NRG1-IT3

Summary

NRG1-IT3 (NRG1 intronic transcript 3, HGNC:43635) is a long non-coding RNA gene on chromosome 8p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43635
Approved symbol	NRG1-IT3
Name	NRG1 intronic transcript 3
Location	8p12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254049
Ensembl biotype	lncRNA
Entrez	100874286
RNAcentral	URS0000520DBB — lncRNA, 505 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000519023, ENST00000657615

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000519023 — 3 exons

Exon	Start	End
ENSE00002110397	32441226	32441436
ENSE00002120590	32442468	32442725
ENSE00002125143	32440746	32440781

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 67.89.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	67.89	silver quality
left testis	UBERON:0004533	66.37	gold quality
right testis	UBERON:0004534	66.07	gold quality
testis	UBERON:0000473	65.80	gold quality
adrenal tissue	UBERON:0018303	59.37	gold quality
multicellular organism	UBERON:0000468	56.72	gold quality
corpus callosum	UBERON:0002336	56.38	gold quality
blood	UBERON:0000178	54.88	gold quality
prefrontal cortex	UBERON:0000451	53.68	gold quality
monocyte	CL:0000576	53.13	gold quality
adrenal gland	UBERON:0002369	52.24	gold quality
primary visual cortex	UBERON:0002436	51.88	gold quality
heart	UBERON:0000948	51.87	silver quality
gastrocnemius	UBERON:0001388	48.42	gold quality
body of pancreas	UBERON:0001150	46.76	silver quality
tibial artery	UBERON:0007610	46.52	gold quality
cerebellar cortex	UBERON:0002129	46.29	silver quality
cerebellar hemisphere	UBERON:0002245	45.63	silver quality
Brodmann (1909) area 9	UBERON:0013540	44.85	gold quality
right hemisphere of cerebellum	UBERON:0014890	44.26	silver quality
intestine	UBERON:0000160	44.09	silver quality
right frontal lobe	UBERON:0002810	43.86	gold quality
spleen	UBERON:0002106	43.67	silver quality
subcutaneous adipose tissue	UBERON:0002190	43.61	gold quality
tibial nerve	UBERON:0001323	43.59	gold quality
nucleus accumbens	UBERON:0001882	43.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	42.61	gold quality
brain	UBERON:0000955	42.52	silver quality
stomach	UBERON:0000945	42.29	silver quality
ascending aorta	UBERON:0001496	42.21	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.