NRAD1

Summary

NRAD1 (non-coding RNA in the aldehyde dehydrogenase 1A pathway, HGNC:26981) is a long non-coding RNA gene on chromosome 13q14.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26981
Approved symbol	NRAD1
Name	non-coding RNA in the aldehyde dehydrogenase 1A pathway
Location	13q14.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233725
Ensembl biotype	lncRNA
Entrez	121838
RNAcentral	URS000075AE17 — lncRNA, 2564 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000423211, ENST00000439707, ENST00000585327, ENST00000587571, ENST00000591799, ENST00000592085, ENST00000609808, ENST00000613822, ENST00000616953, ENST00000617476, ENST00000620454, ENST00000629019, ENST00000772210, ENST00000772211

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423211 — 2 exons

Exon	Start	End
ENSE00001759739	44028306	44029937
ENSE00001788064	44025319	44026894

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 88.41.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0462 / max 9.9255, expressed in 22 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134922	0.0192	9
134925	0.0142	6
134924	0.0128	5

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	88.41	gold quality
bone marrow	UBERON:0002371	79.80	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	75.98	gold quality
skeletal muscle tissue	UBERON:0001134	75.14	silver quality
fallopian tube	UBERON:0003889	74.54	gold quality
minor salivary gland	UBERON:0001830	72.63	gold quality
saliva-secreting gland	UBERON:0001044	71.91	gold quality
corpus callosum	UBERON:0002336	71.68	gold quality
endocervix	UBERON:0000458	71.55	gold quality
metanephros cortex	UBERON:0010533	71.52	gold quality
thymus	UBERON:0002370	71.50	silver quality
placenta	UBERON:0001987	71.44	gold quality
adult mammalian kidney	UBERON:0000082	71.20	gold quality
colonic epithelium	UBERON:0000397	70.82	gold quality
kidney	UBERON:0002113	70.65	gold quality
sural nerve	UBERON:0015488	68.61	gold quality
endometrium	UBERON:0001295	68.21	gold quality
islet of Langerhans	UBERON:0000006	65.97	gold quality
cortex of kidney	UBERON:0001225	65.70	gold quality
quadriceps femoris	UBERON:0001377	65.49	gold quality
cerebellar vermis	UBERON:0004720	64.61	gold quality
ganglionic eminence	UBERON:0004023	64.09	gold quality
uterine cervix	UBERON:0000002	63.82	gold quality
left uterine tube	UBERON:0001303	63.72	gold quality
prefrontal cortex	UBERON:0000451	62.60	gold quality
substantia nigra	UBERON:0002038	61.73	gold quality
lymph node	UBERON:0000029	60.92	gold quality
spinal cord	UBERON:0002240	60.42	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.39	gold quality
superior frontal gyrus	UBERON:0002661	60.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.72

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• ALDH1A3-regulated long non-coding RNA NRAD1 is a potential novel target for triple-negative breast tumors and cancer stem cells. (PMID:31197235)
• Construction and Investigation of an LINC00284-Associated Regulatory Network in Serous Ovarian Carcinoma. (PMID:32076467)
• lncRNA LINC00284 promotes nucleus pulposus cell proliferation and ECM synthesis via regulation of the miR2053p/Wnt/betacatenin axis. (PMID:35322864)
• Potential genetic biomarkers predict adverse pregnancy outcome during early and mid-pregnancy in women with systemic lupus erythematosus. (PMID:36465614)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.