NRAV

Summary

NRAV (negative regulator of antiviral response, HGNC:48588) is a long non-coding RNA gene on chromosome 12q24.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48588
Approved symbol	NRAV
Name	negative regulator of antiviral response
Location	12q24.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248008
Ensembl biotype	lncRNA
OMIM	616207
Entrez	100506668
RNAcentral	URS000075A220 — lncRNA, 1897 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000500741, ENST00000668253, ENST00000669580

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500741 — 2 exons

Exon	Start	End
ENSE00001966414	120490328	120492110
ENSE00001987064	120495823	120495940

Expression profiles

Bgee: expression breadth ubiquitous, 191 present calls, max score 95.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.0321 / max 150.2113, expressed in 1685 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133665	6.9517	1681
133664	0.0804	12

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.50	gold quality
right testis	UBERON:0004534	94.97	gold quality
bronchial epithelial cell	CL:0002328	92.87	gold quality
right uterine tube	UBERON:0001302	92.74	gold quality
testis	UBERON:0000473	92.52	gold quality
bronchus	UBERON:0002185	91.21	gold quality
buccal mucosa cell	CL:0002336	87.71	gold quality
adult organism	UBERON:0007023	86.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.93	gold quality
oviduct epithelium	UBERON:0004804	83.06	gold quality
sperm	CL:0000019	82.42	gold quality
fallopian tube	UBERON:0003889	81.44	gold quality
lower esophagus mucosa	UBERON:0035834	81.31	gold quality
islet of Langerhans	UBERON:0000006	81.28	gold quality
pancreatic ductal cell	CL:0002079	81.18	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.16	gold quality
prefrontal cortex	UBERON:0000451	80.62	gold quality
esophagus mucosa	UBERON:0002469	80.62	gold quality
mucosa of transverse colon	UBERON:0004991	79.53	gold quality
anterior cingulate cortex	UBERON:0009835	79.29	gold quality
ventricular zone	UBERON:0003053	79.12	gold quality
caudate nucleus	UBERON:0001873	78.95	gold quality
hypothalamus	UBERON:0001898	78.95	gold quality
nucleus accumbens	UBERON:0001882	78.88	gold quality
right frontal lobe	UBERON:0002810	78.73	gold quality
Brodmann (1909) area 9	UBERON:0013540	78.73	gold quality
adult mammalian kidney	UBERON:0000082	78.57	gold quality
mucosa of paranasal sinus	UBERON:0005030	78.02	silver quality
right lobe of thyroid gland	UBERON:0001119	77.69	gold quality
neocortex	UBERON:0001950	77.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p/Rab5c Axis To Regulate Vesicle Transportation. (PMID:32102886)
• Long non-coding RNA NRAV enhances proliferation and invasion of hepatocellular carcinoma cells by modulating the Wnt/beta-catenin signaling pathway. (PMID:35436415)
• Long non-coding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming. (PMID:37950445)
• Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients. (PMID:38184893)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.