NR2F2-AS1

Summary

NR2F2-AS1 (NR2F2 antisense RNA 1, HGNC:44222) is a long non-coding RNA gene on chromosome 15q26.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44222
Approved symbol	NR2F2-AS1
Name	NR2F2 antisense RNA 1
Location	15q26.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000247809
Ensembl biotype	lncRNA
Entrez	644192
RNAcentral	URS00009B2465 — lncRNA, 4198 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 156 — 156 lncRNA

ENST00000502125, ENST00000557863, ENST00000558929, ENST00000558935, ENST00000559505, ENST00000560010, ENST00000560170, ENST00000560395, ENST00000560800, ENST00000561344, ENST00000561402, ENST00000616032, ENST00000616608, ENST00000616912, ENST00000618776, ENST00000620029, ENST00000624299, ENST00000656585, ENST00000661764, ENST00000690325, ENST00000692320, ENST00000693368, ENST00000700988, ENST00000701840, ENST00000742807, ENST00000742808, ENST00000742809, ENST00000742810, ENST00000742811, ENST00000743105, ENST00000743106, ENST00000743107, ENST00000743108, ENST00000743109, ENST00000743110, ENST00000743111, ENST00000743112, ENST00000743113, ENST00000743114, ENST00000743115, ENST00000743116, ENST00000743117, ENST00000743118, ENST00000743119, ENST00000743120, ENST00000743121, ENST00000743122, ENST00000743123, ENST00000743124, ENST00000743125, ENST00000743126, ENST00000743127, ENST00000743128, ENST00000743129, ENST00000743130, ENST00000743131, ENST00000743132, ENST00000743133, ENST00000743134, ENST00000743135, ENST00000743136, ENST00000743137, ENST00000743138, ENST00000743139, ENST00000743140, ENST00000743141, ENST00000743142, ENST00000743143, ENST00000743144, ENST00000743145, ENST00000743146, ENST00000743147, ENST00000743148, ENST00000743149, ENST00000743150, ENST00000743151, ENST00000743152, ENST00000743153, ENST00000743154, ENST00000743155, ENST00000743156, ENST00000743157, ENST00000743158, ENST00000743159, ENST00000743160, ENST00000743161, ENST00000743162, ENST00000743163, ENST00000743164, ENST00000743165, ENST00000743166, ENST00000743167, ENST00000743168, ENST00000743169, ENST00000743170, ENST00000743171, ENST00000743172, ENST00000743173, ENST00000743174, ENST00000743175, ENST00000743176, ENST00000743177, ENST00000743178, ENST00000743179, ENST00000743180, ENST00000743181, ENST00000743182, ENST00000743183, ENST00000743184, ENST00000743185, ENST00000743186, ENST00000743187, ENST00000743188, ENST00000743189, ENST00000743190, ENST00000743191, ENST00000743192, ENST00000743193, ENST00000743194, ENST00000743195, ENST00000743196, ENST00000743197, ENST00000743198, ENST00000743199, ENST00000743200, ENST00000743201, ENST00000743202, ENST00000743203, ENST00000743204, ENST00000743205, ENST00000743206, ENST00000743207, ENST00000743208, ENST00000743209, ENST00000743210, ENST00000743211, ENST00000743212, ENST00000743213, ENST00000743214, ENST00000743215, ENST00000743216, ENST00000743217, ENST00000743218, ENST00000743219, ENST00000743220, ENST00000743221, ENST00000743222, ENST00000743223, ENST00000743224, ENST00000743225, ENST00000743226, ENST00000743227, ENST00000743228, ENST00000743229, ENST00000743230, ENST00000743231

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000502125 — 6 exons

Exon	Start	End
ENSE00001963723	96271703	96271798
ENSE00001988220	96290630	96290783
ENSE00003981932	96282832	96282989
ENSE00004081327	96268760	96269996
ENSE00004081344	96327199	96327382
ENSE00004081369	96285326	96285459

Expression profiles

Bgee: expression breadth ubiquitous, 188 present calls, max score 97.96.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.3978 / max 78.0778, expressed in 1034 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
151709	1.6739	803
151708	0.4647	259
151700	0.3841	61
151707	0.3478	163
151706	0.2968	129
151712	0.1321	41
151710	0.0513	15
151711	0.0469	15

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.96	gold quality
left ovary	UBERON:0002119	94.90	gold quality
right ovary	UBERON:0002118	94.29	gold quality
tibial nerve	UBERON:0001323	92.15	gold quality
endocervix	UBERON:0000458	90.20	gold quality
calcaneal tendon	UBERON:0003701	90.11	gold quality
ovary	UBERON:0000992	89.30	gold quality
kidney epithelium	UBERON:0004819	89.14	silver quality
popliteal artery	UBERON:0002250	89.09	gold quality
tibial artery	UBERON:0007610	89.08	gold quality
metanephros cortex	UBERON:0010533	89.04	gold quality
body of uterus	UBERON:0009853	88.88	gold quality
left coronary artery	UBERON:0001626	87.85	gold quality
right coronary artery	UBERON:0001625	86.72	gold quality
coronary artery	UBERON:0001621	86.69	gold quality
stromal cell of endometrium	CL:0002255	86.46	gold quality
left uterine tube	UBERON:0001303	86.44	gold quality
uterine cervix	UBERON:0000002	86.23	gold quality
adrenal tissue	UBERON:0018303	86.09	gold quality
gall bladder	UBERON:0002110	85.88	gold quality
aorta	UBERON:0000947	85.68	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.62	gold quality
colonic epithelium	UBERON:0000397	85.50	gold quality
ectocervix	UBERON:0012249	85.40	gold quality
caput epididymis	UBERON:0004358	85.20	gold quality
metanephros	UBERON:0000081	85.19	gold quality
spleen	UBERON:0002106	85.00	gold quality
cauda epididymis	UBERON:0004360	84.28	gold quality
mucosa of stomach	UBERON:0001199	83.48	gold quality
stomach	UBERON:0000945	83.28	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-11268	yes	2355.29
E-CURD-119	yes	52.66
E-HCAD-35	yes	11.29
E-ANND-3	yes	10.61
E-HCAD-30	no	270.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Downregulation of NR2F2-AS1 induces G1 arrest of colorectal cancer cells by downregulating CDK6. (PMID:31432342)
• LncRNA NR2F2-AS1 positively regulates CDK4 to promote cancer cell proliferation in prostate carcinoma. (PMID:31566058)
• NR2F2-AS1 accelerates cell proliferation through regulating miR-4429/MBD1 axis in cervical cancer. (PMID:32469064)
• The miR-106b/NR2F2-AS1/PLEKHO2 Axis Regulates Migration and Invasion of Colorectal Cancer through the MAPK Pathway. (PMID:34070923)
• lncRNA NR2F2-AS1 inhibits the methylation of miR-494 to regulate oral squamous cell carcinoma cell proliferation. (PMID:34896865)
• Long non-coding RNA NR2F2-AS1: its expanding oncogenic roles in tumor progression. (PMID:35796938)
• Long non-coding RNA NR2F2-AS1 regulates human osteosarcoma growth and metastasis through miR-425-5p-mediated HMGB2. (PMID:36269529)
• LncRNA NR2F2-AS1 inhibits the progression of oral squamous cell carcinoma by mediating the miR-32-5p/SEMA3A axis. (PMID:39177014)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.