NPHP3-AS1

Summary

NPHP3-AS1 (NPHP3 antisense RNA 1, HGNC:24129) is a long non-coding RNA gene on chromosome 3q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24129
Approved symbol	NPHP3-AS1
Name	NPHP3 antisense RNA 1
Location	3q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248724
Ensembl biotype	lncRNA
Entrez	348808
RNAcentral	URS0000CCE05E — lncRNA, 3102 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000489343, ENST00000504440, ENST00000815291, ENST00000815292, ENST00000815293, ENST00000815294, ENST00000815295, ENST00000815296, ENST00000815297, ENST00000815298

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000489343 — 5 exons

Exon	Start	End
ENSE00001955874	132748728	132750777
ENSE00003512174	132721750	132722379
ENSE00003665758	132726361	132726426
ENSE00003698334	132733324	132733444
ENSE00003701765	132727493	132727582

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 83.00.

Top tissues by expression

167 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	83.00	gold quality
secondary oocyte	CL:0000655	79.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.48	gold quality
buccal mucosa cell	CL:0002336	68.04	silver quality
oocyte	CL:0000023	64.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.01	gold quality
sperm	CL:0000019	61.08	gold quality
ventricular zone	UBERON:0003053	59.67	gold quality
cartilage tissue	UBERON:0002418	52.41	gold quality
leukocyte	CL:0000738	51.32	silver quality
monocyte	CL:0000576	50.68	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	46.69	silver quality
skin of hip	UBERON:0001554	46.54	silver quality
islet of Langerhans	UBERON:0000006	46.41	gold quality
body of stomach	UBERON:0001161	46.40	gold quality
gall bladder	UBERON:0002110	46.38	gold quality
pancreas	UBERON:0001264	45.09	gold quality
vastus lateralis	UBERON:0001379	44.93	gold quality
quadriceps femoris	UBERON:0001377	44.81	gold quality
muscle of leg	UBERON:0001383	44.59	silver quality
bone marrow	UBERON:0002371	44.31	silver quality
tibial nerve	UBERON:0001323	44.23	silver quality
gastrocnemius	UBERON:0001388	44.17	silver quality
vermiform appendix	UBERON:0001154	43.75	silver quality
duodenum	UBERON:0002114	43.61	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
stomach	UBERON:0000945	42.82	silver quality
lymph node	UBERON:0000029	42.65	gold quality
superior vestibular nucleus	UBERON:0007227	42.56	gold quality
gingival epithelium	UBERON:0001949	42.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• BIRC5, GAJ5, and lncRNA NPHP3-AS1 Are Correlated with the Development of Atrial Fibrillation-Valvular Heart Disease. (PMID:33518654)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.