# NQO2-AS1 > Gene · canonical: https://sugi.bio/atlas/gene/NQO2-AS1/ > Atlas v1.12.2 · generated 2026-10-13T13:32:47+00:00 ## Summary **NQO2-AS1** (NQO2 antisense RNA 1, HGNC:40407) is a long non-coding RNA gene on chromosome 6p25.2. **At a glance** - **Gene type:** non-coding (lncRNA) — no protein product. - **Sense gene:** antisense to [NQO2](/atlas/gene/NQO2/) — the sense gene carries 3 GWAS associations, 45 ChEMBL molecules (the sense gene's biology, not this transcript's) - **GTEx eGene:** eQTL in 37 tissues, sQTL in 3 (q < 0.05) ## Identifiers ### Gene identifiers | Field | Value | | --- | --- | | HGNC ID | HGNC:40407 | | Approved symbol | NQO2-AS1 | | Name | NQO2 antisense RNA 1 | | Location | 6p25.2 | | Locus type | RNA, long non-coding | | Status | Approved | | Ensembl gene | ENSG00000224846 | | Ensembl biotype | lncRNA | | Entrez | 105374888 | | RNAcentral | URS00026A2453 — lncRNA, 1735 nt, 1 organism(s) | ## Gene structure ### Transcript identifiers **Ensembl transcripts: 8** — 8 lncRNA **Transcript support level (Ensembl TSL; 1 = fully mRNA-supported):** TSL 2: 2 `ENST00000429319`, `ENST00000456189`, `ENST00000658240`, `ENST00000660868`, `ENST00000665347`, `ENST00000793652`, `ENST00000793653`, `ENST00000793654` **RefSeq mRNA: 0** #### Canonical transcript exons `ENST00000429319` — 2 exons | Exon | Start | End | | --- | --- | --- | | ENSE00001668902 | 2989726 | 2990011 | | ENSE00001725799 | 2999013 | 2999134 | ### Expression profiles **Bgee:** expression breadth **ubiquitous**, 153 present calls, max score 85.04. **FANTOM5 (CAGE):** breadth **tissue_specific**, TPM avg 0.1559 / max 19.6253, expressed in 63 samples. **Highest expression (Bgee):** testis, male germ line stem cell (sensu Vertebrata) in testis, primordial germ cell in gonad, adrenal gland cortex, adrenal gland. #### Genetic regulation across tissues (GTEx eQTL / sQTL) NQO2-AS1 is an **eGene** in GTEx v10 — its expression is genetically regulated (eQTL) in **37** tissues and its splicing (sQTL) in **3** (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant's alternative allele. showing 20 of 40 significant tissue × QTL associations: | Tissue | QTL | q-value | Slope | Lead variant | | --- | --- | --- | --- | --- | | Testis | sqtl | 9.6e-151 | +1.70 | 6:2999009:C:T | | Testis | eqtl | 2.6e-141 | +1.08 | 6:2999009:C:T | | Skin Sun Exposed Lower leg | eqtl | 2.6e-103 | +1.06 | 6:2999009:C:T | | Skin Not Sun Exposed Suprapubic | eqtl | 3.9e-90 | +1.04 | 6:2999009:C:T | | Artery Tibial | eqtl | 4.6e-75 | +0.98 | 6:2999009:C:T | | Adipose Subcutaneous | eqtl | 1.0e-58 | +0.92 | 6:2999009:C:T | | Adrenal Gland | eqtl | 2.7e-44 | +1.16 | 6:2999009:C:T | | Adipose Visceral Omentum | eqtl | 4.5e-44 | +0.88 | 6:2999009:C:T | | Artery Aorta | eqtl | 2.6e-37 | +0.92 | 6:2999009:C:T | | Pituitary | eqtl | 1.0e-34 | +1.11 | 6:2999009:C:T | | Whole Blood | eqtl | 1.2e-33 | +0.63 | 6:2999320:G:A | | Thyroid | eqtl | 6.3e-31 | +0.67 | 6:2999009:C:T | | Heart Atrial Appendage | eqtl | 1.1e-30 | +0.88 | 6:2999009:C:T | | Adrenal Gland | sqtl | 2.6e-29 | -1.05 | 6:2999009:C:T | | Nerve Tibial | eqtl | 3.2e-29 | +0.67 | 6:2999009:C:T | | Esophagus Muscularis | eqtl | 1.2e-28 | +0.73 | 6:2999320:G:A | | Liver | eqtl | 3.9e-28 | +1.11 | 6:2999009:C:T | | Breast Mammary Tissue | eqtl | 5.7e-26 | +0.73 | 6:2999009:C:T | | Brain Hypothalamus | eqtl | 3.8e-23 | +0.99 | 6:2999009:C:T | | Esophagus Gastroesophageal Junction | eqtl | 1.4e-22 | +0.87 | 6:2997310:A:C | #### FANTOM5 promoters 1 alternative TSS: | Promoter ID | TPM avg | Samples expressed | | --- | --- | --- | | 71444 | 0.1559 | 63 | #### Top tissues by expression showing 100 of 241 tissues by Bgee expression score (0-100, higher = more expressed): | Tissue | Anatomy ID | Expression score | Quality | | --- | --- | --- | --- | | left testis | UBERON:0004533 | 85.04 | gold quality | | male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 84.45 | silver quality | | right testis | UBERON:0004534 | 84.41 | gold quality | | primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 83.22 | gold quality | | testis | UBERON:0000473 | 81.76 | gold quality | | right adrenal gland cortex | UBERON:0035827 | 78.93 | gold quality | | right adrenal gland | UBERON:0001233 | 78.86 | gold quality | | left adrenal gland cortex | UBERON:0035825 | 77.11 | gold quality | | left adrenal gland | UBERON:0001234 | 76.49 | gold quality | | adrenal tissue | UBERON:0018303 | 75.69 | gold quality | | adrenal cortex | UBERON:0001235 | 74.91 | gold quality | | monocyte | CL:0000576 | 74.27 | gold quality | | adrenal gland | UBERON:0002369 | 74.07 | gold quality | | leukocyte | CL:0000738 | 73.83 | gold quality | | apex of heart | UBERON:0002098 | 73.68 | gold quality | | metanephros cortex | UBERON:0010533 | 67.85 | gold quality | | bone marrow cell | CL:0002092 | 66.71 | silver quality | | lower esophagus mucosa | UBERON:0035834 | 66.19 | gold quality | | islet of Langerhans | UBERON:0000006 | 66.08 | gold quality | | ganglionic eminence | UBERON:0004023 | 65.33 | gold quality | | stromal cell of endometrium | CL:0002255 | 64.54 | gold quality | | hindlimb stylopod muscle | UBERON:0004252 | 64.50 | gold quality | | right coronary artery | UBERON:0001625 | 63.80 | gold quality | | ventricular zone | UBERON:0003053 | 63.32 | gold quality | | granulocyte | CL:0000094 | 62.87 | gold quality | | adult mammalian kidney | UBERON:0000082 | 62.41 | gold quality | | cortex of kidney | UBERON:0001225 | 60.81 | gold quality | | cerebellar hemisphere | UBERON:0002245 | 60.64 | gold quality | | cerebellar cortex | UBERON:0002129 | 60.45 | gold quality | | vermiform appendix | UBERON:0001154 | 60.43 | gold quality | | left coronary artery | UBERON:0001626 | 60.29 | gold quality | | popliteal artery | UBERON:0002250 | 60.25 | gold quality | | tibial artery | UBERON:0007610 | 60.23 | gold quality | | secondary oocyte | CL:0000655 | 59.76 | gold quality | | pancreas | UBERON:0001264 | 59.74 | gold quality | | metanephros | UBERON:0000081 | 59.72 | gold quality | | right hemisphere of cerebellum | UBERON:0014890 | 59.71 | gold quality | | right lobe of liver | UBERON:0001114 | 59.29 | gold quality | | coronary artery | UBERON:0001621 | 59.25 | gold quality | | cerebellum | UBERON:0002037 | 58.93 | gold quality | | adenohypophysis | UBERON:0002196 | 58.92 | gold quality | | aorta | UBERON:0000947 | 58.86 | gold quality | | omental fat pad | UBERON:0010414 | 58.40 | gold quality | | heart left ventricle | UBERON:0002084 | 58.37 | gold quality | | peritoneum | UBERON:0002358 | 58.35 | gold quality | | rectum | UBERON:0001052 | 58.08 | gold quality | | right atrium auricular region | UBERON:0006631 | 58.07 | gold quality | | kidney | UBERON:0002113 | 57.87 | gold quality | | cardiac ventricle | UBERON:0002082 | 57.68 | gold quality | | cardiac atrium | UBERON:0002081 | 57.58 | gold quality | | calcaneal tendon | UBERON:0003701 | 57.44 | gold quality | | adipose tissue of abdominal region | UBERON:0007808 | 57.42 | gold quality | | heart | UBERON:0000948 | 57.40 | gold quality | | descending thoracic aorta | UBERON:0002345 | 57.33 | gold quality | | thoracic aorta | UBERON:0001515 | 57.32 | gold quality | | ascending aorta | UBERON:0001496 | 57.17 | gold quality | | muscle of leg | UBERON:0001383 | 56.97 | gold quality | | body of pancreas | UBERON:0001150 | 56.94 | gold quality | | spleen | UBERON:0002106 | 56.88 | gold quality | | blood | UBERON:0000178 | 56.71 | gold quality | | right uterine tube | UBERON:0001302 | 56.63 | gold quality | | pituitary gland | UBERON:0000007 | 56.61 | gold quality | | gastrocnemius | UBERON:0001388 | 56.31 | gold quality | | gall bladder | UBERON:0002110 | 56.04 | gold quality | | left lobe of thyroid gland | UBERON:0001120 | 55.76 | gold quality | | olfactory segment of nasal mucosa | UBERON:0005386 | 55.51 | gold quality | | anterior cingulate cortex | UBERON:0009835 | 55.43 | gold quality | | thyroid gland | UBERON:0002046 | 55.24 | gold quality | | prefrontal cortex | UBERON:0000451 | 55.13 | gold quality | | right frontal lobe | UBERON:0002810 | 54.76 | gold quality | | small intestine Peyer's patch | UBERON:0003454 | 54.49 | gold quality | | amygdala | UBERON:0001876 | 54.48 | gold quality | | caecum | UBERON:0001153 | 54.43 | gold quality | | anatomical system | UBERON:0000467 | 54.18 | gold quality | | lymph node | UBERON:0000029 | 54.05 | gold quality | | esophagogastric junction muscularis propria | UBERON:0035841 | 54.04 | gold quality | | caudate nucleus | UBERON:0001873 | 54.01 | gold quality | | right ovary | UBERON:0002118 | 53.97 | gold quality | | body of stomach | UBERON:0001161 | 53.94 | gold quality | | right lobe of thyroid gland | UBERON:0001119 | 53.93 | gold quality | | multicellular organism | UBERON:0000468 | 53.89 | gold quality | | material anatomical entity | UBERON:0000465 | 53.88 | gold quality | | upper lobe of left lung | UBERON:0008952 | 53.84 | gold quality | | small intestine | UBERON:0002108 | 53.80 | gold quality | | muscle layer of sigmoid colon | UBERON:0035805 | 53.79 | gold quality | | Brodmann (1909) area 9 | UBERON:0013540 | 53.73 | gold quality | | stomach | UBERON:0000945 | 53.72 | gold quality | | tibial nerve | UBERON:0001323 | 53.60 | gold quality | | lower esophagus | UBERON:0013473 | 53.45 | gold quality | | nucleus accumbens | UBERON:0001882 | 53.34 | gold quality | | lower esophagus muscularis layer | UBERON:0035833 | 53.33 | gold quality | | esophagus | UBERON:0001043 | 53.22 | gold quality | | subcutaneous adipose tissue | UBERON:0002190 | 53.06 | gold quality | | mucosa of stomach | UBERON:0001199 | 52.99 | gold quality | | esophagus mucosa | UBERON:0002469 | 52.90 | gold quality | | C1 segment of cervical spinal cord | UBERON:0006469 | 52.88 | gold quality | | dorsolateral prefrontal cortex | UBERON:0009834 | 52.74 | gold quality | | upper lobe of lung | UBERON:0008948 | 52.54 | gold quality | | hypothalamus | UBERON:0001898 | 52.37 | gold quality | | liver | UBERON:0002107 | 52.29 | gold quality | #### Single-cell (SCXA) Detected in 1 experiment(s), a significant marker in 0. | Experiment | Marker? | Max mean expression | | --- | --- | --- | | [E-ANND-3](https://www.ebi.ac.uk/gxa/sc/experiments/E-ANND-3) | no | 0.77 | ### Regulation **Is transcription factor: no** ### Cross-species orthologs **0 orthologs** ### Genomic neighbors (locus context) Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that). | Symbol | Type | Entrez | | --- | --- | --- | | [MIR4645](/atlas/gene/MIR4645/) | ncRNA | 100616285 | | [LINC01011](/atlas/gene/LINC01011/) | ncRNA | 401232 | | [SERPINB6](/atlas/gene/SERPINB6/) | protein-coding | 5269 | | [SERPINB9](/atlas/gene/SERPINB9/) | protein-coding | 5272 | | [NQO2](/atlas/gene/NQO2/) | protein-coding | 4835 | | [SERPINB9-AS1](/atlas/gene/SERPINB9-AS1/) | ncRNA | 101927730 | ## Protein *Non-coding RNA — no protein product.* ## Function ### Gene-set membership (MSigDB) This non-coding RNA is a member of 9 curated MSigDB gene sets — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data). `chr6p25`, `ALKBH3_TARGET_GENES`, `NAB2_TARGET_GENES`, `RYBP_TARGET_GENES`, `SALL4_TARGET_GENES`, `SAFB2_TARGET_GENES`, `DESCARTES_MAIN_FETAL_MUC13_DMBT1_POSITIVE_CELLS`, `ATXN7L3_TARGET_GENES`, `NR1H4_TARGET_GENES` ## Disease & clinical *No curated disease, variant, or cancer-driver associations.* ## Drugs & pharmacology ### ncRNA–drug associations Curated non-coding-RNA → drug associations (drug response / resistance / target). 2 ncRNA–drug associations: | Drug | Relation | Effect | Condition | | --- | --- | --- | --- | | [Dexamethasone](/atlas/drug/dexamethasone/) | drug_target | up-regulated | cell line (HepG2) | | [Panobinostat](/atlas/drug/panobinostat/) | drug_target | down-regulated | "cell line (SK-NEP-1, G401)" | ## Related Atlas pages - **Associated drugs (ncRNA: response / resistance):** [Dexamethasone](/atlas/drug/dexamethasone/), [Panobinostat](/atlas/drug/panobinostat/)