NSA2

Summary

NSA2 (NSA2 ribosome biogenesis factor, HGNC:30728) is a protein-coding gene on chromosome 5q13.3, encoding Ribosome biogenesis protein NSA2 homolog (O95478). Involved in the biogenesis of the 60S ribosomal subunit. It is a common-essential gene (DepMap: required in 99.8% of cancer cell lines).

This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified.

Source: NCBI Gene 10412 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 33 total
• Cancer dependency (DepMap): dependent in 99.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_014886

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30728
Approved symbol	NSA2
Name	NSA2 ribosome biogenesis factor
Location	5q13.3
Locus type	gene with protein product
Status	Approved
Aliases	HUSSY-29, HCLG1, FLJ94393, TINP1
Ensembl gene	ENSG00000164346
Ensembl biotype	protein_coding
OMIM	612497
Entrez	10412

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000296802, ENST00000513356, ENST00000514918, ENST00000515524, ENST00000610426, ENST00000854645, ENST00000921903

RefSeq mRNA: 3 — MANE Select: NM_014886 NM_001271665, NM_001364506, NM_014886

CCDS: CCDS4025, CCDS75260

Canonical transcript exons

ENST00000610426 — 6 exons

Exon	Start	End
ENSE00001083715	74773868	74774060
ENSE00001083716	74767249	74767363
ENSE00003509721	74770631	74770810
ENSE00003594877	74768931	74769118
ENSE00003654377	74769214	74769364
ENSE00003713421	74776604	74780113

Expression profiles

Bgee: expression breadth ubiquitous, 300 present calls, max score 99.21.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 57.5079 / max 2238.1394, expressed in 1804 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57068	55.9605	1804
57069	1.4463	770
57067	0.1012	4

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	99.21	gold quality
parotid gland	UBERON:0001831	99.18	gold quality
upper leg skin	UBERON:0004262	99.03	gold quality
skin of hip	UBERON:0001554	98.96	gold quality
hair follicle	UBERON:0002073	98.85	gold quality
cervix squamous epithelium	UBERON:0006922	98.85	gold quality
tendon	UBERON:0000043	98.83	gold quality
gluteal muscle	UBERON:0002000	98.80	gold quality
germinal epithelium of ovary	UBERON:0001304	98.73	gold quality
parietal pleura	UBERON:0002400	98.72	gold quality
cauda epididymis	UBERON:0004360	98.61	gold quality
left ovary	UBERON:0002119	98.60	gold quality
seminal vesicle	UBERON:0000998	98.59	gold quality
superficial temporal artery	UBERON:0001614	98.55	gold quality
type B pancreatic cell	CL:0000169	98.54	gold quality
mucosa of sigmoid colon	UBERON:0004993	98.51	gold quality
ovary	UBERON:0000992	98.47	gold quality
pleura	UBERON:0000977	98.45	gold quality
corpus epididymis	UBERON:0004359	98.42	gold quality
tendon of biceps brachii	UBERON:0008188	98.39	gold quality
epithelium of nasopharynx	UBERON:0001951	98.38	gold quality
nasopharynx	UBERON:0001728	98.36	gold quality
caput epididymis	UBERON:0004358	98.33	gold quality
cortical plate	UBERON:0005343	98.33	gold quality
ganglionic eminence	UBERON:0004023	98.29	gold quality
biceps brachii	UBERON:0001507	98.27	gold quality
cartilage tissue	UBERON:0002418	98.27	gold quality
lymph node	UBERON:0000029	98.25	gold quality
colonic mucosa	UBERON:0000317	98.25	gold quality
palpebral conjunctiva	UBERON:0001812	98.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.31

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

26 targeting NSA2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-6515-3P	99.82	68.19	1933
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-6885-3P	99.75	70.36	3187
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-4687-3P	99.48	66.41	968
HSA-MIR-889-5P	99.41	68.75	1025
HSA-MIR-3678-3P	99.31	67.10	1432
HSA-MIR-1273H-3P	99.29	67.55	980
HSA-MIR-499A-3P	99.18	69.20	1392
HSA-MIR-499B-3P	99.18	69.27	1391
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-382-3P	98.83	67.10	1074
HSA-MIR-615-5P	98.10	63.76	591
HSA-MIR-1912-5P	97.94	67.98	832
HSA-MIR-3650	97.88	64.89	693
HSA-MIR-6502-3P	97.86	65.43	569
HSA-MIR-3654	96.43	66.55	646
HSA-MIR-7704	95.30	62.35	115

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 6)

• The yeast ortholog, Nsa2, is a pre-ribosomal factor that is essential for biogenesis of the large ribosomal subunit. (PMID:16861225)
• these results demonstrated that NSA2 is a nucleolar protein involved in cell proliferation and cell cycle regulation. (PMID:19932687)
• Data suggest that circulating NSA2 is elevated in diabetic nephropathy patients with albuminuria, and that renal and circulating NSA2 levels are increased in hyperglycemia in experimental models of diabetes. (PMID:22095236)
• NSA2, which increases in diabetic nephropathy, may be involved in the actions of TGFbeta1 and contribute to the development of diabetic nephropathy. (PMID:23220173)
• TINP1 promotes cell proliferation and significantly reduces p53 and p21 expression. (PMID:23912275)
• Findings indicate a function of Nop-7-associated 2 (NSA2) in the regulation of ribosome biogenesis. (PMID:30243719)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	nsa2	ENSDARG00000007708
mus_musculus	Nsa2	ENSMUSG00000060739
rattus_norvegicus	Nsa2	ENSRNOG00000016530
drosophila_melanogaster	Ip259	FBGN0025366
caenorhabditis_elegans	W09C5.1	WBGENE00012351

Protein

Protein identifiers

Ribosome biogenesis protein NSA2 homolog — O95478 (reviewed: O95478)

Alternative names: Hairy cell leukemia protein 1, TGF-beta-inducible nuclear protein 1

All UniProt accessions (4): A0A0A0MQZ6, O95478, H0YAI9, Q5J7U2

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.

Subunit / interactions. Component of the pre-66S ribosomal particle.

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.

RefSeq proteins (3): NP_001258594, NP_001351435, NP_055701* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR022309	Ribosomal_Se8/biogenesis_NSA2	Family
IPR039411	NSA2_fam	Family

Pfam: PF01201

UniProt features (7 total): chain 1, region of interest 1, short sequence motif 1, compositionally biased region 1, modified residue 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

28 structures.

PDB	Method	Resolution (Å)
8FKV	ELECTRON MICROSCOPY	2.47
8FKW	ELECTRON MICROSCOPY	2.5
8FL3	ELECTRON MICROSCOPY	2.53
8FL7	ELECTRON MICROSCOPY	2.55
8FKX	ELECTRON MICROSCOPY	2.59
8FL6	ELECTRON MICROSCOPY	2.62
8FKY	ELECTRON MICROSCOPY	2.67
8FL2	ELECTRON MICROSCOPY	2.67
8FL9	ELECTRON MICROSCOPY	2.75
8FKT	ELECTRON MICROSCOPY	2.81
8FKU	ELECTRON MICROSCOPY	2.82
8RL2	ELECTRON MICROSCOPY	2.84
8FKS	ELECTRON MICROSCOPY	2.88
8FKR	ELECTRON MICROSCOPY	2.89
8FL4	ELECTRON MICROSCOPY	2.89
8FL0	ELECTRON MICROSCOPY	2.91
8IDY	ELECTRON MICROSCOPY	3
8INF	ELECTRON MICROSCOPY	3
8FKZ	ELECTRON MICROSCOPY	3.04
9QIW	ELECTRON MICROSCOPY	3.04
8INE	ELECTRON MICROSCOPY	3.2
8INK	ELECTRON MICROSCOPY	3.2
8IPD	ELECTRON MICROSCOPY	3.2
8IPY	ELECTRON MICROSCOPY	3.2
8IE3	ELECTRON MICROSCOPY	3.3
8IR1	ELECTRON MICROSCOPY	3.3
8IR3	ELECTRON MICROSCOPY	3.5
8IPX	ELECTRON MICROSCOPY	4.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95478-F1	87.85	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 81, 80

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 178 (showing top): GOBP_RIBOSOME_BIOGENESIS, MODULE_151, PUJANA_CHEK2_PCC_NETWORK, GOBP_MATURATION_OF_LSU_RRNA, GNF2_FBL, SCHLOSSER_SERUM_RESPONSE_DN, GNF2_ST13, GOBP_MATURATION_OF_5_8S_RRNA, BURTON_ADIPOGENESIS_8, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, MODULE_114, GOCC_PRERIBOSOME, GOCC_PRERIBOSOME_LARGE_SUBUNIT_PRECURSOR, GOCC_NUCLEOLUS

GO Biological Process (5): maturation of 5.8S rRNA (GO:0000460), maturation of LSU-rRNA (GO:0000470), rRNA processing (GO:0006364), ribosome biogenesis (GO:0042254), ribosomal large subunit biogenesis (GO:0042273)

GO Molecular Function (1): RNA binding (GO:0003723)

GO Cellular Component (5): nucleolus (GO:0005730), preribosome, large subunit precursor (GO:0030687), nucleus (GO:0005634), preribosome (GO:0030684), ribonucleoprotein complex (GO:1990904)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
rRNA processing	2
ribosome biogenesis	2
ribonucleoprotein complex biogenesis	2
ribosomal large subunit biogenesis	1
RNA processing	1
rRNA metabolic process	1
nucleic acid binding	1
nuclear lumen	1
intracellular membraneless organelle	1
preribosome	1
intracellular membrane-bounded organelle	1
ribonucleoprotein complex	1
protein-containing complex	1

Protein interactions and networks

STRING

2576 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
NSA2	MRTO4	Q9UKD2	928
NSA2	RSL24D1	Q9UHA3	904
NSA2	GNL2	Q13823	904
NSA2	RPF2	Q9H7B2	900
NSA2	GTPBP4	Q9BZE4	892
NSA2	NMD3	Q96D46	840
NSA2	NUPR1	O60356	828
NSA2	WDR74	Q6RFH5	774
NSA2	WDR12	Q9GZL7	770
NSA2	MDN1	Q9NU22	769
NSA2	NIP7	Q9Y221	744
NSA2	PAK1IP1	Q9NWT1	744
NSA2	NOP53	Q9NZM5	719
NSA2	LSG1	Q9H089	706
NSA2	NOP2	P46087	691

IntAct

160 interactions, top by confidence:

A	B	Type	Score
SART3	PRPF4	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
RBM34	RRP8	psi-mi:“MI:0914”(association)	0.640
NSA2	GNL2	psi-mi:“MI:0914”(association)	0.640
RPL28	MAGEB2	psi-mi:“MI:0914”(association)	0.560
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
FGF3	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
ZCRB1	DKC1	psi-mi:“MI:0914”(association)	0.530
N	NOP56	psi-mi:“MI:0914”(association)	0.530
ATP6V1B2	ATP6V1G1	psi-mi:“MI:0914”(association)	0.530
SART3	NSA2	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
KRR1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
NHSL3	NCK2	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
RPL7A	NVL	psi-mi:“MI:0914”(association)	0.530

BioGRID (301): NSA2 (Affinity Capture-MS), NSA2 (Affinity Capture-MS), NSA2 (Affinity Capture-MS), NSA2 (Affinity Capture-MS), RPL26L1 (Affinity Capture-MS), NPM1 (Affinity Capture-MS), RRS1 (Affinity Capture-MS), PTCD3 (Affinity Capture-MS), PABPC4 (Affinity Capture-MS), MAGEA9B (Affinity Capture-MS), GNL2 (Affinity Capture-MS), GTPBP4 (Affinity Capture-MS), MRPS9 (Affinity Capture-MS), CCDC86 (Affinity Capture-MS), MRTO4 (Affinity Capture-MS)

ESM2 similar proteins: A9L994, B2XWK3, D0VWQ3, G1SKF7, G1TFE0, G1U7L1, O95478, P02412, P12001, P17702, P21533, P35980, P40590, P41098, P41105, P46779, P47911, P49205, P69090, P69091, Q02878, Q07020, Q08200, Q27S52, Q2MIA2, Q2MII9, Q2YGT9, Q3SX11, Q3T0L7, Q42351, Q4R5H8, Q4VZN5, Q58DQ3, Q5E973, Q6B860, Q6P1L8, Q6QMZ4, Q70Y05, Q7ZV96, Q7ZWJ7

Diamond homologs: A1CJS8, A1D7P0, A2BK08, A2STM4, A3CSQ2, A3LQ06, A5DCN7, A5DZE1, A6R3Q6, A6S4J2, A6ZR80, A7TIZ1, A8AAJ7, C5A4I6, O28130, O95478, P0CQ60, P0CQ61, P0CU36, P40078, P54055, P61301, Q0UV95, Q0W1L5, Q12UA1, Q1DQ27, Q3SX11, Q465V4, Q4JAP5, Q4P3S7, Q4WX36, Q54GN8, Q5A2Y7, Q5B954, Q6BU14, Q6C6D1, Q6CNC5, Q6FN72, Q6L0D3, Q75CG9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 180 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Peptide chain elongation	17	20.2×	8e-16
Viral mRNA Translation	17	20.2×	8e-16
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	17	19.9×	8e-16
Selenocysteine synthesis	17	19.1×	1e-15
Eukaryotic Translation Termination	17	19.1×	1e-15
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	17	18.7×	1e-15
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	17	18.7×	1e-15
Formation of a pool of free 40S subunits	17	17.8×	2e-15

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal large subunit biogenesis	8	21.6×	5e-07
cytoplasmic translation	18	20.3×	5e-16
negative regulation of viral genome replication	7	16.0×	3e-05
rRNA processing	17	14.7×	6e-13
translation	19	11.9×	6e-13
ribosomal small subunit biogenesis	8	11.1×	7e-05
regulation of alternative mRNA splicing, via spliceosome	6	8.9×	4e-03
RNA processing	6	8.0×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

33 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	24
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1147 predictions. Top by Δscore:

Variant	Effect	Δscore
5:74768921:A:AG	acceptor_gain	1.0000
5:74768922:T:G	acceptor_gain	1.0000
5:74768924:A:AG	acceptor_gain	1.0000
5:74768925:T:G	acceptor_gain	1.0000
5:74768927:A:AG	acceptor_gain	1.0000
5:74768928:T:G	acceptor_gain	1.0000
5:74768929:A:AG	acceptor_gain	1.0000
5:74768930:G:GT	acceptor_gain	1.0000
5:74768930:GC:G	acceptor_gain	1.0000
5:74768930:GCC:G	acceptor_gain	1.0000
5:74768930:GCCA:G	acceptor_gain	1.0000
5:74768930:GCCAC:G	acceptor_gain	1.0000
5:74769066:GC:G	donor_gain	1.0000
5:74769114:AAGAC:A	donor_gain	1.0000
5:74769115:AGAC:A	donor_gain	1.0000
5:74769116:GAC:G	donor_gain	1.0000
5:74769116:GACG:G	donor_gain	1.0000
5:74769117:AC:A	donor_gain	1.0000
5:74769117:ACGT:A	donor_loss	1.0000
5:74769119:G:GG	donor_gain	1.0000
5:74769208:T:TA	acceptor_gain	1.0000
5:74769209:G:A	acceptor_gain	1.0000
5:74769211:TAGT:T	acceptor_loss	1.0000
5:74769212:A:AG	acceptor_gain	1.0000
5:74769213:G:GA	acceptor_gain	1.0000
5:74769213:GT:G	acceptor_gain	1.0000
5:74769213:GTA:G	acceptor_gain	1.0000
5:74769213:GTAT:G	acceptor_gain	1.0000
5:74769213:GTATC:G	acceptor_gain	1.0000
5:74769318:C:G	donor_gain	1.0000

AlphaMissense

1693 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:74770637:T:A	W117R	1.000
5:74770637:T:C	W117R	1.000
5:74770639:G:C	W117C	1.000
5:74770639:G:T	W117C	1.000
5:74770724:T:A	W146R	1.000
5:74770724:T:C	W146R	1.000
5:74770732:A:C	R148S	1.000
5:74770732:A:T	R148S	1.000
5:74770750:C:G	C154W	1.000
5:74770766:T:C	F160L	1.000
5:74770768:T:A	F160L	1.000
5:74770768:T:G	F160L	1.000
5:74770773:G:C	R162T	1.000
5:74770774:A:C	R162S	1.000
5:74770774:A:T	R162S	1.000
5:74770803:G:C	R172T	1.000
5:74770803:G:T	R172M	1.000
5:74770804:G:C	R172S	1.000
5:74770804:G:T	R172S	1.000
5:74773893:T:A	V183E	1.000
5:74773908:T:C	L188P	1.000
5:74773951:T:A	N202K	1.000
5:74773951:T:G	N202K	1.000
5:74773979:G:C	G212R	1.000
5:74773994:G:C	G217R	1.000
5:74774001:T:A	V219D	1.000
5:74774027:G:C	G228R	1.000
5:74774057:T:A	W238R	1.000
5:74774057:T:C	W238R	1.000
5:74776613:C:A	A242D	1.000

dbSNP variants (sampled 300 via entrez): RS1000131685 (5:74776343 C>G,T), RS1000271888 (5:74770026 T>G), RS1000289844 (5:74770500 G>A), RS1000466285 (5:74776662 A>C), RS1000881640 (5:74779683 T>C), RS1001308169 (5:74776768 C>G), RS1001505663 (5:74779481 A>G), RS1001639739 (5:74777202 T>A), RS1002176320 (5:74776688 A>C,T), RS1002290871 (5:74778291 T>G), RS1002306825 (5:74769611 C>G,T), RS1002435323 (5:74772734 T>C), RS1002932186 (5:74778441 C>T), RS1002968590 (5:74775605 A>G), RS1003020113 (5:74772354 C>T)

Disease associations

OMIM: gene MIM:612497 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
dicrotophos	decreases expression	1
deoxynivalenol	increases expression	1
sodium arsenite	decreases expression	1
nivalenol	increases expression	1
chloropicrin	affects expression	1
K 7174	increases expression	1
ICG 001	decreases expression	1
picoxystrobin	decreases expression	1
Arsenic Trioxide	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	decreases phosphorylation	1
Hydrogen Peroxide	affects expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Aflatoxin B1	affects cotreatment, decreases expression	1
Gold Compounds	decreases expression	1
Antirheumatic Agents	increases expression	1
beta-Naphthoflavone	affects cotreatment, decreases expression, increases expression	1
Acrylamide	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.