NRIR

Summary

NRIR (negative regulator of interferon response, HGNC:51269) is a long non-coding RNA gene on chromosome 2p25.2.

This gene is thought to produce a functional long non-coding RNA. This transcript may be a negative regulator of interferon response.

Source: NCBI Gene 104326052 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51269
Approved symbol	NRIR
Name	negative regulator of interferon response
Location	2p25.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lncRNA-CMPK2, lncCMPK2
Ensembl gene	ENSG00000225964
Ensembl biotype	lncRNA
OMIM	620418
Entrez	104326052
RNAcentral	URS00007E487C — lncRNA, 832 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000366140, ENST00000414795, ENST00000662953

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366140 — 3 exons

Exon	Start	End
ENSE00001661581	6833314	6833531
ENSE00001664478	6828514	6828955
ENSE00001698406	6829968	6830106

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 79.79.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.79	gold quality
monocyte	CL:0000576	76.46	gold quality
apex of heart	UBERON:0002098	76.31	gold quality
bone marrow	UBERON:0002371	76.10	gold quality
leukocyte	CL:0000738	75.89	gold quality
right uterine tube	UBERON:0001302	73.70	gold quality
granulocyte	CL:0000094	72.44	gold quality
blood	UBERON:0000178	71.58	gold quality
bone marrow cell	CL:0002092	70.97	gold quality
nucleus accumbens	UBERON:0001882	70.81	gold quality
right lung	UBERON:0002167	70.42	gold quality
left testis	UBERON:0004533	69.08	gold quality
testis	UBERON:0000473	68.78	gold quality
upper lobe of left lung	UBERON:0008952	68.74	gold quality
putamen	UBERON:0001874	68.57	gold quality
right testis	UBERON:0004534	68.30	gold quality
spleen	UBERON:0002106	68.25	gold quality
caudate nucleus	UBERON:0001873	68.13	gold quality
lung	UBERON:0002048	66.52	gold quality
hypothalamus	UBERON:0001898	66.23	gold quality
heart left ventricle	UBERON:0002084	66.04	gold quality
mucosa of transverse colon	UBERON:0004991	65.89	gold quality
adenohypophysis	UBERON:0002196	65.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.32	gold quality
pituitary gland	UBERON:0000007	65.31	gold quality
lymph node	UBERON:0000029	65.25	gold quality
gall bladder	UBERON:0002110	65.18	gold quality
duodenum	UBERON:0002114	65.17	gold quality
substantia nigra	UBERON:0002038	64.94	gold quality
primary visual cortex	UBERON:0002436	64.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• lncRNA-CMPK2 was strongly upregulated in a subset of HCV-infected human livers, suggesting a role in modulation of the IFN response in vivo. (PMID:25122750)
• Investigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever. (PMID:33064349)
• Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients. (PMID:38184893)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.