NRXN1-DT

Summary

NRXN1-DT (NRXN1 divergent transcript, HGNC:52686) is a long non-coding RNA gene on chromosome 2p16.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52686
Approved symbol	NRXN1-DT
Name	NRXN1 divergent transcript
Location	2p16.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	AK127244
Ensembl gene	ENSG00000231918
Ensembl biotype	lncRNA
Entrez	730100
RNAcentral	URS00001142E8 — lncRNA, 3939 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000440698, ENST00000779111, ENST00000779112, ENST00000779113, ENST00000779114, ENST00000843923

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000440698 — 11 exons

Exon	Start	End
ENSE00001602238	51861449	51861488
ENSE00001615025	51052357	51052454
ENSE00001623323	52316232	52316300
ENSE00001626400	51032601	51033016
ENSE00001628126	52406978	52407917
ENSE00001667520	52352874	52352962
ENSE00001674152	52349325	52351286
ENSE00001709174	51762089	51762174
ENSE00001737162	51328389	51328489
ENSE00001762821	51527602	51527660
ENSE00001788374	51378095	51378173

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 67.21.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	67.21	gold quality
ganglionic eminence	UBERON:0004023	57.61	gold quality
prefrontal cortex	UBERON:0000451	52.33	silver quality
monocyte	CL:0000576	49.65	silver quality
placenta	UBERON:0001987	45.91	silver quality
blood	UBERON:0000178	45.34	silver quality
islet of Langerhans	UBERON:0000006	45.06	silver quality
cerebral cortex	UBERON:0000956	44.66	gold quality
body of pancreas	UBERON:0001150	43.39	silver quality
amygdala	UBERON:0001876	42.84	silver quality
Ammon’s horn	UBERON:0001954	40.16	silver quality
corpus callosum	UBERON:0002336	38.93	silver quality
anterior cingulate cortex	UBERON:0009835	38.89	silver quality
caudate nucleus	UBERON:0001873	38.25	silver quality
nucleus accumbens	UBERON:0001882	38.11	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	37.85	silver quality
putamen	UBERON:0001874	36.98	silver quality
adenohypophysis	UBERON:0002196	35.56	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.91

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA LOC730100 is a competing endogenous RNA for miR-760 and promotes FOXA1 expression. miR-760 suppresses glioma progression by targeting FOXA1. (PMID:30914197)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.