NR2F1-AS1

Summary

NR2F1-AS1 (NR2F1 regulatory antisense RNA 1, HGNC:48622) is a long non-coding RNA gene on chromosome 5q15.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48622
Approved symbol	NR2F1-AS1
Name	NR2F1 regulatory antisense RNA 1
Location	5q15
Locus type	RNA, long non-coding
Status	Approved
Aliases	NAS1, FLJ42709
Ensembl gene	ENSG00000237187
Ensembl biotype	lncRNA
Entrez	441094
RNAcentral	URS0000D5A473 — lncRNA, 2677 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 90 — 90 lncRNA

ENST00000503134, ENST00000504474, ENST00000507963, ENST00000510254, ENST00000513055, ENST00000606165, ENST00000606188, ENST00000606233, ENST00000606696, ENST00000606739, ENST00000607112, ENST00000607195, ENST00000607797, ENST00000607831, ENST00000652888, ENST00000653133, ENST00000653235, ENST00000653284, ENST00000653325, ENST00000653419, ENST00000653510, ENST00000653598, ENST00000653643, ENST00000654055, ENST00000654431, ENST00000654617, ENST00000654862, ENST00000655454, ENST00000655613, ENST00000656079, ENST00000656155, ENST00000656231, ENST00000656357, ENST00000656921, ENST00000657648, ENST00000658662, ENST00000659013, ENST00000659336, ENST00000659381, ENST00000659983, ENST00000660272, ENST00000660523, ENST00000660787, ENST00000661182, ENST00000661345, ENST00000661573, ENST00000661661, ENST00000661870, ENST00000663076, ENST00000663096, ENST00000664017, ENST00000664135, ENST00000664168, ENST00000664241, ENST00000664359, ENST00000665047, ENST00000665095, ENST00000665725, ENST00000665798, ENST00000666033, ENST00000666791, ENST00000666995, ENST00000667268, ENST00000667752, ENST00000668988, ENST00000669203, ENST00000669221, ENST00000670457, ENST00000670690, ENST00000670693, ENST00000670813, ENST00000671166, ENST00000671432, ENST00000671514, ENST00000671683, ENST00000815532, ENST00000815533, ENST00000815534, ENST00000815535, ENST00000815536, ENST00000815537, ENST00000815538, ENST00000815539, ENST00000815540, ENST00000815541, ENST00000815542, ENST00000815543, ENST00000815544, ENST00000815545, ENST00000815546

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503134 — 9 exons

Exon	Start	End
ENSE00002024238	93563364	93563463
ENSE00002045799	93554874	93554995
ENSE00002061408	93553761	93553863
ENSE00002062414	93543689	93544024
ENSE00002529348	93544795	93544915
ENSE00003701415	93438703	93438741
ENSE00003859737	93580467	93581199
ENSE00003883365	93411088	93411509
ENSE00003888005	93535185	93535243

Expression profiles

Bgee: expression breadth ubiquitous, 204 present calls, max score 94.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.2457 / max 143.5361, expressed in 1168 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62582	3.0128	966
62581	0.9483	409
62585	0.7872	414
62584	0.4106	226
62586	0.2626	131
62583	0.2045	94
62588	0.1887	88
62580	0.1886	67
62587	0.1429	59
62578	0.0760	28

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
anterior cingulate cortex	UBERON:0009835	94.82	gold quality
right frontal lobe	UBERON:0002810	94.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	94.64	gold quality
prefrontal cortex	UBERON:0000451	94.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.31	gold quality
neocortex	UBERON:0001950	93.48	gold quality
frontal cortex	UBERON:0001870	93.47	gold quality
amygdala	UBERON:0001876	92.79	gold quality
cerebral cortex	UBERON:0000956	91.86	gold quality
ganglionic eminence	UBERON:0004023	91.28	gold quality
cerebellar hemisphere	UBERON:0002245	91.25	gold quality
cerebellar cortex	UBERON:0002129	91.18	gold quality
sperm	CL:0000019	91.05	gold quality
sural nerve	UBERON:0015488	90.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.73	gold quality
primary visual cortex	UBERON:0002436	90.72	gold quality
hypothalamus	UBERON:0001898	90.50	gold quality
cerebellum	UBERON:0002037	90.33	gold quality
superior frontal gyrus	UBERON:0002661	90.02	gold quality
cortical plate	UBERON:0005343	89.97	gold quality
lateral nuclear group of thalamus	UBERON:0002736	89.73	gold quality
caudate nucleus	UBERON:0001873	89.70	gold quality
forebrain	UBERON:0001890	89.42	gold quality
brain	UBERON:0000955	89.19	gold quality
left ovary	UBERON:0002119	89.17	gold quality
tibial nerve	UBERON:0001323	89.08	gold quality
temporal lobe	UBERON:0001871	89.04	gold quality
endothelial cell	CL:0000115	88.70	gold quality
right ovary	UBERON:0002118	88.70	gold quality
putamen	UBERON:0001874	88.40	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	58.27
E-CURD-119	yes	11.35
E-ANND-3	yes	6.89

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• Results demonstrated that NR2F1-AS1 was highly expressed in EC, which involved in the proliferation and migration of EC cells through downregulation of miR-363 to target SOX4 and regulating PI3K/AKT/GSK-3(beta) pathway. (PMID:31109400)
• NR2F1-AS1 regulated miR-423-5p/SOX12 to promote proliferation and invasion of papillary thyroid carcinoma. (PMID:31692033)
• LncRNA NR2F1-AS1 promotes proliferation and metastasis of ESCC cells via regulating EMT. (PMID:32329844)
• Long non-coding NR2F1-AS1 is associated with tumor recurrence in estrogen receptor-positive breast cancers. (PMID:32392629)
• LncRNA NR2F1-AS1 Regulates miR-371a-3p/TOB1 Axis to Suppress Proliferation of Colorectal Cancer Cells. (PMID:32407174)
• lncRNA NR2F1-AS1 promotes breast cancer angiogenesis through activating IGF-1/IGF-1R/ERK pathway. (PMID:32548873)
• Long noncoding RNA NR2F1AS1 facilitates the osteosarcoma cell malignant phenotype via the miR4855p/miR2185p/BIRC5 axis. (PMID:32945459)
• Long non-coding RNA NR2F1-AS1 promoted neuroblastoma progression through miR-493-5p/TRIM2 axis. (PMID:33378023)
• STAT3 activates the transcription of lncRNA NR2F1-AS1 to promote the progression of melanoma via regulating the miR-493-5p/GOLM1 axis. (PMID:33822440)
• Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and DeltaNp63. (PMID:34475402)
• The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis. (PMID:35082283)
• LncRNA nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) aggravates nucleus pulposus cell apoptosis and extracellular matrix degradation. (PMID:35094651)
• Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis. (PMID:35283481)
• A review on the role of NR2F1-AS1 in the development of cancer. (PMID:36410172)
• NR2F1-AS1: A Functional Long Noncoding RNA in Tumorigenesis. (PMID:36644870)
• Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis. (PMID:37575267)
• LncRNA NR2F1-AS1 as a potential biomarker for prognosis in cancer patients: meta and bioinformatics analysis. (PMID:37902251)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.