NRG3-AS1

Summary

NRG3-AS1 (NRG3 antisense RNA 1, HGNC:31429) is a long non-coding RNA gene on chromosome 10q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31429
Approved symbol	NRG3-AS1
Name	NRG3 antisense RNA 1
Location	10q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	Em:AC010157.1
Ensembl gene	ENSG00000225738
Ensembl biotype	lncRNA
Entrez	101929590
RNAcentral	URS000075BCE0 — lncRNA, 490 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 lncRNA, 1 retained_intron

ENST00000440589, ENST00000448936, ENST00000502725, ENST00000505481, ENST00000776230

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000440589 — 3 exons

Exon	Start	End
ENSE00001650568	82225399	82225525
ENSE00001768363	82224213	82224359
ENSE00002087967	82228927	82229179

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 73.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0132 / max 8.1195, expressed in 5 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110373	0.0132	5

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	73.24	gold quality
left testis	UBERON:0004533	70.14	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.09	gold quality
testis	UBERON:0000473	69.75	gold quality
monocyte	CL:0000576	68.58	gold quality
right testis	UBERON:0004534	68.24	gold quality
ganglionic eminence	UBERON:0004023	67.24	gold quality
tonsil	UBERON:0002372	66.69	gold quality
adenohypophysis	UBERON:0002196	63.31	gold quality
pituitary gland	UBERON:0000007	63.21	gold quality
liver	UBERON:0002107	59.63	gold quality
kidney	UBERON:0002113	58.68	gold quality
blood	UBERON:0000178	57.22	gold quality
cortex of kidney	UBERON:0001225	56.99	gold quality
prefrontal cortex	UBERON:0000451	54.93	gold quality
gall bladder	UBERON:0002110	54.53	gold quality
multicellular organism	UBERON:0000468	54.44	gold quality
superior frontal gyrus	UBERON:0002661	54.16	gold quality
thoracic mammary gland	UBERON:0005200	54.09	gold quality
islet of Langerhans	UBERON:0000006	54.07	gold quality
adrenal tissue	UBERON:0018303	53.60	gold quality
lung	UBERON:0002048	52.98	silver quality
lower esophagus mucosa	UBERON:0035834	52.57	gold quality
body of stomach	UBERON:0001161	51.54	gold quality
adult mammalian kidney	UBERON:0000082	51.12	gold quality
primary visual cortex	UBERON:0002436	50.99	gold quality
right lobe of thyroid gland	UBERON:0001119	50.37	gold quality
esophagus mucosa	UBERON:0002469	50.21	gold quality
brain	UBERON:0000955	49.64	gold quality
gastrocnemius	UBERON:0001388	49.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.29

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.