NRG1-IT1

Summary

NRG1-IT1 (NRG1 intronic transcript 1, HGNC:43633) is a long non-coding RNA gene on chromosome 8p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43633
Approved symbol	NRG1-IT1
Name	NRG1 intronic transcript 1
Location	8p12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253974
Ensembl biotype	lncRNA
Entrez	100856811
RNAcentral	URS000075D4D3 — lncRNA, 601 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000520444, ENST00000521463, ENST00000523743, ENST00000523785, ENST00000656776, ENST00000840249, ENST00000840250, ENST00000840251, ENST00000840252, ENST00000840253

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000520444 — 4 exons

Exon	Start	End
ENSE00002102979	32029379	32029485
ENSE00002111788	32061686	32061833
ENSE00002115845	32026231	32026364
ENSE00002130405	32063104	32063472

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 87.73.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0364 / max 30.6738, expressed in 7 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
88353	0.0290	6
88352	0.0073	4

Top tissues by expression

208 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.73	gold quality
left testis	UBERON:0004533	87.62	gold quality
right testis	UBERON:0004534	87.37	gold quality
testis	UBERON:0000473	84.04	gold quality
colonic epithelium	UBERON:0000397	76.06	gold quality
cortical plate	UBERON:0005343	70.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	66.84	gold quality
ganglionic eminence	UBERON:0004023	66.12	gold quality
corpus callosum	UBERON:0002336	65.04	gold quality
buccal mucosa cell	CL:0002336	64.84	silver quality
bone marrow cell	CL:0002092	63.60	silver quality
monocyte	CL:0000576	62.93	gold quality
adrenal tissue	UBERON:0018303	59.71	gold quality
islet of Langerhans	UBERON:0000006	55.06	gold quality
adenohypophysis	UBERON:0002196	54.05	gold quality
gastrocnemius	UBERON:0001388	53.61	gold quality
cerebellar cortex	UBERON:0002129	52.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	52.74	gold quality
cerebellar hemisphere	UBERON:0002245	52.27	gold quality
adrenal gland	UBERON:0002369	52.27	gold quality
substantia nigra pars reticulata	UBERON:0001966	52.20	gold quality
pancreas	UBERON:0001264	51.87	gold quality
cerebellum	UBERON:0002037	51.84	gold quality
pituitary gland	UBERON:0000007	51.50	gold quality
stomach	UBERON:0000945	51.40	gold quality
right adrenal gland cortex	UBERON:0035827	50.32	gold quality
body of pancreas	UBERON:0001150	49.82	gold quality
prefrontal cortex	UBERON:0000451	49.50	gold quality
Brodmann (1909) area 9	UBERON:0013540	49.38	gold quality
body of stomach	UBERON:0001161	48.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.72

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.