellular Component (7): nucleoplasm (GO:0005654), nucleolus (GO:0005730), membrane (GO:0016020), 90S preribosome (GO:0030686), Noc4p-Nop14p complex (GO:0030692), small-subunit processome (GO:0032040), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	2

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3
ribosome biogenesis	2
ribonucleoprotein complex biogenesis	2
nuclear lumen	2
cellular anatomical structure	2
preribosome	2
t-UTP complex	2
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1
maturation of SSU-rRNA	1
rRNA 5’-end processing	1
RNA processing	1
rRNA metabolic process	1
rRNA processing	1
ribosomal small subunit biogenesis	1
nucleic acid binding	1
protein binding	1
RNA binding	1
intracellular membraneless organelle	1
90S preribosome	1
preribosome, small subunit precursor	1
Noc complex	1
nucleolus	1
nuclear protein-containing complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2159 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NOP14	EMG1	Q92979	986
NOP14	BYSL	Q13895	863
NOP14	MAT2A	P31153	828
NOP14	NOC4L	Q9BVI4	821
NOP14	BMS1	Q14692	811
NOP14	UTP14A	Q9BVJ6	811
NOP14	UTP20	O75691	798
NOP14	NAT10	Q9H0A0	782
NOP14	PWP2	Q15269	777
NOP14	RRP12	Q5JTH9	766
NOP14	NOP56	O00567	752
NOP14	PNO1	Q9NRX1	735
NOP14	NOP58	Q9Y2X3	733
NOP14	RRP9	O43818	708
NOP14	TBL3	Q12788	698

IntAct

163 interactions, top by confidence:

A	B	Type	Score
S100B	S100A4	psi-mi:“MI:0914”(association)	0.870
EZH2	EPOP	psi-mi:“MI:0914”(association)	0.730
SEC31A	SEC13	psi-mi:“MI:0914”(association)	0.730
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
BYSL	PARN	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
ZNF414	AHCYL1	psi-mi:“MI:0914”(association)	0.640
STX7	SNAP23	psi-mi:“MI:0914”(association)	0.640
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
RRP8	NVL	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
N	NOP56	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
KRR1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
IPO5	SLC27A2	psi-mi:“MI:0914”(association)	0.530
SEC31A	NOP14	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
DAXX	TNRC18	psi-mi:“MI:0914”(association)	0.530
EDA	AP3B1	psi-mi:“MI:0914”(association)	0.530
PURG	U2SURP	psi-mi:“MI:0914”(association)	0.530
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
NOP14	HMGA1	psi-mi:“MI:0915”(physical association)	0.400
NOP14	HNRNPC	psi-mi:“MI:0915”(physical association)	0.400
Ect2	STX18	psi-mi:“MI:0914”(association)	0.350
Vps4b	CNOT1	psi-mi:“MI:0914”(association)	0.350

BioGRID (237): NOP14 (Affinity Capture-RNA), NOP14 (Affinity Capture-RNA), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS), NOP14 (Affinity Capture-MS)

ESM2 similar proteins: A1A5P2, A6QNR1, A8WY26, D3ZND0, O15213, O59678, P27672, P78316, Q0V8M0, Q15050, Q24K12, Q28IV8, Q2KIH4, Q2KII6, Q3T0Q8, Q3T0Z5, Q3UFY0, Q4KLC4, Q5M985, Q5RAS1, Q5RJT2, Q5TAP6, Q5TJE7, Q5ZKM1, Q640M1, Q6EJB6, Q6P0I6, Q6PFJ1, Q8BK35, Q8IY81, Q8N9T8, Q8NEJ9, Q8R3N1, Q8VDQ9, Q96BZ8, Q96EU6, Q9BRP8, Q9BRR8, Q9BVJ6, Q9C086

Diamond homologs: P78316, Q8R3N1, Q9VEJ2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 186 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	10	25.1×	1e-10
Cap-dependent Translation Initiation	10	25.1×	1e-10
SARS-CoV-1 modulates host translation machinery	10	25.1×	1e-10
Eukaryotic Translation Elongation	10	22.6×	3e-10
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	10	22.1×	4e-10
Influenza Viral RNA Transcription and Replication	12	21.0×	1e-11
rRNA processing in the nucleus and cytosol	16	20.9×	7e-15
rRNA modification in the nucleus and cytosol	13	19.8×	3e-12

GO biological processes:

GO term	Partners	Fold	FDR
maturation of SSU-rRNA	7	32.3×	2e-07
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	7	28.4×	5e-07
ribosomal small subunit biogenesis	20	27.4×	7e-21
cytoplasmic translation	16	17.9×	2e-13
rRNA processing	15	12.8×	2e-10
translation	16	9.9×	1e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

230 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	171
Likely benign	11
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

3180 predictions. Top by Δscore:

Variant	Effect	Δscore
4:2939213:T:TA	donor_gain	1.0000
4:2939344:C:CC	acceptor_gain	1.0000
4:2939526:CA:C	donor_gain	1.0000
4:2939530:TTG:T	donor_gain	1.0000
4:2939555:T:TA	donor_gain	1.0000
4:2940549:CAT:C	donor_gain	1.0000
4:2941576:CCTCA:C	donor_loss	1.0000
4:2941577:CTCA:C	donor_loss	1.0000
4:2941578:TCA:T	donor_loss	1.0000
4:2941579:CA:C	donor_loss	1.0000
4:2941581:C:CT	donor_loss	1.0000
4:2941726:CAGT:C	acceptor_gain	1.0000
4:2944068:CTCA:C	donor_loss	1.0000
4:2944069:TCACC:T	donor_loss	1.0000
4:2944070:CACC:C	donor_loss	1.0000
4:2944222:GGGCA:G	acceptor_gain	1.0000
4:2944223:GGCA:G	acceptor_gain	1.0000
4:2944224:GCA:G	acceptor_gain	1.0000
4:2944225:CA:C	acceptor_gain	1.0000
4:2944225:CAC:C	acceptor_gain	1.0000
4:2944226:AC:A	acceptor_loss	1.0000
4:2944227:C:CC	acceptor_gain	1.0000
4:2945123:CGCA:C	donor_loss	1.0000
4:2945124:GCA:G	donor_loss	1.0000
4:2945125:CA:C	donor_loss	1.0000
4:2945127:C:CT	donor_loss	1.0000
4:2945226:TGAG:T	acceptor_gain	1.0000
4:2945228:AGCT:A	acceptor_loss	1.0000
4:2945229:GC:G	acceptor_loss	1.0000
4:2945230:C:CA	acceptor_loss	1.0000

AlphaMissense

5677 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:2939239:C:G	R808P	0.998
4:2939255:C:G	A803P	0.996
4:2957740:G:T	R66S	0.995
4:2939234:C:G	D810H	0.994
4:2939248:C:G	R805P	0.994
4:2957739:C:G	R66P	0.994
4:2939219:C:G	A815P	0.993
4:2939233:T:G	D810A	0.993
4:2939254:G:T	A803D	0.993
4:2939233:T:A	D810V	0.992
4:2939259:T:A	K801N	0.992
4:2939259:T:G	K801N	0.992
4:2939269:C:G	R798P	0.992
4:2938884:C:G	A841P	0.991
4:2938898:A:G	L836P	0.991
4:2939223:G:C	F813L	0.990
4:2939223:G:T	F813L	0.990
4:2939225:A:G	F813L	0.990
4:2956762:A:G	L127S	0.990
4:2938918:T:A	R829S	0.989
4:2938918:T:G	R829S	0.989
4:2963224:G:C	F32L	0.989
4:2963224:G:T	F32L	0.989
4:2963226:A:G	F32L	0.989
4:2939287:A:G	L792P	0.988
4:2938886:A:G	L840P	0.986
4:2939221:A:G	L814P	0.986
4:2939224:A:G	F813S	0.986
4:2939240:G:T	R808S	0.985
4:2963197:G:C	F41L	0.984

dbSNP variants (sampled 300 via entrez): RS1000019339 (4:2952277 C>T), RS10000927 (4:2938702 C>T), RS1000115863 (4:2962812 G>A,C), RS10002702 (4:2938335 A>C,G,T), RS1000325986 (4:2955796 G>A), RS1000378478 (4:2956070 A>G), RS1000534086 (4:2965341 C>T), RS1000626257 (4:2960707 A>T), RS1000661384 (4:2957084 C>A), RS1000955249 (4:2940749 T>C), RS1001042502 (4:2945375 G>C), RS1001052841 (4:2962327 G>A,C), RS1001094861 (4:2945681 C>G), RS1001186450 (4:2960859 T>C), RS1001277981 (4:2951528 T>C)

Disease associations

OMIM: gene MIM:611526 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004691_6	Huntington’s disease progression	3.000000e-06
GCST008809_2	Smoking behaviour (cigarettes smoked per day)	3.000000e-08
GCST009524_9	Household income (MTAG)	2.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008336	disease progression measurement
EFO:0006525	cigarettes per day measurement
EFO:0009695	household income

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	2
Aflatoxin B1	affects cotreatment, decreases expression, decreases methylation	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
deoxynivalenol	increases expression	1
sodium arsenite	decreases expression	1
aflatoxin B2	increases methylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
2-palmitoylglycerol	increases expression	1
ICG 001	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Acrolein	increases oxidation, increases abundance, affects cotreatment	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Benzo(a)pyrene	increases mutagenesis	1
Cuprizone	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Estradiol	increases expression	1
Haloperidol	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Ozone	affects cotreatment, increases oxidation, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
T-2 Toxin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.