NR4A1AS

Summary

NR4A1AS (NR4A1 antisense RNA, HGNC:54409) is a long non-coding RNA gene on chromosome 12q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54409
Approved symbol	NR4A1AS
Name	NR4A1 antisense RNA
Location	12q13.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	NR4A1-AS1, RP11-1100L3.8, lncMMPA
Ensembl gene	ENSG00000259884
Ensembl biotype	lncRNA
Entrez	115409980
RNAcentral	URS0002123198 — lncRNA, 684 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000564363, ENST00000564531

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000564363 — 2 exons

Exon	Start	End
ENSE00002582680	52058750	52059033
ENSE00002589289	52059101	52059503

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 98.83.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of stomach	UBERON:0001199	98.83	gold quality
gall bladder	UBERON:0002110	98.01	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.73	gold quality
left ovary	UBERON:0002119	96.70	gold quality
left uterine tube	UBERON:0001303	96.57	gold quality
ovary	UBERON:0000992	96.46	gold quality
right ovary	UBERON:0002118	96.46	gold quality
tibial nerve	UBERON:0001323	96.01	gold quality
prostate gland	UBERON:0002367	94.63	gold quality
pituitary gland	UBERON:0000007	94.40	gold quality
adenohypophysis	UBERON:0002196	93.87	gold quality
omental fat pad	UBERON:0010414	93.44	gold quality
right atrium auricular region	UBERON:0006631	93.07	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.12	gold quality
rectum	UBERON:0001052	92.00	gold quality
smooth muscle tissue	UBERON:0001135	91.86	gold quality
tibial artery	UBERON:0007610	91.68	gold quality
popliteal artery	UBERON:0002250	91.64	gold quality
colonic epithelium	UBERON:0000397	91.44	gold quality
cortex of kidney	UBERON:0001225	90.71	gold quality
fallopian tube	UBERON:0003889	90.27	gold quality
ascending aorta	UBERON:0001496	89.07	gold quality
upper lobe of left lung	UBERON:0008952	88.38	gold quality
thoracic aorta	UBERON:0001515	88.30	gold quality
muscle tissue	UBERON:0002385	87.82	gold quality
left coronary artery	UBERON:0001626	87.67	gold quality
thyroid gland	UBERON:0002046	87.67	gold quality
bone marrow cell	CL:0002092	87.61	gold quality
urinary bladder	UBERON:0001255	87.58	gold quality
adipose tissue	UBERON:0001013	87.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• NR4A1AS up-regulates NR4A1 expression by forming RNA-RNA complexes and blocking UPF1-mediated mRNA destabilization, promoting tuumor growth and metastasis in colorectal cancer cells. (PMID:31253658)
• LncRNA RP11-1100L3.8 Involves in the Pathogenesis of Multiple Myeloma by Regulating NR4A1. (PMID:37024444)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.