NPSR1-AS1

Summary

NPSR1-AS1 (NPSR1 antisense RNA 1, HGNC:22128) is a long non-coding RNA gene on chromosome 7p14.3.

This gene is located within a region that has been associated with asthma susceptibility. The locus is considered non-protein-coding based on lack of protein homology and a lack of experimental support for an encoded protein. Three alternatively spliced transcript variants have been identified for this gene.

Source: NCBI Gene 404744 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22128
Approved symbol	NPSR1-AS1
Name	NPSR1 antisense RNA 1
Location	7p14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	AAA1, IMAGE:4827585
Ensembl gene	ENSG00000197085
Ensembl biotype	lncRNA
OMIM	608596
Entrez	404744
RNAcentral	URS000075BCA2 — lncRNA, 1409 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 15 lncRNA, 1 retained_intron

ENST00000358772, ENST00000419766, ENST00000428922, ENST00000431669, ENST00000436945, ENST00000439852, ENST00000539747, ENST00000737194, ENST00000737195, ENST00000737196, ENST00000737197, ENST00000737198, ENST00000737199, ENST00000737200, ENST00000737201, ENST00000737202

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000358772 — 4 exons

Exon	Start	End
ENSE00001754485	34568252	34568372
ENSE00003693991	34758074	34758272
ENSE00003720352	34569712	34569861
ENSE00003737514	34728737	34728816

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 80.73.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1819 / max 48.5055, expressed in 20 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
83523	0.1089	14
83524	0.0234	8
83526	0.0189	10
83525	0.0109	6
83527	0.0105	6
83522	0.0093	5

Top tissues by expression

193 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.26	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.23	gold quality
ganglionic eminence	UBERON:0004023	64.98	gold quality
islet of Langerhans	UBERON:0000006	61.42	gold quality
sural nerve	UBERON:0015488	58.69	silver quality
monocyte	CL:0000576	56.40	gold quality
muscle of leg	UBERON:0001383	55.54	gold quality
pancreas	UBERON:0001264	54.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.73	gold quality
smooth muscle tissue	UBERON:0001135	54.21	gold quality
gastrocnemius	UBERON:0001388	53.80	gold quality
prefrontal cortex	UBERON:0000451	53.49	gold quality
adult mammalian kidney	UBERON:0000082	53.19	gold quality
gall bladder	UBERON:0002110	52.48	gold quality
lower lobe of lung	UBERON:0008949	51.60	silver quality
upper lobe of lung	UBERON:0008948	51.35	silver quality
lower esophagus muscularis layer	UBERON:0035833	50.94	gold quality
right ovary	UBERON:0002118	50.74	gold quality
adrenal tissue	UBERON:0018303	50.60	silver quality
metanephros cortex	UBERON:0010533	49.98	gold quality
kidney	UBERON:0002113	49.92	gold quality
tibial artery	UBERON:0007610	49.38	gold quality
right atrium auricular region	UBERON:0006631	49.24	gold quality
tibial nerve	UBERON:0001323	48.83	gold quality
cardiac atrium	UBERON:0002081	48.68	gold quality
cerebellar vermis	UBERON:0004720	48.32	gold quality
left adrenal gland cortex	UBERON:0035825	47.36	gold quality
heart	UBERON:0000948	47.12	gold quality
muscle layer of sigmoid colon	UBERON:0035805	46.97	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	679.08
E-CURD-119	yes	51.59
E-ANND-3	yes	5.67

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Hypoxia-inducible long noncoding RNA NPSR1-AS1 promotes the proliferation and glycolysis of hepatocellular carcinoma cells by regulating the MAPK/ERK pathway. (PMID:33008585)
• NPSR1-AS1 activates the MAPK pathway to facilitate thyroid cancer cell malignant behaviors via recruiting ELAVL1 to stabilize NPSR1 mRNA. (PMID:35030041)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.