NRON

Summary

NRON (non-coding repressor of NFAT, HGNC:37079) is a non-coding RNA gene on chromosome 9q33.3.

Predicted to act upstream of or within negative regulation of dephosphorylation; regulation of calcineurin-NFAT signaling cascade; and regulation of cytokine production. Predicted to be part of ribonucleoprotein complex.

Source: NCBI Gene 641373 — RefSeq curated summary.

At a glance

• Gene type: non-coding (misc_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37079
Approved symbol	NRON
Name	non-coding repressor of NFAT
Location	9q33.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00194
Ensembl gene	ENSG00000253079
Ensembl biotype	misc_RNA
OMIM	609618
Entrez	641373
RNAcentral	URS000075EE86 — lncRNA, 2730 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 misc_RNA

ENST00000517270

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517270 — 1 exons

Exon	Start	End
ENSE00002089547	126408041	126408410

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 89.34.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.34	gold quality
corpus callosum	UBERON:0002336	76.41	gold quality
bone marrow cell	CL:0002092	71.80	silver quality
bone marrow	UBERON:0002371	70.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.42	gold quality
skeletal muscle tissue	UBERON:0001134	63.81	gold quality
myometrium	UBERON:0001296	60.18	silver quality
tonsil	UBERON:0002372	60.07	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	59.56	gold quality
placenta	UBERON:0001987	58.40	gold quality
primary visual cortex	UBERON:0002436	58.22	gold quality
muscle of leg	UBERON:0001383	57.39	gold quality
prefrontal cortex	UBERON:0000451	57.21	gold quality
gastrocnemius	UBERON:0001388	56.79	gold quality
monocyte	CL:0000576	56.64	gold quality
liver	UBERON:0002107	56.25	gold quality
blood	UBERON:0000178	55.72	gold quality
thoracic mammary gland	UBERON:0005200	55.06	gold quality
right lobe of liver	UBERON:0001114	54.90	gold quality
kidney	UBERON:0002113	53.55	gold quality
uterine cervix	UBERON:0000002	52.58	silver quality
stomach	UBERON:0000945	52.02	gold quality
heart left ventricle	UBERON:0002084	51.31	gold quality
adrenal gland	UBERON:0002369	50.77	gold quality
tibial artery	UBERON:0007610	50.50	gold quality
heart	UBERON:0000948	49.87	gold quality
left adrenal gland cortex	UBERON:0035825	49.01	gold quality
body of pancreas	UBERON:0001150	48.93	gold quality
adult mammalian kidney	UBERON:0000082	48.83	gold quality
body of stomach	UBERON:0001161	48.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• The effects of NRON on HIV-1 replication are shown to be mediated by NFAT, and the viral Nef and Vpu proteins to modulate NFAT activity through their effects on NRON. (PMID:25728138)
• NRON Long noncoding RNA potently suppresses the viral transcription by decreasing the cellular abundance of viral transactivator protein Tat. (PMID:27291871)
• elevation of circulating NRON and MHRT predicts heart failure (HF) and may be considered as novel biomarkers of HF. (PMID:28296001)
• LncNRON may function as a new HCC prognostic marker. (PMID:29772429)
• expression of an age-accumulated lncRNA (NRON) was decreased, whereas that of its immunity-related target gene (NFAT) was increased, in both CD28(null)CD8(+) T cells and CMVpp65CD8(+) T cells of elderly individuals with persistent cytomegalovirus infection (PMID:30415066)
• data indicated that NRON alleviates atrial fibrosis via promoting NFATc3 phosphorylation. (PMID:30895498)
• LncRNA snaR was up-regulated in triple-negative breast cancer tissues and was inversely correlated with NRON. . NRON overexpression inhibited cancer cell proliferation and down-regulated snaR. The snaR overexpression reduced the effects of NRON overexpression. (PMID:30996114)
• Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjogren’s Syndrome Patients. (PMID:34261974)
• LncRNA NRON negatively regulates cisplatin-induced cell apoptosis via downregulating miR-31 in esophageal squamous cell carcinomas. (PMID:35075603)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.