NRSN2-AS1

Summary

NRSN2-AS1 (NRSN2 antisense RNA 1, HGNC:51222) is a long non-coding RNA gene on chromosome 20p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51222
Approved symbol	NRSN2-AS1
Name	NRSN2 antisense RNA 1
Location	20p13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225377
Ensembl biotype	lncRNA
Entrez	100507459
RNAcentral	URS000075BD29 — lncRNA, 1394 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000414676, ENST00000442637, ENST00000657126, ENST00000662580, ENST00000736482, ENST00000736483, ENST00000736484, ENST00000736485, ENST00000736486, ENST00000736487, ENST00000736488, ENST00000736489

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414676 — 3 exons

Exon	Start	End
ENSE00001599125	319687	320781
ENSE00001722595	322378	322565
ENSE00004069921	325142	325301

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 81.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5912 / max 32.3279, expressed in 1200 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185965	1.6129	912
185964	0.8485	514
185967	0.1299	49

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	81.41	gold quality
heart left ventricle	UBERON:0002084	80.87	gold quality
right atrium auricular region	UBERON:0006631	80.50	gold quality
cardiac ventricle	UBERON:0002082	79.83	gold quality
rectum	UBERON:0001052	79.05	gold quality
cardiac atrium	UBERON:0002081	78.39	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.36	gold quality
sural nerve	UBERON:0015488	78.30	gold quality
heart	UBERON:0000948	77.85	gold quality
lower esophagus muscularis layer	UBERON:0035833	77.68	gold quality
lower esophagus	UBERON:0013473	77.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.55	gold quality
transverse colon	UBERON:0001157	77.52	gold quality
metanephros cortex	UBERON:0010533	77.40	gold quality
mucosa of transverse colon	UBERON:0004991	77.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	77.00	gold quality
left lobe of thyroid gland	UBERON:0001120	76.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.50	gold quality
tibial artery	UBERON:0007610	75.95	gold quality
popliteal artery	UBERON:0002250	75.94	gold quality
islet of Langerhans	UBERON:0000006	75.93	gold quality
right lobe of thyroid gland	UBERON:0001119	75.88	gold quality
body of stomach	UBERON:0001161	75.43	gold quality
thyroid gland	UBERON:0002046	75.42	gold quality
right adrenal gland cortex	UBERON:0035827	75.08	gold quality
right adrenal gland	UBERON:0001233	75.06	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.04	gold quality
smooth muscle tissue	UBERON:0001135	74.96	gold quality
left adrenal gland cortex	UBERON:0035825	74.92	gold quality
left adrenal gland	UBERON:0001234	74.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.36

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA NRSN2-AS1 facilitates tumorigenesis and progression of ovarian cancer via miR-744-5p/PRKX axis. (PMID:34791059)
• Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1. (PMID:35715622)
• Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/beta-catenin pathway. (PMID:37875515)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.